Detailed information for compound 605321

Basic information

Technical information
  • TDR Targets ID: 605321
  • Name: 2-(4-amino-2,3-dimethylpyridin-1-ium-1-yl)-1- (4-methoxyphenyl)ethanone
  • MW: 271.334 | Formula: C16H19N2O2+
  • H donors: 1 H acceptors: 1 LogP: 2.55 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(=O)C[n+]1ccc(c(c1C)C)N
  • InChi: 1S/C16H18N2O2/c1-11-12(2)18(9-8-15(11)17)10-16(19)13-4-6-14(20-3)7-5-13/h4-9,17H,10H2,1-3H3/p+1
  • InChiKey: LSKHBSODWYCLIB-UHFFFAOYSA-O  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-amino-2,3-dimethyl-pyridin-1-ium-1-yl)-1-(4-methoxyphenyl)ethanone
  • 2-(4-amino-2,3-dimethyl-1-pyridin-1-iumyl)-1-(4-methoxyphenyl)ethanone
  • 4-Amino-1-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-2,3-dimethyl-pyridinium
  • BAS 00187764
  • ZINC05003765

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0325 0.0801 0.0801
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0051 0.0062 0.0062
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0051 0.0062 0.0062
Brugia malayi hypothetical protein 0.0053 0.0067 0.0252
Trypanosoma brucei protein kinase, putative 0.0057 0.0077 0.1602
Trypanosoma brucei ISWI complex protein 0.0207 0.0483 1
Plasmodium falciparum phd finger protein, putative 0.0237 0.0564 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.0077 0.1408
Echinococcus granulosus histone lysine methyltransferase setb 0.0325 0.0801 0.0801
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0032 0.0118
Echinococcus granulosus sterol regulatory element binding protein 0.0088 0.0163 0.0163
Echinococcus granulosus lysine specific demethylase 6a 0.0076 0.0131 0.0131
Brugia malayi photoreceptor-specific nuclear receptor 0.0051 0.0062 0.0234
Brugia malayi SET domain containing protein 0.0034 0.0016 0.0059
Echinococcus multilocularis Bromodomain containing protein 0.0032 0.0011 0.0011
Echinococcus multilocularis ecdysone induced protein 78C 0.0051 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0032 0.0011 0.0043
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.0527 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0048 0.0053 0.104
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Brugia malayi hypothetical protein 0.0964 0.2527 0.946
Schistosoma mansoni hypothetical protein 0.0085 0.0155 0.0155
Schistosoma mansoni hypothetical protein 0.0085 0.0155 0.0155
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0053 0.0053
Trichomonas vaginalis bromodomain containing protein, putative 0.0032 0.0011 0.0041
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0032 0.0374
Onchocerca volvulus 0.0052 0.0066 0.025
Schistosoma mansoni hypothetical protein 0.0032 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0088 0.0163 0.0646
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0062 0.0234
Brugia malayi Niemann-Pick C1 protein precursor 0.0206 0.0481 0.1799
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0298 0.073 0.073
Schistosoma mansoni hypothetical protein 0.0032 0.0011 0.0011
Brugia malayi Bromodomain containing protein 0.0032 0.0011 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Toxoplasma gondii bromodomain-containing protein 0.0032 0.0011 0.0194
Plasmodium falciparum SNF2 helicase, putative 0.0029 0.0003 0.0056
Schistosoma mansoni myst-related protein 0.0033 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.073 0.289
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.0077 0.0077
Loa Loa (eye worm) bromodomain containing protein 0.0032 0.0011 0.0043
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0032 0.0032
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0062 0.0234
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0067 0.1193
Mycobacterium leprae Probable lipase LipE 0.0035 0.0019 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0076 0.0131 0.0518
Plasmodium falciparum EELM2 domain-containing protein, putative 0.0029 0.0003 0.0056
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Echinococcus multilocularis PH interacting protein 0.0032 0.0011 0.0011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0099 1
Echinococcus multilocularis protein patched 0.0088 0.0163 0.0163
Schistosoma mansoni bromodomain containing protein 0.0061 0.009 0.009
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0051 0.0062 0.0062
Onchocerca volvulus 0.0051 0.0062 0.0235
Schistosoma mansoni hypothetical protein 0.0085 0.0155 0.0155
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0048 0.0053 0.0053
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0077 0.0388
Onchocerca volvulus 0.0753 0.1957 0.7743
Trypanosoma brucei Bromodomain factor 1 0.0032 0.0011 0.0227
Brugia malayi Isocitrate dehydrogenase 0.0048 0.0053 0.0199
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0019 0.0081
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0051 0.0062 0.0234
Loa Loa (eye worm) CBP-B 0.0032 0.0011 0.0043
Loa Loa (eye worm) hypothetical protein 0.0406 0.102 0.4037
Loa Loa (eye worm) CHromoDomain protein family member 0.0029 0.0003 0.0013
Echinococcus granulosus phd finger protein 10 0.0029 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0049 0.0057 0.0227
Echinococcus multilocularis geminin 0.0856 0.2237 0.2237
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0094 0.0179 0.3171
Schistosoma mansoni SET domain protein 0.0034 0.0016 0.0016
Echinococcus granulosus remodeling and spacing factor 1 0.0029 0.0003 0.0003
Trypanosoma cruzi Bromodomain factor 1 0.0032 0.0011 0.0162
Echinococcus granulosus Bromodomain containing protein 0.0032 0.0011 0.0011
Trichomonas vaginalis bromodomain containing protein, putative 0.0032 0.0011 0.0041
Brugia malayi Steroid receptor seven-up type 2 0.0051 0.0062 0.0234
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Echinococcus multilocularis expressed conserved protein 0.0193 0.0447 0.0447
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0053 0.1099
Schistosoma mansoni zinc finger protein 0.0207 0.0483 0.0483
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0077 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0051 0.0062 0.0234
Echinococcus multilocularis Zinc finger, DBF type 0.0029 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0062 0.0234
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0094 0.0179 0.0179
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0011 0.0194
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0094 0.0179 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Loa Loa (eye worm) hypothetical protein 0.0051 0.0062 0.0247
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Schistosoma mansoni ap endonuclease 0.004 0.0032 0.0032
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.0077 0.1202
Toxoplasma gondii ABC1 family protein 0.0035 0.0019 0.0333
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0032 0.0011 0.0041
Onchocerca volvulus Protein ultraspiracle homolog 0.0051 0.0062 0.0235
Echinococcus granulosus PHD and RING finger domain containing protein 1 0.0029 0.0003 0.0003
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0062 0.0234
Onchocerca volvulus 0.0081 0.0143 0.0556
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0013
Schistosoma mansoni phd finger protein 0.0029 0.0003 0.0003
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0077 0.0388
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0034 0.0015 0.0061
Schistosoma mansoni lozenge 0.0121 0.0251 0.0251
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0325 0.0801 0.0801
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.0077 0.1602
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0032 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Onchocerca volvulus 0.0058 0.0081 0.0309
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0308 0.0756 0.0756
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0003 0.0013
Schistosoma mansoni cpg binding protein 0.0087 0.016 0.016
Trichomonas vaginalis bromodomain and PHD finger-containing protein, putative 0.0032 0.0011 0.0041
Echinococcus granulosus Niemann Pick C1 protein 0.0206 0.0481 0.0481
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0032 0.0561
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Brugia malayi hypothetical protein 0.0753 0.1957 0.7328
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0076 0.0131 0.266
Schistosoma mansoni bromodomain containing protein 0.0032 0.0011 0.0011
Trichomonas vaginalis bromodomain containing protein, putative 0.0032 0.0011 0.0041
Loa Loa (eye worm) hypothetical protein 0.0551 0.1411 0.5586
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Brugia malayi jmjC domain containing protein 0.0076 0.0131 0.049
Leishmania major hypothetical protein, conserved 0.0076 0.0131 0.2539
Loa Loa (eye worm) hypothetical protein 0.0032 0.0011 0.0043
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0077 0.0133 0.2762
Echinococcus granulosus ecdysone induced protein 78C 0.0051 0.0062 0.0062
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0048 0.0053 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Trypanosoma cruzi bromodomain factor 2 protein 0.0032 0.0011 0.0162
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0187 0.0187
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0051 0.0062 0.0062
Echinococcus granulosus snurportin 1 0.0298 0.073 0.073
Plasmodium vivax SNF2 family N-terminal domain containing protein 0.0029 0.0003 0.0056
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0051 0.0062 0.0062
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Leishmania major hypothetical protein, conserved 0.0035 0.0019 0.0166
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0077 0.0077
Onchocerca volvulus 0.0964 0.2527 1
Echinococcus granulosus jumonji domain containing protein 0.0329 0.0814 0.0814
Brugia malayi jmjC domain containing protein 0.0076 0.0131 0.049
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0081 0.0143 0.2536
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0032 0.0011 0.0194
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0062 0.0062
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Schistosoma mansoni hypothetical protein 0.0029 0.0003 0.0003
Brugia malayi PHD-finger family protein 0.0029 0.0003 0.0012
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0308 0.0756 0.0756
Schistosoma mansoni ap endonuclease 0.004 0.0032 0.0032
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0062 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0051 0.0062 0.0247
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Echinococcus multilocularis PHD finger protein 14 0.0029 0.0003 0.0003
Brugia malayi Bromodomain containing protein 0.1017 0.2671 1
Brugia malayi polybromodomain protein 0.0032 0.0011 0.0041
Entamoeba histolytica hypothetical protein 0.0036 0.002 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Schistosoma mansoni dpf3 0.0029 0.0003 0.0003
Toxoplasma gondii hypothetical protein 0.0032 0.0011 0.0194
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Brugia malayi polybromodomain protein 0.0032 0.0011 0.0041
Echinococcus granulosus phd finger protein 12 0.0029 0.0003 0.0003
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Schistosoma mansoni hypothetical protein 0.0029 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0051 0.0062 0.0247
Schistosoma mansoni zinc finger protein 0.0029 0.0003 0.0003
Echinococcus granulosus ATPase family AAA domain containing protein 2B 0.0032 0.0011 0.0011
Schistosoma mansoni jumonji/arid domain-containing protein 0.0316 0.0777 0.0777
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0074
Schistosoma mansoni jumonji domain containing protein 0.0616 0.1587 0.1587
Echinococcus granulosus bromodomain containing 2 0.0032 0.0011 0.0011
Echinococcus granulosus transcription initiation factor TFIID subunit 1 0.0032 0.0011 0.0011
Echinococcus multilocularis remodeling and spacing factor 1 0.0029 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0076 0.0131 0.0518
Brugia malayi PHD-finger family protein 0.0029 0.0003 0.0012
Brugia malayi RNA, U transporter 1 0.0079 0.0139 0.0521
Echinococcus granulosus histone acetyltransferase KAT2B 0.0032 0.0011 0.0011
Echinococcus granulosus histone acetyltransferase myst4 0.0029 0.0003 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0019 0.0081
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0051 0.0062 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0163 0.0836
Schistosoma mansoni hypothetical protein 0.0029 0.0003 0.0003
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Trypanosoma brucei bromodomain factor 2 protein, putative 0.0032 0.0011 0.0227
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0076 0.0131 0.0131
Schistosoma mansoni hypothetical protein 0.0032 0.0011 0.0011
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0051 0.0062 0.0062
Trypanosoma cruzi Bromodomain, putative 0.0032 0.0011 0.0162
Brugia malayi hypothetical protein 0.0034 0.0017 0.0062
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0048 0.0053 0.1099
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0003 0.0003
Trypanosoma brucei Bromodomain, putative 0.0032 0.0011 0.0227
Echinococcus multilocularis Niemann Pick C1 protein 0.0206 0.0481 0.0481
Loa Loa (eye worm) jmjC domain-containing protein 0.0489 0.1244 0.4923
Echinococcus multilocularis tumor protein p63 0.0358 0.0892 0.0892
Loa Loa (eye worm) hypothetical protein 0.0052 0.0066 0.0262
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0088 0.0163 0.0646
Entamoeba histolytica hypothetical protein 0.0036 0.002 0.0203
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0048 0.0053 0.0675
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0775 0.2017 0.2017
Trypanosoma cruzi Bromodomain, putative 0.0032 0.0011 0.0162
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0019 0.0081
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0032 0.0011 0.0194
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0011 0.0162
Echinococcus granulosus fetal alzheimer antigen falz 0.0308 0.0756 0.0756
Brugia malayi Bromodomain containing protein 0.0032 0.0011 0.0041
Echinococcus granulosus global transcription activator snf2l2 0.0032 0.0011 0.0011
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Echinococcus multilocularis polybromo 1 0.0032 0.0011 0.0011
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Brugia malayi beta-lactamase family protein 0.0035 0.0019 0.007
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0077 0.0133 0.2762
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Echinococcus granulosus JmjC domain containing protein 4 0.0076 0.0131 0.0131
Plasmodium falciparum histone-lysine N-methyltransferase, H3 lysine-4 specific 0.0029 0.0003 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0032 0.0011 0.0041
Schistosoma mansoni patched 1 0.0088 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0053 0.0067 0.0266
Brugia malayi hypothetical protein 0.0036 0.002 0.0077
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0053 0.104
Trichomonas vaginalis bromodomain containing protein, putative 0.0032 0.0011 0.0041
Schistosoma mansoni fyve-containing 0.0029 0.0003 0.0003
Brugia malayi jmjC domain containing protein 0.0316 0.0777 0.2908
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Echinococcus granulosus histone acetyltransferase myst3 0.0029 0.0003 0.0003
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0032 0.1602
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0051 0.0062 0.0247
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0032 0.0032
Echinococcus granulosus uro adherence factor A 0.0029 0.0003 0.0003
Echinococcus multilocularis 0.0032 0.0011 0.0011
Brugia malayi Bromodomain containing protein 0.0032 0.0011 0.0041
Toxoplasma gondii PHD-finger domain-containing protein 0.0077 0.0133 0.2367
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0003 0.0056
Loa Loa (eye worm) hypothetical protein 0.0956 0.2506 0.9917
Echinococcus multilocularis snurportin 1 0.0298 0.073 0.073
Onchocerca volvulus 0.0034 0.0016 0.005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0074
Plasmodium falciparum bromodomain protein 1 0.0032 0.0011 0.0194
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0003 0.0056
Echinococcus multilocularis TAF3 RNA polymerase II, TATA box binding protein 0.0029 0.0003 0.0003
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0067 0.1335
Echinococcus granulosus bromodomain containing protein 8 0.0032 0.0011 0.0011
Echinococcus granulosus phd:f box containing protein 0.0076 0.0131 0.0131
Trypanosoma brucei Bromodomain, putative 0.0032 0.0011 0.0227
Loa Loa (eye worm) hypothetical protein 0.0051 0.0062 0.0247
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0279 0.0678 0.0678
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0003 0.0003
Echinococcus multilocularis protein kinase C binding protein 1 0.0032 0.0011 0.0011
Schistosoma mansoni PHD zinc finger protein XAP135-related 0.0029 0.0003 0.0003
Brugia malayi TAZ zinc finger family protein 0.0032 0.0011 0.0041
Schistosoma mansoni polybromo-1 0.0032 0.0011 0.0011
Toxoplasma gondii bromodomain-containing protein 0.0032 0.0011 0.0194
Schistosoma mansoni phosphatidylserine receptor 0.0076 0.0131 0.0131
Brugia malayi steroid hormone receptor 0.0051 0.0062 0.0234
Toxoplasma gondii AP2 domain transcription factor AP2VIIa-7 0.0029 0.0003 0.0056
Schistosoma mansoni CREB-binding protein 2 0.0032 0.0011 0.0011
Schistosoma mansoni coup transcription factor 0.0051 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0051 0.0062 0.0247
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0013
Schistosoma mansoni cpg binding protein 0.0058 0.0081 0.0081
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0019 0.5
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Echinococcus granulosus polybromo 1 0.0032 0.0011 0.0011
Schistosoma mansoni helicase 0.0032 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0013
Brugia malayi jmjC domain containing protein 0.0775 0.2017 0.7553
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0076 0.0131 0.2321
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0003 0.0056
Trichomonas vaginalis bromodomain containing protein, putative 0.0032 0.0011 0.0041
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0029 0.0003 0.0003
Onchocerca volvulus 0.0032 0.0011 0.0031
Trichomonas vaginalis bromodomain-containing protein 4, brd4, putative 0.0032 0.0011 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0179 0.0179
Echinococcus multilocularis lysine specific demethylase 5B 0.0029 0.0003 0.0003
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.081 0.2113 0.2113
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0032 0.0011 0.0041
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0051 0.0062 0.0247
Entamoeba histolytica hypothetical protein 0.0036 0.002 0.0203
Trypanosoma cruzi Bromodomain, putative 0.0032 0.0011 0.0162
Echinococcus granulosus PH interacting protein 0.0032 0.0011 0.0011
Echinococcus granulosus expressed conserved protein 0.0193 0.0447 0.0447
Echinococcus granulosus protein kinase C binding protein 1 0.0032 0.0011 0.0011
Brugia malayi Pre-SET motif family protein 0.0094 0.0179 0.0669
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.0077 0.1408
Brugia malayi CHE-14 protein 0.0088 0.0163 0.0611
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0099 0.1583
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0062 0.0234
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0051 0.0062 0.0062
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0019 0.007
Echinococcus multilocularis lysine specific demethylase 6a 0.0076 0.0131 0.0131
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0649 0.1676 0.6633
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0077 0.1547
Plasmodium falciparum zinc finger protein, putative 0.0033 0.0013 0.0226
Echinococcus multilocularis phd finger protein 10 0.0029 0.0003 0.0003
Onchocerca volvulus 0.0035 0.0019 0.0062
Schistosoma mansoni cpg binding protein 0.0087 0.016 0.016
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0051 0.0062 0.0062
Echinococcus granulosus CREB binding protein 0.0032 0.0011 0.0011
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Onchocerca volvulus Bile acid receptor homolog 0.0051 0.0062 0.0235
Schistosoma mansoni hypothetical protein 0.0032 0.0011 0.0011
Echinococcus multilocularis methyl CpG binding domain protein 2 0.023 0.0547 0.0547
Echinococcus multilocularis Protein lozenge 0.0121 0.0251 0.0251
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0062 0.0062
Loa Loa (eye worm) isocitrate dehydrogenase 0.0048 0.0053 0.021
Schistosoma mansoni nuclear hormone receptor 0.0051 0.0062 0.0062
Brugia malayi Pre-SET motif family protein 0.0649 0.1676 0.6275
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0095 0.0182 0.0182
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0187 0.0187
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Loa Loa (eye worm) hypothetical protein 0.0051 0.0062 0.0247
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0053 0.0941
Toxoplasma gondii PHD-finger domain-containing protein 0.0237 0.0564 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0062 0.0062
Brugia malayi isocitrate dehydrogenase 0.0048 0.0053 0.0199
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0486 0.1236 0.1236
Loa Loa (eye worm) hypothetical protein 0.0519 0.1325 0.5244
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0187 0.0187
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0126 0.0266 0.0266
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0077 0.0388
Echinococcus granulosus peregrin 0.0269 0.065 0.065
Brugia malayi CHD4 protein 0.0029 0.0003 0.0012
Schistosoma mansoni phd/f-box containing protein 0.0076 0.0131 0.0131
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0032 0.0149
Onchocerca volvulus 0.0094 0.0179 0.0695
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0029 0.0003 0.0003
Echinococcus granulosus CREB binding protein 0.0032 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0032 0.0011 0.0043
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0077 0.0133 0.2367
Schistosoma mansoni protein phosphatase 2C 0.0076 0.0131 0.0131
Brugia malayi jmjC domain containing protein 0.0076 0.0131 0.049
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Schistosoma mansoni bromodomain containing protein 0.0859 0.2243 0.2243
Loa Loa (eye worm) beta-lactamase 0.0035 0.0019 0.0074
Trichomonas vaginalis esterase, putative 0.0035 0.0019 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Brugia malayi Bromodomain containing protein 0.0269 0.065 0.2433
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0032 0.0438
Brugia malayi hypothetical protein 0.0029 0.0003 0.0012
Echinococcus granulosus FTZ F1 alpha 0.0051 0.0062 0.0062
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0076 0.0131 0.266
Echinococcus multilocularis histone acetyltransferase myst4 0.0029 0.0003 0.0003
Brugia malayi Bromodomain associated family protein 0.0029 0.0003 0.0012
Plasmodium vivax bromodomain protein, putative 0.0032 0.0011 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0062 0.0234
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0099 0.1759
Loa Loa (eye worm) BRM protein 0.0032 0.0011 0.0043
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0003 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0051 0.0062 0.0247
Loa Loa (eye worm) hypothetical protein 0.0032 0.0011 0.0043
Loa Loa (eye worm) hypothetical protein 0.0237 0.0564 0.223
Brugia malayi PHD-finger family protein 0.0029 0.0003 0.0012
Loa Loa (eye worm) runx1 0.0121 0.0251 0.0993
Echinococcus multilocularis uro adherence factor A 0.0029 0.0003 0.0003
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.0077 0.0077
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0187 0.0702
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Brugia malayi CXXC zinc finger family protein 0.0058 0.0081 0.0303
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Loa Loa (eye worm) hypothetical protein 0.0206 0.0481 0.1902
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Schistosoma mansoni jumonji/arid domain-containing protein 0.0316 0.0777 0.0777
Loa Loa (eye worm) hypothetical protein 0.0076 0.0131 0.0518
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0187 0.0187
Echinococcus multilocularis bromodomain containing 2 0.0032 0.0011 0.0011
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0051 0.0062 0.0062
Giardia lamblia PHD finger protein 15 0.0237 0.0564 1
Toxoplasma gondii histone acetyltransferase TAF1/250 0.0032 0.0011 0.0194
Plasmodium vivax bromodomain protein, putative 0.0032 0.0011 0.0194
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0099 0.0099
Echinococcus granulosus methyl CpG binding domain protein 2 0.023 0.0547 0.0547
Trypanosoma cruzi Bromodomain, putative 0.0032 0.0011 0.0162
Echinococcus multilocularis microtubule associated protein 2 0.3731 1 1
Schistosoma mansoni transcription initiation factor tfiid 0.0032 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0032 0.0011 0.0043
Brugia malayi hypothetical protein 0.0029 0.0003 0.0012
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0032 0.0593
Entamoeba histolytica ankyrin repeat protein, putative 0.0032 0.0011 0.00000022363
Brugia malayi bromodomain containing protein 0.0032 0.0011 0.0041
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Brugia malayi Bromodomain containing protein 0.0032 0.0011 0.0041
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0019 0.0019
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0032 0.0655
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Echinococcus multilocularis PHD finger protein rhinoceros 0.0237 0.0564 0.0564
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0032 0.0593
Echinococcus granulosus dnaJ subfamily B 0.0825 0.2154 0.2154
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Trichomonas vaginalis lymphoid specific helicase, putative 0.0032 0.0011 0.0041
Loa Loa (eye worm) hypothetical protein 0.0325 0.0801 0.3171
Entamoeba histolytica hypothetical protein 0.0036 0.002 0.0203
Echinococcus multilocularis peregrin 0.0269 0.065 0.065
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0051 0.0062 0.0234
Onchocerca volvulus 0.0035 0.0019 0.0062
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0077 0.1547
Brugia malayi Bromodomain containing protein 0.0032 0.0011 0.0041
Schistosoma mansoni hypothetical protein 0.0029 0.0003 0.0003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0019 0.0019
Echinococcus granulosus PHD finger protein 14 0.0029 0.0003 0.0003
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0032 0.5
Schistosoma mansoni phd finger protein 0.0029 0.0003 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0019 0.0325
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Echinococcus multilocularis global transcription activator snf2l2 0.0032 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0019 0.0019
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0051 0.0062 0.0062
Echinococcus multilocularis zinc finger protein 0.0268 0.0648 0.0648
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0076 0.0131 0.2321
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0775 0.2017 0.2017
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0029 0.0003 0.0003
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0187 0.0742
Echinococcus multilocularis phd finger protein 12 0.0029 0.0003 0.0003
Brugia malayi acetyltransferase, GNAT family protein 0.0032 0.0011 0.0041
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.0062 0.0234
Schistosoma mansoni bromodomain containing 0.0032 0.0011 0.0011
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0032 0.0561
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0013
Echinococcus multilocularis CREB binding protein 0.0032 0.0011 0.0011
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0048 0.0053 0.0941
Echinococcus granulosus zinc finger protein 0.0268 0.0648 0.0648
Toxoplasma gondii bromodomain-containing protein 0.0032 0.0011 0.0194
Brugia malayi PHD-finger family protein 0.0237 0.0564 0.211
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0099 1
Echinococcus multilocularis PHD and RING finger domain containing protein 1 0.0029 0.0003 0.0003
Echinococcus granulosus Niemann Pick C1 protein 0.0294 0.0719 0.0719
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Leishmania major hypothetical protein, conserved 0.0053 0.0067 0.1193
Schistosoma mansoni hypothetical protein 0.0036 0.002 0.002
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0032 0.0011 0.0194
Echinococcus multilocularis phd:f box containing protein 0.0076 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0106 0.0212 0.0839
Echinococcus granulosus cpg binding protein 0.0087 0.016 0.016
Echinococcus multilocularis bromodomain containing protein 8 0.0032 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Plasmodium falciparum bromodomain protein 2, putative 0.0032 0.0011 0.0194
Loa Loa (eye worm) acetyltransferase 0.0032 0.0011 0.0043
Loa Loa (eye worm) hypothetical protein 0.0051 0.0062 0.0247
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.0077 0.1547
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Echinococcus granulosus tumor protein p63 0.0358 0.0892 0.0892
Plasmodium vivax JmjC domain containing protein 0.0076 0.0131 0.2321
Trypanosoma brucei AAA ATPase, putative 0.0032 0.0011 0.0227
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0032 0.0149
Toxoplasma gondii exonuclease III APE 0.004 0.0032 0.0561
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0486 0.1236 0.1236
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.0062 0.0062
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0053 0.0941
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0019 0.0081
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Schistosoma mansoni requim req/dpf2 0.0029 0.0003 0.0003
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0105 0.0209 0.0209
Schistosoma mansoni hypothetical protein 0.0237 0.0564 0.0564
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0074
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0032 0.0254
Schistosoma mansoni hypothetical protein 0.0029 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0013
Schistosoma mansoni RAR-like nuclear receptor 0.0051 0.0062 0.0062
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.0077 0.0077
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0057 0.0227
Echinococcus granulosus TAF3 RNA polymerase II TATA box binding protein 0.0029 0.0003 0.0003
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0032 0.0011 0.0041
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0032 0.0441
Echinococcus multilocularis Bromodomain containing protein 0.0032 0.0011 0.0011
Brugia malayi ecdysteroid receptor 0.0051 0.0062 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Schistosoma mansoni retinoic acid receptor RXR 0.0051 0.0062 0.0062
Echinococcus multilocularis histone acetyltransferase myst3 0.0029 0.0003 0.0003
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0032 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Echinococcus granulosus Protein patched homolog 1 0.0088 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0013
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0048 0.0053 0.0053
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0032 0.0011 0.0194
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.081 0.2113 0.2113
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Schistosoma mansoni hypothetical protein 0.0856 0.2237 0.2237
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0099 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0143 0.0143
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0067 0.1193
Trichomonas vaginalis hypothetical protein 0.0032 0.0011 0.0041
Schistosoma mansoni zinc finger protein 0.0268 0.0648 0.0648
Onchocerca volvulus Brd8 homolog 0.0032 0.0011 0.0031
Brugia malayi Hypothetical C28H8.9 in chromosome III 0.0029 0.0003 0.0012
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0206 0.0481 1
Schistosoma mansoni myst-related protein 0.0033 0.0013 0.0013
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Echinococcus multilocularis dnaJ subfamily B 0.0825 0.2154 0.2154
Schistosoma mansoni hypothetical protein 0.0077 0.0133 0.0133
Schistosoma mansoni myst histone acetyltransferase 0.0029 0.0003 0.0003
Trichomonas vaginalis hypothetical protein 0.0032 0.0011 0.0041
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0074
Brugia malayi PHD-finger family protein 0.034 0.0843 0.3155
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0081 0.0321
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.0077 0.1373
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Schistosoma mansoni methyl-cpg binding protein mbd 0.023 0.0547 0.0547
Echinococcus multilocularis thyroid hormone receptor alpha 0.0051 0.0062 0.0062
Entamoeba histolytica hypothetical protein 0.0033 0.0013 0.0038
Schistosoma mansoni hypothetical protein 0.0034 0.0015 0.0015
Trypanosoma cruzi ISWI complex protein 0.0207 0.0483 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0062 0.0247
Echinococcus multilocularis jumonji domain containing protein 0.0329 0.0814 0.0814
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.002 0.002
Loa Loa (eye worm) PHD-finger family protein 0.0279 0.0678 0.2682
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0051 0.0062 0.0234
Onchocerca volvulus Alhambra homolog 0.0237 0.0564 0.2221
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0013
Toxoplasma gondii bromodomain-containing protein 0.0032 0.0011 0.0194
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0032 0.0011 0.0194
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0062 0.0062
Brugia malayi beta-lactamase family protein 0.0035 0.0019 0.007
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0051 0.0062 0.0062
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0032 0.0125
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0057 0.0215
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0187 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0057 0.0215
Echinococcus multilocularis lysine specific demethylase 5A 0.0286 0.0698 0.0698
Trypanosoma brucei Bromodomain, putative 0.0032 0.0011 0.0227
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0051 0.0062 0.0062
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0019 0.0333
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Loa Loa (eye worm) F/Y-rich family protein 0.0029 0.0003 0.0013
Echinococcus granulosus PHD finger protein rhinoceros 0.0237 0.0564 0.0564
Brugia malayi jmjC domain containing protein 0.0076 0.0131 0.049
Schistosoma mansoni hypothetical protein 0.0085 0.0155 0.0155
Plasmodium vivax hypothetical protein, conserved 0.0237 0.0564 1
Brugia malayi nuclear hormone receptor 0.0051 0.0062 0.0234
Leishmania major hypothetical protein, conserved 0.0207 0.0483 1
Onchocerca volvulus 0.0032 0.0011 0.0031
Brugia malayi Bromodomain containing protein 0.0032 0.0011 0.0041
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0019 0.0074
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.0077 0.1547
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Loa Loa (eye worm) jmjC domain-containing protein 0.0316 0.0777 0.3074
Echinococcus multilocularis cpg binding protein 0.0087 0.016 0.016
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0143 0.0143
Loa Loa (eye worm) steroid hormone receptor 0.0051 0.0062 0.0247
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0099 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Loa Loa (eye worm) hypothetical protein 0.0964 0.2527 1
Schistosoma mansoni phd finger protein 0.0032 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0051 0.0062 0.0247
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Schistosoma mansoni methyl-cpg binding protein mbd 0.023 0.0547 0.0547
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0019 0.0389
Plasmodium vivax bromodomain protein, putative 0.0032 0.0011 0.0194
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0051 0.0062 0.0235
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0099 0.0099
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0032 0.0011 0.0041
Schistosoma mansoni hypothetical protein 0.0825 0.2154 0.2154
Schistosoma mansoni hypothetical protein 0.0207 0.0483 0.0483
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0089 0.0166 0.0166
Echinococcus multilocularis ATPase family AAA domain containing protein 2B 0.0032 0.0011 0.0011
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.002 0.002
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0051 0.0062 0.0062
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0325 0.0801 0.0801
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0105 0.0209 0.0209
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0099 0.1868
Echinococcus granulosus Bromodomain containing protein 0.0032 0.0011 0.0011
Brugia malayi MAP kinase sur-1 0.0057 0.0077 0.029
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Onchocerca volvulus 0.0738 0.1917 0.7586
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0013
Schistosoma mansoni hepatitis B virus X associated protein hbxa 0.0029 0.0003 0.0003
Echinococcus multilocularis isocitrate dehydrogenase 0.0048 0.0053 0.0053
Trypanosoma brucei Ring finger domain/PHD-finger, putative 0.0029 0.0003 0.0066
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Echinococcus granulosus jumonji domain containing 1A 0.0076 0.0131 0.0131
Brugia malayi Bromodomain containing protein 0.0032 0.0011 0.0041
Loa Loa (eye worm) MH2 domain-containing protein 0.0247 0.0591 0.2339
Brugia malayi beta-lactamase 0.0035 0.0019 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Loa Loa (eye worm) hypothetical protein 0.0061 0.009 0.0355
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0032 0.0011 0.0041
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0143 0.0143
Loa Loa (eye worm) PHD-finger family protein 0.0237 0.0564 0.223
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0053 0.0053
Brugia malayi Bromodomain containing protein 0.0518 0.1322 0.4951
Loa Loa (eye worm) hypothetical protein 0.0032 0.0011 0.0043
Loa Loa (eye worm) jmjC domain-containing protein 0.0076 0.0131 0.0518
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Loa Loa (eye worm) hypothetical protein 0.0108 0.0217 0.0858
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Loa Loa (eye worm) jmjC domain-containing protein 0.0076 0.0131 0.0518
Trypanosoma cruzi bromodomain-containing protein 3 0.0032 0.0011 0.0162
Onchocerca volvulus Bromodomain adjacent to zinc finger domain protein 1A homolog 0.0032 0.0011 0.0031
Onchocerca volvulus 0.0035 0.0019 0.0062
Trichomonas vaginalis set domain proteins, putative 0.0738 0.1917 1
Echinococcus multilocularis FTZ F1 alpha 0.0051 0.0062 0.0062
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0051 0.0062 0.0247
Plasmodium vivax SET domain containing protein 0.0037 0.0024 0.0419
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0019 0.0081
Loa Loa (eye worm) transcription factor SMAD2 0.0247 0.0591 0.2339
Trichomonas vaginalis bromodomain-containing protein 3, brd3, putative 0.0032 0.0011 0.0041
Plasmodium vivax SET domain protein, putative 0.0094 0.0179 0.3171
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0032 0.0011 0.0011
Brugia malayi F/Y-rich N-terminus family protein 0.0124 0.026 0.0974
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0048 0.0053 0.0941
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0067 0.1335
Schistosoma mansoni steroid hormone receptor ad4bp 0.0051 0.0062 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Echinococcus multilocularis protein dispatched 1 0.0101 0.0197 0.0197
Toxoplasma gondii histone lysine methyltransferase SET1 0.0145 0.0317 0.562
Trichomonas vaginalis bromodomain containing protein, putative 0.0032 0.0011 0.0041
Loa Loa (eye worm) hypothetical protein 0.058 0.149 0.5897
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Loa Loa (eye worm) hypothetical protein 0.0032 0.0011 0.0043
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Brugia malayi nuclear receptor NHR-88 0.0051 0.0062 0.0234
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0067 0.1193
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0053 0.0892
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0067 0.1193
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0099 0.0099
Brugia malayi PHD-finger family protein 0.0106 0.0212 0.0794
Schistosoma mansoni microtubule-associated protein tau 0.3731 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0074
Echinococcus multilocularis sterol regulatory element binding protein 0.0088 0.0163 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0051 0.0062 0.0234
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0067 0.1392
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0003 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0051 0.0062 0.0234
Plasmodium falciparum JmjC domain-containing protein, putative 0.0076 0.0131 0.2321
Echinococcus granulosus lysine specific demethylase 5B 0.0029 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0051 0.0062 0.0234
Loa Loa (eye worm) hypothetical protein 0.0964 0.2527 1
Brugia malayi MH2 domain containing protein 0.0247 0.0591 0.2212
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0076 0.0131 0.2708
Echinococcus granulosus lysine specific demethylase 5A 0.0316 0.0777 0.0777
Schistosoma mansoni hypothetical protein 0.0856 0.2237 0.2237
Echinococcus granulosus Zinc finger DBF type 0.0029 0.0003 0.0003
Echinococcus multilocularis jumonji domain containing 1A 0.0076 0.0131 0.0131
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0143 0.2536
Brugia malayi PHD-finger family protein 0.0029 0.0003 0.0012
Loa Loa (eye worm) bromodomain containing protein 0.0239 0.0569 0.2253
Echinococcus granulosus geminin 0.0856 0.2237 0.2237
Schistosoma mansoni bromodomain-containing protein 3 brd3 0.0032 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0753 0.1957 0.7746
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0143 0.0537
Plasmodium falciparum bromodomain protein, putative 0.0032 0.0011 0.0194
Trypanosoma cruzi Bromodomain, putative 0.0032 0.0011 0.0162
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0003 0.0056
Toxoplasma gondii bromodomain-containing protein 0.0032 0.0011 0.0194
Loa Loa (eye worm) hypothetical protein 0.0081 0.0143 0.0568
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0032 0.0011 0.0041
Loa Loa (eye worm) hypothetical protein 0.0032 0.0011 0.0043
Schistosoma mansoni zinc finger protein 0.0029 0.0003 0.0003
Trypanosoma cruzi ISWI complex protein 0.0207 0.0483 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0011 0.0041
Toxoplasma gondii SWI2/SNF2-containing PHD finger protein 0.0029 0.0003 0.0056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0187 0.0187
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0237 0.0564 0.0564
Echinococcus multilocularis Niemann Pick C1 protein 0.0294 0.0719 0.0719
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0051 0.0062 0.0247
Toxoplasma gondii PHD-finger domain-containing protein 0.0237 0.0564 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.0077 0.0306
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0015 0.0058
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0032 0.0011 0.0011
Brugia malayi AF-10 protein 0.0077 0.0133 0.0499
Brugia malayi ATPase, AAA family protein 0.0032 0.0011 0.0041
Onchocerca volvulus 0.0032 0.0011 0.0031
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0053 0.0053
Echinococcus multilocularis JmjC domain containing protein 4 0.0076 0.0131 0.0131
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1576 0.4182 0.4182
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0011 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0019 0.0325
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0209 0.0489 0.0489
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0131 0.0131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0051 0.0062 0.0247
Brugia malayi BRM protein 0.0032 0.0011 0.0041
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0019 0.0019

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. ChEMBL. 22096101
CC50 (functional) > 10 uM Huh7 cytotoxicity for Pf inhibitors Novartis-GNF Malaria Box. No reference
CC50 > 10 uM NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) ChEMBL. 18579783
EC50 (functional) = 0.438 uM PF proliferation inhibition 3D7 Novartis-GNF Malaria Box. No reference
EC50 (functional) = 0.438 uM NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
EC50 (functional) > 0.665 uM W2 Pf proliferation inhibition Novartis-GNF Malaria Box. No reference
EC50 (functional) > 0.665 uM NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
IFI promiscuity index = 0 IFI promiscuity index Novartis-GNF Malaria Box. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 18579783

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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