Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.1468 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.1468 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.1468 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.1468 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0356 | 0.0356 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.3746 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0356 | 0.0356 |
Echinococcus multilocularis | chromobox protein 1 | 0.0072 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.3746 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1468 | 0.1468 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.1468 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0.0356 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.1468 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0072 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0176 | 0.1199 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.1468 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.2751 | 0.2751 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.1468 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.1468 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0043 | 0.4867 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0072 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.1468 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.4317 | 0.2714 |
Brugia malayi | chromobox protein homolog 3 | 0.004 | 0.4317 | 0.4317 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.1468 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.3746 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0072 | 1 | 1 |
Schistosoma mansoni | chromobox protein | 0.0072 | 1 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0356 | 0.0356 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.1468 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0176 | 0.1199 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.3746 | 0.3746 |
Brugia malayi | hypothetical protein | 0.0037 | 0.3746 | 0.3746 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.1468 | 0.5 |
Echinococcus granulosus | chromobox protein 1 | 0.0072 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.3746 | 0.3746 |
Trichomonas vaginalis | chromobox protein, putative | 0.0043 | 0.4867 | 0.3419 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1468 | 0.1468 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.1468 | 0.1468 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.1468 | 0.1468 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.1468 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0176 | 0.1199 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0356 | 0.0356 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0176 | 0.1199 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.4317 | 0.2714 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.1468 | 0.1468 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1468 | 0.1468 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.004 | 0.4317 | 0.8381 |
Onchocerca volvulus | 0.0032 | 0.2751 | 0.3773 | |
Trichomonas vaginalis | chromobox protein, putative | 0.0043 | 0.4867 | 0.3419 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.3746 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0072 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.3746 | 0.3746 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0356 | 0.2422 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.3746 | 0.3746 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0.0356 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0356 | 0.0356 |
Trichomonas vaginalis | chromobox protein, putative | 0.0072 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.1468 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.4317 | 0.4317 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.0356 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0072 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 1 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 2.09 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 2.5 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 2.6 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 97 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 97 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 3.64 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -2 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 1 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 97 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 97 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 7.81 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.01545 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.