Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | protein kinase C II. | 0.0249834 | 0.61824 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0352357 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.029331 | 0.78013 | 0.78013 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0249834 | 0.61824 | 0.61824 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0186981 | 0.384201 | 0.578282 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0249834 | 0.61824 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.029331 | 0.78013 | 0.78013 |
Loa Loa (eye worm) | hypothetical protein | 0.0335058 | 0.935587 | 0.935587 |
Loa Loa (eye worm) | hypothetical protein | 0.0125551 | 0.155457 | 0.155457 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0147929 | 0.238782 | 0.5 |
Echinococcus granulosus | protein kinase C gamma type | 0.0145233 | 0.228744 | 0.369992 |
Echinococcus multilocularis | protein kinase c iota type | 0.0100795 | 0.0632742 | 0.102346 |
Loa Loa (eye worm) | hypothetical protein | 0.029331 | 0.78013 | 0.78013 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0147929 | 0.238782 | 0.386229 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0145233 | 0.228744 | 0.369992 |
Onchocerca volvulus | 0.029331 | 0.78013 | 0.5 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0249834 | 0.61824 | 1 |
Echinococcus granulosus | protein kinase c iota type | 0.0100795 | 0.0632742 | 0.102346 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0249834 | 0.61824 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0186981 | 0.384201 | 0.621443 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.00874597 | 0.0136171 | 0.0136171 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0186981 | 0.384201 | 0.578282 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0186981 | 0.384201 | 0.621443 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0205702 | 0.453909 | 0.734195 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 11.62 uM | Huh7 cytotoxicity for Pf inhibitors | Novartis-GNF Malaria Box. | No reference |
CC50 | = 11.62 uM | NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) | ChEMBL. | 18579783 |
EC50 (functional) | = 0.2877 uM | PF proliferation inhibition 3D7 | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | = 0.2877 uM | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
EC50 (functional) | = 0.528 uM | W2 Pf proliferation inhibition | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | = 0.528 uM | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
EC50 (functional) | = 1.19 uM | Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
EC50 (functional) | = 2.64 uM | Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
IC50 (functional) | = 0.1047 uM | NOVARTIS: Antimalarial liver stage activity measured as reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells by immuno-fluorescence, and median schizont size at 10uM compound concentration | ChEMBL. | 22096101 |
IFI promiscuity index | = 0.03846 | IFI promiscuity index | Novartis-GNF Malaria Box. | No reference |
Percent growth inhibition (functional) | = 74.1 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by YOYO-3 red dye | Saint Jude. | 20485428 |
Percent growth inhibition (functional) | = 109.9 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by SYBR green dye | Saint Jude. | 20485428 |
Schizont size (functional) | = 75.78 um | NOVARTIS: Antimalarial liver stage activity measured as reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells by immuno-fluorescence, and median schizont size at 10uM compound concentration | ChEMBL. | 22096101 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium yoelii | ChEMBL23 | 22096101 | |
Plasmodium falciparum | ChEMBL23 | 18579783 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.