Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Acetylcholinesterase | Starlite/ChEMBL | No references |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0123 | 0.1193 | 0.1193 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.2991 | 0.2991 |
Plasmodium vivax | hypothetical protein, conserved | 0.0123 | 0.1193 | 0.5 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0123 | 0.1193 | 0.1193 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0041 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.2991 | 0.2991 |
Toxoplasma gondii | hypothetical protein | 0.0123 | 0.1193 | 0.5 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0123 | 0.1193 | 0.1193 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0123 | 0.1193 | 0.1193 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0123 | 0.1193 | 0.1193 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0123 | 0.1193 | 0.1193 |
Plasmodium falciparum | transporter, putative | 0.0123 | 0.1193 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1193 | 0.1193 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1193 | 0.1193 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0246 | 0.2991 | 0.2991 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0123 | 0.1193 | 0.1193 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.2991 | 0.2991 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1193 | 0.1193 |
Onchocerca volvulus | 0.0123 | 0.1193 | 0.1193 | |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0123 | 0.1193 | 0.5 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0123 | 0.1193 | 0.1193 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0041 | 0 | 0.5 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0123 | 0.1193 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.2991 | 0.2991 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0123 | 0.1193 | 0.1193 |
Toxoplasma gondii | hypothetical protein | 0.0123 | 0.1193 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0724 | 1 | 1 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0123 | 0.1193 | 0.1193 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0123 | 0.1193 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0123 | 0.1193 | 0.1193 |
Plasmodium falciparum | amino acid transporter, putative | 0.0123 | 0.1193 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0724 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0123 | 0.1193 | 0.1193 |
Onchocerca volvulus | 0.0123 | 0.1193 | 0.1193 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0246 | 0.2991 | 0.2991 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1193 | 0.1193 |
Onchocerca volvulus | 0.0724 | 1 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0246 | 0.2991 | 0.2991 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0123 | 0.1193 | 0.1193 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0123 | 0.1193 | 0.1193 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0123 | 0.1193 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1193 | 0.1193 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1193 | 0.1193 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0123 | 0.1193 | 0.1193 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0724 | 1 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0724 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.2991 | 0.2991 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0123 | 0.1193 | 0.1193 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0123 | 0.1193 | 0.1193 |
Echinococcus granulosus | carboxylesterase 5A | 0.0246 | 0.2991 | 0.2991 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.2991 | 0.2991 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0123 | 0.1193 | 0.1193 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0123 | 0.1193 | 0.1193 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0123 | 0.1193 | 0.1193 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0246 | 0.2991 | 0.2991 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0123 | 0.1193 | 0.1193 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0724 | 1 | 0.5 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0123 | 0.1193 | 0.1193 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.2991 | 0.2991 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1193 | 0.1193 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0123 | 0.1193 | 0.1193 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.2991 | 0.2991 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0123 | 0.1193 | 0.1193 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0123 | 0.1193 | 0.1193 |
Brugia malayi | hypothetical protein | 0.0123 | 0.1193 | 0.1193 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0724 | 1 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0724 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0724 | 1 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0724 | 1 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0724 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0041 | 0 | 0.5 |
Onchocerca volvulus | 0.0123 | 0.1193 | 0.1193 | |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0123 | 0.1193 | 0.1193 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0123 | 0.1193 | 0.1193 |
Plasmodium vivax | amine transporter, putative | 0.0123 | 0.1193 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0724 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0123 | 0.1193 | 0.1193 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Compound evaluated in vivo for reversing the scopolamine dementia dark avoidance (SDDA) in mice expressed number of active dosages versus the total number of dosages evaluated; 3/3 and active | ChEMBL. | No reference | |
Activity (functional) | 0 | Compound evaluated in vivo for reversing the scopolamine dementia dark avoidance (SDDA) in mice expressed number of active dosages versus the total number of dosages evaluated; 3/3 and active | ChEMBL. | No reference |
Dose (binding) | = 0.625 mg kg-1 | Dose required to exhibit robust maximal effect for acetylcholinesterase (AChE) inhibition following intraperitoneal administration | ChEMBL. | No reference |
Dose (binding) | = 0.625 mg kg-1 | Dose required to exhibit robust maximal effect for acetylcholinesterase (AChE) inhibition following intraperitoneal administration | ChEMBL. | No reference |
ED50 (binding) | = 8.3 mg kg-1 | Compound was evaluated ex vivo for the inhibition of acetylcholinesterase (AChEI) one hour after oral administration | ChEMBL. | No reference |
ED50 (binding) | = 8.3 mg kg-1 | Compound was evaluated ex vivo for the inhibition of acetylcholinesterase (AChEI) one hour after oral administration | ChEMBL. | No reference |
IC50 (binding) | = 100 nM | Inhibition of human AChE by Ellmans test | ChEMBL. | 20684567 |
IC50 (binding) | = 0.13 uM | Compound was evaluated in vitro in rats for the inhibition of brain (striatal) acetylcholinesterase (AChEI) using acetylthiocholine as substrate; 0.084-0.19 | ChEMBL. | No reference |
IC50 (binding) | = 0.13 uM | Compound was evaluated in vitro in rats for the inhibition of brain (striatal) acetylcholinesterase (AChEI) using acetylthiocholine as substrate; 0.084-0.19 | ChEMBL. | No reference |
IC50 (binding) | = 0.19 uM | Compound was evaluated in vitro for the inhibition of human serum Butyrylcholinesterase using butyrylthiocholine as substrate; 0.15-0.22 | ChEMBL. | No reference |
IC50 (binding) | = 0.19 uM | Compound was evaluated in vitro for the inhibition of human serum Butyrylcholinesterase using butyrylthiocholine as substrate; 0.15-0.22 | ChEMBL. | No reference |
Inhibition (binding) | = 0 % | Tested for percent ex vivo inhibition of rat striatal acetylcholinesterase at peroral dose of 10 mg/kg at 24 hr | ChEMBL. | No reference |
Inhibition (binding) | = 0 % | Tested for percent ex vivo inhibition of rat striatal acetylcholinesterase at peroral dose of 10 mg/kg at 24 hr | ChEMBL. | No reference |
Inhibition (binding) | = 3 % | Tested for percent ex vivo inhibition of rat striatal acetylcholinesterase at peroral dose of 10 mg/kg at 6 hr | ChEMBL. | No reference |
Inhibition (binding) | = 3 % | Tested for percent ex vivo inhibition of rat striatal acetylcholinesterase at peroral dose of 10 mg/kg at 6 hr | ChEMBL. | No reference |
Inhibition (binding) | = 20 % | Tested for percent ex vivo inhibition of rat striatal acetylcholinesterase at peroral dose of 20 mg/kg at 24 hr | ChEMBL. | No reference |
Inhibition (binding) | = 20 % | Tested for percent ex vivo inhibition of rat striatal acetylcholinesterase at peroral dose of 20 mg/kg at 24 hr | ChEMBL. | No reference |
Inhibition (binding) | = 56 % | Tested for percent ex vivo inhibition of rat striatal acetylcholinesterase at peroral dose of 10 mg/kg at 4 hr | ChEMBL. | No reference |
Inhibition (binding) | = 56 % | Tested for percent ex vivo inhibition of rat striatal acetylcholinesterase at peroral dose of 10 mg/kg at 4 hr | ChEMBL. | No reference |
Inhibition (binding) | = 67 % | Tested for percent ex vivo inhibition of rat striatal acetylcholinesterase at peroral dose of 10 mg/kg at 1 hr | ChEMBL. | No reference |
Inhibition (binding) | = 67 % | Tested for percent ex vivo inhibition of rat striatal acetylcholinesterase at peroral dose of 10 mg/kg at 1 hr | ChEMBL. | No reference |
Inhibition (binding) | = 82 % | Tested for percent ex vivo inhibition of rat striatal acetylcholinesterase at peroral dose of 20 mg/kg at 1 hr | ChEMBL. | No reference |
Inhibition (binding) | = 82 % | Tested for percent ex vivo inhibition of rat striatal acetylcholinesterase at peroral dose of 20 mg/kg at 6 hr | ChEMBL. | No reference |
Inhibition (binding) | = 82 % | Tested for percent ex vivo inhibition of rat striatal acetylcholinesterase at peroral dose of 20 mg/kg at 1 hr | ChEMBL. | No reference |
Inhibition (binding) | = 82 % | Tested for percent ex vivo inhibition of rat striatal acetylcholinesterase at peroral dose of 20 mg/kg at 6 hr | ChEMBL. | No reference |
Inhibition (binding) | = 84 % | Tested for percent ex vivo inhibition of rat striatal acetylcholinesterase at peroral dose of 20 mg/kg at 4 hr | ChEMBL. | No reference |
Inhibition (binding) | = 84 % | Tested for percent ex vivo inhibition of rat striatal acetylcholinesterase at peroral dose of 20 mg/kg at 4 hr | ChEMBL. | No reference |
Response (functional) | = 21 % | The percent of animals in the scopolamine-drug group with latencies greater than the cutoff time at subcutaneous dose of 0.1 mg/kg | ChEMBL. | No reference |
Response (functional) | = 21 % | The percent of animals in the scopolamine-drug group with latencies greater than the cutoff time at subcutaneous dose of 0.1 mg/kg | ChEMBL. | No reference |
Response (functional) | = 28 % | The percent of animals in the scopolamine-drug group with latencies greater than the cutoff time at subcutaneous dose of 0.3 mg/kg | ChEMBL. | No reference |
Response (functional) | = 28 % | The percent of animals in the scopolamine-drug group with latencies greater than the cutoff time at subcutaneous dose of 0.3 mg/kg | ChEMBL. | No reference |
Response (functional) | = 40 % | The percent of animals in the scopolamine-drug group with latencies greater than the cutoff time at subcutaneous dose of 0.03 mg/kg | ChEMBL. | No reference |
Response (functional) | = 40 % | The percent of animals in the scopolamine-drug group with latencies greater than the cutoff time at subcutaneous dose of 0.03 mg/kg | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.