Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.0845 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0845 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0015 | 0.0002 | 0.0002 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.164 | 0.164 |
Brugia malayi | TAR-binding protein | 0.0123 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0002 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.3053 | 0.3053 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.0845 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0845 | 0.0845 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.3053 | 0.3053 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.2684 | 0.2684 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2684 | 0.2684 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0845 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0845 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0123 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.0845 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.3053 | 0.3053 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.164 | 0.164 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0002 |
Echinococcus granulosus | tar DNA binding protein | 0.0123 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0845 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.2684 | 0.2684 |
Brugia malayi | Isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.2684 | 0.2684 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2684 | 0.2684 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.2684 | 0.2684 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0002 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.0845 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0002 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | RNA binding protein | 0.0123 | 1 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0015 | 0.0002 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.3053 | 0.3053 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0845 | 0.0845 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0045 | 0.0045 |
Brugia malayi | isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0002 |
Echinococcus multilocularis | tar DNA binding protein | 0.0123 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0123 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.2684 | 0.2684 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0123 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.2684 | 0.2684 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.164 | 0.164 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2684 | 0.2684 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 1.32 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 2 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 2.36 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 2.64 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 92 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 99 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 3.13 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -3 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 2 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 92 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 99 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.16 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.69921 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.