Detailed information for compound 606662

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 275.73 | Formula: C15H14ClNO2
  • H donors: 1 H acceptors: 1 LogP: 4.07 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(C(=NO)c1ccc(cc1)Cl)c1ccccc1
  • InChi: 1S/C15H14ClNO2/c1-19-15(12-5-3-2-4-6-12)14(17-18)11-7-9-13(16)10-8-11/h2-10,15,18H,1H3/b17-14-
  • InChiKey: GWIGKMUIRGDAEF-VKAVYKQESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0108 0.0355 0.0321
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0054 0.0049
Plasmodium falciparum carbamoyl phosphate synthetase 0.0211 0.0776 0.1053
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0171 0.0611 0.0594
Echinococcus multilocularis pyruvate kinase 0.0053 0.0126 0.008
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0231 0.0212
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0086 0.0261 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0664
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0417 0.1627 1
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0086 0.0261 0.0216
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0355 0.0311
Entamoeba histolytica pyruvate kinase, putative 0.0047 0.01 0.0335
Plasmodium falciparum pyruvate kinase 0.0067 0.0184 0.0229
Echinococcus multilocularis phosphoglycerate kinase 1 0.0171 0.0611 0.0568
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0063 0.0832
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0086 0.0261 0.0216
Trypanosoma brucei unspecified product 0.0613 0.2433 0.2435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0013 0.0003
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0102 0.0055
Mycobacterium tuberculosis Probable lipase LipE 0.0108 0.0355 0.0833
Toxoplasma gondii LsmAD domain-containing protein 0.0075 0.0216 0.0197
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0231 0.357
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0331 0.1274 0.3302
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0156 0.0113
Mycobacterium leprae conserved hypothetical protein 0.0108 0.0355 0.09
Toxoplasma gondii pyruvate kinase PyKII 0.0034 0.005 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0024 0.019
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0321 0.0277
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0355 0.5715
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0102 0.0055
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0211 0.0776 0.1194
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0231 0.0527
Entamoeba histolytica hypothetical protein 0.0035 0.0054 0.0044
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0104 0.0155
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0156 0.0113
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0932 0.3748 1
Brugia malayi hypothetical protein 0.0141 0.0491 0.0462
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0083 0.0037
Trypanosoma brucei pyruvate kinase 1 0.0067 0.0184 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0074 0.1022
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0063 0.0166 0.0195
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0331 0.1274 0.201
Trichomonas vaginalis sucrase-isomaltase, putative 0.0034 0.0047 0.0578
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0007
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0054 0.0022
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.2446 0.999 0.999
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0086 0.0261 0.035
Loa Loa (eye worm) hypothetical protein 0.0067 0.0184 0.0142
Chlamydia trachomatis phosphoglycerate kinase 0.0171 0.0611 0.1667
Loa Loa (eye worm) hypothetical protein 0.0047 0.01 0.0055
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0086 0.0261 0.0337
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0211 0.0776 0.1053
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0231 0.0186
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0231 0.0477
Treponema pallidum phosphoglycerate kinase 0.0171 0.0611 1
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0331 0.1274 0.1234
Echinococcus multilocularis tumor protein p63 0.0408 0.159 0.1551
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0102 0.0057
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0083 0.0037
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0331 0.1274 0.201
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB 0.0086 0.0261 0.0649
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0007
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0277 0.024
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.2361 0.9637 1
Brugia malayi Fli-1 protein 0.0232 0.0862 0.085
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0211 0.0776 0.0734
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0086 0.0261 0.0215
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0119 0.0197
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0078 0.0032
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0355 0.5715
Loa Loa (eye worm) hypothetical protein 0.0086 0.0261 0.0223
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0331 0.1274 0.1234
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0104 0.0358
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0331 0.1274 0.1259
Echinococcus multilocularis lysosomal alpha glucosidase 0.0152 0.0536 0.0492
Loa Loa (eye worm) hypothetical protein 0.0078 0.0231 0.0191
Onchocerca volvulus 0.0048 0.0107 0.0087
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0034 0.0047 0.0578
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0086 0.0261 0.0261
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0104 0.0134
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0108 0.0355 0.0321
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0104 0.0059
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0932 0.3748 0.6065
Trypanosoma brucei PAB1-binding protein , putative 0.0075 0.0216 0.0216
Mycobacterium leprae Probable biotinylated protein homolog TB7.3 0.0086 0.0261 0.0649
Loa Loa (eye worm) hypothetical protein 0.0108 0.0355 0.0321
Echinococcus multilocularis protein patched 0.0042 0.0083 0.0037
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0216 0.0273
Echinococcus granulosus pyruvate kinase 0.0034 0.005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0171 0.0611 0.0588
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0063 0.0832
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0102 0.1496
Loa Loa (eye worm) hypothetical protein 0.0108 0.0355 0.0321
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0102 0.0348
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0086 0.0261 0.0215
Trichomonas vaginalis alpha-glucosidase, putative 0.0034 0.0047 0.0578
Echinococcus multilocularis expressed conserved protein 0.0093 0.029 0.0245
Plasmodium vivax phosphoglycerate kinase, putative 0.0171 0.0611 0.0824
Leishmania major carboxylase, putative 0.0932 0.3748 0.3722
Mycobacterium tuberculosis Probable lipase LipD 0.0108 0.0355 0.0833
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0119 0.0074
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0086 0.0261 0.056
Loa Loa (eye worm) hypothetical protein 0.0108 0.0355 0.0321
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0331 0.1274 0.1234
Trichomonas vaginalis pyruvate kinase, putative 0.0067 0.0184 0.2856
Mycobacterium ulcerans esterase/lipase LipP 0.0108 0.0355 0.0813
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0076 0.0222 0.0182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0013 0.0003
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0331 0.1274 0.3302
Leishmania major acetyl-CoA carboxylase, putative 0.2446 0.999 1
Schistosoma mansoni hypothetical protein 0.0035 0.0054 0.0008
Schistosoma mansoni pyruvate carboxylase 0.0932 0.3748 0.3723
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0102 0.1496
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0152 0.0536 0.051
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0086 0.0261 0.0337
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0231 0.0294
Schistosoma mansoni acetyl-CoA carboxylase 0.2446 0.999 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide acyltransferase E2 component 0.0086 0.0261 0.0087
Onchocerca volvulus 0.006 0.0154 0.13
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0102 0.0057
Schistosoma mansoni hypothetical protein 0.0041 0.0076 0.0031
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0932 0.3748 0.3723
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0086 0.0261 0.0243
Trypanosoma brucei phosphoglycerate kinase, putative 0.0063 0.0166 0.0166
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0277 0.0233
Trypanosoma brucei phosphoglycerate kinase 0.0171 0.0611 0.0612
Onchocerca volvulus Pyruvate kinase homolog 0.0067 0.0184 0.2063
Toxoplasma gondii ABC1 family protein 0.0108 0.0355 0.0337
Leishmania major pyruvate kinase 0.0067 0.0184 0.0137
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0034 0.0047 0.0028
Mycobacterium tuberculosis Probable hydrolase 0.0108 0.0355 0.0833
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0086 0.0261 0.0223
Plasmodium falciparum pyruvate kinase 2 0.0034 0.005 0.0042
Mycobacterium leprae Probable pyruvate kinase PykA 0.0067 0.0184 0.0441
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0086 0.0261 0.0261
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0086 0.0261 0.0223
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0104 0.0134
Onchocerca volvulus Pyruvate kinase homolog 0.0067 0.0184 0.2063
Trypanosoma brucei phosphoglycerate kinase 0.0171 0.0611 0.0612
Echinococcus multilocularis lysosomal alpha glucosidase 0.0152 0.0536 0.0492
Entamoeba histolytica hypothetical protein 0.0035 0.0054 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0013 0.0003
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0108 0.0355 0.0813
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0932 0.3748 0.6065
Loa Loa (eye worm) pyruvate kinase 0.0067 0.0184 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0063 0.0832
Loa Loa (eye worm) hypothetical protein 0.0042 0.0083 0.0037
Trypanosoma brucei glucosidase, putative 0.0034 0.0047 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0024 0.019
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0932 0.3748 1
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0086 0.0261 0.0216
Echinococcus granulosus beta LACTamase domain containing family member 0.0108 0.0355 0.0311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0102 0.1496
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0331 0.1274 0.1235
Loa Loa (eye worm) pyruvate kinase 0.0067 0.0184 0.0142
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.088 0.0868
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0083 0.0037
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0171 0.0611 0.0924
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0231 0.0185
Trichomonas vaginalis alpha-glucosidase, putative 0.0034 0.0047 0.0578
Echinococcus multilocularis pyruvate kinase 0.0034 0.005 0.0004
Trichomonas vaginalis alpha-glucosidase, putative 0.0034 0.0047 0.0578
Chlamydia trachomatis pyruvate kinase 0.0067 0.0184 0.0387
Mycobacterium leprae Probable lipase LipE 0.0108 0.0355 0.09
Leishmania major phosphoglycerate kinase B, cytosolic 0.0171 0.0611 0.0567
Brugia malayi beta-lactamase family protein 0.0108 0.0355 0.0321
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0693 0.2763 0.7337
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0024 0.019
Giardia lamblia Pyruvate kinase 0.0067 0.0184 0.085
Brugia malayi Ets-domain containing protein 0.0076 0.0222 0.0182
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0086 0.0261 0.0619
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0315 0.027
Trichomonas vaginalis alpha-glucosidase, putative 0.0034 0.0047 0.0578
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0102 0.009
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0932 0.3748 0.3752
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0231 0.0527
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0277 0.0233
Schistosoma mansoni hypothetical protein 0.0041 0.0076 0.0031
Echinococcus multilocularis neutral alpha glucosidase AB 0.0034 0.0047 0.0001
Echinococcus granulosus pyruvate kinase 0.0034 0.005 0.0004
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0171 0.0611 1
Giardia lamblia GTOR 0.0047 0.0102 0.0335
Echinococcus multilocularis beta LACTamase domain containing family member 0.0108 0.0355 0.031
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.0885 0.0843
Loa Loa (eye worm) hypothetical protein 0.0099 0.0315 0.0279
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0108 0.0355 0.0321
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0355 0.0467
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.2446 0.999 1
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0154 0.0109
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0277 0.0233
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0315 0.0279
Schistosoma mansoni pyruvate kinase 0.0067 0.0184 0.0139
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0355 0.5715
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0315 0.1693
Brugia malayi CHE-14 protein 0.0042 0.0083 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0355 0.0504
Leishmania major hypothetical protein, conserved 0.0075 0.0216 0.0169
Leishmania major carbamoyl-phosphate synthase, putative 0.0211 0.0776 0.0733
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0331 0.1274 0.3317
Echinococcus multilocularis GA binding protein alpha chain 0.0076 0.0222 0.0177
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0211 0.0776 0.1953
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0932 0.3748 1
Plasmodium vivax pyruvate kinase, putative 0.0067 0.0184 0.0229
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0104 0.0134
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0489 0.0446
Mycobacterium ulcerans beta-lactamase 0.0108 0.0355 0.0813
Schistosoma mansoni alpha-glucosidase 0.0131 0.0449 0.0405
Chlamydia trachomatis biotin carboxylase 0.0846 0.3395 1
Schistosoma mansoni hypothetical protein 0.0515 0.2033 0.1998
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0054 0.0049
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0086 0.0261 0.058
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0171 0.0611 0.1526
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0086 0.0261 0.058
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0211 0.0776 0.1194
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0119 0.0074
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0104 0.0134
Loa Loa (eye worm) hypothetical protein 0.0075 0.0216 0.0175
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0231 0.0567
Trichomonas vaginalis maltase-glucoamylase, putative 0.0034 0.0047 0.0578
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0108 0.0355 0.0833
Trichomonas vaginalis esterase, putative 0.0108 0.0355 0.5715
Echinococcus granulosus phosphoglycerate kinase 1 0.0171 0.0611 0.0568
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0171 0.0611 0.0924
Schistosoma mansoni phosphoglycerate kinase 0.0171 0.0611 0.0568
Brugia malayi Phosphoglycerate kinase 0.0063 0.0166 0.0124
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0053 0.0034
Echinococcus multilocularis pyruvate kinase 0.0034 0.005 0.0004
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0054 0.0008
Toxoplasma gondii pyruvate kinase PyK1 0.0067 0.0184 0.0165
Mycobacterium ulcerans pyruvate carboxylase 0.0932 0.3748 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.0166 0.0195
Loa Loa (eye worm) hypothetical protein 0.0065 0.0177 0.0135
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0083 0.0037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0277 0.0233
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0355 0.0311
Onchocerca volvulus 0.0088 0.0271 0.4328
Brugia malayi MH2 domain containing protein 0.0236 0.088 0.0868
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.2446 0.999 1
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0086 0.0261 0.0216
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0086 0.0261 0.0337
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0331 0.1274 0.3366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0664
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0932 0.3748 0.3722
Chlamydia trachomatis acetyl-CoA carboxylase biotin carboxyl carrier protein 0.0086 0.0261 0.0619
Mycobacterium tuberculosis Conserved protein 0.0108 0.0355 0.0833
Schistosoma mansoni patched 1 0.0042 0.0083 0.0037
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0086 0.0261 0.056
Schistosoma mansoni ets-related 0.0232 0.0862 0.0821
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0108 0.0355 0.0833
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.177 0.7204 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0034 0.0047 0.0001
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0932 0.3748 1
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0331 0.1274 0.3317
Brugia malayi beta-lactamase family protein 0.0108 0.0355 0.0321
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0054 0.0008
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0331 0.1274 0.3302
Schistosoma mansoni alpha-glucosidase 0.0131 0.0449 0.0405
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0664
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0034 0.0047 0.0578
Brugia malayi Pyruvate kinase, M2 isozyme 0.0067 0.0184 0.0142
Schistosoma mansoni aspartate carbamoyltransferase 0.0211 0.0776 0.0734
Plasmodium falciparum phosphoglycerate kinase 0.0171 0.0611 0.0824
Brugia malayi hypothetical protein 0.0035 0.0054 0.0007
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0231 0.0212
Plasmodium vivax ataxin-2 like protein, putative 0.0075 0.0216 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0664
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0104 0.0227
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0211 0.0776 0.1551
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0489 0.0446
Mycobacterium ulcerans phosphoglycerate kinase 0.0171 0.0611 0.1507
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0102 0.0103
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0086 0.0261 0.0216
Mycobacterium tuberculosis Conserved protein 0.0108 0.0355 0.0833
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0086 0.0261 0.0223
Giardia lamblia Phosphoglycerate kinase 0.0171 0.0611 0.356
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.0166 0.0195
Entamoeba histolytica hypothetical protein 0.0035 0.0054 0.0044
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0007
Brugia malayi Pyruvate kinase, muscle isozyme 0.0067 0.0184 0.0142
Echinococcus granulosus expressed conserved protein 0.0093 0.029 0.0246
Trypanosoma brucei pyruvate kinase 1, putative 0.0067 0.0184 0.0184
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0277 0.0233
Echinococcus multilocularis pyruvate kinase 0.0067 0.0184 0.0138
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0355 0.5715
Brugia malayi Carboxyl transferase domain containing protein 0.2361 0.9637 1
Echinococcus multilocularis protein dispatched 1 0.0048 0.0107 0.0062
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0171 0.0611 0.1588
Loa Loa (eye worm) hypothetical protein 0.006 0.0154 0.0111
Loa Loa (eye worm) hypothetical protein 0.0108 0.0355 0.0321
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0355 0.5715
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0086 0.0261 0.0243
Trichomonas vaginalis alpha-glucosidase, putative 0.0034 0.0047 0.0578
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0023 0.017
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.0166 0.0119
Echinococcus granulosus GA binding protein alpha chain 0.0076 0.0222 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0063 0.0832
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0216 0.0273
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0331 0.1274 0.201
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.177 0.7204 1
Loa Loa (eye worm) fli-1 protein 0.0232 0.0862 0.085
Entamoeba histolytica phosphoglycerate kinase, putative 0.0171 0.0611 0.3569
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0104 0.0155
Schistosoma mansoni hypothetical protein 0.0048 0.0107 0.0062
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0331 0.1274 0.2967
Loa Loa (eye worm) hypothetical protein 0.0237 0.0885 0.0874
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0086 0.0261 0.0619
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0086 0.0261 0.0215
Loa Loa (eye worm) pyruvate kinase-PB 0.0047 0.01 0.0055
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0086 0.0261 0.035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0038 0.0427
Echinococcus granulosus geminin 0.0515 0.2033 0.1998
Loa Loa (eye worm) hypothetical protein 0.006 0.0156 0.0113
Brugia malayi hypothetical protein 0.0237 0.0885 0.0874
Onchocerca volvulus Pyruvate kinase homolog 0.0067 0.0184 0.2063
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0063 0.0025
Trypanosoma cruzi pyruvate kinase 2, putative 0.0067 0.0184 0.0223
Trichomonas vaginalis pyruvate kinase, putative 0.0067 0.0184 0.2856
Onchocerca volvulus 0.0141 0.0491 1
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0932 0.3748 0.372
Plasmodium vivax pyruvate kinase 2, putative 0.0034 0.005 0.0042
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0171 0.0611 0.1082
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0007
Leishmania major hypothetical protein, conserved 0.0108 0.0355 0.0309
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0932 0.3748 1
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0086 0.0261 0.035
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0086 0.0261 0.0216
Loa Loa (eye worm) hypothetical protein 0.0052 0.0122 0.0078
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0063 0.0063
Brugia malayi hypothetical protein 0.0075 0.0216 0.0175
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0231 0.0186
Onchocerca volvulus 0.0108 0.0355 0.649
Schistosoma mansoni hypothetical protein 0.0041 0.0078 0.0032
Treponema pallidum pyruvate carboxylase subunit B 0.0086 0.0261 0.4088
Echinococcus multilocularis pyruvate kinase 0.0067 0.0184 0.0138
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0102 0.0057
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0104 0.0134
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0086 0.0261 0.035
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0107 0.0063
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0932 0.3748 0.3723
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0083 0.1166
Echinococcus multilocularis Biotin lipoyl attachment 0.0086 0.0261 0.0216
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0104 0.0358
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0932 0.3748 0.3723
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0067 0.0184 0.0371
Toxoplasma gondii carbamoylphosphate synthetase 0.0211 0.0776 0.0759
Loa Loa (eye worm) hypothetical protein 0.0048 0.0104 0.0059
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0102 0.0348
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0331 0.1274 0.1276
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0331 0.1274 0.3366
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0063 0.0015
Trypanosoma brucei hypothetical protein, conserved 0.0108 0.0355 0.0355
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0086 0.0261 0.0243
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0277 0.024
Echinococcus granulosus acetyl coenzyme A carboxylase 1 0.2446 0.999 1
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0086 0.0261 0.0243
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0331 0.1274 0.3302
Brugia malayi Phosphoglycerate kinase 0.0171 0.0611 0.0588
Mycobacterium ulcerans hypothetical protein 0.0086 0.0261 0.056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0023 0.017
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0104 0.0059
Echinococcus multilocularis pyruvate kinase 0.0034 0.005 0.0004
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0104 0.0057
Loa Loa (eye worm) hypothetical protein 0.0041 0.0078 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0664
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0664
Loa Loa (eye worm) hypothetical protein 0.0141 0.0491 0.0462
Echinococcus granulosus pyruvate kinase 0.0067 0.0184 0.0139
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0104 0.0134
Brugia malayi hypothetical protein 0.0048 0.0107 0.0062
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0086 0.0261 0.0337
Schistosoma mansoni hypothetical protein 0.0515 0.2033 0.1998
Chlamydia trachomatis dihydrolipoamide acetyltransferase 0.0086 0.0261 0.0619
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0331 0.1274 0.3366
Brugia malayi Glycosyl hydrolases family 31 protein 0.0152 0.0536 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0063 0.0832
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0119 0.0269
Leishmania major phosphoglycerate kinase C, glycosomal 0.0171 0.0611 0.0567
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0102 0.0057
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0063 0.0166 0.0195
Schistosoma mansoni gabp alpha 0.0076 0.0222 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0013 0.0003
Trypanosoma brucei phosphoglycerate kinase 0.0063 0.0166 0.0166
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0086 0.0261 0.0261
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0315 0.027
Echinococcus multilocularis geminin 0.0515 0.2033 0.1996
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0108 0.0355 0.0833
Mycobacterium ulcerans hypothetical protein 0.0108 0.0355 0.0813
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0102 0.0057
Entamoeba histolytica hypothetical protein 0.0035 0.0054 0.0044
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0086 0.0261 0.0216
Mycobacterium tuberculosis Probable esterase LipL 0.0108 0.0355 0.0833
Schistosoma mansoni alpha glucosidase 0.0034 0.0047 0.0001
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0086 0.0261 0.035
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0331 0.1274 0.3302
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0063 0.0166 0.0195
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0102 0.0103
Loa Loa (eye worm) hypothetical protein 0.0086 0.0261 0.0223
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0104 0.0059
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0086 0.0261 0.058
Loa Loa (eye worm) hypothetical protein 0.0108 0.0355 0.0321
Echinococcus granulosus lysosomal alpha glucosidase 0.0152 0.0536 0.0493
Echinococcus granulosus pyruvate kinase 0.0067 0.0184 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0034 0.0357
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0104 0.0057
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0119 0.0197
Mycobacterium ulcerans hypothetical protein 0.0048 0.0104 0.0134
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0211 0.0776 0.0777
Schistosoma mansoni pyruvate kinase 0.0067 0.0184 0.0139
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.088 0.0868
Wolbachia endosymbiont of Brugia malayi branched-chain alpha-keto acid dehydrogenase subunit E2 0.0086 0.0261 0.0087
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0171 0.0611 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0067 0.0184 0.0223
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0104 0.0227
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0331 0.1274 0.3302
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0007
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0171 0.0611 0.0594
Leishmania major pyruvate kinase 0.0067 0.0184 0.0137
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0086 0.0261 0.0243
Mycobacterium tuberculosis Conserved protein 0.0108 0.0355 0.0833
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.0885 0.0844
Schistosoma mansoni hypothetical protein 0.0041 0.0076 0.0031
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0417 0.1627 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0216 0.0276
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0355 0.0504
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0216 0.0276
Toxoplasma gondii pyruvate carboxylase 0.0932 0.3748 0.374
Brugia malayi Probable ClpP-like protease 0.0078 0.0231 0.0191
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0331 0.1274 0.3651
Schistosoma mansoni pyruvate kinase 0.0034 0.005 0.0004
Onchocerca volvulus 0.0108 0.0355 0.649
Onchocerca volvulus 0.0108 0.0355 0.649
Echinococcus granulosus tumor protein p63 0.0408 0.159 0.1552
Mycobacterium ulcerans lipase LipD 0.0108 0.0355 0.0813
Loa Loa (eye worm) hypothetical protein 0.0086 0.0261 0.0223
Trypanosoma cruzi acetyl-CoA carboxylase 0.1514 0.615 1
Trypanosoma brucei acetyl-CoA carboxylase 0.2446 0.999 1
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0932 0.3748 0.3752
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0086 0.0261 0.035
Loa Loa (eye worm) hypothetical protein 0.0048 0.0104 0.0059
Mycobacterium ulcerans pyruvate kinase 0.0067 0.0184 0.035
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0054 0.0008
Echinococcus granulosus Biotin lipoyl attachment 0.0086 0.0261 0.0216
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0102 0.009
Schistosoma mansoni survival motor neuron protein 0.0048 0.0107 0.0062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0277 0.0233
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0277 0.0233
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0932 0.3748 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0104 0.0134
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0231 0.0294
Brugia malayi beta-lactamase 0.0108 0.0355 0.0321
Echinococcus granulosus pyruvate kinase 0.0034 0.005 0.0004
Brugia malayi Ets-domain containing protein 0.0076 0.0222 0.0182
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0231 0.0477
Loa Loa (eye worm) hypothetical protein 0.0048 0.0104 0.0059
Loa Loa (eye worm) beta-lactamase 0.0108 0.0355 0.0321
Loa Loa (eye worm) pyruvate kinase 0.0067 0.0184 0.0142
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0104 0.0358
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0211 0.0776 0.0734
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0086 0.0261 0.0215
Schistosoma mansoni hypothetical protein 0.0041 0.0076 0.0031
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0331 0.1274 0.1235
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0086 0.0261 0.0261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0664
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0932 0.3748 1
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0086 0.0261 0.0337
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0156 0.0113
Schistosoma mansoni phosphoglycerate kinase 0.0171 0.0611 0.0568
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0086 0.0261 0.035
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0104 0.0057

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) > 10 uM Huh7 cytotoxicity for Pf inhibitors Novartis-GNF Malaria Box. No reference
EC50 (functional) > 0.912 uM PF proliferation inhibition 3D7 Novartis-GNF Malaria Box. No reference
EC50 (functional) > 1.607 uM W2 Pf proliferation inhibition Novartis-GNF Malaria Box. No reference
IFI promiscuity index = 0 IFI promiscuity index Novartis-GNF Malaria Box. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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