Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.00783326 | 1 | 1 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.00283536 | 0.0322062 | 0.0322062 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.00783326 | 1 | 1 |
Trypanosoma cruzi | phosphatidylinositol 4-kinase alpha, putative | 0.00496371 | 0.444341 | 0.444341 |
Trypanosoma cruzi | phosphatidylinositol 4-kinase alpha, putative | 0.00496371 | 0.444341 | 0.444341 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.00783326 | 1 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.00783326 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.00783326 | 1 | 1 |
Brugia malayi | phosphatidylinositol 4-kinase, catalytic, alpha polypeptide | 0.00496371 | 0.444341 | 0.444341 |
Toxoplasma gondii | phosphatidylinositol 3- and 4-kinase | 0.00290127 | 0.0449702 | 0.0449702 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.00783326 | 1 | 1 |
Plasmodium vivax | phosphatidylinositol 3-kinase, putative | 0.00266904 | 0 | 0.5 |
Toxoplasma gondii | fructose-bisphospatase I | 0.00283536 | 0.0322062 | 0.0322062 |
Entamoeba histolytica | phosphatidylinositol 4-kinase, putative | 0.00496371 | 0.444341 | 1 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.00283536 | 0.0322062 | 0.0322062 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.00496371 | 0.444341 | 1 |
Echinococcus multilocularis | phosphatidylinositol 4 kinase alpha | 0.00496371 | 0.444341 | 0.444341 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.00783326 | 1 | 1 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.00266904 | 0 | 0.5 |
Trichomonas vaginalis | phosphatidylinositol 4-kinase, putative | 0.00496371 | 0.444341 | 1 |
Leishmania major | 0.00783326 | 1 | 1 | |
Toxoplasma gondii | fructose-bisphospatase II | 0.00783326 | 1 | 1 |
Schistosoma mansoni | phosphatidylinositol 4-kinase | 0.00496371 | 0.444341 | 0.444341 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.00283536 | 0.0322062 | 0.0322062 |
Leishmania major | phosphatidylinositol 4-kinase alpha, putative | 0.00496371 | 0.444341 | 0.444341 |
Loa Loa (eye worm) | phosphatidylinositol 4-kinase type 3 alpha isoform 1 | 0.00496371 | 0.444341 | 0.444341 |
Plasmodium falciparum | phosphatidylinositol 3-kinase | 0.00266904 | 0 | 0.5 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.00783326 | 1 | 1 |
Echinococcus granulosus | phosphatidylinositol 4 kinase alpha | 0.00496371 | 0.444341 | 0.444341 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.00283536 | 0.0322062 | 0.0322062 |
Trypanosoma brucei | phosphatidylinositol 4-kinase alpha, putative | 0.00496371 | 0.444341 | 0.444341 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. | ChEMBL. | 22096101 | |
CC50 (functional) | > 100 uM | Huh7 cytotoxicity for Pf inhibitors | Novartis-GNF Malaria Box. | No reference |
CC50 | > 100 uM | NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) | ChEMBL. | 18579783 |
EC50 (functional) | > 1.992 uM | W2 Pf proliferation inhibition | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | > 1.992 uM | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
EC50 (functional) | > 12.5 uM | PF proliferation inhibition 3D7 | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | > 12.5 uM | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
IFI promiscuity index | = 0 | IFI promiscuity index | Novartis-GNF Malaria Box. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 18579783 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.