Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Alpha-cholesterol (functional) | < 83.8 % | Hypolipidemic activity was assessed by measuring alphacholesterol in Sprague-Dawley male rats at 50 mg/kg | ChEMBL. | 6502593 |
Body weight (functional) | = 245 g | Hypolipidemic activity of the compound was assessed by measuring body weight in Sprague-Dawley male rats at 50 mg/kg | ChEMBL. | 6502593 |
Carnitine acetyl transferase (functional) | = 10 mg of protein | Hypolipidemic activity of the compound was assessed in Variation of the carnitine acetyl transferase was expressed as units per mg of protein in Sprague-Dawley male rats at 50 mg/kg | ChEMBL. | 6502593 |
Catalase (functional) | = 77 mg of protein | Hypolipidemic activity of the compound was assessed inVariation of the liver enzyme catalase was expressed as units per mg of protein in Sprague-Dawley male rats at 50 mg/kg | ChEMBL. | 6502593 |
Cholesterol (functional) | < 57.3 mg 100ml-1 | Hypolipidemic activity was assessed by measuring cholesterol in Sprague-Dawley male rats at 50 mg/kg | ChEMBL. | 6502593 |
Cholesterol (functional) | < 548.8 mg 100ml-1 | Hyperlipidemic activity of the compound was assessed by measuring cholesterol in Sprague-Dawley male rats at 50 mg/kg | ChEMBL. | 6502593 |
Enoyl-CoA hydratase (functional) | = 2.5 uM min-1mg-1 | Hypolipidemic activity of the compound was assessed inVariation of the enoyl-CoA oxide (micromol/min mg) in Sprague-Dawley male rats at 50 mg/kg | ChEMBL. | 6502593 |
LD50 (ADMET) | = 1085 mg kg-1 | Evaluated for the dose that causes 50 % lethality in Sprague-Dawley male rats | ChEMBL. | 6502593 |
Liver weight (functional) | = 4.5 g (100g of body weight)-1 | Hypolipidemic activity of the compound was assessed by measuring liver weight in Sprague-Dawley male rats at 50 mg/kg | ChEMBL. | 6502593 |
Liver weight (functional) | < 6.29 g 100g-1 | Hyperlipidemic activity of the compound was assessed by measuring liver weight in Sprague-Dawley male rats at 50 mg/kg | ChEMBL. | 6502593 |
Palmitoyl-CoA oxid (functional) | = 0.088 uM min-1mg-1 | Hypolipidemic activity of the compound was assessed inVariation of palmitoyl-CoA oxide (micromol/min mg) in Sprague-Dawley male rats at 50 mg/kg | ChEMBL. | 6502593 |
Triglycerides (functional) | < 67.3 M | Hypolipidemic activity was assessed by measuring triglycerides in Sprague-Dawley male rats at 50 mg/kg | ChEMBL. | 6502593 |
Triglycerides (functional) | < 215.6 mg 100ml-1 | Hyperlipidemic activity of the compound was assessed by measuring triglycerides in Sprague-Dawley male rats at 50 mg/kg | ChEMBL. | 6502593 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.