Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0017 | 0 | 0.5 |
Echinococcus granulosus | chromobox protein 1 | 0.0074 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0356 | 0.0356 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.1468 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.1468 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0356 | 0.2422 |
Schistosoma mansoni | chromobox protein | 0.0074 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0356 | 0.0356 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.1468 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.0176 | 0.1199 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0017 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.4317 | 0.2714 |
Trichomonas vaginalis | chromobox protein, putative | 0.0044 | 0.4867 | 0.3419 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.4317 | 0.4317 |
Brugia malayi | hypothetical protein | 0.0038 | 0.3746 | 0.3746 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0044 | 0.4867 | 1 |
Onchocerca volvulus | 0.0032 | 0.2751 | 0.3773 | |
Echinococcus granulosus | chromobox protein 1 | 0.0074 | 1 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.1468 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.1468 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.0176 | 0.1199 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1468 | 0.1468 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0356 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.1468 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0356 | 0.0356 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.3746 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0019 | 0.0356 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.1468 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.1468 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.3746 | 0.3746 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.4317 | 0.2714 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.0176 | 0.1199 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.2751 | 0.2751 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.1468 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0.0356 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.1468 | 0.1468 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1468 | 0.1468 |
Brugia malayi | chromobox protein homolog 3 | 0.0041 | 0.4317 | 0.4317 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.1468 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.1468 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.3746 | 0.3746 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.3746 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.1468 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0074 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0074 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0074 | 1 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0074 | 1 | 1 |
Schistosoma mansoni | chromobox protein | 0.0074 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0356 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1468 | 0.1468 |
Trichomonas vaginalis | chromobox protein, putative | 0.0044 | 0.4867 | 0.3419 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.1468 | 0.1468 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0356 | 0.0356 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.0176 | 0.1199 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.3746 | 0.3746 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.3746 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.4317 | 0.8381 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0 | 0.5 |
Echinococcus multilocularis | chromobox protein 1 | 0.0074 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.1468 | 0.1468 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.1468 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.3746 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.1468 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.1468 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.3746 | 0.3746 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. | ChEMBL. | 22096101 | |
CC50 (functional) | > 100 uM | Huh7 cytotoxicity for Pf inhibitors | Novartis-GNF Malaria Box. | No reference |
CC50 | > 100 uM | NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) | ChEMBL. | 18579783 |
EC50 (functional) | = 1.824 uM | PF proliferation inhibition 3D7 | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | = 1.824 uM | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
EC50 (functional) | = 2.514 uM | W2 Pf proliferation inhibition | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | = 2.514 uM | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
IFI promiscuity index | = 0.03361 | IFI promiscuity index | Novartis-GNF Malaria Box. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 18579783 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.