TDR Targets

Basic information

Technical information

TDR Targets ID: 604918
Name: 1-(4-ethylpiperazin-1-yl)-3-(4-methoxyphenoxy )propan-2-ol
MW: 294.389 | Formula: C16H26N2O3
H donors: 1 H acceptors: 1 LogP: 1.46 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCN1CCN(CC1)CC(COc1ccc(cc1)OC)O
InChi: 1S/C16H26N2O3/c1-3-17-8-10-18(11-9-17)12-14(19)13-21-16-6-4-15(20-2)5-7-16/h4-7,14,19H,3,8-13H2,1-2H3
InChiKey: IEXYZOVSQTYJSL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(4-ethyl-1-piperazinyl)-3-(4-methoxyphenoxy)propan-2-ol
Oprea1_447834
Oprea1_037920

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tubulin subunit gamma	0.0136442	0.422311	0.422311
Trypanosoma cruzi	alpha tubulin, putative	0.0190474	0.692802	0.681386
Brugia malayi	Tubulin beta chain	0.00772007	0.125737	0.125737
Echinococcus multilocularis	tubulin subunit TubB	0.0190474	0.692802	0.692802
Leishmania major	alpha tubulin	0.0190474	0.692802	0.681386
Trypanosoma brucei	alpha tubulin	0.0190474	0.692802	0.681386
Echinococcus multilocularis	tubulin alpha chain	0.0190474	0.692802	0.692802
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.00772007	0.125737	0.0932473
Loa Loa (eye worm)	hypothetical protein	0.0190474	0.692802	0.692802
Schistosoma mansoni	tyrosine kinase	0.0162995	0.555237	0.555237
Trichomonas vaginalis	tubulin beta chain, putative	0.0190474	0.692802	0.681386
Echinococcus multilocularis	Tubulin beta 2C chain	0.0251838	1	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0190474	0.692802	0.692802
Trypanosoma cruzi	tubulin gamma chain	0.0136442	0.422311	0.400842
Brugia malayi	Tubulin alpha-2 chain	0.0190474	0.692802	0.692802
Brugia malayi	tubulin alpha chain - mouse	0.0190474	0.692802	0.692802
Schistosoma mansoni	tubulin subunit beta	0.0251838	1	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0190474	0.692802	0.692802
Echinococcus multilocularis	hypothetical protein	0.0190474	0.692802	0.692802
Giardia lamblia	Beta tubulin	0.0251838	1	1
Schistosoma mansoni	tubulin subunit beta	0.00592416	0.0358307	0.0358307
Schistosoma mansoni	alpha tubulin	0.0190474	0.692802	0.692802
Loa Loa (eye worm)	tubulin alpha chain	0.0190474	0.692802	0.692802
Echinococcus multilocularis	tubulin alpha chain	0.0190474	0.692802	0.692802
Loa Loa (eye worm)	hypothetical protein	0.0113273	0.306322	0.306322
Leishmania major	beta tubulin	0.0251838	1	1
Trypanosoma brucei	beta tubulin	0.0251838	1	1
Trypanosoma cruzi	epsilon tubulin, putative	0.0136442	0.422311	0.400842
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0190474	0.692802	0.692802
Echinococcus granulosus	tubulin alpha 1C chain	0.0190474	0.692802	0.692802
Echinococcus granulosus	tubulin alpha chain	0.0190474	0.692802	0.692802
Leishmania major	beta tubulin	0.0251838	1	1
Mycobacterium tuberculosis	Cell division protein FtsZ	0.00592416	0.0358307	0.5
Echinococcus granulosus	Tubulin beta 2C chain	0.0251838	1	1
Loa Loa (eye worm)	tubulin alpha chain	0.0190474	0.692802	0.692802
Echinococcus granulosus	tubulin delta chain	0.00592416	0.0358307	0.0358307
Entamoeba histolytica	tubulin family protein	0.0251838	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0251838	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0251838	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.00772007	0.125737	0.0932473
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0251838	1	1
Leishmania major	beta tubulin	0.0251838	1	1
Loa Loa (eye worm)	hypothetical protein	0.00544827	0.0120066	0.0120066
Echinococcus granulosus	peroxisome assembly protein 26	0.0190474	0.692802	0.692802
Trichomonas vaginalis	tubulin beta chain, putative	0.0190474	0.692802	0.681386
Toxoplasma gondii	beta tubulin	0.0251838	1	1
Echinococcus granulosus	alpha tubulin	0.0190474	0.692802	0.692802
Trypanosoma brucei	alpha tubulin	0.0190474	0.692802	0.681386
Echinococcus granulosus	tubulin alpha 3 chain	0.0190474	0.692802	0.692802
Echinococcus granulosus	tubulin subunit beta	0.0251838	1	1
Echinococcus multilocularis	epidermal growth factor receptor	0.00875757	0.177676	0.177676
Leishmania major	beta tubulin	0.0251838	1	1
Schistosoma mansoni	tubulin subunit epsilon	0.0136442	0.422311	0.422311
Leishmania major	alpha tubulin	0.0190474	0.692802	0.681386
Trypanosoma brucei	tubulin gamma chain	0.0136442	0.422311	0.400842
Trypanosoma brucei	beta tubulin	0.0136442	0.422311	0.400842
Echinococcus granulosus	Tubulin beta 2C chain	0.0251838	1	1
Loa Loa (eye worm)	tubulin beta chain	0.00592416	0.0358307	0.0358307
Schistosoma mansoni	tubulin subunit beta	0.0251838	1	1
Schistosoma mansoni	tubulin subunit alpha	0.0190474	0.692802	0.692802
Trichomonas vaginalis	tubulin, putative	0.00772007	0.125737	0.0932473
Leishmania major	beta tubulin	0.0251838	1	1
Brugia malayi	Tubulin alpha chain	0.00592416	0.0358307	0.0358307
Trichomonas vaginalis	tubulin alpha chain, putative	0.00772007	0.125737	0.0932473
Trichomonas vaginalis	tubulin beta chain, putative	0.0190474	0.692802	0.681386
Echinococcus multilocularis	beta tubulin	0.0251838	1	1
Schistosoma mansoni	tyrosine kinase	0.00866518	0.17305	0.17305
Trichomonas vaginalis	tubulin alpha chain, putative	0.0251838	1	1
Leishmania major	alpha tubulin	0.0190474	0.692802	0.681386
Echinococcus granulosus	tubulin alpha 1C chain	0.0190474	0.692802	0.692802
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0190474	0.692802	0.681386
Leishmania major	beta tubulin	0.0251838	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0113273	0.306322	0.280544
Plasmodium falciparum	alpha tubulin 1	0.0190474	0.692802	0.681386
Echinococcus granulosus	tubulin subunit TubB	0.0190474	0.692802	0.692802
Schistosoma mansoni	tubulin subunit beta	0.0251838	1	1
Trypanosoma brucei	beta tubulin	0.0251838	1	1
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0251838	1	1
Trypanosoma brucei	alpha tubulin, putative	0.00772007	0.125737	0.0932473
Brugia malayi	Tubulin gamma chain	0.0136442	0.422311	0.422311
Leishmania major	beta tubulin	0.0251838	1	1
Toxoplasma gondii	beta-tubulin, putative	0.0251838	1	1
Trypanosoma brucei	beta tubulin	0.0251838	1	1
Loa Loa (eye worm)	tubulin beta-2A chain	0.0251838	1	1
Toxoplasma gondii	beta-1 tubulin, putative	0.0251838	1	1
Leishmania major	beta tubulin	0.0251838	1	1
Brugia malayi	beta-tubulin, identical	0.0251838	1	1
Mycobacterium ulcerans	cell division protein FtsZ	0.00592416	0.0358307	0.5
Schistosoma mansoni	tyrosine kinase	0.00866518	0.17305	0.17305
Leishmania major	beta tubulin	0.0251838	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0190474	0.692802	0.692802
Schistosoma mansoni	tyrosine kinase	0.00875757	0.177676	0.177676
Schistosoma mansoni	tubulin subunit alpha	0.0190474	0.692802	0.692802
Echinococcus granulosus	epidermal growth factor receptor	0.0162995	0.555237	0.555237
Echinococcus multilocularis	Tubulin beta 2C chain	0.0251838	1	1
Echinococcus multilocularis	tubulin beta 1 chain	0.0251838	1	1
Leishmania major	alpha tubulin	0.0190474	0.692802	0.681386
Plasmodium vivax	tubulin epsilon chain, putative	0.0136442	0.422311	0.400842
Schistosoma mansoni	tyrosine kinase	0.00875757	0.177676	0.177676
Leishmania major	alpha tubulin	0.0190474	0.692802	0.681386
Echinococcus multilocularis	tubulin alpha 3 chain	0.0190474	0.692802	0.692802
Loa Loa (eye worm)	beta-tubulin	0.0251838	1	1
Echinococcus multilocularis	tubulin alpha	0.0136442	0.422311	0.422311
Trypanosoma brucei	alpha tubulin	0.0190474	0.692802	0.681386
Loa Loa (eye worm)	tubulin alpha 2	0.00540316	0.0097485	0.0097485
Onchocerca volvulus		0.00772007	0.125737	0.5
Trypanosoma cruzi	beta tubulin, putative	0.0251838	1	1
Leishmania major	gamma-tubulin	0.0136442	0.422311	0.400842
Entamoeba histolytica	tubulin alpha-1 chain	0.0190474	0.692802	0.46823
Echinococcus granulosus	Tubulin alpha 1 chain	0.0190474	0.692802	0.692802
Plasmodium falciparum	alpha tubulin 2	0.0190474	0.692802	0.681386
Brugia malayi	Cell division protein ftsZ	0.00592416	0.0358307	0.0358307
Giardia lamblia	Alpha-tubulin	0.0190474	0.692802	0.681386
Plasmodium vivax	tubulin alpha chain, putative	0.0190474	0.692802	0.681386
Echinococcus granulosus	tubulin beta 1 chain	0.0251838	1	1
Schistosoma mansoni	alpha tubulin	0.0190474	0.692802	0.692802
Trichomonas vaginalis	tubulin gamma chain, putative	0.0136442	0.422311	0.400842
Echinococcus granulosus	Tubulin beta 2C chain	0.0251838	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0131232	0.396228	0.373791
Loa Loa (eye worm)	tubulin beta chain	0.0251838	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.00772007	0.125737	0.0932473
Echinococcus multilocularis	Tubulin beta 2C chain	0.0251838	1	1
Giardia lamblia	Alpha-tubulin	0.0190474	0.692802	0.681386
Plasmodium falciparum	tubulin epsilon chain, putative	0.0136442	0.422311	0.400842
Brugia malayi	Tubulin beta chain	0.00592416	0.0358307	0.0358307
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0190474	0.692802	0.692802
Plasmodium vivax	tubulin alpha chain, putative	0.0190474	0.692802	0.681386
Leishmania major	alpha tubulin	0.0190474	0.692802	0.681386
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0190474	0.692802	0.681386
Brugia malayi	alpha-tubulin	0.0190474	0.692802	0.692802
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.00875757	0.177676	0.177676
Trichomonas vaginalis	tubulin beta chain, putative	0.0190474	0.692802	0.681386
Echinococcus multilocularis	tubulin subunit beta	0.0251838	1	1
Treponema pallidum	cell division protein FtsZ	0.00592416	0.0358307	0.5
Loa Loa (eye worm)	BEN-1 protein	0.0251838	1	1
Giardia lamblia	Beta tubulin	0.0251838	1	1
Schistosoma mansoni	tubulin subunit delta	0.00592416	0.0358307	0.0358307
Leishmania major	beta tubulin	0.0251838	1	1
Echinococcus granulosus	tubulin alpha chain	0.0190474	0.692802	0.692802
Loa Loa (eye worm)	alpha-tubulin	0.0190474	0.692802	0.692802
Echinococcus multilocularis	tubulin gamma 1 chain	0.0136442	0.422311	0.422311
Brugia malayi	Calcitonin receptor-like protein seb-1	0.00544827	0.0120066	0.0120066
Echinococcus granulosus	beta tubulin	0.0251838	1	1
Plasmodium vivax	tubulin gamma chain, putative	0.0136442	0.422311	0.400842
Loa Loa (eye worm)	alpha-tubulin	0.0190474	0.692802	0.692802
Entamoeba histolytica	tubulin family protein	0.0251838	1	1
Echinococcus granulosus	tubulin gamma 1 chain	0.0136442	0.422311	0.422311
Echinococcus multilocularis	peroxisome assembly protein 26	0.0190474	0.692802	0.692802
Echinococcus multilocularis	tubulin delta chain	0.00592416	0.0358307	0.0358307
Loa Loa (eye worm)	hypothetical protein	0.0131232	0.396228	0.396228
Echinococcus multilocularis	tubulin alpha chain	0.0190474	0.692802	0.692802
Echinococcus granulosus	tubulin epsilon chain	0.0136442	0.422311	0.422311
Leishmania major	alpha tubulin	0.0190474	0.692802	0.681386
Trypanosoma brucei	alpha tubulin	0.0190474	0.692802	0.681386
Leishmania major	alpha tubulin	0.0190474	0.692802	0.681386
Leishmania major	alpha tubulin	0.0190474	0.692802	0.681386
Schistosoma mansoni	tyrosine kinase	0.00866518	0.17305	0.17305
Plasmodium falciparum	tubulin beta chain	0.0251838	1	1
Leishmania major	beta tubulin	0.0251838	1	1
Leishmania major	beta tubulin	0.0251838	1	1
Giardia lamblia	Beta tubulin	0.0251838	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0251838	1	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.0251838	1	1
Brugia malayi	Tubulin alpha-2 chain	0.0190474	0.692802	0.692802
Loa Loa (eye worm)	tubulin alpha 2	0.0131232	0.396228	0.396228
Schistosoma mansoni	tubulin subunit beta	0.0251838	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0251838	1	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0162995	0.555237	0.555237
Trichomonas vaginalis	tubulin, putative	0.0251838	1	1
Schistosoma mansoni	tubulin subunit alpha	0.00592416	0.0358307	0.0358307
Trichomonas vaginalis	tubulin beta chain, putative	0.0190474	0.692802	0.681386
Echinococcus granulosus	epidermal growth factor receptor	0.00875757	0.177676	0.177676
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.00544827	0.0120066	0.0120066
Echinococcus granulosus	Tubulin alpha 1 chain	0.0190474	0.692802	0.692802
Trichomonas vaginalis	tubulin, putative	0.00772007	0.125737	0.0932473
Brugia malayi	Tubulin alpha chain	0.0190474	0.692802	0.692802
Leishmania major	beta tubulin	0.0251838	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0251838	1	1
Echinococcus granulosus	tubulin alpha chain	0.0190474	0.692802	0.692802
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0190474	0.692802	0.692802
Echinococcus granulosus	tubulin beta 4A class IVa	0.0251838	1	1
Toxoplasma gondii	alpha-tubulin I, putative	0.0190474	0.692802	0.681386
Leishmania major	alpha tubulin	0.0190474	0.692802	0.681386
Brugia malayi	tubulin alpha-2 chain	0.0190474	0.692802	0.692802
Leishmania major	alpha tubulin	0.0190474	0.692802	0.681386
Giardia lamblia	Gamma tubulin	0.0136442	0.422311	0.400842
Schistosoma mansoni	tubulin subunit beta	0.0251838	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0136442	0.422311	0.400842
Leishmania major	epsilon tubulin, putative	0.0136442	0.422311	0.400842
Loa Loa (eye worm)	tubulin beta-1 chain	0.0251838	1	1
Trypanosoma cruzi	epsilon tubulin, putative	0.0136442	0.422311	0.400842
Loa Loa (eye worm)	tubulin gamma chain	0.0136442	0.422311	0.422311
Echinococcus multilocularis	tubulin alpha 1C chain	0.0190474	0.692802	0.692802
Trichomonas vaginalis	tubulin beta chain, putative	0.0190474	0.692802	0.681386
Trypanosoma brucei	beta tubulin	0.0251838	1	1
Echinococcus granulosus	tubulin alpha chain	0.0190474	0.692802	0.692802
Echinococcus multilocularis	tubulin epsilon chain	0.0136442	0.422311	0.422311
Leishmania major	beta tubulin	0.0251838	1	1
Echinococcus granulosus	tubulin alpha	0.0136442	0.422311	0.422311
Leishmania major	beta tubulin	0.0251838	1	1
Plasmodium falciparum	tubulin gamma chain	0.0136442	0.422311	0.400842
Toxoplasma gondii	alpha tubulin TUBA1	0.0190474	0.692802	0.681386
Echinococcus multilocularis	beta tubulin	0.0251838	1	1
Plasmodium vivax	tubulin beta chain, putative	0.0251838	1	1
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.00592416	0.0358307	0.5
Schistosoma mansoni	alpha tubulin	0.0190474	0.692802	0.692802
Schistosoma mansoni	tubulin subunit beta	0.0251838	1	1
Loa Loa (eye worm)	tubulin alpha 2	0.0131232	0.396228	0.396228
Echinococcus multilocularis	tubulin alpha 3 chain	0.0190474	0.692802	0.692802
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.00544827	0.0120066	0.0120066
Echinococcus multilocularis	epidermal growth factor receptor	0.0162995	0.555237	0.555237
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0131232	0.396228	0.396228
Schistosoma mansoni	tubulin subunit alpha	0.0190474	0.692802	0.692802
Echinococcus granulosus	beta tubulin	0.0251838	1	1
Brugia malayi	Tubulin beta-1 chain	0.0251838	1	1
Loa Loa (eye worm)	BEN-1 protein	0.0251838	1	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0190474	0.692802	0.692802
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0136442	0.422311	0.400842
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0251838	1	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0190474	0.692802	0.692802
Mycobacterium leprae	cell division protein FtsZ	0.00592416	0.0358307	0.5
Leishmania major	beta tubulin	0.0251838	1	1
Leishmania major	alpha tubulin	0.0190474	0.692802	0.681386
Trypanosoma brucei	epsilon tubulin	0.0136442	0.422311	0.400842
Trichomonas vaginalis	tubulin beta chain, putative	0.00772007	0.125737	0.0932473
Leishmania major	beta tubulin	0.0251838	1	1
Leishmania major	beta tubulin	0.0251838	1	1
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0113273	0.306322	0.306322
Echinococcus multilocularis	tubulin alpha chain	0.0190474	0.692802	0.692802
Entamoeba histolytica	tubulin alpha chain, putative	0.0190474	0.692802	0.46823
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0190474	0.692802	0.681386
Trypanosoma brucei	epsilon tubulin	0.0136442	0.422311	0.400842
Echinococcus granulosus	tubulin alpha chain	0.0190474	0.692802	0.692802
Brugia malayi	Furin-like cysteine rich region family protein	0.0162995	0.555237	0.555237
Trichomonas vaginalis	tubulin alpha chain, putative	0.0136442	0.422311	0.400842
Trypanosoma brucei	epsilon tubulin	0.0136442	0.422311	0.400842
Echinococcus granulosus	Tubulin beta 2C chain	0.0251838	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)		NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence.	ChEMBL.	22096101
CC50 (functional)	> 100 uM	Huh7 cytotoxicity for Pf inhibitors	Novartis-GNF Malaria Box.	No reference
CC50	> 100 uM	NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)	ChEMBL.	18579783
EC50 (functional)	= 2.806 uM	PF proliferation inhibition 3D7	Novartis-GNF Malaria Box.	No reference
EC50 (functional)	= 2.806 uM	NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay	ChEMBL.	18579783
EC50 (functional)	> 9.19 uM	W2 Pf proliferation inhibition	Novartis-GNF Malaria Box.	No reference
EC50 (functional)	> 9.19 uM	NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay	ChEMBL.	18579783
IFI promiscuity index	= 0	IFI promiscuity index	Novartis-GNF Malaria Box.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	18579783

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL530293
Search by Novartis-GNF Malaria Box

Bibliographic References

No literature references available for this target.

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Detailed information for compound 604918