TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 415.57 | Formula: C27H33N3O
H donors: 1 H acceptors: 0 LogP: 5.12 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: c1ccc(cc1)C[C@H]1CN(CCN1CCNCCOc1ccccc1)c1ccccc1
InChi: 1S/C27H33N3O/c1-4-10-24(11-5-1)22-26-23-30(25-12-6-2-7-13-25)20-19-29(26)18-16-28-17-21-31-27-14-8-3-9-15-27/h1-15,26,28H,16-23H2/t26-/m0/s1
InChiKey: QVAUXAHBFWNZGE-SANMLTNESA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0348	0.2642
Echinococcus granulosus	tar DNA binding protein	0.0133	0.2676	0.3803
Schistosoma mansoni	hypothetical protein	0.0066	0.1177	0.1794
Echinococcus multilocularis	tar DNA binding protein	0.0133	0.2676	0.3803
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0417	0.3168
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.1317	1
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0178	0.0382
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0013	0	0.5
Treponema pallidum	NADH oxidase	0.0013	0	0.5
Leishmania major	hypothetical protein, conserved	0.0072	0.1317	1
Schistosoma mansoni	lamin	0.0053	0.0896	0.1366
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0133	0.2676	0.3912
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0072	0.1317	0.1317
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0053	0.0896	0.1125
Mycobacterium tuberculosis	Probable lipase LipE	0.0072	0.1317	0.1317
Plasmodium falciparum	thioredoxin reductase	0.0038	0.0555	1
Schistosoma mansoni	gabp alpha	0.0072	0.1306	0.1989
Schistosoma mansoni	hypothetical protein	0.0308	0.6562	1
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0178	0.1354
Echinococcus multilocularis	musashi	0.0053	0.0896	0.1274
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0147	0.2982	0.4392
Trypanosoma brucei	hypothetical protein, conserved	0.0072	0.1317	1
Echinococcus granulosus	GA binding protein alpha chain	0.0072	0.1306	0.1856
Schistosoma mansoni	thyroid hormone receptor	0.0137	0.276	0.4206
Schistosoma mansoni	hypothetical protein	0.0143	0.2885	0.4396
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0417	0.0636
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0072	0.1317	0.1783
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0178	0.0253
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0066	0.1177	0.1564
Loa Loa (eye worm)	hypothetical protein	0.0061	0.1074	0.1402
Trichomonas vaginalis	set domain proteins, putative	0.0253	0.5352	1
Brugia malayi	RNA recognition motif domain containing protein	0.0133	0.2676	0.5733
Echinococcus multilocularis	GA binding protein alpha chain	0.0072	0.1306	0.1856
Brugia malayi	MH2 domain containing protein	0.012	0.2387	0.5115
Loa Loa (eye worm)	hypothetical protein	0.0026	0.028	0.016
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0066	0.1177	0.1673
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0209	0.4356	0.9334
Echinococcus multilocularis	lamin	0.0053	0.0896	0.1274
Toxoplasma gondii	thioredoxin reductase	0.0038	0.0555	0.4216
Schistosoma mansoni	tar DNA-binding protein	0.0133	0.2676	0.4077
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0147	0.2982	0.4239
Mycobacterium tuberculosis	Probable lipase LipD	0.0072	0.1317	0.1317
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0417	0.0593
Schistosoma mansoni	intermediate filament proteins	0.0053	0.0896	0.1366
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.1317	0.246
Mycobacterium ulcerans	esterase/lipase LipP	0.0072	0.1317	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0097	0.186	0.186
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0417	0.0374
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.2387	0.346
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1317	0.1783
Trypanosoma cruzi	trypanothione reductase, putative	0.0038	0.0555	0.4216
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0226	0.0423
Schistosoma mansoni	tar DNA-binding protein	0.0133	0.2676	0.4077
Loa Loa (eye worm)	glutathione reductase	0.0038	0.0555	0.059
Mycobacterium tuberculosis	Conserved protein	0.0072	0.1317	0.1317
Loa Loa (eye worm)	intermediate filament protein	0.0053	0.0896	0.1125
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0778	0.1186
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0258	0.0125
Brugia malayi	Fli-1 protein	0.0218	0.4563	0.9778
Loa Loa (eye worm)	RNA binding protein	0.0133	0.2676	0.3912
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0874	0.109
Trichomonas vaginalis	esterase, putative	0.0072	0.1317	0.246
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0087	0.1644	0.1644
Schistosoma mansoni	tar DNA-binding protein	0.0133	0.2676	0.4077
Plasmodium falciparum	importin beta, putative	0.0029	0.0348	0.6266
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1317	0.1783
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0417	0.0636
Schistosoma mansoni	thyroid hormone receptor	0.0137	0.276	0.4206
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1317	0.1783
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0066	0.1177	0.1673
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0147	0.2982	0.4544
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0308	0.6562	1
Plasmodium vivax	glutathione reductase, putative	0.0038	0.0555	0.4216
Mycobacterium ulcerans	beta-lactamase	0.0072	0.1317	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.1317	0.246
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0348	0.2642
Onchocerca volvulus		0.0253	0.5352	1
Schistosoma mansoni	importin beta-1	0.0029	0.0348	0.053
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0038	0.0555	0.0555
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0026	0.028	0.0398
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0039	0.0567	0.0805
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0209	0.4356	0.6544
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.2387	0.346
Plasmodium vivax	hypothetical protein, conserved	0.0072	0.1317	1
Echinococcus granulosus	lamin	0.0053	0.0896	0.1274
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0226	0.0423
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0013	0	0.5
Echinococcus multilocularis	lamin dm0	0.0053	0.0896	0.1274
Mycobacterium tuberculosis	Probable hydrolase	0.0072	0.1317	0.1317
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0147	0.2982	0.4239
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0348	0.2642
Mycobacterium tuberculosis	Probable esterase LipL	0.0072	0.1317	0.1317
Mycobacterium tuberculosis	Probable oxidoreductase	0.0097	0.186	0.186
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0391	0.0556
Brugia malayi	RNA, U transporter 1	0.0082	0.1532	0.3283
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0127	0.2533	0.36
Schistosoma mansoni	tar DNA-binding protein	0.0133	0.2676	0.4077
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0066	0.1177	0.2522
Echinococcus granulosus	beta LACTamase domain containing family member	0.0072	0.1317	0.1872
Onchocerca volvulus		0.0053	0.0896	0.0971
Toxoplasma gondii	ABC1 family protein	0.0072	0.1317	1
Mycobacterium ulcerans	lipase LipD	0.0072	0.1317	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.1317	0.2007
Plasmodium vivax	thioredoxin reductase, putative	0.0038	0.0555	0.4216
Loa Loa (eye worm)	hypothetical protein	0.0143	0.2885	0.4239
Echinococcus granulosus	GPCR family 2	0.0066	0.1177	0.1673
Onchocerca volvulus		0.0072	0.1317	0.1823
Brugia malayi	intermediate filament protein	0.0053	0.0896	0.192
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0087	0.1644	0.6017
Trichomonas vaginalis	ran, putative	0.0021	0.0178	0.0333
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0066	0.1177	0.1673
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0226	0.1719
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0147	0.2982	0.639
Onchocerca volvulus		0.0072	0.1317	0.1823
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0209	0.4356	0.9334
Brugia malayi	Pre-SET motif family protein	0.0223	0.4667	1
Brugia malayi	beta-lactamase family protein	0.0072	0.1317	0.2822
Brugia malayi	RNA binding protein	0.0133	0.2676	0.5733
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.1317	0.246
Mycobacterium tuberculosis	Probable dehydrogenase	0.0087	0.1644	0.1644
Brugia malayi	Thioredoxin reductase	0.0038	0.0555	0.119
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0026	0.028	0.0398
Echinococcus multilocularis	GPCR, family 2	0.0066	0.1177	0.1673
Brugia malayi	Intermediate filament tail domain containing protein	0.0053	0.0896	0.192
Schistosoma mansoni	hypothetical protein	0.0066	0.1177	0.1794
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0226	0.0423
Brugia malayi	beta-lactamase family protein	0.0072	0.1317	0.2822
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0097	0.186	0.186
Schistosoma mansoni	hypothetical protein	0.0066	0.1177	0.1794
Echinococcus granulosus	snurportin 1	0.0308	0.6562	0.9328
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0066	0.1177	0.1673
Onchocerca volvulus		0.0072	0.1317	0.1823
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0417	0.0593
Echinococcus multilocularis	tumor protein p63	0.0329	0.7035	1
Brugia malayi	beta-lactamase	0.0072	0.1317	0.2822
Schistosoma mansoni	lamin	0.0053	0.0896	0.1366
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0178	0.3212
Schistosoma mansoni	ran	0.0021	0.0178	0.0272
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0147	0.2982	0.4239
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0896	0.1125
Brugia malayi	glutathione reductase	0.0038	0.0555	0.119
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0348	0.0494
Brugia malayi	Ets-domain containing protein	0.0072	0.1306	0.2798
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0258	0.0125
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0072	0.1317	0.1872
Mycobacterium tuberculosis	Conserved protein	0.0072	0.1317	0.1317
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0087	0.1644	0.1644
Echinococcus granulosus	tumor protein p63	0.0329	0.7035	1
Plasmodium vivax	SET domain protein, putative	0.0032	0.0417	0.3168
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0147	0.2982	0.4239
Echinococcus granulosus	lamin dm0	0.0053	0.0896	0.1274
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.1317	0.246
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.1317	0.2007
Schistosoma mansoni	ets-related	0.0218	0.4563	0.6953
Leishmania major	GTP-binding protein, putative	0.0021	0.0178	0.1354
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0178	0.1354
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0029	0.0343	0.0259
Onchocerca volvulus		0.0048	0.0778	0.0732
Loa Loa (eye worm)	TAR-binding protein	0.0133	0.2676	0.3912
Brugia malayi	latrophilin 2 splice variant baaae	0.0143	0.2885	0.6181
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0147	0.2982	0.4544
Brugia malayi	Pre-SET motif family protein	0.0032	0.0417	0.0894
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0087	0.1644	0.1644
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0013	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0778	0.094
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0178	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0178	0.1354
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0178	0.0253
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0223	0.4667	0.7031
Schistosoma mansoni	ran	0.0021	0.0178	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0348	0.0266
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0178	0.1354
Loa Loa (eye worm)	beta-lactamase	0.0072	0.1317	0.1783
Loa Loa (eye worm)	hypothetical protein	0.0209	0.4356	0.6544
Schistosoma mansoni	tar DNA-binding protein	0.0133	0.2676	0.4077
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0072	0.1317	0.1317
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1317	0.1783
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0072	0.1317	0.2822
Schistosoma mansoni	hypothetical protein	0.0127	0.2533	0.386
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0072	0.1306	0.1766
Trypanosoma brucei	trypanothione reductase	0.0038	0.0555	0.4216
Brugia malayi	cytoplasmic intermediate filament protein	0.0029	0.0343	0.0736
Schistosoma mansoni	hypothetical protein	0.0066	0.1177	0.1794
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1317	0.1783
Brugia malayi	Ets-domain containing protein	0.0072	0.1306	0.2798
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1317	0.1783
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0072	0.1317	0.1317
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0348	0.0494
Leishmania major	trypanothione reductase	0.0038	0.0555	0.4216
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0147	0.2982	0.4544
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0087	0.1644	0.1644
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0072	0.1317	1
Onchocerca volvulus		0.0053	0.0896	0.0971
Echinococcus granulosus	thioredoxin glutathione reductase	0.0039	0.0567	0.0805
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0226	0.1719
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.1317	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0137	0.276	0.3923
Plasmodium falciparum	glutathione reductase	0.0038	0.0555	1
Brugia malayi	Importin beta-1 subunit	0.0029	0.0348	0.0745
Entamoeba histolytica	hypothetical protein	0.0023	0.0226	1
Loa Loa (eye worm)	thioredoxin reductase	0.0038	0.0555	0.059
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0348	0.2642
Mycobacterium tuberculosis	Probable reductase	0.0087	0.1644	0.1644
Brugia malayi	TAR-binding protein	0.0133	0.2676	0.5733
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0417	0.0636
Mycobacterium ulcerans	hypothetical protein	0.0072	0.1317	1
Echinococcus granulosus	intermediate filament protein	0.0053	0.0896	0.1274
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0097	0.186	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.1317	0.246
Loa Loa (eye worm)	fli-1 protein	0.0218	0.4563	0.6868
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1177	0.1564
Brugia malayi	Latrophilin receptor protein 2	0.0066	0.1177	0.2522
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0127	0.2533	0.36
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0417	0.0636
Echinococcus multilocularis	snurportin 1	0.0308	0.6562	0.9328
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0417	0.0593
Mycobacterium tuberculosis	Conserved protein	0.0072	0.1317	0.1317
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0178	0.1354

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)		NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence.	ChEMBL.	22096101
CC50 (functional)	> 5.32 uM	Huh7 cytotoxicity for Pf inhibitors	Novartis-GNF Malaria Box.	No reference
CC50	> 5.32 uM	NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)	ChEMBL.	18579783
EC50 (functional)	= 0.1997 uM	W2 Pf proliferation inhibition	Novartis-GNF Malaria Box.	No reference
EC50 (functional)	= 0.1997 uM	NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay	ChEMBL.	18579783
EC50 (functional)	= 0.2613 uM	PF proliferation inhibition 3D7	Novartis-GNF Malaria Box.	No reference
EC50 (functional)	= 0.2613 uM	NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay	ChEMBL.	18579783
IFI promiscuity index	= 0.01235	IFI promiscuity index	Novartis-GNF Malaria Box.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	18579783

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL602606
Search by Novartis-GNF Malaria Box

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 605953