Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.152663 | 0.78013 | 0.78013 |
Loa Loa (eye worm) | hypothetical protein | 0.152663 | 0.78013 | 0.78013 |
Schistosoma mansoni | serine/threonine protein kinase | 0.130035 | 0.61824 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.174393 | 0.935587 | 0.935587 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0973211 | 0.384201 | 0.578282 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0755916 | 0.228744 | 0.369992 |
Echinococcus granulosus | protein kinase c epsilon type | 0.130035 | 0.61824 | 1 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0455215 | 0.0136171 | 0.0136171 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.130035 | 0.61824 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0653476 | 0.155457 | 0.155457 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.107065 | 0.453909 | 0.734195 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0769947 | 0.238782 | 0.5 |
Echinococcus granulosus | protein kinase c iota type | 0.0524625 | 0.0632742 | 0.102346 |
Loa Loa (eye worm) | hypothetical protein | 0.152663 | 0.78013 | 0.78013 |
Onchocerca volvulus | 0.152663 | 0.78013 | 0.5 | |
Brugia malayi | protein kinase C II. | 0.130035 | 0.61824 | 1 |
Echinococcus granulosus | protein kinase C gamma type | 0.0755916 | 0.228744 | 0.369992 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0769947 | 0.238782 | 0.386229 |
Loa Loa (eye worm) | hypothetical protein | 0.183397 | 1 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0973211 | 0.384201 | 0.621443 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0973211 | 0.384201 | 0.621443 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0973211 | 0.384201 | 0.578282 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.130035 | 0.61824 | 0.61824 |
Echinococcus multilocularis | protein kinase c iota type | 0.0524625 | 0.0632742 | 0.102346 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. | ChEMBL. | 22096101 | |
CC50 (functional) | > 0.654 uM | Huh7 cytotoxicity for Pf inhibitors | Novartis-GNF Malaria Box. | No reference |
CC50 | > 0.654 uM | NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) | ChEMBL. | 18579783 |
EC50 (functional) | = 0.02984 uM | W2 Pf proliferation inhibition | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | = 0.02984 uM | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
EC50 (functional) | > 1.25 uM | PF proliferation inhibition 3D7 | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | > 1.25 uM | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
IFI promiscuity index | = 0.01923 | IFI promiscuity index | Novartis-GNF Malaria Box. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 18579783 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.