Detailed information for compound 606433

Basic information

Technical information
  • TDR Targets ID: 606433
  • Name: 6,8-dichloro-7-hydroxychromen-2-one
  • MW: 231.032 | Formula: C9H4Cl2O3
  • H donors: 1 H acceptors: 2 LogP: 2.81 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1ccc2c(o1)c(Cl)c(c(c2)Cl)O
  • InChi: 1S/C9H4Cl2O3/c10-5-3-4-1-2-6(12)14-9(4)7(11)8(5)13/h1-3,13H
  • InChiKey: QNHURTAKNXBFQQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6,8-dichloro-7-hydroxy-chromen-2-one
  • 6,8-dichloro-7-hydroxy-2-chromenone
  • 6,8-dichloro-7-hydroxy-coumarin
  • Oprea1_744236

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.00000000015149 0.0000000011631
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.1269 0.1269
Leishmania major GTP-binding protein, putative 0.0023 0.038 0.029
Mycobacterium tuberculosis Conserved hypothetical protein 0.0061 0.1539 0.1892
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.149 0.149
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.1103 0.1036
Onchocerca volvulus 0.0039 0.0876 0.0817
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0532 0.0532
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.038 0.038
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1539 0.1485
Echinococcus granulosus lamin 0.0028 0.0532 0.0532
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0876 0.5398
Leishmania major DNA polymerase kappa, putative 0.0019 0.0248 0.0155
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0876 0.0876
Mycobacterium ulcerans beta-lactamase 0.0039 0.0876 0.1319
Entamoeba histolytica hypothetical protein 0.0038 0.0821 0.405
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.1883 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.038 0.2467
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0174 0.0078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1134 0.1134
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.1093 0.1025
Schistosoma mansoni terminal deoxycytidyl transferase 0.0061 0.1539 0.1539
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.038 0.038
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.1883 0.1839
Schistosoma mansoni ran 0.0023 0.038 0.038
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.095 0.095
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.038 0.029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1134 0.1134
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0156 0.4465 0.4499
Echinococcus multilocularis musashi 0.0028 0.0532 0.0532
Leishmania major importin beta-1 subunit, putative 0.0026 0.0452 0.0365
Trichomonas vaginalis DNA polymerase eta, putative 0.0061 0.1539 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.149 0.149
Loa Loa (eye worm) hypothetical protein 0.0019 0.0248 0.0248
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0876 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0212 0.0545
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0039 0.0876 0.0876
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0019 0.0248 0.1907
Echinococcus multilocularis dna polymerase eta 0.0089 0.2394 0.2394
Schistosoma mansoni importin beta-1 0.0032 0.0635 0.0635
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0635 0.0554
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0452 0.2458
Loa Loa (eye worm) hypothetical protein 0.0028 0.0532 0.0532
Mycobacterium tuberculosis Conserved hypothetical protein 0.0174 0.5007 0.6699
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0331 0.9805 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0876 0.1319
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0206 0.5977 0.5977
Loa Loa (eye worm) hypothetical protein 0.0028 0.0516 0.0516
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.1883 0.1883
Onchocerca volvulus 0.0039 0.0876 0.0817
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0876 0.0973
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0174 0.2738
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.1539 0.2713
Schistosoma mansoni hypothetical protein 0.0177 0.5101 0.5101
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0174 0.0174
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0876 0.0876
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0174 0.0078
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.1883 0.1883
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1539 0.1485
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0876 0.133
Leishmania major DNA damage repair protein, putative 0.0019 0.0248 0.0155
Brugia malayi mbt repeat family protein 0.0052 0.1269 0.1927
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0061 0.1539 0.1892
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.038 0.038
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0248 0.0155
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.1883 0.286
Trypanosoma brucei unspecified product 0.0061 0.1539 0.1485
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.038 0.2915
Brugia malayi mbt repeat family protein 0.0052 0.1269 0.1927
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.1539 0.1485
Brugia malayi follicle stimulating hormone receptor 0.0225 0.6584 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.1883 0.1883
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0174 0.0174
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0174 0.0174
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0532 0.0808
Brugia malayi beta-lactamase 0.0039 0.0876 0.133
Loa Loa (eye worm) hypothetical protein 0.0039 0.0876 0.0876
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.1269 0.1269
Schistosoma mansoni hypothetical protein 0.0317 0.9401 0.9401
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0876 0.0973
Plasmodium falciparum importin beta, putative 0.0032 0.0635 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0174 0.0174
Entamoeba histolytica hypothetical protein 0.0038 0.0821 0.405
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0452 0.2458
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.1269 0.1269
Trichomonas vaginalis esterase, putative 0.0039 0.0876 0.5398
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0452 0.0365
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.1269 0.1269
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0958 0.0886
Loa Loa (eye worm) hypothetical protein 0.0059 0.149 0.149
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0174 0.0174
Giardia lamblia DNA damage repair protein 0.0019 0.0248 0.1613
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1134 0.1134
Echinococcus granulosus dna polymerase kappa 0.0061 0.1539 0.1539
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0085 0.0085
Trypanosoma brucei unspecified product 0.0042 0.0958 0.0886
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.1539 0.2713
Loa Loa (eye worm) hypothetical protein 0.0039 0.0876 0.0876
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.1539 0.1485
Echinococcus multilocularis lamin 0.0028 0.0532 0.0532
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.1405 0.1346
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0473 0.0719
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1539 0.1485
Echinococcus multilocularis snurportin 1 0.0337 1 1
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0635 0.0635
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0532 0.0532
Mycobacterium tuberculosis Conserved protein 0.0039 0.0876 0.0973
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0061 0.1539 0.1539
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.1539 0.1485
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1539 0.1485
Echinococcus multilocularis geminin 0.0177 0.5101 0.5101
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.038 0.0577
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0156 0.4465 0.4499
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0375 0.5908
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0473 0.2604
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0248 0.0155
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0174 0.1336
Toxoplasma gondii ABC1 family protein 0.0039 0.0876 0.6725
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.038 0.2931
Schistosoma mansoni lamin 0.0028 0.0532 0.0532
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0206 0.5977 0.5977
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0876 0.0973
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.1134 0.1723
Loa Loa (eye worm) hypothetical protein 0.0165 0.474 0.474
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.1093 0.1025
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.1539 0.1485
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.1883 0.1839
Schistosoma mansoni DNA polymerase IV / kappa 0.0019 0.0248 0.0248
Brugia malayi RNA, U transporter 1 0.009 0.242 0.3675
Brugia malayi hypothetical protein 0.0038 0.0821 0.1247
Entamoeba histolytica hypothetical protein 0.0038 0.0821 0.405
Trichomonas vaginalis ran, putative 0.0023 0.038 0.1955
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0174 0.0078
Schistosoma mansoni DNA polymerase eta 0.0089 0.2394 0.2394
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0876 0.0802
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0047 0.1103 0.8472
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0876 0.0802
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.0248 0.1907
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1134 0.1134
Leishmania major DNA polymerase kappa, putative 0.0061 0.1539 0.1485
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0061 0.1539 0.1485
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0876 0.0973
Brugia malayi hypothetical protein 0.0165 0.474 0.7199
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0635 0.4877
Trypanosoma cruzi DNA polymerase eta, putative 0.0089 0.2394 0.2366
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0876 0.5398
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.1093 0.1025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1134 0.1134
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0131 0.0131
Entamoeba histolytica Ran family GTPase 0.0023 0.038 0.1579
Loa Loa (eye worm) RecQ helicase 0.0026 0.0473 0.0473
Brugia malayi polk-prov protein 0.0019 0.0248 0.0377
Mycobacterium tuberculosis Conserved protein 0.0039 0.0876 0.0973
Loa Loa (eye worm) hypothetical protein 0.0013 0.0069 0.0069
Mycobacterium tuberculosis Conserved protein 0.0039 0.0876 0.0973
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1134 0.1134
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0635 0.0554
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0248 0.0155
Mycobacterium ulcerans hypothetical protein 0.0174 0.5007 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0248 0.0155
Schistosoma mansoni hypothetical protein 0.0337 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0248 0.0155
Schistosoma mansoni intermediate filament proteins 0.0028 0.0532 0.0532
Leishmania major DNA polymerase eta, putative 0.0047 0.1103 0.1036
Loa Loa (eye worm) hypothetical protein 0.0089 0.2394 0.2394
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.6584 0.6584
Mycobacterium leprae Probable lipase LipE 0.0039 0.0876 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.1539 0.1485
Brugia malayi Importin beta-1 subunit 0.0032 0.0635 0.0965
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0876 0.0876
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.038 0.029
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0156 0.4465 0.4499
Entamoeba histolytica deoxycytidyl transferase, putative 0.0061 0.1539 0.8073
Schistosoma mansoni lamin 0.0028 0.0532 0.0532
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.1539 0.1485
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.038 0.5977
Leishmania major mitochondrial DNA polymerase beta 0.0331 0.9805 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0876 0.0973
Plasmodium vivax importin-beta 2, putative 0.0032 0.0635 0.6572
Echinococcus granulosus importin subunit beta 1 0.0032 0.0635 0.0635
Echinococcus granulosus geminin 0.0177 0.5101 0.5101
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0085 0.0085
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.1269 0.1269
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1134 0.1134
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.1269 0.1269
Loa Loa (eye worm) beta-lactamase 0.0039 0.0876 0.0876
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0876 0.5
Plasmodium falciparum DNA repair protein REV1, putative 0.0019 0.0248 0.3909
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0174 0.0174
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1539 0.1485
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.1134 0.1134
Echinococcus granulosus bloom syndrome protein 0.0026 0.0473 0.0473
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.038 0.029
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.1883 0.1839
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0958 0.0886
Echinococcus granulosus dna polymerase eta 0.0089 0.2394 0.2394
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0876 0.0973
Echinococcus granulosus transcription factor Dp 1 0.0042 0.095 0.095
Leishmania major DNA polymerase eta, putative 0.0089 0.2394 0.2366
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1539 0.1485
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1539 0.1485
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0174 0.0078
Loa Loa (eye worm) MBCTL1 0.0059 0.149 0.149
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0958 0.0886
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0174 0.1336
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0821 0.0821
Loa Loa (eye worm) hypothetical protein 0.0013 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0038 0.0821 0.0821
Mycobacterium ulcerans lipase LipD 0.0039 0.0876 0.1319
Loa Loa (eye worm) hypothetical protein 0.0032 0.0635 0.0635
Leishmania major hypothetical protein, conserved 0.0039 0.0876 0.0802
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0337 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0876 0.5398
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0821 0.0821
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1539 0.1485
Loa Loa (eye worm) hypothetical protein 0.0039 0.0876 0.0876
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.1269 0.1269
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.1883 0.1839
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0061 0.1539 0.1539
Loa Loa (eye worm) hypothetical protein 0.0052 0.1269 0.1269
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0206 0.158
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0248 0.0155
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.149 0.149
Schistosoma mansoni ran 0.0023 0.038 0.038
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.149 0.149
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0473 0.0473
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0331 0.9805 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.1539 0.1485
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0131 0.0198
Trypanosoma brucei unspecified product 0.0042 0.0958 0.0886
Brugia malayi ImpB/MucB/SamB family protein 0.0089 0.2394 0.3637
Trypanosoma brucei chrX additional, unordered contigs 0.0019 0.0248 0.0155
Echinococcus multilocularis dna polymerase kappa 0.0061 0.1539 0.1539
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0876 0.0973
Loa Loa (eye worm) hypothetical protein 0.0039 0.0876 0.0876
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0876 0.0876
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0061 0.1539 0.1539
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0248 0.0155
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0174 0.0078
Brugia malayi beta-lactamase family protein 0.0039 0.0876 0.133
Trypanosoma brucei DNA polymerase eta, putative 0.0089 0.2394 0.2366
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0452 0.2458
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.1269 0.1269
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0876 0.0802
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.1883 0.1883
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0248 0.0155
Brugia malayi intermediate filament protein 0.0028 0.0532 0.0808
Plasmodium vivax DNA repair protein REV1, putative 0.0019 0.0248 0.106
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.149 0.149
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.1269 0.175
Loa Loa (eye worm) hypothetical protein 0.0039 0.0876 0.0876
Onchocerca volvulus 0.0165 0.474 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0331 0.9805 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1539 0.1485
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0174 0.0174
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0876 0.1319
Loa Loa (eye worm) hypothetical protein 0.0014 0.0085 0.0085
Brugia malayi ImpB/MucB/SamB family protein 0.0061 0.1539 0.2338
Onchocerca volvulus 0.0039 0.0876 0.0817
Echinococcus granulosus lamin dm0 0.0028 0.0532 0.0532
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0876 0.5398
Onchocerca volvulus 0.0052 0.1269 0.175
Schistosoma mansoni hypothetical protein 0.0177 0.5101 0.5101
Entamoeba histolytica hypothetical protein 0.0038 0.0821 0.405
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0304 0.0304
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0876 0.5398
Toxoplasma gondii hypothetical protein 0.0053 0.1302 1
Brugia malayi isocitrate dehydrogenase 0.0017 0.0174 0.0264
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0876 0.0876
Echinococcus multilocularis lamin dm0 0.0028 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.0132 0.3723 0.3723
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0174 0.0264
Mycobacterium ulcerans hypothetical protein 0.0039 0.0876 0.1319
Echinococcus granulosus intermediate filament protein 0.0028 0.0532 0.0532
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0248 0.0155
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.1093 0.1025
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0061 0.1539 1
Giardia lamblia DINP protein human, muc B family 0.0061 0.1539 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0473 0.2604
Brugia malayi beta-lactamase family protein 0.0039 0.0876 0.133
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0248 0.0155
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.149 0.2263
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1539 0.1485
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0252 0.7389 1
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0821 0.0821
Entamoeba histolytica hypothetical protein 0.0026 0.0452 0.1985
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0061 0.1539 0.1539

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. ChEMBL. 22096101
CC50 (functional) > 10 uM Huh7 cytotoxicity for Pf inhibitors Novartis-GNF Malaria Box. No reference
CC50 > 10 uM NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) ChEMBL. 18579783
EC50 (functional) > 0.2338 uM W2 Pf proliferation inhibition Novartis-GNF Malaria Box. No reference
EC50 (functional) > 0.2338 uM NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
EC50 (functional) > 1.25 uM PF proliferation inhibition 3D7 Novartis-GNF Malaria Box. No reference
EC50 (functional) > 1.25 uM NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
IFI promiscuity index = 0.07143 IFI promiscuity index Novartis-GNF Malaria Box. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 18579783

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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