Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Mus musculus | thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | methionine aminopeptidase 2 | 0.049 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0188 | 0.2723 | 0.2723 |
Trypanosoma brucei | methionine aminopeptidase 2, putative | 0.049 | 1 | 1 |
Entamoeba histolytica | methionine aminopeptidase, putative | 0.049 | 1 | 0.5 |
Plasmodium vivax | methionine aminopeptidase 2, putative | 0.049 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0188 | 0.2723 | 0.2723 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0185 | 0.2649 | 0.1076 |
Echinococcus multilocularis | sodium channel protein | 0.0464 | 0.9382 | 0.9382 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.2217 | 0.2217 |
Leishmania major | methionine aminopeptidase 2, putative | 0.049 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0188 | 0.2723 | 0.2723 |
Loa Loa (eye worm) | initiation factor 2-associated protein | 0.049 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.7573 | 0.7573 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0203 | 0.3076 | 0.3076 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.049 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0188 | 0.2723 | 0.2723 |
Onchocerca volvulus | Methionine aminopeptidase 2 homolog | 0.049 | 1 | 1 |
Schistosoma mansoni | methionyl aminopeptidase 2 (M24 family) | 0.049 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0185 | 0.2649 | 0.2649 |
Echinococcus granulosus | thymidylate synthase | 0.0389 | 0.7573 | 0.7573 |
Echinococcus multilocularis | thymidylate synthase | 0.0389 | 0.7573 | 0.7573 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0464 | 0.9382 | 0.9382 |
Loa Loa (eye worm) | thymidylate synthase | 0.0389 | 0.7573 | 0.7573 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.049 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0389 | 0.7573 | 0.5 |
Echinococcus granulosus | methionyl aminopeptidase 2 | 0.049 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0389 | 0.7573 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.049 | 1 | 1 |
Toxoplasma gondii | methionine aminopeptidase 2, putative | 0.049 | 1 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 2 | 0.049 | 1 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.049 | 1 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.049 | 1 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.049 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0203 | 0.3076 | 0.3076 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0464 | 0.9382 | 0.7454 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.7573 | 0.6699 |
Giardia lamblia | Methionine aminopeptidase | 0.049 | 1 | 0.5 |
Echinococcus granulosus | sodium channel protein | 0.0464 | 0.9382 | 0.9382 |
Brugia malayi | thymidylate synthase | 0.0389 | 0.7573 | 0.7573 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.049 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0389 | 0.7573 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.46 | Inhibition of thymidylate synthase | ChEMBL. | 20153089 |
IC50 (functional) | = 0.16 uM | In vitro inhibition of L1210 cell growth in culture. | ChEMBL. | 2033585 |
IC50 (functional) | = 0.16 uM | In vitro inhibition of L1210 cell growth in culture. | ChEMBL. | 2033585 |
IC50 (binding) | = 0.35 uM | In vitro inhibition of partially purified L1210 thymidylate synthase (TS). | ChEMBL. | 2033585 |
IC50 (binding) | = 0.35 uM | In vitro inhibition of partially purified L1210 thymidylate synthase (TS). | ChEMBL. | 2033585 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 2033585 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.