Detailed information for compound 605831

Basic information

Technical information
  • TDR Targets ID: 605831
  • Name: octyl N-[6-(octoxycarbonylamino)hexyl]carbama te
  • MW: 428.649 | Formula: C24H48N2O4
  • H donors: 2 H acceptors: 2 LogP: 7.93 Rotable bonds: 25
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCOC(=O)NCCCCCCNC(=O)OCCCCCCCC
  • InChi: 1S/C24H48N2O4/c1-3-5-7-9-13-17-21-29-23(27)25-19-15-11-12-16-20-26-24(28)30-22-18-14-10-8-6-4-2/h3-22H2,1-2H3,(H,25,27)(H,26,28)
  • InChiKey: ICVPGHUJIKSPFD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[6-[(octoxy-oxomethyl)amino]hexyl]carbamic acid octyl ester
  • N-[6-(octoxycarbonylamino)hexyl]carbamic acid octyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis cysteine--tRNA ligase 0.00234573 0.00657598 0.5
Echinococcus granulosus potassium voltage gated channel protein 0.00157637 0.0000637172 0.000330185
Loa Loa (eye worm) hypothetical protein 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis short transient receptor potential channel 6 0.00157637 0.0000637172 0.000330185
Brugia malayi Cyclic-nucleotide gated cation channel 0.00157637 0.0000637172 0.00968938
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.00157637 0.0000637172 0.00968938
Loa Loa (eye worm) hypothetical protein 0.00157637 0.0000637172 0.00968938
Loa Loa (eye worm) hypothetical protein 0.00157637 0.0000637172 0.00968938
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis shaker cognate 0.00157637 0.0000637172 0.000330185
Echinococcus multilocularis voltage gated potassium channel 0.00157637 0.0000637172 0.000330185
Schistosoma mansoni hypothetical protein 0.00157637 0.0000637172 0.00968938
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.00157637 0.0000637172 0.00968938
Schistosoma mansoni transient receptor potential channel 4 0.00157637 0.0000637172 0.00968938
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0243669 0.192974 1
Schistosoma mansoni transient receptor potential channel 0.00157637 0.0000637172 0.00968938
Echinococcus granulosus potassium voltage gated channel subfamily A 0.00157637 0.0000637172 0.000330185
Treponema pallidum cysteinyl-tRNA synthetase 0.00234573 0.00657598 0.5
Schistosoma mansoni voltage-gated ion channel 0.00157637 0.0000637172 0.00968938
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.00157637 0.0000637172 0.00968938
Echinococcus granulosus potassium voltage gated channel subfamily D 0.00157637 0.0000637172 0.000330185
Echinococcus multilocularis TRP (transient receptor potential) channel 0.00157637 0.0000637172 0.000330185
Loa Loa (eye worm) voltage-dependent calcium channel 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis cysteinyl tRNA synthetase 0.00234573 0.00657598 0.034077
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.00157637 0.0000637172 0.000330185
Echinococcus multilocularis voltage gated potassium channel 0.00157637 0.0000637172 0.000330185
Echinococcus granulosus TRP transient receptor potential channel 0.00157637 0.0000637172 0.000330185
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis potassium voltage gated channel protein 0.00157637 0.0000637172 0.000330185
Echinococcus granulosus hyperpolarization activated cyclic 0.00157637 0.0000637172 0.000330185
Loa Loa (eye worm) hypothetical protein 0.00157637 0.0000637172 0.00968938
Echinococcus granulosus short transient receptor potential channel 6 0.00157637 0.0000637172 0.000330185
Echinococcus granulosus voltage gated potassium channel 0.00157637 0.0000637172 0.000330185
Schistosoma mansoni voltage-gated potassium channel 0.00157637 0.0000637172 0.00968938
Brugia malayi Transient-receptor-potential like protein 0.00157637 0.0000637172 0.00968938
Schistosoma mansoni voltage-gated potassium channel 0.00157637 0.0000637172 0.00968938
Echinococcus granulosus transient receptor potential cation channel 0.00157637 0.0000637172 0.000330185
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.00157637 0.0000637172 0.000330185
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.00157637 0.0000637172 0.00968938
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.00234573 0.00657598 1
Brugia malayi voltage-dependent calcium channel 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.00157637 0.0000637172 0.000330185
Schistosoma mansoni voltage-gated potassium channel 0.00157637 0.0000637172 0.00968938
Schistosoma mansoni cysteinyl-tRNA synthetase 0.00234573 0.00657598 1
Schistosoma mansoni voltage-gated potassium channel 0.00157637 0.0000637172 0.00968938
Schistosoma mansoni inositol 145-trisphosphate receptor 0.00157637 0.0000637172 0.00968938
Loa Loa (eye worm) hypothetical protein 0.00157637 0.0000637172 0.00968938
Echinococcus granulosus potassium voltage gated channel protein 0.00157637 0.0000637172 0.000330185
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.00157637 0.0000637172 0.00968938
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.00157637 0.0000637172 0.000330185
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.00157637 0.0000637172 0.00968938
Brugia malayi olfactory channel protein osm-9 0.00157637 0.0000637172 0.00968938
Loa Loa (eye worm) hypothetical protein 0.00157637 0.0000637172 0.00968938
Echinococcus granulosus transient receptor potential cation channel 0.00157637 0.0000637172 0.000330185
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.00157637 0.0000637172 0.00968938
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.00157637 0.0000637172 0.000330185
Schistosoma mansoni voltage-gated potassium channel 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.00157637 0.0000637172 0.000330185
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.00234573 0.00657598 1
Schistosoma mansoni voltage-gated potassium channel 0.00157637 0.0000637172 0.00968938
Schistosoma mansoni voltage-gated potassium channel 0.00157637 0.0000637172 0.00968938
Schistosoma mansoni vesicular amine transporter 0.00157637 0.0000637172 0.00968938
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.00157637 0.0000637172 0.00968938
Schistosoma mansoni calcium-activated potassium channel 0.00157637 0.0000637172 0.00968938
Echinococcus granulosus voltage gated potassium channel 0.00157637 0.0000637172 0.000330185
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.00234573 0.00657598 1
Loa Loa (eye worm) hypothetical protein 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis potassium voltage gated channel protein 0.00157637 0.0000637172 0.000330185
Schistosoma mansoni voltage-gated potassium channel 0.00157637 0.0000637172 0.00968938
Schistosoma mansoni voltage-gated potassium channel 0.00157637 0.0000637172 0.00968938
Echinococcus granulosus short transient receptor potential channel 6 0.00157637 0.0000637172 0.000330185
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.00220856 0.00541492 0.821712
Plasmodium falciparum cysteine--tRNA ligase 0.00234573 0.00657598 1
Echinococcus multilocularis sodium leak channel non selective protein 0.00157637 0.0000637172 0.000330185
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.00157637 0.0000637172 0.000330185
Echinococcus granulosus potassium voltage gated channel subfamily H 0.00157637 0.0000637172 0.000330185
Echinococcus granulosus voltage dependent calcium channel 0.00157637 0.0000637172 0.000330185
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.00234573 0.00657598 1
Echinococcus granulosus potassium large conductance calcium activated 0.00157637 0.0000637172 0.000330185
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.00157637 0.0000637172 0.00968938
Loa Loa (eye worm) hypothetical protein 0.00157637 0.0000637172 0.00968938
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis potassium voltage gated channel protein 0.00157637 0.0000637172 0.000330185
Leishmania major cysteinyl-tRNA synthetase, putative 0.00234573 0.00657598 0.033758
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00157637 0.0000637172 0.00968938
Loa Loa (eye worm) hypothetical protein 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.00157637 0.0000637172 0.000330185
Echinococcus multilocularis ryanodine receptor 44f 0.00157637 0.0000637172 0.000330185
Plasmodium falciparum cysteine--tRNA ligase 0.00234573 0.00657598 1
Giardia lamblia Cysteinyl-tRNA synthetase 0.00234573 0.00657598 0.5
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.00157637 0.0000637172 0.000330185
Echinococcus multilocularis conserved hypothetical protein 0.00157637 0.0000637172 0.000330185
Echinococcus granulosus transient receptor potential cation channel 0.00157637 0.0000637172 0.000330185
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.00157637 0.0000637172 0.00968938
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.00157637 0.0000637172 0.00968938
Schistosoma mansoni voltage-dependent calcium channel 0.00157637 0.0000637172 0.00968938
Echinococcus granulosus two pore calcium channel protein 1 0.00157637 0.0000637172 0.000330185
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.00157637 0.0000637172 0.000330185
Schistosoma mansoni voltage-gated potassium channel 0.00157637 0.0000637172 0.00968938
Loa Loa (eye worm) ion channel NompC 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis hyperpolarization activated cyclic 0.00157637 0.0000637172 0.000330185
Echinococcus multilocularis transient receptor potential gamma protein 0.00157637 0.0000637172 0.000330185
Loa Loa (eye worm) ryanodine receptor 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis transfer RNA-Gly 0.00157637 0.0000637172 0.000330185
Schistosoma mansoni voltage-gated potassium channel 0.00157637 0.0000637172 0.00968938
Echinococcus granulosus transient receptor potential cation channel 0.00157637 0.0000637172 0.000330185
Echinococcus granulosus potassium voltage gated channel protein 0.00157637 0.0000637172 0.000330185
Loa Loa (eye worm) hypothetical protein 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis transient receptor potential cation channel 0.00157637 0.0000637172 0.000330185
Echinococcus granulosus voltage dependent calcium channel 0.00157637 0.0000637172 0.000330185
Echinococcus multilocularis transient receptor potential cation channel 0.00157637 0.0000637172 0.000330185
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.00157637 0.0000637172 0.00968938
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.00220856 0.00541492 0.821712
Echinococcus multilocularis voltage dependent calcium channel 0.00157637 0.0000637172 0.000330185
Echinococcus granulosus hypothetical protein 0.00157637 0.0000637172 0.000330185
Echinococcus granulosus calcium activated potassium channel 0.00157637 0.0000637172 0.000330185
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00157637 0.0000637172 0.00968938
Schistosoma mansoni two-pore calcium channel 0.00157637 0.0000637172 0.00968938
Brugia malayi hypothetical protein 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.00157637 0.0000637172 0.000330185
Loa Loa (eye worm) hypothetical protein 0.00157637 0.0000637172 0.00968938
Loa Loa (eye worm) voltage-gated potassium channel 0.00157637 0.0000637172 0.00968938
Loa Loa (eye worm) hypothetical protein 0.00157637 0.0000637172 0.00968938
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.00157637 0.0000637172 0.00968938
Schistosoma mansoni voltage-gated potassium channel 0.00157637 0.0000637172 0.00968938
Echinococcus granulosus transient receptor potential cation channel 0.00157637 0.0000637172 0.000330185
Leishmania major dihydrofolate reductase-thymidylate synthase 0.00220856 0.00541492 0.0277393
Schistosoma mansoni voltage-gated potassium channel 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis sodium channel protein 0.0243669 0.192974 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis transient receptor potential cation channel 0.00157637 0.0000637172 0.000330185
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00157637 0.0000637172 0.00968938
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.00157637 0.0000637172 0.00968938
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.00157637 0.0000637172 0.00968938
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.00234573 0.00657598 0.00657598
Echinococcus multilocularis potassium voltage gated channel protein 0.00157637 0.0000637172 0.000330185
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.00157637 0.0000637172 0.000330185
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.00234573 0.00657598 0.5
Echinococcus granulosus potassium voltage gated channel subfamily D 0.00157637 0.0000637172 0.000330185
Echinococcus granulosus cysteinyl tRNA synthetase 0.00234573 0.00657598 0.034077
Onchocerca volvulus 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.00157637 0.0000637172 0.000330185
Echinococcus granulosus potassium voltage gated channel protein 0.00157637 0.0000637172 0.000330185
Loa Loa (eye worm) hypothetical protein 0.00157637 0.0000637172 0.00968938
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.119709 1 1
Loa Loa (eye worm) hypothetical protein 0.00157637 0.0000637172 0.00968938
Loa Loa (eye worm) hypothetical protein 0.00157637 0.0000637172 0.00968938
Schistosoma mansoni voltage-gated potassium channel 0.00157637 0.0000637172 0.00968938
Loa Loa (eye worm) hypothetical protein 0.00157637 0.0000637172 0.00968938
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.00157637 0.0000637172 0.00968938
Loa Loa (eye worm) hypothetical protein 0.00157637 0.0000637172 0.00968938
Echinococcus granulosus shaker cognate 0.00157637 0.0000637172 0.000330185
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.00157637 0.0000637172 0.00968938
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.00157637 0.0000637172 0.00968938
Schistosoma mansoni voltage-gated potassium channel 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.00157637 0.0000637172 0.000330185
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.00157637 0.0000637172 0.00968938
Brugia malayi ion channel NompC 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.00157637 0.0000637172 0.000330185
Schistosoma mansoni ryanodine receptor related 0.00157637 0.0000637172 0.00968938
Brugia malayi cysteinyl tRNA synthetase protein 1 0.00234573 0.00657598 1
Echinococcus granulosus hyperpolarization activated cyclic 0.00157637 0.0000637172 0.000330185
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis transient receptor potential cation channel 0.00157637 0.0000637172 0.000330185
Loa Loa (eye worm) calcium channel 0.00157637 0.0000637172 0.00968938
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.00157637 0.0000637172 0.00968938
Echinococcus granulosus ryanodine receptor 44f 0.00157637 0.0000637172 0.000330185
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.00157637 0.0000637172 0.000330185
Echinococcus granulosus sodium channel protein 0.0243669 0.192974 1
Loa Loa (eye worm) voltage-gated calcium channel 0.00157637 0.0000637172 0.00968938
Plasmodium vivax cysteine--tRNA ligase, putative 0.00234573 0.00657598 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.00157637 0.0000637172 0.000330185
Echinococcus granulosus cyclic nucleotide gated cation channel 0.00157637 0.0000637172 0.000330185
Schistosoma mansoni 60S ribosomal protein L21 0.00157637 0.0000637172 0.00968938
Echinococcus granulosus potassium voltage gated channel subfamily D 0.00157637 0.0000637172 0.000330185
Brugia malayi cation channel family protein 0.00157637 0.0000637172 0.00968938
Mycobacterium leprae Probable cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.119709 1 1
Loa Loa (eye worm) hypothetical protein 0.00157637 0.0000637172 0.00968938
Loa Loa (eye worm) voltage-gated potassium channel 0.00157637 0.0000637172 0.00968938
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.119709 1 1
Echinococcus granulosus potassium voltage gated channel subfamily C 0.00157637 0.0000637172 0.000330185
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.00157637 0.0000637172 0.000330185
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.00157637 0.0000637172 0.000330185
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.00157637 0.0000637172 0.00968938
Loa Loa (eye worm) hypothetical protein 0.00157637 0.0000637172 0.00968938
Echinococcus granulosus cyclic nucleotide gated cation channel 0.00157637 0.0000637172 0.000330185
Echinococcus multilocularis two pore calcium channel protein 2 0.00157637 0.0000637172 0.000330185
Echinococcus granulosus transient receptor potential gamma protein 0.00157637 0.0000637172 0.000330185
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.00220856 0.00541492 0.821712
Schistosoma mansoni voltage-gated potassium channel 0.00157637 0.0000637172 0.00968938
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0243669 0.192974 1
Loa Loa (eye worm) hypothetical protein 0.00157637 0.0000637172 0.00968938
Echinococcus granulosus potassium voltage gated channel subfamily H 0.00157637 0.0000637172 0.000330185
Schistosoma mansoni voltage-gated potassium channel 0.00157637 0.0000637172 0.00968938
Schistosoma mansoni voltage-gated potassium channel 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis two pore calcium channel protein 1 0.00157637 0.0000637172 0.000330185
Echinococcus granulosus two pore calcium channel protein 2 0.00157637 0.0000637172 0.000330185
Schistosoma mansoni transient receptor potential channel 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis transient receptor potential cation channel 0.00157637 0.0000637172 0.000330185
Echinococcus granulosus transient receptor potential cation channel 0.00157637 0.0000637172 0.000330185
Loa Loa (eye worm) hypothetical protein 0.00157637 0.0000637172 0.00968938
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.00234573 0.00657598 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.00157637 0.0000637172 0.000330185
Onchocerca volvulus 0.00234573 0.00657598 1
Echinococcus multilocularis voltage gated hydrogen channel 1 0.00157637 0.0000637172 0.000330185
Echinococcus granulosus sodium leak channel non selective protein 0.00157637 0.0000637172 0.000330185
Loa Loa (eye worm) hypothetical protein 0.00157637 0.0000637172 0.00968938
Echinococcus granulosus voltage gated hydrogen channel 1 0.00157637 0.0000637172 0.000330185
Echinococcus multilocularis voltage dependent calcium channel 0.00157637 0.0000637172 0.000330185
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.00234573 0.00657598 1
Echinococcus multilocularis potassium large conductance calcium activated 0.00157637 0.0000637172 0.000330185
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.00157637 0.0000637172 0.000330185
Echinococcus multilocularis short transient receptor potential channel 6 0.00157637 0.0000637172 0.000330185
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.00157637 0.0000637172 0.00968938
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.00157637 0.0000637172 0.000330185
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.00157637 0.0000637172 0.00968938
Schistosoma mansoni voltage-gated cation channel 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis calcium activated potassium channel 0.00157637 0.0000637172 0.000330185
Schistosoma mansoni transient receptor potential channel 0.00157637 0.0000637172 0.00968938
Echinococcus granulosus leucyl tRNA synthetase 0.00234573 0.00657598 0.034077
Echinococcus multilocularis transient receptor potential cation channel 0.00157637 0.0000637172 0.000330185
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.00234573 0.00657598 0.5
Schistosoma mansoni cysteinyl-tRNA synthetase 0.00234573 0.00657598 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00157637 0.0000637172 0.00968938
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.00157637 0.0000637172 0.00968938
Loa Loa (eye worm) hypothetical protein 0.00234573 0.00657598 1
Brugia malayi cation channel family protein 0.00157637 0.0000637172 0.00968938
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.00157637 0.0000637172 0.000330185
Echinococcus granulosus potassium voltage gated channel protein 0.00157637 0.0000637172 0.000330185

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. ChEMBL. 22096101
CC50 (functional) > 100 uM Huh7 cytotoxicity for Pf inhibitors Novartis-GNF Malaria Box. No reference
CC50 > 100 uM NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) ChEMBL. 18579783
EC50 (functional) = 4.19 uM W2 Pf proliferation inhibition Novartis-GNF Malaria Box. No reference
EC50 (functional) = 4.19 uM NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
EC50 (functional) > 12.5 uM PF proliferation inhibition 3D7 Novartis-GNF Malaria Box. No reference
EC50 (functional) > 12.5 uM NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
IFI promiscuity index = 0.05882 IFI promiscuity index Novartis-GNF Malaria Box. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 18579783

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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