Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0329 | 1 |
Onchocerca volvulus | 0.0049 | 0.1122 | 1 | |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0329 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0367 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.3638 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0329 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0145 | 0.0398 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0329 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.0429 | 0.1266 | |
Brugia malayi | RNA recognition motif domain containing protein | 0.0129 | 0.3638 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0429 | 0.1181 |
Echinococcus multilocularis | tar DNA binding protein | 0.0129 | 0.3638 | 0.3638 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0429 | 0.0429 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0329 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1122 | 0.3084 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0367 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0129 | 0.3638 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0145 | 0.0398 |
Onchocerca volvulus | 0.0027 | 0.0429 | 0.1266 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0367 | 0.101 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0329 | 0.0793 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0429 | 0.1072 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0429 | 0.0429 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0145 | 0.139 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0329 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0329 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0129 | 0.3638 | 0.3638 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0095 | 0.0142 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0367 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0329 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0429 | 0.1181 |
Echinococcus multilocularis | tumor protein p63 | 0.0332 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.3638 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0329 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0329 | 0.0793 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0367 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0367 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0145 | 0.0398 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0329 | 0.0793 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0044 | 0.0121 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0329 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.3638 | 1 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0429 | 0.0429 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0367 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0329 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0367 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0329 | 1 |
Brugia malayi | TAR-binding protein | 0.0129 | 0.3638 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0367 | 0.0899 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0429 | 0.0429 |
Loa Loa (eye worm) | TAR-binding protein | 0.0129 | 0.3638 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0129 | 0.3638 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.3638 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0367 | 1 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0429 | 0.1072 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0145 | 0.0398 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0329 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0329 | 0.0905 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0329 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.1122 | 0.2158 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0414 | 0.1139 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0329 | 0.0905 |
Brugia malayi | RNA binding protein | 0.0129 | 0.3638 | 1 |
Echinococcus granulosus | lamin | 0.0027 | 0.0429 | 0.0429 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0429 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0145 | 0.0398 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0145 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.3638 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0429 | 0.1181 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0329 | 0.0905 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0329 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -0.85 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = -0.33 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = -0.11 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 1 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 1 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 98 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 0.76 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 0 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 1 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 1 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 98 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.47 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.34145 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.