Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | T-complex protein 1, beta subunit | 0.0024 | 0.0082 | 0.0132 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.006 | 0.0475 | 0.0475 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0214 | 0.0424 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0095 | 0.0865 | 0.1281 |
Loa Loa (eye worm) | hypothetical protein | 0.0354 | 0.3753 | 0.6006 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.106 | 0.16 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.106 | 0.1711 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0163 | 0.1621 | 0.2617 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0915 | 0.1363 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0036 | 0.0217 | 0.6136 |
Onchocerca volvulus | 0.0053 | 0.0407 | 0.014 | |
Plasmodium vivax | SET domain protein, putative | 0.006 | 0.0475 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0407 | 0.0532 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0049 | 0.0353 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.106 | 0.1711 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0053 | 0.0407 | 0.0532 |
Echinococcus granulosus | tar DNA binding protein | 0.0574 | 0.6195 | 0.8437 |
Trypanosoma brucei | glucosidase, putative | 0.0036 | 0.0214 | 0.2286 |
Trichomonas vaginalis | chaperonin, putative | 0.0024 | 0.0082 | 0.0162 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0036 | 0.0214 | 0.0424 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0233 | 0.2402 | 0.3271 |
Schistosoma mansoni | lamin | 0.0053 | 0.0407 | 0.0658 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0029 | 0.0131 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0396 | 0.0515 |
Plasmodium falciparum | T-complex protein 1 subunit beta | 0.0024 | 0.0082 | 0.2324 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0036 | 0.0217 | 0.6158 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.2402 | 0.3795 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0049 | 0.0353 | 0.2996 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0112 | 0.106 | 0.16 |
Schistosoma mansoni | kinase | 0.0051 | 0.0385 | 0.0621 |
Echinococcus granulosus | geminin | 0.0365 | 0.3873 | 0.5274 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0214 | 0.1549 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.006 | 0.0475 | 0.0766 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0353 | 0.0444 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0606 | 0.6121 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0214 | 0.0424 |
Plasmodium falciparum | glutathione reductase | 0.0048 | 0.0352 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.0938 | 0.1853 |
Mycobacterium tuberculosis | Probable reductase | 0.0111 | 0.1043 | 0.8837 |
Leishmania major | trypanothione reductase | 0.0048 | 0.0352 | 0.3756 |
Echinococcus multilocularis | tumor protein p63 | 0.0677 | 0.7342 | 0.7342 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0095 | 0.0865 | 0.1396 |
Brugia malayi | hypothetical protein | 0.0094 | 0.0862 | 0.1392 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0057 | 0.045 | 0.0613 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0123 | 0.118 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0217 | 0.0221 |
Echinococcus granulosus | GPCR family 2 | 0.0112 | 0.106 | 0.1444 |
Brugia malayi | Thioredoxin reductase | 0.0048 | 0.0352 | 0.0569 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0048 | 0.0352 | 0.0352 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0089 | 0.0012 |
Trypanosoma brucei | trypanothione reductase | 0.0048 | 0.0352 | 0.3756 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0101 | 0.0938 | 0.1514 |
Schistosoma mansoni | lamin | 0.0053 | 0.0407 | 0.0658 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0354 | 0.3753 | 0.6006 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0048 | 0.0352 | 0.3756 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.0195 | 0.1651 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0101 | 0.0938 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0125 | 0.12 | 0.1828 |
Brugia malayi | MH2 domain containing protein | 0.0125 | 0.12 | 0.1936 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0862 | 0.1277 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.0865 | 0.0865 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0111 | 0.1043 | 0.834 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0049 | 0.0353 | 0.3173 |
Trichomonas vaginalis | set domain proteins, putative | 0.0472 | 0.5062 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0048 | 0.0352 | 0.048 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0111 | 0.1043 | 0.8837 |
Treponema pallidum | NADH oxidase | 0.0017 | 0 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0415 | 0.4425 | 0.7143 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0123 | 0.118 | 1 |
Plasmodium vivax | T-complex protein 1 subunit beta, putative | 0.0024 | 0.0082 | 0.1725 |
Echinococcus multilocularis | musashi | 0.0053 | 0.0407 | 0.0407 |
Trichomonas vaginalis | CAMK family protein kinase | 0.005 | 0.037 | 0.0731 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0163 | 0.1621 | 0.2519 |
Echinococcus multilocularis | lamin dm0 | 0.0053 | 0.0407 | 0.0407 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0101 | 0.0938 | 1 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0036 | 0.0214 | 0.0214 |
Giardia lamblia | Kinase, PLK | 0.0101 | 0.0938 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0677 | 0.7342 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0053 | 0.0407 | 0.0658 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0217 | 0.0221 |
Onchocerca volvulus | 0.0094 | 0.0859 | 0.1097 | |
Brugia malayi | AMP-binding enzyme family protein | 0.0049 | 0.0353 | 0.0571 |
Leishmania major | T-complex protein 1, beta subunit, putative | 0.0024 | 0.0082 | 0.0873 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0606 | 0.0978 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.0938 | 0.1853 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.0865 | 0.1396 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.0195 | 0.1651 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0071 | 0.0606 | 0.0606 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.0865 | 0.1396 |
Brugia malayi | glutathione reductase | 0.0048 | 0.0352 | 0.0569 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.0865 | 0.1178 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0862 | 0.1277 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0163 | 0.1621 | 0.1621 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0214 | 0.0424 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0341 | 0.0551 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0049 | 0.0353 | 0.3769 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0214 | 0.2286 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0048 | 0.0352 | 0.0442 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0214 | 0.0424 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0341 | 0.0551 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0049 | 0.0353 | 0.3173 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0112 | 0.106 | 0.106 |
Brugia malayi | TAR-binding protein | 0.0574 | 0.6195 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.006 | 0.0475 | 0.0766 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0353 | 0.0444 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0217 | 0.0221 |
Echinococcus granulosus | intermediate filament protein | 0.0053 | 0.0407 | 0.0555 |
Toxoplasma gondii | t-complex protein beta subunit | 0.0024 | 0.0082 | 0.1725 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0036 | 0.0214 | 0.0292 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0606 | 0.6121 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0049 | 0.0353 | 1 |
Brugia malayi | intermediate filament protein | 0.0053 | 0.0407 | 0.0658 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0071 | 0.0606 | 0.0825 |
Echinococcus multilocularis | lamin | 0.0053 | 0.0407 | 0.0407 |
Onchocerca volvulus | 0.0099 | 0.0915 | 0.1216 | |
Brugia malayi | hypothetical protein | 0.0233 | 0.2402 | 0.3877 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.0195 | 0.1651 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0123 | 0.118 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0053 | 0.0407 | 0.0555 |
Echinococcus multilocularis | GPCR, family 2 | 0.0112 | 0.106 | 0.106 |
Giardia lamblia | TCP-1 chaperonin subunit beta | 0.0024 | 0.0082 | 0.0873 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0214 | 0.1549 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0 | 0.5 |
Trypanosoma brucei | polo-like protein kinase | 0.0101 | 0.0938 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.0865 | 0.1396 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0123 | 0.118 | 1 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0024 | 0.0082 | 0.0132 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0101 | 0.0938 | 0.0938 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.0938 | 0.1853 |
Toxoplasma gondii | thioredoxin reductase | 0.0048 | 0.0352 | 0.7421 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0101 | 0.0938 | 0.1264 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0242 | 0.2507 | 0.4046 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.006 | 0.0475 | 0.0766 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0112 | 0.106 | 0.1711 |
Loa Loa (eye worm) | glutathione reductase | 0.0048 | 0.0352 | 0.0442 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0415 | 0.4425 | 0.7105 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0101 | 0.0938 | 0.1514 |
Echinococcus granulosus | chaperonin containing TCP1 subunit 2 beta | 0.0024 | 0.0082 | 0.0112 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0354 | 0.3753 | 0.6059 |
Schistosoma mansoni | alpha-glucosidase | 0.014 | 0.137 | 0.2211 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0049 | 0.0353 | 1 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0024 | 0.0082 | 0.0132 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0036 | 0.0217 | 0.1838 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0111 | 0.1043 | 0.8837 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0048 | 0.0352 | 0.2985 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0214 | 0.0424 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0036 | 0.0214 | 0.0424 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0049 | 0.0353 | 1 |
Echinococcus multilocularis | chaperonin containing TCP1, subunit 2 (beta) | 0.0024 | 0.0082 | 0.0082 |
Schistosoma mansoni | tar DNA-binding protein | 0.0574 | 0.6195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.01 | 0.003 |
Echinococcus granulosus | lamin | 0.0053 | 0.0407 | 0.0555 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.0938 | 0.1853 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0049 | 0.0353 | 0.3769 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.0865 | 0.0865 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0125 | 0.12 | 0.1828 |
Mycobacterium ulcerans | hypothetical protein | 0.0049 | 0.0353 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0049 | 0.0353 | 0.0571 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0217 | 0.0221 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0049 | 0.0353 | 0.3173 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0217 | 0.0221 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0112 | 0.106 | 0.1711 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0089 | 0.0012 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.106 | 0.1711 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.006 | 0.0475 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.014 | 0.137 | 0.2211 |
Schistosoma mansoni | tar DNA-binding protein | 0.0574 | 0.6195 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0049 | 0.0353 | 0.0571 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.106 | 0.1711 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0163 | 0.1621 | 0.1621 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0112 | 0.106 | 0.106 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0026 | 0.01 | 0.0136 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0574 | 0.6195 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.006 | 0.0475 | 0.0475 |
Onchocerca volvulus | 0.006 | 0.0475 | 0.0283 | |
Brugia malayi | RNA binding protein | 0.0574 | 0.6195 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0029 | 0.0131 | 0.0212 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.006 | 0.0475 | 0.0766 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0111 | 0.1043 | 0.8837 |
Trypanosoma brucei | T-complex protein 1, beta subunit, putative | 0.0024 | 0.0082 | 0.0873 |
Trichomonas vaginalis | CAMK family protein kinase | 0.005 | 0.037 | 0.0731 |
Onchocerca volvulus | 0.0472 | 0.5062 | 1 | |
Trypanosoma cruzi | T-complex protein 1, beta subunit, putative | 0.0024 | 0.0082 | 0.0873 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.0938 | 0.1853 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0112 | 0.106 | 0.1444 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0233 | 0.2402 | 0.2402 |
Schistosoma mansoni | tar DNA-binding protein | 0.0574 | 0.6195 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.0938 | 0.1853 |
Schistosoma mansoni | hypothetical protein | 0.0242 | 0.2507 | 0.4046 |
Onchocerca volvulus | 0.0049 | 0.0353 | 0.0026 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0574 | 0.6195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0353 | 0.0444 |
Onchocerca volvulus | 0.0053 | 0.0407 | 0.014 | |
Brugia malayi | hypothetical protein | 0.0071 | 0.0606 | 0.0978 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0111 | 0.1043 | 0.8837 |
Trichomonas vaginalis | chaperonin-60kD, ch60, putative | 0.0024 | 0.0082 | 0.0162 |
Echinococcus multilocularis | geminin | 0.0365 | 0.3873 | 0.3873 |
Schistosoma mansoni | hypothetical protein | 0.0365 | 0.3873 | 0.6251 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0475 | 0.0643 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0163 | 0.1621 | 0.2208 |
Brugia malayi | Pre-SET motif family protein | 0.006 | 0.0475 | 0.0766 |
Schistosoma mansoni | alpha glucosidase | 0.0036 | 0.0214 | 0.0346 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.2507 | 0.3967 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0036 | 0.0214 | 0.0217 |
Loa Loa (eye worm) | intermediate filament protein | 0.0053 | 0.0407 | 0.0532 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0354 | 0.3753 | 0.6059 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0049 | 0.0353 | 0.2996 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0214 | 0.0424 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0049 | 0.0353 | 0.3769 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.0195 | 0.1651 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0214 | 0.0424 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0111 | 0.1043 | 0.8837 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0606 | 0.6121 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0036 | 0.0217 | 0.4569 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0049 | 0.0353 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0341 | 0.0551 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.0938 | 0.1853 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0214 | 0.4518 |
Schistosoma mansoni | hypothetical protein | 0.0365 | 0.3873 | 0.6251 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0606 | 0.6121 |
Schistosoma mansoni | intermediate filament proteins | 0.0053 | 0.0407 | 0.0658 |
Plasmodium vivax | glutathione reductase, putative | 0.0048 | 0.0352 | 0.7421 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.006 | 0.0475 | 0.0647 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0214 | 0.2286 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.0865 | 0.1178 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0024 | 0.0082 | 0.0132 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0101 | 0.0938 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0071 | 0.0606 | 0.0978 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0036 | 0.0214 | 0.2286 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0026 | 0.01 | 0.01 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0036 | 0.0217 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0574 | 0.6195 | 0.6195 |
Loa Loa (eye worm) | RNA binding protein | 0.0574 | 0.6195 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0574 | 0.6195 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0574 | 0.6195 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0048 | 0.0352 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0101 | 0.0938 | 0.1277 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0049 | 0.0353 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0099 | 0.0915 | 0.1477 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0036 | 0.0214 | 0.0346 |
Loa Loa (eye worm) | TAR-binding protein | 0.0574 | 0.6195 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0049 | 0.0353 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0112 | 0.106 | 0.1444 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0048 | 0.0352 | 0.7421 |
Schistosoma mansoni | eyes absent homolog | 0.0094 | 0.0862 | 0.1392 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0101 | 0.0938 | 0.14 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0101 | 0.0938 | 1 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0024 | 0.0082 | 0.0132 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 1.91 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 2.73 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 4.42 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 34 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 94 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 99 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 7.97 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -2 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 34 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 94 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 99 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.27 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.5342 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.