Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0082 | 0.0339 | 0.0339 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0216 | 0.2055 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0087 | 0.0404 | 0.2382 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.0082 | 0.0339 | 0.0239 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0072 | 0.0204 | 0.0884 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0072 | 0.0204 | 0.0884 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0157 | 0.1289 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0072 | 0.0204 | 0.0884 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1081 | 0.1548 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0072 | 0.0204 | 0.0204 |
Schistosoma mansoni | coup transcription factor | 0.0072 | 0.0204 | 0.0204 |
Schistosoma mansoni | nuclear hormone receptor | 0.0072 | 0.0204 | 0.0204 |
Onchocerca volvulus | Matrilysin homolog | 0.0188 | 0.1695 | 1 |
Schistosoma mansoni | pyruvate carboxylase | 0.0082 | 0.0339 | 0.0339 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0072 | 0.0204 | 0.0204 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0072 | 0.0204 | 0.0884 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0072 | 0.0204 | 0.0884 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0104 | 0.0619 | 0.0732 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0072 | 0.0204 | 0.0884 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0134 | 0.0999 | 1 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0082 | 0.0339 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0072 | 0.0204 | 0.0884 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0072 | 0.0204 | 0.0884 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.0209 | 0.1958 | 0.3097 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.014 | 0.1081 | 0.1081 |
Echinococcus granulosus | acetyl coenzyme A carboxylase 1 | 0.0216 | 0.2055 | 0.3269 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0072 | 0.0204 | 0.0204 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0216 | 0.2055 | 1 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.0209 | 0.1958 | 0.8475 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0072 | 0.0204 | 0.0884 |
Brugia malayi | nuclear receptor NHR-88 | 0.0072 | 0.0204 | 0.0884 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.0082 | 0.0339 | 0.0239 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.0082 | 0.0339 | 0.5 |
Onchocerca volvulus | 0.0072 | 0.0204 | 0.1204 | |
Mycobacterium ulcerans | pyruvate carboxylase | 0.0082 | 0.0339 | 0.5 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0514 | 0.5865 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0104 | 0.0619 | 0.0732 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0216 | 0.2055 | 0.3269 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0082 | 0.0339 | 0.0339 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0072 | 0.0204 | 0.0884 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0244 | 0.2411 | 0.3899 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0072 | 0.0204 | 0.0204 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0072 | 0.0204 | 0.1204 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0082 | 0.0339 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0072 | 0.0204 | 0.0884 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0514 | 0.5865 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0072 | 0.0204 | 0.0884 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0082 | 0.0339 | 0.5 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0157 | 0.1289 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.0619 | 0.0619 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0072 | 0.0204 | 0.0204 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0072 | 0.0204 | 0.1204 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0072 | 0.0204 | 0.0884 |
Loa Loa (eye worm) | matrixin family protein | 0.0196 | 0.1796 | 0.2813 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0072 | 0.0204 | 0.0204 |
Brugia malayi | Matrixin family protein | 0.0196 | 0.1796 | 0.7777 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0176 | 0.1539 | 0.2357 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0072 | 0.0204 | 0.0204 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.0082 | 0.0339 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.1539 | 0.1539 |
Chlamydia trachomatis | biotin carboxylase | 0.0075 | 0.0242 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0082 | 0.0339 | 0.5 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0514 | 0.5865 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0072 | 0.0204 | 0.0884 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0072 | 0.0204 | 0.0884 |
Loa Loa (eye worm) | matrixin family protein | 0.0087 | 0.0404 | 0.0353 |
Brugia malayi | ecdysteroid receptor | 0.0072 | 0.0204 | 0.0884 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0072 | 0.0204 | 0.1204 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0216 | 0.2055 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0072 | 0.0204 | 0.0204 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0072 | 0.0204 | 0.0204 |
Brugia malayi | nuclear hormone receptor | 0.0072 | 0.0204 | 0.0884 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.0082 | 0.0339 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.1539 | 0.1539 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0072 | 0.0204 | 0.0884 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0072 | 0.0204 | 0.0884 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0216 | 0.2055 | 0.2055 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0514 | 0.5865 | 0.5865 |
Brugia malayi | hypothetical protein | 0.0236 | 0.231 | 1 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0244 | 0.2411 | 0.3899 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0216 | 0.2055 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 6 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 7.95 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 8.43 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 8.52 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 23 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 94 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 2.19 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -4 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 6 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 23 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 94 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 5.98 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 1.04018 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.