Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | PHD-finger family protein | 0.0029 | 0.1148 | 0.1148 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.006 | 0.2963 | 0.2963 |
Trypanosoma brucei | PHD-zinc-finger like domain containing protein, putative | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0095 | 0.5027 | 1 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.018 | 1 | 1 |
Giardia lamblia | PHD finger protein 15 | 0.0029 | 0.1148 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0095 | 0.5027 | 0.5027 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3147 | 0.8113 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.3147 | 0.5155 |
Schistosoma mansoni | jumonji domain containing protein | 0.0076 | 0.3879 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3147 | 0.8113 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.3147 | 0.3147 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0035 | 0.1506 | 0.1506 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3147 | 0.8113 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3147 | 0.8113 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0029 | 0.1148 | 0.1148 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.3147 | 0.3147 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.1148 | 0.2959 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.3147 | 0.5155 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0095 | 0.5027 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.1506 | 0.3883 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.3147 | 0.3147 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0035 | 0.1506 | 0.0925 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.1506 | 0.3883 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.3147 | 0.3147 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0029 | 0.1148 | 1 |
Brugia malayi | RNA binding protein | 0.0063 | 0.3147 | 0.3147 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.1815 | 0.1721 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0029 | 0.1148 | 0.2959 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.2366 | 0.2366 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1148 | 0.1148 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0035 | 0.1506 | 0.0925 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0029 | 0.1148 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3147 | 0.8113 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Plasmodium falciparum | phd finger protein, putative | 0.0029 | 0.1148 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0029 | 0.1148 | 0.1148 |
Brugia malayi | jmjC domain containing protein | 0.0035 | 0.1506 | 0.1506 |
Plasmodium vivax | hypothetical protein, conserved | 0.0029 | 0.1148 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.3147 | 0.3147 |
Trypanosoma brucei | PHD-zinc-finger like domain containing protein, putative | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.1815 | 0.1721 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 10 uM | Huh7 cytotoxicity for Pf inhibitors | Novartis-GNF Malaria Box. | No reference |
CC50 (functional) | > 100 uM | Huh7 cytotoxicity for Pf inhibitors | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | = 0.543 uM | PF proliferation inhibition 3D7 | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | = 1.337 uM | W2 Pf proliferation inhibition | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | = 4.81 uM | W2 Pf proliferation inhibition | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | > 12.5 uM | PF proliferation inhibition 3D7 | Novartis-GNF Malaria Box. | No reference |
IFI promiscuity index | = 0 | IFI promiscuity index | Novartis-GNF Malaria Box. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.