TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 556.312 | Formula: C25H26Cl4N4O2
H donors: 1 H acceptors: 3 LogP: 7.61 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: O=C(Nc1cc(nn1c1ccc(c(c1)Cl)Cl)C(C)(C)C)CN(C(=O)c1ccc(c(c1)Cl)Cl)C(C)C
InChi: 1S/C25H26Cl4N4O2/c1-14(2)32(24(35)15-6-8-17(26)19(28)10-15)13-23(34)30-22-12-21(25(3,4)5)31-33(22)16-7-9-18(27)20(29)11-16/h6-12,14H,13H2,1-5H3,(H,30,34)
InChiKey: QDZVJLDNKVLQDC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Cathepsin F homolog	0.002	0.0146	0.111
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0986	0.1453
Brugia malayi	Cathepsin L-like precursor	0.002	0.0146	0.0215
Brugia malayi	beta-lactamase family protein	0.0073	0.1316	0.1939
Onchocerca volvulus		0.0059	0.101	0.7674
Plasmodium falciparum	glutathione reductase	0.0048	0.0754	1
Brugia malayi	cytoplasmic intermediate filament protein	0.0032	0.0404	0.0595
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0121	0.2367	0.2314
Trypanosoma cruzi	cysteine peptidase, putative	0.0076	0.1387	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0146	0.111
Plasmodium falciparum	thioredoxin reductase	0.0048	0.0754	1
Echinococcus multilocularis	tumor protein p63	0.037	0.7848	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0048	0.0754	0.5202
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0121	0.2367	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0146	0.111
Onchocerca volvulus		0.0059	0.101	0.7674
Leishmania major	trypanothione reductase	0.0048	0.0754	0.5202
Leishmania major	cathepsin L-like protease	0.002	0.0146	0.059
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.1387	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0032	0.0404	0.0595
Trypanosoma cruzi	cysteine peptidase, putative	0.0076	0.1387	1
Onchocerca volvulus		0.002	0.0146	0.111
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0017	0.0068	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0146	0.111
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0146	0.01
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0146	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0896	0.1321
Brugia malayi	Intermediate filament tail domain containing protein	0.0059	0.101	0.1488
Mycobacterium ulcerans	esterase/lipase LipP	0.0073	0.1316	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0146	0.111
Echinococcus granulosus	beta LACTamase domain containing family member	0.0073	0.1316	0.1677
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.1316	1
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0029	0.0334	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0028	0.031	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0334	0.0493
Leishmania major	cathepsin L-like protease	0.002	0.0146	0.059
Loa Loa (eye worm)	intermediate filament protein	0.0059	0.101	0.1488
Brugia malayi	Cathepsin L-like precursor	0.002	0.0146	0.0215
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0109	0.2099	0.2045
Onchocerca volvulus		0.0073	0.1316	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0017	0.0068	0.5
Trichomonas vaginalis	penicillin-binding protein, putative	0.0073	0.1316	1
Brugia malayi	Cathepsin L-like precursor	0.002	0.0146	0.0215
Leishmania major	cathepsin L-like protease	0.0076	0.1387	1
Schistosoma mansoni	cellular tumor antigen P53	0.0054	0.0896	0.1321
Plasmodium vivax	vivapain-2	0.002	0.0146	0.0624
Leishmania major	cysteine peptidase A (CPA)	0.002	0.0146	0.059
Echinococcus granulosus	cathepsin l cysteine peptidase	0.002	0.0146	0.0186
Leishmania major	cathepsin L-like protease	0.002	0.0146	0.059
Brugia malayi	MH2 domain containing protein	0.0143	0.2853	0.4205
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0146	0.111
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.1387	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.002	0.0146	0.0186
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0146	0.111
Leishmania major	cathepsin L-like protease	0.002	0.0146	0.059
Trichomonas vaginalis	penicillin-binding protein, putative	0.0073	0.1316	1
Brugia malayi	RNA recognition motif domain containing protein	0.0321	0.6786	1
Toxoplasma gondii	thioredoxin reductase	0.0048	0.0754	0.5499
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0146	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0073	0.1316	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1316	0.1939
Schistosoma mansoni	intermediate filament proteins	0.0059	0.101	0.1488
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.007	0.1241	0.8893
Mycobacterium tuberculosis	Conserved protein	0.0073	0.1316	0.1256
Treponema pallidum	NADH oxidase	0.0017	0.0068	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0321	0.6786	1
Loa Loa (eye worm)	cysteine protease	0.002	0.0146	0.0215
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.1387	1
Leishmania major	cathepsin L-like protease	0.0076	0.1387	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.0048	0.0754	0.0961
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0146	0.111
Loa Loa (eye worm)	transcription factor SMAD2	0.0143	0.2853	0.4205
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.1387	1
Loa Loa (eye worm)	RNA binding protein	0.0321	0.6786	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0146	0.111
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0017	0.0068	0.01
Echinococcus multilocularis	lamin dm0	0.0059	0.101	0.121
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0109	0.2099	0.7457
Loa Loa (eye worm)	hypothetical protein	0.002	0.0146	0.0215
Loa Loa (eye worm)	glutathione reductase	0.0048	0.0754	0.1112
Loa Loa (eye worm)	thioredoxin reductase	0.0048	0.0754	0.1112
Brugia malayi	glutathione reductase	0.0048	0.0754	0.1112
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0048	0.0754	0.0882
Trichomonas vaginalis	esterase, putative	0.0073	0.1316	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0073	0.1316	0.1256
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1316	0.1939
Leishmania major	hypothetical protein, conserved	0.0073	0.1316	0.946
Echinococcus granulosus	cathepsin l1	0.002	0.0146	0.0186
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0073	0.1316	0.1939
Brugia malayi	intermediate filament protein	0.0059	0.101	0.1488
Echinococcus granulosus	lamin dm0	0.0059	0.101	0.1287
Trypanosoma cruzi	cruzipain precursor, putative	0.0076	0.1387	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0146	0.111
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0146	0.01
Brugia malayi	Cathepsin L-like precursor	0.002	0.0146	0.0215
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0146	0.111
Brugia malayi	beta-lactamase family protein	0.0073	0.1316	0.1939
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0146	0.111
Plasmodium falciparum	cysteine proteinase falcipain 3	0.002	0.0146	0.1135
Schistosoma mansoni	lamin	0.0059	0.101	0.1488
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0321	0.6786	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0109	0.2099	0.2045
Onchocerca volvulus		0.002	0.0146	0.111
Mycobacterium tuberculosis	Probable reductase	0.0109	0.2099	0.2045
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0109	0.2099	0.2045
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0146	0.111
Onchocerca volvulus		0.002	0.0146	0.111
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0146	0.111
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0073	0.1316	0.1256
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1316	0.1939
Brugia malayi	RNA binding protein	0.0321	0.6786	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0073	0.1316	0.1939
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0146	0.111
Trichomonas vaginalis	glutathione reductase, putative	0.0017	0.0068	0.0518
Toxoplasma gondii	ABC1 family protein	0.0073	0.1316	1
Loa Loa (eye worm)	ctsf protein	0.002	0.0146	0.0215
Schistosoma mansoni	tar DNA-binding protein	0.0321	0.6786	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0146	0.111
Trypanosoma cruzi	major cysteine proteinase, putative	0.006	0.1027	0.7269
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0017	0.0068	0.01
Trypanosoma cruzi	cysteine peptidase, putative	0.0076	0.1387	1
Plasmodium vivax	thioredoxin reductase, putative	0.0048	0.0754	0.5499
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.1387	1
Onchocerca volvulus		0.002	0.0146	0.111
Mycobacterium tuberculosis	Conserved protein	0.0073	0.1316	0.1256
Plasmodium vivax	hypothetical protein, conserved	0.0073	0.1316	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0146	0.111
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0146	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1316	0.1939
Loa Loa (eye worm)	fibroinase	0.002	0.0146	0.0215
Echinococcus multilocularis	musashi	0.0059	0.101	0.121
Onchocerca volvulus		0.0073	0.1316	1
Onchocerca volvulus		0.002	0.0146	0.111
Echinococcus multilocularis	cysteine protease	0.002	0.0146	0.01
Trichomonas vaginalis	mercuric reductase, putative	0.0017	0.0068	0.0518
Echinococcus multilocularis	lamin	0.0059	0.101	0.121
Trypanosoma brucei	hypothetical protein, conserved	0.0073	0.1316	0.946
Plasmodium vivax	glutathione reductase, putative	0.0048	0.0754	0.5499
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.002	0.0146	0.1135
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0059	0.101	0.1488
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0146	0.111
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0073	0.1316	0.1939
Entamoeba histolytica	cysteine protease, putative	0.002	0.0146	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0073	0.1316	0.1256
Plasmodium vivax	vivapain-2	0.002	0.0146	0.0624
Onchocerca volvulus		0.0054	0.0896	0.6812
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0146	0.111
Mycobacterium tuberculosis	Probable hydrolase	0.0073	0.1316	0.1256
Loa Loa (eye worm)	TAR-binding protein	0.0321	0.6786	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0073	0.1316	0.1256
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.1387	1
Brugia malayi	Thioredoxin reductase	0.0048	0.0754	0.1112
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0146	0.01
Echinococcus multilocularis	cysteine protease	0.002	0.0146	0.01
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0146	0.111
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.002	0.0146	0.0215
Trypanosoma cruzi	cysteine peptidase, putative	0.002	0.0146	0.059
Echinococcus granulosus	lamin	0.0059	0.101	0.1287
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.1316	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.1387	1
Brugia malayi	beta-lactamase	0.0073	0.1316	0.1939
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.1316	0.946
Echinococcus granulosus	intermediate filament protein	0.0059	0.101	0.1287
Mycobacterium ulcerans	lipase LipD	0.0073	0.1316	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.1387	1
Schistosoma mansoni	tar DNA-binding protein	0.0321	0.6786	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.1387	1
Echinococcus multilocularis	tar DNA binding protein	0.0321	0.6786	0.8634
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0017	0.0068	0.5
Mycobacterium ulcerans	beta-lactamase	0.0073	0.1316	1
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0029	0.0334	0.0426
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0146	0.111
Brugia malayi	TAR-binding protein	0.0321	0.6786	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.002	0.0146	0.1135
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0048	0.0754	0.0691
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.1316	0.946
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0121	0.2367	0.2314
Schistosoma mansoni	lamin	0.0059	0.101	0.1488
Brugia malayi	Cathepsin L-like precursor	0.002	0.0146	0.0215
Schistosoma mansoni	tar DNA-binding protein	0.0321	0.6786	1
Mycobacterium tuberculosis	Conserved protein	0.0073	0.1316	0.1256
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1316	0.1939
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.1387	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0146	0.111
Mycobacterium ulcerans	hypothetical protein	0.0073	0.1316	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0109	0.2099	0.2045
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0109	0.2099	0.2045
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0146	0.0215
Trypanosoma brucei	trypanothione reductase	0.0048	0.0754	0.5202
Leishmania major	cathepsin L-like protease	0.0076	0.1387	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0146	0.111
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0146	0.0215
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0017	0.0068	0.0087
Mycobacterium tuberculosis	Probable lipase LipD	0.0073	0.1316	0.1256
Onchocerca volvulus		0.002	0.0146	0.111
Echinococcus granulosus	tar DNA binding protein	0.0321	0.6786	0.8646
Loa Loa (eye worm)	hypothetical protein	0.0059	0.101	0.1488
Leishmania major	cathepsin L-like protease	0.002	0.0146	0.059
Loa Loa (eye worm)	hypothetical protein	0.0028	0.031	0.0458
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0146	0.111
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.1316	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.1387	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0146	0.111
Onchocerca volvulus		0.002	0.0146	0.111
Brugia malayi	Cathepsin L-like precursor	0.002	0.0146	0.0215
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0073	0.1316	0.1256
Onchocerca volvulus		0.0073	0.1316	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0146	0.111
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0146	0.0215
Loa Loa (eye worm)	MH2 domain-containing protein	0.0143	0.2853	0.4205
Schistosoma mansoni	tar DNA-binding protein	0.0321	0.6786	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0121	0.2367	0.2314
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0073	0.1316	0.1604
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0146	0.01
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0146	0.111
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1316	0.1939
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0073	0.1316	0.1939
Toxoplasma gondii	cathepsin CPL	0.002	0.0146	0.0624
Loa Loa (eye worm)	beta-lactamase	0.0073	0.1316	0.1939
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0017	0.0068	0.5
Echinococcus granulosus	tumor protein p63	0.037	0.7848	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0146	0.111

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)		NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence.	ChEMBL.	22096101
CC50 (functional)	> 10 uM	Huh7 cytotoxicity for Pf inhibitors	Novartis-GNF Malaria Box.	No reference
CC50	> 10 uM	NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)	ChEMBL.	18579783
EC50 (functional)	= 0.356 uM	W2 Pf proliferation inhibition	Novartis-GNF Malaria Box.	No reference
EC50 (functional)	= 0.356 uM	NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay	ChEMBL.	18579783
EC50 (functional)	= 1.014 uM	PF proliferation inhibition 3D7	Novartis-GNF Malaria Box.	No reference
EC50 (functional)	= 1.014 uM	NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay	ChEMBL.	18579783
IFI promiscuity index	= 0.01852	IFI promiscuity index	Novartis-GNF Malaria Box.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	18579783

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL578307
Search by Novartis-GNF Malaria Box

Bibliographic References

No literature references available for this target.

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Detailed information for compound 606009