Detailed information for compound 60516

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 356.44 | Formula: C15H24N4O4S
  • H donors: 3 H acceptors: 4 LogP: -0.26 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CC(C(=O)N1CSCC1C(=O)N)NC(=O)C1CCC(=O)N1)C
  • InChi: 1S/C15H24N4O4S/c1-8(2)5-10(18-14(22)9-3-4-12(20)17-9)15(23)19-7-24-6-11(19)13(16)21/h8-11H,3-7H2,1-2H3,(H2,16,21)(H,17,20)(H,18,22)
  • InChiKey: UXUVPCLULUSRSX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0164 0.1013 0.2744
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0074 0.0368 0.0406
Loa Loa (eye worm) hypothetical protein 0.0164 0.1013 0.1249
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0041 0.0127 0.0136
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0333 0.222 0.2805
Loa Loa (eye worm) hypothetical protein 0.0074 0.0368 0.0419
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0154 0.0939 0.2416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0095 0.0227
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0024 0.0003 0.0008
Schistosoma mansoni nuclear receptor nhr-48 0.0035 0.0086 0.0083
Onchocerca volvulus 0.009 0.0478 0.1175
Loa Loa (eye worm) hypothetical protein 0.0042 0.0135 0.012
Echinococcus granulosus ecdysone induced protein 78C 0.0074 0.0368 0.0406
Brugia malayi ImpB/MucB/SamB family protein 0.012 0.0696 0.0844
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1127 0.7917 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0113 0.0278
Brugia malayi hypothetical protein 0.0039 0.0115 0.0097
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1014 0.7106 0.8958
Mycobacterium ulcerans DNA polymerase IV 0.012 0.0696 0.1755
Loa Loa (eye worm) nuclear receptor NHR-67 0.0035 0.0086 0.0057
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0154 0.0939 0.23
Schistosoma mansoni Smad4 0.0034 0.0077 0.0075
Echinococcus granulosus pyruvate kinase 0.0509 0.3486 0.3871
Brugia malayi hypothetical protein 0.0132 0.0784 0.0957
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0185 0.0447
Loa Loa (eye worm) pyruvate kinase 0.0107 0.0604 0.0723
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0049 0.0185 0.0177
Trypanosoma brucei pyruvate kinase 1, putative 0.0509 0.3486 0.8558
Echinococcus granulosus DNA polymerase subunit gamma 0.0097 0.053 0.0586
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0154 0.0939 0.23
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0095 0.0227
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0049 0.0185 0.0182
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0591 0.4074 1
Brugia malayi DNA polymerase I family protein 0.0097 0.053 0.0631
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0049 0.0185 0.0177
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0041 0.0127 0.0076
Brugia malayi photoreceptor-specific nuclear receptor 0.0074 0.0368 0.0422
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0062 0.0145
Trichomonas vaginalis glutamate synthase, putative 0.0041 0.0127 0.0307
Entamoeba histolytica thioredoxin reductase, putative 0.0041 0.0127 0.0032
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0041 0.0127 0.0032
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0044 0.0147 0.0194
Trypanosoma cruzi DNA polymerase kappa, putative 0.012 0.0696 0.1702
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0058 0.0062
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0102 0.006
Echinococcus granulosus nuclear receptor nhr 48 0.0035 0.0086 0.0093
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0154 0.0939 0.23
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0723 0.5016 0.5571
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0074 0.0368 0.0422
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0074 0.0368 0.0406
Mycobacterium ulcerans glutamate synthase subunit beta 0.0041 0.0127 0.0076
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0041 0.0127 0.0113
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0309 0.2051 0.489
Schistosoma mansoni pyruvate kinase 0.0261 0.1709 0.1706
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0074 0.0368 0.0419
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0041 0.0127 0.0139
Echinococcus granulosus pyruvate kinase 0.0261 0.1709 0.1896
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0154 0.0939 0.2305
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0041 0.0127 0.0113
Plasmodium falciparum pyruvate kinase 2 0.0261 0.1709 0.4748
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.1471 0.1839
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0041 0.0127 0.0136
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0077 0.0045
Toxoplasma gondii pyruvate kinase PyKII 0.0261 0.1709 0.478
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0115 0.0112
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0151 0.0917 0.2409
Schistosoma mansoni DNA polymerase eta 0.012 0.0696 0.0693
Brugia malayi Pre-SET motif family protein 0.0034 0.0081 0.0054
Echinococcus multilocularis thyroid hormone receptor alpha 0.0074 0.0368 0.0406
Trypanosoma brucei DNA polymerase IV, putative 0.012 0.0696 0.1708
Echinococcus multilocularis dna polymerase eta 0.012 0.0696 0.077
Loa Loa (eye worm) programmed cell death 8 0.0041 0.0127 0.011
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0057
Trypanosoma brucei DNA polymerase IV, putative 0.012 0.0696 0.1708
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0044 0.0101
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0074 0.0368 0.0406
Giardia lamblia Glutamate synthase 0.0041 0.0127 0.0065
Brugia malayi Steroid receptor seven-up type 2 0.0074 0.0368 0.0422
Loa Loa (eye worm) nuclear hormone receptor 0.0035 0.0086 0.0057
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0074 0.0368 0.0406
Trypanosoma brucei unspecified product 0.0083 0.0428 0.1051
Loa Loa (eye worm) hypothetical protein 0.0039 0.0116 0.0095
Mycobacterium ulcerans monoxygenase 0.0041 0.0127 0.0076
Brugia malayi Probable ATP-dependent helicase DHX35 0.0037 0.01 0.0078
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0054 0.022 0.0241
Trypanosoma cruzi trypanothione reductase, putative 0.0154 0.0939 0.23
Giardia lamblia Thioredoxin reductase 0.0041 0.0127 0.0065
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0127 0.0307
Schistosoma mansoni cpg binding protein 0.0095 0.0515 0.0512
Giardia lamblia Rrm3p helicase 0.0591 0.4074 1
Loa Loa (eye worm) hypothetical protein 0.0509 0.3486 0.4432
Echinococcus granulosus thioredoxin glutathione reductase 0.0445 0.3022 0.3355
Brugia malayi ecdysteroid receptor 0.0074 0.0368 0.0422
Giardia lamblia DNA polymerase alpha subunit A 0.0046 0.0161 0.0149
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.012 0.0696 0.0841
Schistosoma mansoni smad1 5 8 and 0.0076 0.0378 0.0375
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.012 0.0696 0.1702
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0102 0.006
Echinococcus multilocularis smad 0.0076 0.0378 0.0417
Brugia malayi DNA polymerase alpha catalytic subunit 0.0044 0.0147 0.0138
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0154 0.0939 0.23
Echinococcus granulosus pyruvate kinase 0.0261 0.1709 0.1896
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.2051 0.503
Loa Loa (eye worm) hypothetical protein 0.0345 0.2308 0.2916
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0057
Entamoeba histolytica disulphide oxidoreductase, putative 0.0041 0.0127 0.0032
Echinococcus multilocularis dnaJ subfamily B 0.1279 0.9001 1
Loa Loa (eye worm) glutathione reductase 0.0445 0.3022 0.3834
Mycobacterium ulcerans NADH dehydrogenase 0.0041 0.0127 0.0076
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0509 0.3486 0.4312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0095 0.0227
Brugia malayi Nuclear hormone receptor-like 1 0.0074 0.0368 0.0422
Echinococcus multilocularis pyruvate kinase 0.0261 0.1709 0.1896
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0309 0.2051 0.489
Echinococcus granulosus smad 0.0076 0.0378 0.0417
Schistosoma mansoni nuclear hormone receptor 0.0035 0.0086 0.0083
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0154 0.0939 0.2305
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0113 0.0271
Echinococcus multilocularis hypothetical protein 0.0097 0.053 0.0586
Plasmodium vivax thioredoxin reductase, putative 0.0445 0.3022 0.8636
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0049 0.0185 0.0447
Echinococcus multilocularis pyruvate kinase 0.0509 0.3486 0.3871
Schistosoma mansoni coup transcription factor 0.0074 0.0368 0.0365
Leishmania major pyruvate kinase 0.0509 0.3486 0.8557
Trichomonas vaginalis pyruvate kinase, putative 0.0509 0.3486 0.8557
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0591 0.4074 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0041 0.0127 0.0139
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0076 0.0378 0.0417
Schistosoma mansoni smad1 5 8 and 0.0076 0.0378 0.0375
Brugia malayi nuclear receptor NHR-88 0.0074 0.0368 0.0422
Echinococcus multilocularis pyruvate kinase 0.0261 0.1709 0.1896
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0127 0.0307
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0041 0.0127 0.0313
Loa Loa (eye worm) hypothetical protein 0.0074 0.0364 0.0415
Trypanosoma brucei DNA damage repair protein, putative 0.0037 0.0102 0.0249
Loa Loa (eye worm) hypothetical protein 0.012 0.0696 0.0841
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0003 0.0008
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0041 0.0127 0.0139
Echinococcus granulosus FTZ F1 alpha 0.0074 0.0368 0.0406
Brugia malayi pyruvate kinase, muscle isozyme 0.0107 0.0604 0.0726
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.012 0.0696 0.0693
Schistosoma mansoni DNA polymerase IV / kappa 0.0037 0.0102 0.0099
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.2051 0.503
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0102 0.0249
Schistosoma mansoni nuclear receptor 0.0035 0.0086 0.0083
Echinococcus granulosus Nuclear hormone receptor HR96 0.0035 0.0086 0.0093
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0041 0.0127 0.0307
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0127 0.0313
Trypanosoma cruzi DNA polymerase eta, putative 0.012 0.0696 0.1702
Trichomonas vaginalis glutamate synthase, putative 0.0041 0.0127 0.0307
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0591 0.4074 0.4524
Loa Loa (eye worm) hypothetical protein 0.0074 0.0368 0.0419
Echinococcus multilocularis cpg binding protein 0.0095 0.0515 0.0569
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0154 0.0939 0.2519
Loa Loa (eye worm) hypothetical protein 0.0074 0.0368 0.0419
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0041 0.0127 0.0307
Loa Loa (eye worm) hypothetical protein 0.0037 0.0102 0.0077
Brugia malayi MH2 domain containing protein 0.0076 0.0378 0.0435
Onchocerca volvulus Pyruvate kinase homolog 0.0509 0.3486 1
Schistosoma mansoni glutamate synthase 0.0041 0.0127 0.0125
Schistosoma mansoni sulfide quinone reductase 0.0041 0.0127 0.0125
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.1965 0.482
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0154 0.0939 0.23
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0042 0.0096
Brugia malayi MH1 domain containing protein 0.0076 0.0378 0.0435
Onchocerca volvulus 0.0074 0.0368 0.0852
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0723 0.5016 0.64
Toxoplasma gondii pyruvate kinase PyK1 0.0509 0.3486 1
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0127 0.0307
Trypanosoma brucei DNA polymerase kappa, putative 0.012 0.0696 0.1708
Trypanosoma brucei unspecified product 0.0024 0.0003 0.0008
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0115 0.0125
Trypanosoma brucei DNA polymerase kappa, putative 0.012 0.0696 0.1708
Plasmodium vivax pyruvate kinase, putative 0.0509 0.3486 1
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0041 0.0127 0.0307
Trypanosoma cruzi DNA damage repair protein, putative 0.0037 0.0102 0.0243
Toxoplasma gondii hypothetical protein 0.0048 0.0178 0.0284
Mycobacterium ulcerans ferredoxin reductase 0.0041 0.0127 0.0076
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0102 0.0243
Trypanosoma cruzi DNA damage repair protein, putative 0.0037 0.0102 0.0243
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0035 0.0086 0.0093
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0086 0.0093
Toxoplasma gondii selenide, water dikinase 0.0041 0.0127 0.0136
Leishmania major pyruvate kinase 0.0509 0.3486 0.8557
Onchocerca volvulus 0.0035 0.0086 0.0026
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0154 0.0939 0.104
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0074 0.0368 0.0406
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0041 0.0127 0.0139
Loa Loa (eye worm) DEAH box polypeptide 35 0.0037 0.01 0.0075
Trypanosoma brucei DNA polymerase IV, putative 0.012 0.0696 0.1708
Brugia malayi MH1 domain containing protein 0.0076 0.0378 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0113 0.0271
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0115 0.0125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0074 0.0368 0.0419
Brugia malayi nuclear receptor RXR 0.0035 0.0086 0.006
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0074 0.0368 0.0365
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.0957 0.1064
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0041 0.0127 0.0076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.2051 0.503
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.2051 0.503
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.2051 0.503
Echinococcus multilocularis pyruvate kinase 0.0402 0.2717 0.3016
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0035 0.0086 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.012 0.0696 0.1708
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0843 0.2068
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0102 0.0249
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0074 0.0368 0.0852
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0081 0.0078
Echinococcus multilocularis FTZ F1 alpha 0.0074 0.0368 0.0406
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0023 0.0051
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.2051 0.503
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0428 0.1051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0074 0.0368 0.0419
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0428 0.1051
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0041 0.0127 0.0139
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0154 0.0939 0.0936
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0041 0.0127 0.0307
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0041 0.0127 0.0139
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0154 0.0939 0.2519
Schistosoma mansoni smad 0.0034 0.0077 0.0075
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0074 0.0368 0.0365
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0074 0.0368 0.0406
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0154 0.0939 0.2474
Brugia malayi glutamate synthase 0.0041 0.0127 0.0113
Toxoplasma gondii histone lysine methyltransferase SET1 0.0171 0.1062 0.2881
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.1965 0.482
Loa Loa (eye worm) MH1 domain-containing protein 0.0076 0.0378 0.0432
Schistosoma mansoni pyruvate kinase 0.0509 0.3486 0.3485
Brugia malayi MH2 domain containing protein 0.0076 0.0378 0.0435
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0041 0.0127 0.0136
Loa Loa (eye worm) Smad1 0.0076 0.0378 0.0432
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0154 0.0939 0.2474
Schistosoma mansoni hypothetical protein 0.0039 0.0115 0.0112
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0035 0.0086 0.0026
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0041 0.0127 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0044 0.0101
Trypanosoma brucei DNA polymerase kappa, putative 0.012 0.0696 0.1708
Loa Loa (eye worm) hypothetical protein 0.0074 0.0368 0.0419
Schistosoma mansoni zinc finger protein 0.0035 0.0086 0.0083
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0151 0.0917 0.1014
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0154 0.0939 0.1042
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0041 0.0127 0.0076
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0154 0.0939 0.23
Brugia malayi MH1 domain containing protein 0.0042 0.0135 0.0123
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0185 0.0184
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0035 0.0086 0.0093
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0057
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0023 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0034 0.0077 0.0045
Brugia malayi Thioredoxin reductase 0.0445 0.3022 0.3836
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0035 0.0086 0.0083
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0041 0.0127 0.0307
Giardia lamblia Pyruvate kinase 0.0509 0.3486 0.8521
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0035 0.0086 0.0026
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0154 0.0939 0.2474
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0113 0.0272
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1127 0.7917 1
Plasmodium vivax DNA polymerase alpha, putative 0.0044 0.0147 0.0194
Echinococcus granulosus pyruvate kinase 0.0261 0.1709 0.1896
Loa Loa (eye worm) hypothetical protein 0.0097 0.053 0.0628
Plasmodium falciparum pyruvate kinase 0.0509 0.3486 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0154 0.0939 0.104
Echinococcus granulosus dnaJ subfamily B 0.1279 0.9001 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0154 0.0939 0.23
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0041 0.0127 0.0139
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0113 0.0646 0.078
Giardia lamblia Fructose-bisphosphate aldolase 0.0309 0.2051 0.4907
Trypanosoma cruzi trypanothione reductase, putative 0.0445 0.3022 0.7416
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0074 0.0368 0.0406
Toxoplasma gondii thioredoxin reductase 0.0445 0.3022 0.8636
Echinococcus granulosus glutamate synthase 0.0041 0.0127 0.0139
Echinococcus multilocularis ecdysone induced protein 78C 0.0074 0.0368 0.0406
Entamoeba histolytica hypothetical protein, conserved 0.0591 0.4074 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0023 0.0051
Echinococcus granulosus Smad4 0.0076 0.0378 0.0417
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0095 0.0041
Loa Loa (eye worm) hypothetical protein 0.0074 0.0368 0.0419
Trypanosoma brucei NADH dehydrogenase 0.0041 0.0127 0.0313
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0041 0.0127 0.0307
Leishmania major trypanothione reductase 0.0445 0.3022 0.7416
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0041 0.0127 0.0307
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0102 0.0249
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0041 0.0127 0.0139
Brugia malayi Pre-SET motif family protein 0.0228 0.1471 0.1842
Trichomonas vaginalis mercuric reductase, putative 0.0154 0.0939 0.23
Trichomonas vaginalis glutathione reductase, putative 0.0154 0.0939 0.23
Brugia malayi hypothetical protein 0.0164 0.1013 0.1252
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.012 0.0696 0.077
Trypanosoma brucei DNA damage repair protein, putative 0.0037 0.0102 0.0249
Loa Loa (eye worm) steroid hormone receptor 0.0074 0.0368 0.0419
Mycobacterium tuberculosis Probable reductase 0.1014 0.7106 0.8958
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0428 0.1051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0074 0.0368 0.0419
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0041 0.0127 0.0136
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0041 0.0127 0.0076
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0154 0.0939 0.23
Onchocerca volvulus 0.026 0.1696 0.4747
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0035 0.0086 0.0093
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0057
Onchocerca volvulus 0.0035 0.0086 0.0026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0081 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0023 0.0051
Onchocerca volvulus Protein ultraspiracle homolog 0.0074 0.0368 0.0852
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0723 0.5016 0.5015
Loa Loa (eye worm) hypothetical protein 0.0034 0.0081 0.005
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0121 0.0704 0.0702
Brugia malayi MH2 domain containing protein 0.0034 0.0077 0.0049
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0127 0.0307
Mycobacterium leprae Probable pyruvate kinase PykA 0.0509 0.3486 0.4312
Trypanosoma cruzi pyruvate kinase 2, putative 0.0509 0.3486 0.8557
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0057
Echinococcus multilocularis thioredoxin glutathione reductase 0.0445 0.3022 0.3355
Loa Loa (eye worm) MH2 domain-containing protein 0.1113 0.7814 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0057
Schistosoma mansoni pyruvate kinase 0.0509 0.3486 0.3485
Echinococcus granulosus dna polymerase eta 0.012 0.0696 0.077
Onchocerca volvulus Pyruvate kinase homolog 0.0509 0.3486 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0041 0.0127 0.0307
Schistosoma mansoni DNA polymerase gamma 0.0097 0.053 0.0528
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0074 0.0368 0.0365
Loa Loa (eye worm) hypothetical protein 0.0039 0.0116 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0074 0.0368 0.0422
Echinococcus granulosus mothers against decapentaplegic 6 0.0034 0.0077 0.0083
Schistosoma mansoni terminal deoxycytidyl transferase 0.012 0.0696 0.0693
Leishmania major hypothetical protein, conserved 0.0041 0.0127 0.0307
Loa Loa (eye worm) hypothetical protein 0.0074 0.0368 0.0419
Brugia malayi glutathione reductase 0.0445 0.3022 0.3836
Brugia malayi pyruvate kinase 0.0107 0.0604 0.0726
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0134 0.0322
Loa Loa (eye worm) CXXC zinc finger family protein 0.009 0.0478 0.0561
Brugia malayi nuclear receptor RXR 0.0039 0.0116 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0074 0.0368 0.0422
Trypanosoma brucei DNA polymerase kappa, putative 0.012 0.0696 0.1708
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0041 0.0127 0.0313
Trypanosoma cruzi pyruvate kinase 2, putative 0.0509 0.3486 0.8557
Trypanosoma brucei ingi protein (ORF1) 0.0024 0.0003 0.0008
Schistosoma mansoni retinoic acid receptor RXR 0.0074 0.0368 0.0365
Schistosoma mansoni cpg binding protein 0.009 0.0478 0.0475
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0154 0.0939 0.1157
Echinococcus multilocularis Smad4 0.0076 0.0378 0.0417
Schistosoma mansoni Smad4 0.0076 0.0378 0.0375
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0591 0.4074 1
Schistosoma mansoni nuclear hormone receptor 0.0074 0.0368 0.0365
Loa Loa (eye worm) thioredoxin reductase 0.0445 0.3022 0.3834
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0591 0.4074 0.4524
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0127 0.0307
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0041 0.0127 0.0032
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0039 0.0116 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.012 0.0696 0.1708
Mycobacterium tuberculosis Probable dehydrogenase 0.1014 0.7106 0.8958
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0127 0.0307
Leishmania major DNA polymerase eta, putative 0.012 0.0696 0.1702
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0074 0.0368 0.0419
Leishmania major NADH dehydrogenase, putative 0.0041 0.0127 0.0307
Brugia malayi nuclear receptor NHR-67 0.0035 0.0086 0.006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.2051 0.503
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1014 0.7106 0.8958
Echinococcus multilocularis dna polymerase kappa 0.012 0.0696 0.077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0095 0.0227
Brugia malayi mothers against decapentaplegic homolog 3 0.0034 0.0077 0.0049
Trypanosoma brucei DNA polymerase eta, putative 0.012 0.0696 0.1708
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0049 0.0185 0.0202
Trypanosoma cruzi NADH dehydrogenase, putative 0.0041 0.0127 0.0307
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0057
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0049 0.0185 0.0447
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0074 0.0368 0.0365
Loa Loa (eye worm) hypothetical protein 0.0041 0.0127 0.011
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0116 0.0099
Treponema pallidum fructose-bisphosphate aldolase 0.0309 0.2051 1
Schistosoma mansoni RAR-like nuclear receptor 0.0074 0.0368 0.0365
Brugia malayi Nuclear hormone receptor E75 0.0035 0.0086 0.006
Plasmodium vivax pyruvate kinase 2, putative 0.0261 0.1709 0.478
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0037 0.0102 0.006
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0041 0.0127 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0074 0.0368 0.0422
Loa Loa (eye worm) hypothetical protein 0.0039 0.0116 0.0095
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0102 0.0243
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0041 0.0127 0.0136
Schistosoma mansoni disulfide oxidoreductase 0.0041 0.0127 0.0125
Brugia malayi Pyruvate kinase, muscle isozyme 0.0509 0.3486 0.4434
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0041 0.0127 0.0307
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0074 0.0368 0.0422
Loa Loa (eye worm) hypothetical protein 0.0039 0.0116 0.0095
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0049 0.0185 0.0447
Loa Loa (eye worm) hypothetical protein 0.0355 0.2381 0.301
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0723 0.5016 0.5571
Schistosoma mansoni nuclear receptor 0.0035 0.0086 0.0083
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1014 0.7106 0.8958
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0081 0.0087
Onchocerca volvulus Bile acid receptor homolog 0.0074 0.0368 0.0852
Schistosoma mansoni nuclear hormone receptor 0.0035 0.0086 0.0083
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0154 0.0939 0.23
Schistosoma mansoni hypothetical protein 0.0591 0.4074 0.4072
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0074 0.0368 0.0365
Mycobacterium tuberculosis Probable oxidoreductase 0.1127 0.7917 1
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0041 0.0127 0.0076
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0113 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0074 0.0368 0.0422
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0154 0.0939 0.2474
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0081 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0095 0.0227
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0074 0.0364 0.0842
Brugia malayi conserved hypotetical protein 0.0035 0.0086 0.006
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0074 0.0368 0.0422
Trypanosoma cruzi NADH dehydrogenase, putative 0.0041 0.0127 0.0307
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0049 0.0185 0.0447
Brugia malayi polk-prov protein 0.0037 0.0102 0.008
Echinococcus granulosus thyroid hormone receptor alpha 0.0035 0.0086 0.0093
Plasmodium falciparum thioredoxin reductase 0.0445 0.3022 0.8628
Brugia malayi nuclear hormone receptor family member odr-7 0.0035 0.0086 0.006
Loa Loa (eye worm) transcription factor SMAD2 0.1113 0.7814 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0076 0.0378 0.0417
Plasmodium vivax ferrodoxin reductase, putative 0.0041 0.0127 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0042 0.0096
Leishmania major hypothetical protein, conserved 0.0041 0.0127 0.0307
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0074 0.0368 0.0422
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0154 0.0939 0.1158
Schistosoma mansoni glutamate synthase 0.0041 0.0127 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0095 0.0227
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0049 0.0185 0.0453
Plasmodium vivax DNA repair protein REV1, putative 0.0037 0.0102 0.006
Mycobacterium ulcerans DNA polymerase IV 0.012 0.0696 0.1755
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1014 0.7106 0.8958
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0154 0.0939 0.2519
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0041 0.0127 0.0076
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0057
Leishmania major hypothetical protein, conserved 0.0041 0.0127 0.0307
Plasmodium falciparum glutathione reductase 0.0154 0.0939 0.2474
Loa Loa (eye worm) hypothetical protein 0.0262 0.1714 0.2152
Schistosoma mansoni hypothetical protein 0.0041 0.0127 0.0125
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1127 0.7917 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0023 0.0051
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0057
Trypanosoma cruzi DNA polymerase kappa, putative 0.012 0.0696 0.1702
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.012 0.0696 0.077
Loa Loa (eye worm) MH2 domain-containing protein 0.0076 0.0378 0.0432
Echinococcus granulosus dna polymerase kappa 0.012 0.0696 0.077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0095 0.0227
Trichomonas vaginalis set domain proteins, putative 0.026 0.1696 0.4158
Trypanosoma cruzi DNA polymerase kappa, putative 0.012 0.0696 0.1702
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0154 0.0939 0.2474
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0127 0.0307
Leishmania major DNA polymerase eta, putative 0.0037 0.0102 0.0243
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0042 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0074 0.0368 0.0422
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0591 0.4074 1
Brugia malayi orphan nuclear receptor NR2E1 0.0035 0.0086 0.006
Trichomonas vaginalis pyruvate kinase, putative 0.0509 0.3486 0.8557
Schistosoma mansoni hypothetical protein 0.0081 0.0418 0.0416
Loa Loa (eye worm) pyruvate kinase-PB 0.0355 0.2381 0.301
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0134 0.0322
Loa Loa (eye worm) hypothetical protein 0.0039 0.0116 0.0095
Brugia malayi MH1 domain containing protein 0.0042 0.0135 0.0123
Plasmodium vivax glutathione reductase, putative 0.0445 0.3022 0.8636
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0154 0.0939 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0039 0.0116 0.0126
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0074 0.0368 0.0406
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0591 0.4074 1
Chlamydia trachomatis pyruvate kinase 0.0509 0.3486 1
Brugia malayi hypothetical protein 0.0039 0.0116 0.0099
Brugia malayi nuclear hormone receptor 0.0074 0.0368 0.0422
Onchocerca volvulus Pyruvate kinase homolog 0.0509 0.3486 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.0185 0.0453
Loa Loa (eye worm) hypothetical protein 0.007 0.0339 0.0382
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0023 0.0051
Brugia malayi hypothetical protein 0.0035 0.0086 0.006
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0041 0.0127 0.0307
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0723 0.5016 0.6402
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0057
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0151 0.0917 0.1014
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.1965 0.4823
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0041 0.0127 0.0313
Onchocerca volvulus 0.0041 0.0127 0.0147
Brugia malayi MH2 domain containing protein 0.1113 0.7814 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0042 0.0044
Leishmania major DNA polymerase kappa, putative 0.0037 0.0102 0.0243
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0035 0.0086 0.006
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0843 0.2063
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0041 0.0127 0.0076
Brugia malayi ecdysone receptor 0.0035 0.0086 0.006
Trypanosoma brucei unspecified product 0.012 0.0696 0.1708
Brugia malayi CXXC zinc finger family protein 0.009 0.0478 0.0564
Plasmodium falciparum glutathione reductase 0.0445 0.3022 0.8628
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.012 0.0696 0.1702
Brugia malayi ImpB/MucB/SamB family protein 0.012 0.0696 0.0844
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0081 0.0087
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0134 0.0329
Entamoeba histolytica deoxycytidyl transferase, putative 0.012 0.0696 0.1467
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0102 0.0243
Echinococcus granulosus mothers against decapentaplegic 2 0.0034 0.0077 0.0083
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0074 0.0368 0.0365
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0041 0.0127 0.0136
Toxoplasma gondii NADPH-glutathione reductase 0.0154 0.0939 0.2519
Brugia malayi Nuclear hormone receptor E75 0.0035 0.0086 0.006
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0591 0.4074 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0074 0.0368 0.0419
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0192 0.1208 0.1206
Giardia lamblia NADH oxidase lateral transfer candidate 0.0154 0.0939 0.2108
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0049 0.0185 0.0202
Giardia lamblia GTOR 0.0049 0.0185 0.0209
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0057
Mycobacterium ulcerans pyruvate kinase 0.0509 0.3486 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0134 0.0322
Echinococcus multilocularis pyruvate kinase 0.0261 0.1709 0.1896
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0076 0.0378 0.0375
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0041 0.0127 0.0076
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0154 0.0939 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0023 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0133 0.0321
Trypanosoma cruzi DNA polymerase kappa, putative 0.012 0.0696 0.1702
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0185 0.0447
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0035 0.0086 0.0083
Loa Loa (eye worm) hypothetical protein 0.0141 0.0844 0.1032
Plasmodium falciparum thioredoxin reductase 0.0154 0.0939 0.2474
Brugia malayi nuclear receptor NHR-88 0.0035 0.0086 0.006
Mycobacterium ulcerans hypothetical protein 0.0157 0.0957 0.2526
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0074 0.0368 0.0422
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0074 0.0368 0.0422
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0041 0.0127 0.0136
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0116 0.0113
Trypanosoma brucei trypanothione reductase 0.0445 0.3022 0.7418
Loa Loa (eye worm) pyruvate kinase 0.0509 0.3486 0.4432
Schistosoma mansoni cpg binding protein 0.0095 0.0515 0.0512
Brugia malayi steroid hormone receptor 0.0074 0.0368 0.0422
Entamoeba histolytica DNA repair and recombination protein, putative 0.0591 0.4074 1
Schistosoma mansoni smad 0.0076 0.0378 0.0375
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1014 0.7106 0.8958
Schistosoma mansoni steroid hormone receptor ad4bp 0.0074 0.0368 0.0365
Leishmania major DNA damage repair protein, putative 0.0037 0.0102 0.0243
Echinococcus multilocularis mothers against decapentaplegic 5 0.0076 0.0378 0.0417
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0113 0.0271
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0154 0.0939 0.2305
Echinococcus granulosus pyruvate kinase 0.0509 0.3486 0.3871
Mycobacterium ulcerans hypothetical protein 0.0041 0.0127 0.0076
Brugia malayi Pyruvate kinase, M2 isozyme 0.0509 0.3486 0.4434
Loa Loa (eye worm) hypothetical protein 0.0074 0.0368 0.0419
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0199 0.0483
Trypanosoma brucei ingi protein (ORF1) 0.0024 0.0003 0.0008
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0154 0.0939 0.2305
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0041 0.0127 0.0032
Schistosoma mansoni thyroid hormone receptor 0.0074 0.0368 0.0365
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0074 0.0368 0.0406
Echinococcus multilocularis mothers against decapentaplegic 2 0.0034 0.0077 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0044 0.0101
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0041 0.0127 0.0065
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0035 0.0086 0.0093
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0041 0.0127 0.011
Schistosoma mansoni smad1 5 8 and 0.0076 0.0378 0.0375
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0081 0.0078
Entamoeba histolytica pyruvate kinase, putative 0.0355 0.2381 0.5725
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0154 0.0939 0.23
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0113 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.0591 0.4074 1
Loa Loa (eye worm) pyruvate kinase 0.0509 0.3486 0.4432
Echinococcus granulosus cpg binding protein 0.0095 0.0515 0.0569
Trypanosoma brucei pyruvate kinase 1 0.0509 0.3486 0.8558
Brugia malayi hypothetical protein 0.0035 0.0086 0.006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.2051 0.503
Leishmania major DNA polymerase kappa, putative 0.012 0.0696 0.1702
Trypanosoma brucei DNA polymerase kappa, putative 0.012 0.0696 0.1708
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0041 0.0127 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0113 0.0271
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0591 0.4074 1
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0116 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0074 0.0368 0.0422
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0843 0.2063
Trypanosoma brucei DNA polymerase kappa, putative 0.012 0.0696 0.1708
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0041 0.0127 0.0313
Echinococcus multilocularis glutamate synthase 0.0041 0.0127 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0185 0.0447
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0127 0.0307
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0074 0.0368 0.0422
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0035 0.0086 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.012 0.0696 0.1708
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0154 0.0939 0.23
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0074 0.0368 0.0419
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.1965 0.482
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0023 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.012 0.0696 0.1708
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0039 0.0116 0.0095
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0113 0.0646 0.078
Loa Loa (eye worm) pyruvate kinase 0.0509 0.3486 0.4432
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0041 0.0127 0.0032
Giardia lamblia DINP protein human, muc B family 0.012 0.0696 0.1496
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0185 0.0187
Trichomonas vaginalis apoptosis inducing factor, putative 0.0041 0.0127 0.0307
Echinococcus granulosus TGF beta signal transducer SmadC 0.0076 0.0378 0.0417
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0054 0.022 0.0241
Trypanosoma brucei chrX additional, unordered contigs 0.0037 0.0102 0.0249
Loa Loa (eye worm) nuclear factor I 0.0042 0.0135 0.012
Echinococcus multilocularis mothers against decapentaplegic 6 0.0034 0.0077 0.0083
Schistosoma mansoni glutamate synthase 0.0041 0.0127 0.0125
Mycobacterium ulcerans dehydrogenase 0.0041 0.0127 0.0076
Brugia malayi tailless protein 0.0035 0.0086 0.006
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0445 0.3022 0.3716
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0057
Schistosoma mansoni Smad4 0.0034 0.0077 0.0075
Mycobacterium tuberculosis Conserved hypothetical protein 0.012 0.0696 0.0729
Echinococcus multilocularis pyruvate kinase 0.0509 0.3486 0.3871
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0074 0.0368 0.0406
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0041 0.0127 0.0113
Schistosoma mansoni thyroid hormone receptor 0.0074 0.0368 0.0365
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0154 0.0939 0.23
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0081 0.0078
Trypanosoma brucei unspecified product 0.0083 0.0428 0.1051
Echinococcus granulosus Nuclear hormone receptor HR96 0.0035 0.0086 0.0093
Schistosoma mansoni hypothetical protein 0.1279 0.9001 0.9001
Brugia malayi nuclear hormone receptor 0.0035 0.0086 0.006
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0041 0.0127 0.0307
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0074 0.0368 0.0406
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0041 0.0127 0.0076
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0041 0.0127 0.0139
Schistosoma mansoni sulfide quinone reductase 0.0041 0.0127 0.0125
Trichomonas vaginalis DNA polymerase eta, putative 0.012 0.0696 0.1702
Brugia malayi Smad1 0.0076 0.0378 0.0435
Echinococcus multilocularis nuclear receptor nhr 48 0.0035 0.0086 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0102 0.0249
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0041 0.0127 0.0139
Plasmodium falciparum ferrodoxin reductase-like protein 0.0041 0.0127 0.0076
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0054 0.022 0.0217
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0074 0.0368 0.0406
Treponema pallidum NADH oxidase 0.0154 0.0939 0.4219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0069 0.0164
Loa Loa (eye worm) hypothetical protein 0.0037 0.01 0.0075
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0086 0.0093
Brugia malayi nuclear hormone receptor family member nhr-6 0.0035 0.0086 0.006
Giardia lamblia Pyruvate kinase 0.0261 0.1709 0.4046
Loa Loa (eye worm) hypothetical protein 0.0074 0.0368 0.0419
Loa Loa (eye worm) DR-78 0.0035 0.0086 0.0057
Onchocerca volvulus 0.0034 0.0081 0.0011
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0077 0.0045
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.012 0.0696 0.0729
Brugia malayi hypothetical protein 0.0039 0.0116 0.0099
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0039 0.0116 0.0113
Trypanosoma brucei RNA helicase, putative 0.0081 0.0418 0.1027
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0074 0.0368 0.0406

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 0 % Thyrotropin releasing activity (TSH) of the compound was evaluated by measuring the TSH response to the compound by radioimmunoassay in two doses in the rat ChEMBL. 3091831
ED50 (functional) = 31.4 mg kg-1 Dose of the compound that inhibited cataleptic effect of haloperidol in rat by 50% ChEMBL. 3091831
Sleeping time (functional) = 17.2 min Reduction of hexobarbital induced sleeping time in mice. ChEMBL. 3091831

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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