Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0037 | 0.2768 | 0.2768 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.237 | 0.237 |
Onchocerca volvulus | 0.0027 | 0.1562 | 0.5 | |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.1562 | 0.1452 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.1562 | 0.1562 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0129 | 0.0129 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.1562 | 0.1562 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.4301 | 0.4301 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0096 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 0.1562 | 0.1452 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.2768 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.1562 | 0.1452 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.1562 | 0.1452 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.2768 | 0.2674 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.2768 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.15 | 0.15 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.237 | 0.227 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.1562 | 0.1562 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.4301 | 0.4301 |
Schistosoma mansoni | lamin | 0.0027 | 0.1562 | 0.1452 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.2768 | 0.2674 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.1562 | 0.1452 |
Echinococcus multilocularis | lamin | 0.0027 | 0.1562 | 0.1452 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.4301 | 0.4301 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.1562 | 0.1562 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0129 | 0.0129 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0096 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.2768 | 0.2674 |
Echinococcus multilocularis | musashi | 0.0027 | 0.1562 | 0.1452 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0129 | 0.0129 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.237 | 0.237 |
Echinococcus granulosus | lamin | 0.0027 | 0.1562 | 0.1452 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0129 | 0.0129 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0096 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.4301 | 0.4301 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.2768 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.2768 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1562 | 0.1562 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 0.1562 | 0.5 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.2768 | 0.2674 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. | ChEMBL. | 22096101 | |
CC50 (functional) | > 10 uM | Huh7 cytotoxicity for Pf inhibitors | Novartis-GNF Malaria Box. | No reference |
CC50 | > 10 uM | NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) | ChEMBL. | 18579783 |
EC50 (functional) | > 0.467 uM | PF proliferation inhibition 3D7 | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | > 0.467 uM | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
EC50 (functional) | > 1.735 uM | W2 Pf proliferation inhibition | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | > 1.735 uM | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
IFI promiscuity index | = 0 | IFI promiscuity index | Novartis-GNF Malaria Box. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 18579783 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.