TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 331.75 | Formula: C17H14ClNO4
H donors: 2 H acceptors: 3 LogP: 3.54 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)[C@@H]1Nc2c([C@H]1COC(=O)c1ccccc1)ccc(c2)Cl
InChi: 1S/C17H14ClNO4/c18-11-6-7-12-13(15(16(20)21)19-14(12)8-11)9-23-17(22)10-4-2-1-3-5-10/h1-8,13,15,19H,9H2,(H,20,21)/t13-,15-/m1/s1
InChiKey: NRSDKJSXWCVMIC-UKRRQHHQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	DNA polymerase IV	0.004	0.0434	0.4752
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprB	0.0019	0.0099	0.1083
Giardia lamblia	Thioredoxin reductase	0.0019	0.0099	0.1083
Schistosoma mansoni	glutamate synthase	0.0019	0.0099	0.0099
Echinococcus multilocularis	smad	0.0018	0.0093	0.0081
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0464	0.7097	0.8962
Brugia malayi	Thioredoxin reductase	0.0203	0.3002	0.7435
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.007	0.0913	0.304
Trypanosoma cruzi	2,4-dienoyl-coa reductase fadh1, putative	0.0019	0.0099	0.0329
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0017	0.007	0.0232
Loa Loa (eye worm)	hypothetical protein	0.009	0.1218	0.3016
Mycobacterium tuberculosis	Probable reductase	0.0464	0.7097	0.8962
Echinococcus granulosus	smad	0.0018	0.0093	0.0081
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.007	0.0913	0.304
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprA	0.0019	0.0099	0.1083
Leishmania major	NADH dehydrogenase, putative	0.0019	0.0099	0.0329
Trypanosoma brucei	hypothetical protein, conserved	0.0019	0.0099	0.0329
Trypanosoma brucei	NADH dehydrogenase	0.0019	0.0099	0.0329
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.007	0.0913	0.304
Echinococcus granulosus	flap endonuclease 1	0.0029	0.0257	0.0639
Trypanosoma brucei	NADPH:adrenodoxin oxidoreductase, mitochondrial, putative	0.0019	0.0099	0.0329
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0017	0.007	0.0232
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0434	0.1445
Mycobacterium leprae	Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate	0.0019	0.0099	0.0037
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.004	0.0434	0.0434
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.007	0.0913	0.0913
Trypanosoma brucei	trypanothione reductase	0.0203	0.3002	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1108	0.2743
Echinococcus granulosus	Smad4	0.0018	0.0093	0.0081
Echinococcus granulosus	apoptosis inducing factor 1 mitochondrial	0.0019	0.0099	0.01
Loa Loa (eye worm)	Smad1	0.0018	0.0093	0.0231
Trypanosoma cruzi	trypanothione reductase, putative	0.0203	0.3002	1
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.007	0.0913	1
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.004	0.0434	0.4115
Plasmodium falciparum	glutathione reductase	0.007	0.0913	0.304
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0464	0.7097	0.8962
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprA	0.0019	0.0099	0.1083
Mycobacterium leprae	Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE)	0.0019	0.0099	0.0037
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.004	0.0434	0.1445
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0515	0.7911	1
Mycobacterium tuberculosis	Possible dehydrogenase/reductase	0.0019	0.0099	0.0037
Trypanosoma brucei	DNA polymerase eta, putative	0.004	0.0434	0.1445
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0019	0.0099	0.01
Plasmodium vivax	flap endonuclease 1, putative	0.0029	0.0257	0.0856
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.007	0.0913	0.2875
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0017	0.007	0.0232
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0018	0.0093	0.0093
Mycobacterium ulcerans	oxidoreductase	0.0017	0.007	0.0762
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0083	0.1108	0.354
Brugia malayi	MH2 domain containing protein	0.0018	0.0093	0.0231
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0017	0.007	0.0232
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0029	0.0257	0.0856
Schistosoma mansoni	disulfide oxidoreductase	0.0019	0.0099	0.0099
Loa Loa (eye worm)	flap endonuclease-1	0.0029	0.0257	0.0636
Mycobacterium tuberculosis	Probable dehydrogenase	0.0464	0.7097	0.8962
Mycobacterium tuberculosis	Conserved hypothetical protein	0.004	0.0434	0.0464
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0515	0.7911	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.0203	0.3002	1
Brugia malayi	NADPH:adrenodoxin oxidoreductase, mitochondrial precursor	0.0019	0.0099	0.0245
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0434	0.1445
Trichomonas vaginalis	DNA polymerase eta, putative	0.004	0.0434	0.4115
Brugia malayi	hypothetical protein	0.0017	0.007	0.0172
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0434	0.1445
Brugia malayi	ImpB/MucB/SamB family protein	0.004	0.0434	0.1074
Mycobacterium leprae	THIOREDOXIN TRXC (TRX) (MPT46)	0.0019	0.0099	0.0037
Mycobacterium ulcerans	DNA polymerase IV	0.004	0.0434	0.4752
Brugia malayi	glutathione reductase	0.0203	0.3002	0.7435
Giardia lamblia	Glutamate synthase	0.0019	0.0099	0.1083
Echinococcus granulosus	NADPH:adrenodoxin oxidoreductase	0.0019	0.0099	0.01
Toxoplasma gondii	NADH dehydrogenase (NDH2-II)	0.0019	0.0099	0.0329
Trypanosoma brucei	2,4-dienoyl-coa reductase-like protein	0.0019	0.0099	0.0329
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0018	0.0093	0.0081
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0019	0.0099	0.0329
Mycobacterium ulcerans	thioredoxin reductase TrxB2	0.0019	0.0099	0.1083
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.007	0.0913	0.304
Loa Loa (eye worm)	programmed cell death 8	0.0019	0.0099	0.0245
Mycobacterium ulcerans	NADH dehydrogenase Ndh	0.0019	0.0099	0.1083
Loa Loa (eye worm)	hypothetical protein	0.0017	0.007	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0024	0.018	0.0445
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0029	0.0257	0.0856
Trypanosoma brucei	unspecified product	0.0028	0.0239	0.0795
Schistosoma mansoni	terminal deoxycytidyl transferase	0.004	0.0434	0.0434
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.007	0.0913	0.304
Brugia malayi	MH2 domain containing protein	0.0018	0.0093	0.0231
Mycobacterium tuberculosis	Probable thioredoxin reductase TrxB2 (TRXR) (TR)	0.0019	0.0099	0.0037
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0019	0.0099	0.0329
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0017	0.007	0.0232
Leishmania major	hypothetical protein, conserved	0.0019	0.0099	0.0329
Brugia malayi	MH2 domain containing protein	0.0269	0.4037	1
Plasmodium falciparum	thioredoxin reductase	0.0203	0.3002	1
Brugia malayi	MH1 domain containing protein	0.0018	0.0093	0.0231
Giardia lamblia	DINP protein human, muc B family	0.004	0.0434	0.4752
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.004	0.0434	0.1242
Echinococcus multilocularis	dna polymerase kappa	0.004	0.0434	0.1242
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0434	0.1445
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0434	0.1445
Brugia malayi	glutamate synthase	0.0019	0.0099	0.0245
Schistosoma mansoni	sulfide quinone reductase	0.0019	0.0099	0.0099
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.007	0.0913	0.304
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0018	0.0093	0.0081
Trypanosoma cruzi	2,4-dienoyl-coa reductase-like protein, putative	0.0019	0.0099	0.0329
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0434	0.1445
Brugia malayi	Smad1	0.0018	0.0093	0.0231
Mycobacterium tuberculosis	Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase)	0.0019	0.0099	0.0037
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0019	0.0099	0.01
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.007	0.0913	0.304
Echinococcus granulosus	dna polymerase kappa	0.004	0.0434	0.1242
Trichomonas vaginalis	mercuric reductase, putative	0.007	0.0913	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0434	0.1445
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0434	0.1445
Echinococcus multilocularis	Smad4	0.0018	0.0093	0.0081
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.007	0.0913	0.304
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0052	0.0619	0.1532
Toxoplasma gondii	selenide, water dikinase	0.0019	0.0099	0.0329
Plasmodium falciparum	type II NADH:ubiquinone oxidoreductase	0.0019	0.0099	0.0329
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.007	0.0913	0.304
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.007	0.0913	0.304
Leishmania major	trypanothione reductase	0.0203	0.3002	1
Mycobacterium ulcerans	dehydrogenase	0.0017	0.007	0.0762
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0083	0.1108	0.354
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0434	0.1445
Leishmania major	2,4-dienoyl-coa reductase fadh1, putative	0.0019	0.0099	0.0329
Mycobacterium ulcerans	NADH dehydrogenase Ndh1	0.0019	0.0099	0.1083
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0029	0.0257	0.0856
Leishmania major	UDP-galactopyranose mutase	0.0017	0.007	0.0232
Plasmodium falciparum	ferrodoxin reductase-like protein	0.0019	0.0099	0.0329
Echinococcus multilocularis	flap endonuclease 1	0.0029	0.0257	0.0639
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.007	0.0913	0.1075
Mycobacterium ulcerans	dehydrogenase	0.0019	0.0099	0.1083
Schistosoma mansoni	glutamate synthase	0.0019	0.0099	0.0099
Schistosoma mansoni	glutamate synthase	0.0019	0.0099	0.0099
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0464	0.7097	0.8962
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0434	0.1445
Loa Loa (eye worm)	pyridine nucleotide-disufhide oxidoreductase	0.0019	0.0099	0.0245
Schistosoma mansoni	flap endonuclease-1	0.0026	0.0213	0.0213
Trypanosoma cruzi	NADH dehydrogenase, putative	0.0019	0.0099	0.0329
Brugia malayi	ImpB/MucB/SamB family protein	0.004	0.0434	0.1074
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.007	0.0913	0.2875
Onchocerca volvulus		0.009	0.1218	1
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0018	0.0093	0.0081
Trypanosoma brucei	unspecified product	0.004	0.0434	0.1445
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0434	0.1445
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0017	0.007	0.0762
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0019	0.0099	0.01
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0434	0.1445
Plasmodium falciparum	thioredoxin reductase	0.007	0.0913	0.304
Echinococcus multilocularis	NADPH:adrenodoxin oxidoreductase	0.0019	0.0099	0.01
Trypanosoma brucei	pyridine nucleotide-disulphide oxidoreductase, putative	0.0019	0.0099	0.0329
Mycobacterium tuberculosis	NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase)	0.0019	0.0099	0.0037
Plasmodium vivax	ferrodoxin reductase, putative	0.0019	0.0099	0.0329
Schistosoma mansoni	amine oxidase	0.0017	0.007	0.007
Loa Loa (eye worm)	hypothetical protein	0.0017	0.007	0.0172
Loa Loa (eye worm)	MH2 domain-containing protein	0.0018	0.0093	0.0231
Trichomonas vaginalis	glutathione reductase, putative	0.007	0.0913	1
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0019	0.0099	0.0245
Mycobacterium leprae	PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE)	0.0019	0.0099	0.0037
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.007	0.0913	0.304
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.007	0.0913	0.304
Echinococcus granulosus	dna polymerase eta	0.004	0.0434	0.1242
Mycobacterium ulcerans	hypothetical protein	0.0019	0.0099	0.1083
Trypanosoma brucei	unspecified product	0.0028	0.0239	0.0795
Plasmodium vivax	hypothetical protein, conserved	0.0017	0.007	0.0232
Toxoplasma gondii	non-proton pumping type-II NADH dehydrogenase I	0.0019	0.0099	0.0329
Mycobacterium ulcerans	ferredoxin reductase	0.0019	0.0099	0.1083
Loa Loa (eye worm)	hypothetical protein	0.004	0.0434	0.1074
Echinococcus multilocularis	sulfide:quinone oxidoreductase	0.0019	0.0099	0.01
Mycobacterium tuberculosis	Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate	0.0019	0.0099	0.0037
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.007	0.0913	0.304
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0515	0.7911	1
Echinococcus multilocularis	apoptosis inducing factor 1 mitochondrial	0.0019	0.0099	0.01
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.007	0.0913	1
Loa Loa (eye worm)	glutathione reductase	0.0203	0.3002	0.7435
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0239	0.0795
Mycobacterium ulcerans	monoxygenase	0.0019	0.0099	0.1083
Echinococcus granulosus	sulfide:quinone oxidoreductase	0.0019	0.0099	0.01
Mycobacterium ulcerans	glutamate synthase subunit beta	0.0019	0.0099	0.1083
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.007	0.0913	0.304
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0017	0.007	0.0232
Plasmodium falciparum	NAD(P)H-dependent glutamate synthase, putative	0.0019	0.0099	0.0329
Plasmodium falciparum	protoporphyrinogen oxidase	0.0017	0.007	0.0232
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0099	0.0329
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0434	0.1445
Trypanosoma cruzi	pyridine nucleotide-disulphide oxidoreductase, putative	0.0019	0.0099	0.0329
Loa Loa (eye worm)	MH2 domain-containing protein	0.0269	0.4037	1
Mycobacterium ulcerans	NADPH dependent 2,4-dienoyl-CoA reductase FadH	0.0019	0.0099	0.1083
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0099	0.0245
Leishmania major	hypothetical protein, conserved	0.0019	0.0099	0.0329
Schistosoma mansoni	smad	0.0018	0.0093	0.0093
Treponema pallidum	NADH oxidase	0.007	0.0913	1
Trypanosoma cruzi	NADH dehydrogenase, putative	0.0019	0.0099	0.0329
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.007	0.0913	0.226
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0434	0.1445
Schistosoma mansoni	Smad4	0.0018	0.0093	0.0093
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.007	0.0913	0.304
Trichomonas vaginalis	flap endonuclease-1, putative	0.0029	0.0257	0.1941
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.007	0.0913	1
Plasmodium vivax	thioredoxin reductase, putative	0.0203	0.3002	1
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0017	0.007	0.007
Loa Loa (eye worm)	thioredoxin reductase	0.0203	0.3002	0.7435
Mycobacterium ulcerans	NADH dehydrogenase	0.0019	0.0099	0.1083
Echinococcus multilocularis	dna polymerase eta	0.004	0.0434	0.1242
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0099	0.0329
Mycobacterium ulcerans	monoamine oxidase	0.0017	0.007	0.0762
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.007	0.0913	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.007	0.0913	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.007	0.0913	0.304
Toxoplasma gondii	thioredoxin reductase	0.0203	0.3002	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0434	0.1445
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.007	0.0913	0.304
Brugia malayi	Flap endonuclease-1	0.0029	0.0257	0.0636
Plasmodium falciparum	glutathione reductase	0.0203	0.3002	1
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0017	0.007	0.0232
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0239	0.0795
Entamoeba histolytica	deoxycytidyl transferase, putative	0.004	0.0434	1
Plasmodium vivax	glutathione reductase, putative	0.0203	0.3002	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.007	0.0913	0.304
Plasmodium vivax	hypothetical protein, conserved	0.0017	0.007	0.0232
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0464	0.7097	0.8962
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0019	0.0099	0.01
Echinococcus multilocularis	glutamate synthase	0.0019	0.0099	0.01
Trypanosoma cruzi	pyridine nucleotide-disulphide oxidoreductase, putative	0.0019	0.0099	0.0329
Trypanosoma brucei	pyridine nucleotide-disulphide oxidoreductase, putative	0.0019	0.0099	0.0329
Schistosoma mansoni	sulfide quinone reductase	0.0019	0.0099	0.0099
Schistosoma mansoni	amine oxidase	0.0017	0.007	0.007
Leishmania major	2,4-dienoyl-coa reductase-like protein	0.0019	0.0099	0.0329
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0434	0.1445
Brugia malayi	SWIRM domain containing protein	0.009	0.1218	0.3016
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0203	0.3002	0.3739
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.004	0.0434	0.1074
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0464	0.7097	0.8962
Schistosoma mansoni	smad1 5 8 and	0.0018	0.0093	0.0093
Echinococcus granulosus	glutamate synthase	0.0019	0.0099	0.01
Leishmania major	hypothetical protein, conserved	0.0019	0.0099	0.0329
Schistosoma mansoni	smad1 5 8 and	0.0018	0.0093	0.0093
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.007	0.0913	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0515	0.7911	1
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.007	0.0913	0.304
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0029	0.0257	0.0856
Echinococcus granulosus	pyridine nucleotide disulfide oxidoreductase	0.0019	0.0099	0.01
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1108	0.2743
Leishmania major	DNA polymerase kappa, putative	0.004	0.0434	0.1445
Chlamydia trachomatis	thioredoxin reductase	0.0019	0.0099	0.0348
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0017	0.007	0.0762
Plasmodium falciparum	flap endonuclease 1	0.0029	0.0257	0.0856
Leishmania major	DNA polymerase eta, putative	0.004	0.0434	0.1445
Giardia lamblia	Glycerol-3-phosphate dehydrogenase	0.0019	0.0099	0.1083
Loa Loa (eye worm)	MH1 domain-containing protein	0.0018	0.0093	0.0231
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.004	0.0434	0.0464
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.007	0.0913	0.304
Trypanosoma cruzi	DNA polymerase eta, putative	0.004	0.0434	0.1445
Giardia lamblia	Flap structure-specific endonuclease	0.0029	0.0257	0.2814
Giardia lamblia	NADH oxidase lateral transfer candidate	0.007	0.0913	1
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0052	0.0619	0.1532
Loa Loa (eye worm)	transcription factor SMAD2	0.0269	0.4037	1
Plasmodium vivax	type II NADH:ubiquinone oxidoreductase, putative	0.0019	0.0099	0.0329
Trypanosoma cruzi	NADPH:adrenodoxin oxidoreductase, mitochondrial, putative	0.0019	0.0099	0.0329
Entamoeba histolytica	Flap nuclease, putative	0.0029	0.0257	0.4717
Toxoplasma gondii	histone lysine-specific demethylase	0.0017	0.007	0.0232
Mycobacterium tuberculosis	Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase)	0.0019	0.0099	0.0037
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0017	0.007	0.0762
Brugia malayi	MH1 domain containing protein	0.0018	0.0093	0.0231
Schistosoma mansoni	smad1 5 8 and	0.0018	0.0093	0.0093
Plasmodium vivax	NAD(P)H-dependent glutamate synthase, putative	0.0019	0.0099	0.0329
Trypanosoma cruzi	trypanothione reductase, putative	0.007	0.0913	0.304
Echinococcus multilocularis	pyridine nucleotide disulfide oxidoreductase	0.0019	0.0099	0.01
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0019	0.0099	0.0329
Echinococcus granulosus	mothers against decapentaplegic 5	0.0018	0.0093	0.0081
Brugia malayi	amine oxidase, flavin-containing family protein	0.0024	0.018	0.0445
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0083	0.1108	0.1108
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0239	0.0795
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0434	0.1445
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0203	0.3002	1
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0019	0.0099	0.0245
Toxoplasma gondii	NADPH-glutathione reductase	0.007	0.0913	0.304
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.007	0.0913	0.304
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.004	0.0434	0.1242
Schistosoma mansoni	DNA polymerase eta	0.004	0.0434	0.0434
Schistosoma mansoni	hypothetical protein	0.0019	0.0099	0.0099

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 100 uM	Inhibition of [3H]-L-689,560 binding to Glycine site of NMDA receptor of rat cortical membranes	ChEMBL.	No reference
IC50 (binding)	> 100 uM	Inhibition of [3H]-L-689,560 binding to Glycine site of NMDA receptor of rat cortical membranes	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 60471