Detailed information for compound 606018

Basic information

Technical information
  • TDR Targets ID: 606018
  • Name: Maybridge1_004820
  • MW: 375.464 | Formula: C23H25N3O2
  • H donors: 1 H acceptors: 2 LogP: 4.37 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(=O)/C(=C/NC1CCN(CC1)Cc1ccccc1)/C#N
  • InChi: 1S/C23H25N3O2/c1-28-22-9-7-19(8-10-22)23(27)20(15-24)16-25-21-11-13-26(14-12-21)17-18-5-3-2-4-6-18/h2-10,16,21,25H,11-14,17H2,1H3/b20-16+
  • InChiKey: ZUUWRPVQFWNWID-CAPFRKAQSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • KM 08560
  • SR-01000640156-1

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0074 0.086 0.0976
Loa Loa (eye worm) latrophilin receptor protein 2 0.016 0.2084 0.2373
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0153 0.0153
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.086 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0122 0.014
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.1027 0.5531
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.181 0.3781
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0122 0.1112
Echinococcus granulosus tumor protein p63 0.0351 0.4787 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0122 0.0255
Trypanosoma brucei trypanothione reductase 0.0038 0.0347 0.4035
Loa Loa (eye worm) beta-lactamase 0.0074 0.086 0.0976
Echinococcus multilocularis Smad4 0.0024 0.0159 0.0332
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0019 0.0021
Schistosoma mansoni importin beta-1 0.0029 0.0232 0.0492
Brugia malayi Calcitonin receptor-like protein seb-1 0.0506 0.6985 0.797
Brugia malayi Smad1 0.0024 0.0159 0.0181
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0122 1
Loa Loa (eye worm) glutathione reductase 0.0038 0.0347 0.039
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0892 0.1863
Schistosoma mansoni tar DNA-binding protein 0.0202 0.2675 0.5671
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0232 0.2699
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0019 0.0015
Schistosoma mansoni thyroid hormone receptor 0.0135 0.1725 0.3658
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0202 0.2675 0.3048
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0347 0.0535
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0091 0.1099 0.2297
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.086 0.1824
Loa Loa (eye worm) hypothetical protein 0.0051 0.0544 0.0614
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0195 0.0222
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0091 0.1099 1
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.086 0.086
Plasmodium vivax SET domain protein, putative 0.0091 0.1099 1
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.086 0.1326
Loa Loa (eye worm) hypothetical protein 0.0026 0.0188 0.0208
Schistosoma mansoni ran 0.0022 0.0122 0.0259
Schistosoma mansoni hypothetical protein 0.0314 0.4259 0.9031
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0232 0.2112
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0347 0.3157
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.181 0.2065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.1099 0.2331
Plasmodium vivax hypothetical protein, conserved 0.0074 0.086 0.7824
Brugia malayi Ets-domain containing protein 0.0071 0.0816 0.0932
Schistosoma mansoni lamin 0.0027 0.0195 0.0413
Brugia malayi Pre-SET motif family protein 0.0091 0.1099 0.1254
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0159 0.0332
Echinococcus granulosus snurportin 1 0.0314 0.4259 0.8898
Brugia malayi MH2 domain containing protein 0.0355 0.4849 0.5533
Schistosoma mansoni Smad4 0.0024 0.0159 0.0337
Loa Loa (eye worm) Smad1 0.0024 0.0159 0.0175
Schistosoma mansoni hypothetical protein 0.016 0.2084 0.4419
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.1163 0.1792
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0354 0.074
Echinococcus multilocularis lamin 0.0027 0.0195 0.0406
Mycobacterium ulcerans hypothetical protein 0.0074 0.086 1
Schistosoma mansoni tar DNA-binding protein 0.0202 0.2675 0.5671
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.086 0.086
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.1163 1
Schistosoma mansoni hypothetical protein 0.0076 0.0892 0.1891
Loa Loa (eye worm) TAR-binding protein 0.0202 0.2675 0.3048
Brugia malayi RNA recognition motif domain containing protein 0.0202 0.2675 0.3052
Echinococcus multilocularis tumor protein p63 0.0351 0.4787 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.086 0.0976
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0159 0.0332
Brugia malayi MH1 domain containing protein 0.0024 0.0159 0.0181
Schistosoma mansoni lamin 0.0027 0.0195 0.0413
Brugia malayi Latrophilin receptor protein 2 0.016 0.2084 0.2378
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0816 0.1705
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0159 0.0175
Brugia malayi MH2 domain containing protein 0.0024 0.0159 0.0181
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0153 0.0153
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.181 0.3838
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0354 0.074
Schistosoma mansoni smad1 5 8 and 0.0024 0.0159 0.0337
Schistosoma mansoni gabp alpha 0.0071 0.0816 0.1731
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0122 0.3524
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0122 0.0133
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0347 0.4035
Plasmodium vivax importin-beta 2, putative 0.0029 0.0232 0.2112
Entamoeba histolytica hypothetical protein 0.0076 0.0892 1
Trichomonas vaginalis ran, putative 0.0022 0.0122 0.0122
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.086 0.086
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0159 0.0332
Mycobacterium tuberculosis Conserved protein 0.0074 0.086 0.1326
Loa Loa (eye worm) hypothetical protein 0.0074 0.086 0.0976
Loa Loa (eye worm) fli-1 protein 0.0215 0.2853 0.3251
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0159 0.0337
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0232 0.2699
Schistosoma mansoni ets-related 0.0215 0.2853 0.6049
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.1027 0.1584
Mycobacterium tuberculosis Conserved protein 0.0074 0.086 0.1326
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0 0.5
Echinococcus multilocularis musashi 0.0027 0.0195 0.0406
Entamoeba histolytica hypothetical protein 0.0076 0.0892 1
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.086 0.086
Brugia malayi Pre-SET motif family protein 0.0632 0.8764 1
Schistosoma mansoni thyroid hormone receptor 0.0135 0.1725 0.3658
Brugia malayi hypothetical protein 0.0076 0.0892 0.1017
Echinococcus multilocularis smad 0.0024 0.0159 0.0332
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.181 0.3781
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0632 0.8764 1
Toxoplasma gondii ABC1 family protein 0.0074 0.086 0.7824
Mycobacterium tuberculosis Conserved protein 0.0074 0.086 0.1326
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0122 0.1422
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.086 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.0259
Trichomonas vaginalis set domain proteins, putative 0.0719 1 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0122 0.0255
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.086 0.0976
Entamoeba histolytica hypothetical protein 0.0076 0.0892 1
Echinococcus multilocularis snurportin 1 0.0314 0.4259 0.8898
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.086 0.1326
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.086 0.1824
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.181 0.3838
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0159 0.0332
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.086 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0153 0.1784
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.1027 0.1584
Echinococcus multilocularis thyroid hormone receptor alpha 0.0135 0.1725 0.3604
Brugia malayi glutathione reductase 0.0038 0.0347 0.0396
Echinococcus granulosus lamin dm0 0.0027 0.0195 0.0406
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.086 0.1797
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0122 0.1422
Brugia malayi latrophilin 2 splice variant baaae 0.0346 0.4717 0.5382
Loa Loa (eye worm) transcription factor SMAD2 0.0355 0.4849 0.553
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.1027 0.1584
Schistosoma mansoni hypothetical protein 0.016 0.2084 0.4419
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0892 0.1891
Echinococcus granulosus importin subunit beta 1 0.0029 0.0232 0.0485
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.181 0.3781
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.1583 0.3308
Onchocerca volvulus 0.0074 0.086 0.0679
Brugia malayi intermediate filament protein 0.0027 0.0195 0.0222
Echinococcus granulosus tar DNA binding protein 0.0202 0.2675 0.5588
Brugia malayi RNA, U transporter 1 0.0084 0.1 0.1141
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.1163 0.1792
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0091 0.1099 0.2297
Onchocerca volvulus 0.0051 0.0544 0.0356
Brugia malayi TAR-binding protein 0.0202 0.2675 0.3052
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.086 0.0981
Loa Loa (eye worm) hypothetical protein 0.0074 0.086 0.0976
Schistosoma mansoni smad1 5 8 and 0.0024 0.0159 0.0337
Schistosoma mansoni hypothetical protein 0.016 0.2084 0.4419
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.016 0.2084 0.4354
Brugia malayi beta-lactamase family protein 0.0074 0.086 0.0981
Mycobacterium tuberculosis Probable reductase 0.0086 0.1027 0.1584
Loa Loa (eye worm) hypothetical protein 0.0074 0.086 0.0976
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0 0.5
Schistosoma mansoni hypothetical protein 0.0346 0.4717 1
Brugia malayi MH1 domain containing protein 0.0024 0.0159 0.0181
Leishmania major importin beta-1 subunit, putative 0.0024 0.0153 0.1784
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.086 0.1326
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.016 0.2084 0.2378
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.086 0.1326
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0816 0.1705
Plasmodium falciparum importin beta, putative 0.0029 0.0232 0.669
Schistosoma mansoni tar DNA-binding protein 0.0202 0.2675 0.5671
Loa Loa (eye worm) hypothetical protein 0.0091 0.1099 0.1249
Mycobacterium ulcerans beta-lactamase 0.0074 0.086 1
Brugia malayi Fli-1 protein 0.0215 0.2853 0.3256
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.016 0.2084 0.4354
Schistosoma mansoni intermediate filament proteins 0.0027 0.0195 0.0413
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0091 0.1099 0.2331
Loa Loa (eye worm) hypothetical protein 0.0027 0.0195 0.0216
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0471 0.6487 1
Echinococcus granulosus lamin 0.0027 0.0195 0.0406
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0122 0.1422
Echinococcus multilocularis lamin dm0 0.0027 0.0195 0.0406
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0544 0.1152
Loa Loa (eye worm) hypothetical protein 0.006 0.0671 0.076
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0506 0.6985 0.797
Plasmodium vivax glutathione reductase, putative 0.0038 0.0347 0.3157
Echinococcus granulosus histone lysine methyltransferase setb 0.0091 0.1099 0.2297
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.1099 0.2331
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.1163 0.1792
Leishmania major trypanothione reductase 0.0038 0.0347 0.4035
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0153 0.0153
Brugia malayi MH1 domain containing protein 0.0013 0.0006 0.0006
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.016 0.2084 0.4354
Echinococcus granulosus GPCR family 2 0.016 0.2084 0.4354
Brugia malayi Ets-domain containing protein 0.0071 0.0816 0.0932
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.181 0.3781
Leishmania major GTP-binding protein, putative 0.0022 0.0122 0.1422
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.1583 0.3308
Plasmodium falciparum glutathione reductase 0.0038 0.0347 1
Onchocerca volvulus 0.0074 0.086 0.0679
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.086 0.1326
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0195 0.0216
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0816 0.0926
Loa Loa (eye worm) MH2 domain-containing protein 0.0355 0.4849 0.553
Brugia malayi RNA binding protein 0.0202 0.2675 0.3052
Loa Loa (eye worm) hypothetical protein 0.0346 0.4717 0.5379
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.086 0.1326
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.086 1
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0347 0.039
Loa Loa (eye worm) RNA binding protein 0.0202 0.2675 0.3048
Echinococcus granulosus intermediate filament protein 0.0027 0.0195 0.0406
Brugia malayi beta-lactamase 0.0074 0.086 0.0981
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0087 0.1052 0.2198
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0232 0.0485
Onchocerca volvulus 0.0091 0.1099 0.0923
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.181 0.3838
Brugia malayi Importin beta-1 subunit 0.0029 0.0232 0.0265
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0314 0.4259 0.4857
Trichomonas vaginalis esterase, putative 0.0074 0.086 0.086
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0122 0.1112
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.086 0.086
Schistosoma mansoni hypothetical protein 0.0125 0.1583 0.3357
Echinococcus multilocularis tar DNA binding protein 0.0202 0.2675 0.5588
Loa Loa (eye worm) hypothetical protein 0.0506 0.6985 0.7969
Echinococcus multilocularis GPCR, family 2 0.016 0.2084 0.4354
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.1027 0.1584
Brugia malayi beta-lactamase family protein 0.0074 0.086 0.0981
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.181 0.206
Schistosoma mansoni ran 0.0022 0.0122 0.0259
Schistosoma mansoni tar DNA-binding protein 0.0202 0.2675 0.5671
Schistosoma mansoni tar DNA-binding protein 0.0202 0.2675 0.5671
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.086 1
Echinococcus granulosus smad 0.0024 0.0159 0.0332
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.1099 0.2331
Toxoplasma gondii thioredoxin reductase 0.0038 0.0347 0.3157
Brugia malayi Thioredoxin reductase 0.0038 0.0347 0.0396
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.1027 0.1584
Brugia malayi MH1 domain containing protein 0.0013 0.0006 0.0006
Schistosoma mansoni smad 0.0024 0.0159 0.0337
Leishmania major hypothetical protein, conserved 0.0074 0.086 1
Schistosoma mansoni smad1 5 8 and 0.0024 0.0159 0.0337
Entamoeba histolytica hypothetical protein 0.0024 0.0153 0.0405
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0506 0.6985 0.7969
Entamoeba histolytica hypothetical protein 0.0076 0.0892 1
Brugia malayi MH2 domain containing protein 0.0024 0.0159 0.0181
Echinococcus granulosus Smad4 0.0024 0.0159 0.0332
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0159 0.0175
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0195 0.0216
Schistosoma mansoni hypothetical protein 0.016 0.2084 0.4419
Mycobacterium ulcerans lipase LipD 0.0074 0.086 1
Treponema pallidum NADH oxidase 0.0013 0 0.5
Loa Loa (eye worm) hypothetical protein 0.016 0.2084 0.2373
Plasmodium falciparum thioredoxin reductase 0.0038 0.0347 1
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.086 0.1326
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.086 0.1797
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0892 0.1863
Loa Loa (eye worm) hypothetical protein 0.0074 0.086 0.0976
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.016 0.2084 0.4354
Onchocerca volvulus 0.0074 0.086 0.0679

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. ChEMBL. 22096101
CC50 (functional) > 10 uM Huh7 cytotoxicity for Pf inhibitors Novartis-GNF Malaria Box. No reference
CC50 > 10 uM NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) ChEMBL. 18579783
CC50 (functional) = 24.77 uM Huh7 cytotoxicity for Pf inhibitors Novartis-GNF Malaria Box. No reference
EC50 (functional) = 0.1771 uM PF proliferation inhibition 3D7 Novartis-GNF Malaria Box. No reference
EC50 (functional) = 0.2564 uM PF proliferation inhibition 3D7 Novartis-GNF Malaria Box. No reference
EC50 (functional) = 0.2564 uM NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
EC50 (functional) = 0.875 uM W2 Pf proliferation inhibition Novartis-GNF Malaria Box. No reference
EC50 (functional) > 1.575 uM W2 Pf proliferation inhibition Novartis-GNF Malaria Box. No reference
EC50 (functional) > 1.575 uM NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
IFI promiscuity index = 0.03333 IFI promiscuity index Novartis-GNF Malaria Box. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 18579783

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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