TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 372.46 | Formula: C15H20N2O5S2
H donors: 3 H acceptors: 5 LogP: 0.5 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OC1CCN(C1)C(=S)SC1=C(C(=O)O)N2[C@H]([C@H]1C)[C@H](C2=O)[C@H](O)C
InChi: 1S/C15H20N2O5S2/c1-6-10-9(7(2)18)13(20)17(10)11(14(21)22)12(6)24-15(23)16-4-3-8(19)5-16/h6-10,18-19H,3-5H2,1-2H3,(H,21,22)/t6-,7-,8?,9-,10-/m1/s1
InChiKey: RGVLIQFYPAPJQR-OCMJYRRLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	AKH receptor	0.0065	0.0465	0.0481
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0133	0.1324	0.1324
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.005	0.0266	0.0276
Loa Loa (eye worm)	G-protein coupled receptor	0.0065	0.0465	0.0481
Onchocerca volvulus		0.0031	0.0019	0.0141
Schistosoma mansoni	amine GPCR	0.0229	0.2555	0.2642
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0065	0.0465	0.0481
Echinococcus granulosus	chromobox protein 1	0.007	0.0518	0.0536
Brugia malayi	hypothetical protein	0.0065	0.0465	0.0481
Echinococcus multilocularis	neuroligin	0.0133	0.1324	0.1324
Plasmodium falciparum	thioredoxin reductase	0.0047	0.0232	1
Brugia malayi	Carboxylesterase family protein	0.0133	0.1324	0.1369
Brugia malayi	Serotonin receptor	0.0065	0.0465	0.0481
Brugia malayi	jmjC domain containing protein	0.0095	0.0849	0.0878
Echinococcus multilocularis	neuropeptide Y receptor	0.0065	0.0465	0.0465
Echinococcus multilocularis	carboxylesterase 5A	0.0785	0.9669	0.9669
Schistosoma mansoni	neuropeptide F-like receptor	0.0065	0.0465	0.0481
Mycobacterium tuberculosis	Probable phytoene synthase PhyA	0.0079	0.0644	0.3373
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0165	0.0117
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0065	0.0465	0.0481
Schistosoma mansoni	jumonji domain containing protein	0.0076	0.0597	0.0618
Brugia malayi	hypothetical protein	0.0065	0.0465	0.0481
Echinococcus granulosus	para nitrobenzyl esterase	0.0133	0.1324	0.1369
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0133	0.1324	0.1369
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0065	0.0465	0.0481
Plasmodium vivax	glutathione reductase, putative	0.0047	0.0232	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0065	0.0465	0.0481
Schistosoma mansoni	neuropeptide receptor	0.0065	0.0465	0.0481
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0065	0.0465	0.0465
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0065	0.0465	0.0481
Echinococcus multilocularis	chromobox protein 1	0.007	0.0518	0.0518
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0095	0.0849	0.0878
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0039	0.0127	0.0957
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0065	0.0465	0.3512
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.012	0.1161	0.7604
Onchocerca volvulus		0.0065	0.0465	0.3512
Echinococcus granulosus	rhodopsin orphan GPCR	0.0065	0.0465	0.0481
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0133	0.1324	0.8938
Onchocerca volvulus		0.0065	0.0465	0.3512
Brugia malayi	chromobox protein homolog 3	0.0039	0.0127	0.0131
Brugia malayi	putative neuropeptide receptor NPR1	0.0065	0.0465	0.0481
Onchocerca volvulus		0.0065	0.0465	0.3512
Schistosoma mansoni	hypothetical protein	0.0065	0.0465	0.0481
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.3366	1
Trichomonas vaginalis	chromobox protein, putative	0.007	0.0518	0.1209
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0065	0.0465	0.0465
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0065	0.0465	0.0465
Plasmodium falciparum	glutathione reductase	0.0047	0.0232	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0065	0.0465	0.0481
Brugia malayi	Thioredoxin reductase	0.0047	0.0232	0.024
Leishmania major	hypothetical protein, conserved	0.0079	0.0644	0.155
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0065	0.0465	0.0481
Onchocerca volvulus		0.0065	0.0465	0.3512
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0065	0.0465	0.0465
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0292	0.3366	0.5
Loa Loa (eye worm)	hypothetical protein	0.0785	0.9669	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0035	0.0078	0.0081
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0065	0.0465	0.0481
Onchocerca volvulus		0.0133	0.1324	1
Loa Loa (eye worm)	carboxylesterase	0.0133	0.1324	0.1369
Echinococcus multilocularis	neuropeptide Y receptor	0.0065	0.0465	0.0465
Echinococcus multilocularis	neuropeptide receptor	0.0065	0.0465	0.0465
Brugia malayi	G protein-coupled receptor	0.0065	0.0465	0.0481
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0065	0.0465	0.0481
Echinococcus multilocularis	g protein coupled receptor	0.0065	0.0465	0.0465
Echinococcus multilocularis	g-protein coupled receptor	0.0065	0.0465	0.0465
Mycobacterium tuberculosis	Probable dehydrogenase	0.0108	0.1007	0.6344
Echinococcus granulosus	neuropeptide s receptor	0.0065	0.0465	0.0481
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0065	0.0465	0.0481
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0065	0.0465	0.0465
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.012	0.1161	0.3447
Echinococcus multilocularis	acetylcholinesterase	0.0785	0.9669	0.9669
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0078	0.0081
Brugia malayi	Carboxylesterase family protein	0.0133	0.1324	0.1369
Echinococcus multilocularis	g protein coupled receptor	0.0065	0.0465	0.0465
Trypanosoma brucei	squalene synthase, putative	0.0255	0.2889	1
Brugia malayi	G-protein coupled receptor	0.0065	0.0465	0.0481
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0065	0.0465	0.0481
Echinococcus granulosus	g-protein coupled receptor	0.0065	0.0465	0.0481
Onchocerca volvulus		0.0065	0.0465	0.3512
Brugia malayi	Serotonin receptor	0.0065	0.0465	0.0481
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0065	0.0465	0.0481
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0133	0.1324	0.1369
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0065	0.0465	0.0465
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0065	0.0465	0.0465
Brugia malayi	Carboxylesterase family protein	0.0133	0.1324	0.1369
Schistosoma mansoni	neuropeptide receptor	0.0065	0.0465	0.0481
Onchocerca volvulus		0.0065	0.0465	0.3512
Echinococcus granulosus	allatostatin A receptor	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0065	0.0465	0.0481
Brugia malayi	larval opioid receptor	0.0065	0.0465	0.0481
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0047	0.0232	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1324	0.1369
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0019	0.0019
Trichomonas vaginalis	spcc417.12 protein, putative	0.0133	0.1324	0.3696
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Onchocerca volvulus		0.0065	0.0465	0.3512
Schistosoma mansoni	neuropeptide F-like receptor	0.0065	0.0465	0.0481
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0078	0.0081
Leishmania major	squalene synthase, putative	0.0255	0.2889	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0065	0.0465	0.0465
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0065	0.0465	0.0481
Schistosoma mansoni	hypothetical protein	0.0065	0.0465	0.0481
Brugia malayi	putative neuropeptide receptor	0.0065	0.0465	0.0481
Brugia malayi	Carboxylesterase family protein	0.0133	0.1324	0.1369
Onchocerca volvulus		0.0065	0.0465	0.3512
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Brugia malayi	neuropeptide F receptor	0.0065	0.0465	0.0481
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.0465	0.0481
Echinococcus granulosus	serotonin receptor	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Echinococcus multilocularis	allatostatin A receptor	0.0065	0.0465	0.0465
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Brugia malayi	Dopamine receptor	0.0065	0.0465	0.0481
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.3366	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.0465	0.0481
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0065	0.0465	0.0481
Echinococcus granulosus	hypothetical protein	0.0065	0.0465	0.0481
Schistosoma mansoni	myosin xvIII	0.0065	0.0465	0.0481
Echinococcus multilocularis	acetylcholinesterase	0.0785	0.9669	0.9669
Schistosoma mansoni	neuropeptide receptor	0.0065	0.0465	0.0481
Echinococcus multilocularis	serotonin receptor	0.0065	0.0465	0.0465
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Toxoplasma gondii	thioredoxin reductase	0.0047	0.0232	1
Brugia malayi	hypothetical protein	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.3366	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0143	0.1453	1
Brugia malayi	Melatonin receptor type 1A	0.0065	0.0465	0.0481
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0065	0.0465	0.0481
Schistosoma mansoni	amine GPCR	0.0065	0.0465	0.0481
Echinococcus multilocularis	dro:myosuppressin receptor	0.0065	0.0465	0.0465
Brugia malayi	hypothetical protein	0.0065	0.0465	0.0481
Loa Loa (eye worm)	heterochromatin protein 1	0.007	0.0518	0.0536
Trypanosoma cruzi	phytoene synthase, putative	0.0079	0.0644	0.155
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Echinococcus granulosus	rhodopsin orphan GPCR	0.0065	0.0465	0.0481
Echinococcus multilocularis	orexin receptor type 2	0.0065	0.0465	0.0465
Echinococcus multilocularis	g protein coupled receptor	0.0065	0.0465	0.0465
Brugia malayi	G protein-coupled receptor F59B2.13	0.0065	0.0465	0.0481
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0065	0.0465	0.0465
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.012	0.1161	0.7604
Trypanosoma cruzi	squalene synthase, putative	0.0255	0.2889	1
Loa Loa (eye worm)	acetylcholinesterase 1	0.0785	0.9669	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.3366	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0065	0.0465	0.0465
Schistosoma mansoni	amine GPCR	0.0065	0.0465	0.0481
Loa Loa (eye worm)	carboxylesterase	0.0785	0.9669	1
Mycobacterium ulcerans	carboxylesterase, LipT	0.0133	0.1324	0.8398
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1324	0.1369
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Echinococcus granulosus	neuropeptide receptor	0.0065	0.0465	0.0481
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.3366	1
Echinococcus multilocularis	fmrfamide receptor	0.0065	0.0465	0.0465
Echinococcus granulosus	tm gpcr rhodopsin	0.0065	0.0465	0.0481
Brugia malayi	GnHR receptor homolog	0.0065	0.0465	0.0481
Onchocerca volvulus		0.0065	0.0465	0.3512
Onchocerca volvulus		0.0065	0.0465	0.3512
Onchocerca volvulus		0.0065	0.0465	0.3512
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0065	0.0465	0.0465
Onchocerca volvulus		0.0065	0.0465	0.3512
Loa Loa (eye worm)	carboxylesterase	0.0133	0.1324	0.1369
Brugia malayi	glutathione reductase	0.0047	0.0232	0.024
Onchocerca volvulus		0.0065	0.0465	0.3512
Echinococcus granulosus	rhodopsin orphan GPCR	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Echinococcus granulosus	acetylcholinesterase	0.0785	0.9669	1
Onchocerca volvulus		0.0065	0.0465	0.3512
Echinococcus granulosus	Squalene phytoene synthase	0.0079	0.0644	0.0666
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0108	0.1007	0.6344
Schistosoma mansoni	adenoreceptor	0.0065	0.0465	0.0481
Brugia malayi	G-protein coupled receptor	0.0065	0.0465	0.0481
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0065	0.0465	0.0481
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0133	0.1324	0.1369
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0143	0.1453	1
Echinococcus multilocularis	fmrfamide receptor	0.0065	0.0465	0.0465
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.0465	0.0481
Schistosoma mansoni	amine GPCR	0.0065	0.0465	0.0481
Trypanosoma cruzi	squalene synthase, putative	0.0255	0.2889	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Brugia malayi	hypothetical protein	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Brugia malayi	hypothetical protein	0.0065	0.0465	0.0481
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0133	0.1324	0.8938
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0108	0.1007	0.6344
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0108	0.1007	0.6344
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0065	0.0465	0.0465
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0065	0.0465	0.0481
Onchocerca volvulus	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog	0.0079	0.0644	0.4864
Schistosoma mansoni	hypothetical protein	0.0065	0.0465	0.0481
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0785	0.9669	1
Echinococcus multilocularis	sex peptide receptor	0.0065	0.0465	0.0465
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0065	0.0465	0.0465
Echinococcus granulosus	g protein coupled receptor	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Brugia malayi	hypothetical protein	0.0065	0.0465	0.0481
Loa Loa (eye worm)	neuropeptide F receptor	0.0065	0.0465	0.0481
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0065	0.0465	0.0465
Echinococcus granulosus	tm gpcr rhodopsin	0.0065	0.0465	0.0481
Brugia malayi	hypothetical protein	0.0065	0.0465	0.0481
Schistosoma mansoni	amine GPCR	0.0065	0.0465	0.0481
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0065	0.0465	0.0481
Echinococcus multilocularis	lysine specific demethylase 5A	0.0035	0.0078	0.0078
Echinococcus granulosus	chromobox protein 1	0.007	0.0518	0.0536
Mycobacterium tuberculosis	Probable oxidoreductase	0.012	0.1161	0.7604
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0133	0.1324	0.1369
Schistosoma mansoni	hypothetical protein	0.0065	0.0465	0.0481
Echinococcus granulosus	neuroligin	0.0133	0.1324	0.1369
Echinococcus granulosus	thioredoxin glutathione reductase	0.0047	0.0232	0.024
Loa Loa (eye worm)	jmjC domain-containing protein	0.006	0.0397	0.0411
Brugia malayi	Carboxylesterase family protein	0.0785	0.9669	1
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1324	0.1369
Brugia malayi	hypothetical protein	0.0065	0.0465	0.0481
Brugia malayi	ORL1-like opioid receptor	0.0065	0.0465	0.0481
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0065	0.0465	0.0481
Brugia malayi	Dopamine receptor protein 1	0.0065	0.0465	0.0481
Mycobacterium tuberculosis	Probable reductase	0.0108	0.1007	0.6344
Onchocerca volvulus		0.0133	0.1324	1
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1324	0.1369
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0065	0.0465	0.3512
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Echinococcus granulosus	G protein coupled receptor 139	0.0065	0.0465	0.0481
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0065	0.0465	0.0465
Echinococcus multilocularis	chromobox protein 1	0.007	0.0518	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Echinococcus multilocularis	neuropeptide receptor	0.0065	0.0465	0.0465
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0146	0.0146
Schistosoma mansoni	chromobox protein	0.007	0.0518	0.0536
Brugia malayi	sulfakinin receptor protein	0.0065	0.0465	0.0481
Schistosoma mansoni	hypothetical protein	0.0079	0.0644	0.0666
Echinococcus granulosus	rhodopsin orphan GPCR	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Schistosoma mansoni	biogenic amine receptor	0.0065	0.0465	0.0481
Echinococcus multilocularis	para nitrobenzyl esterase	0.0133	0.1324	0.1324
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0165	0.0117
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0133	0.1324	0.1369
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0065	0.0465	0.0465
Echinococcus multilocularis	neuropeptide s receptor	0.0065	0.0465	0.0465
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Echinococcus granulosus	neuropeptide Y receptor	0.0065	0.0465	0.0481
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.0465	0.0481
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0108	0.1007	0.6344
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.0465	0.0481
Loa Loa (eye worm)	thioredoxin reductase	0.0047	0.0232	0.024
Giardia lamblia	Fructose-bisphosphate aldolase	0.0292	0.3366	1
Loa Loa (eye worm)	glutathione reductase	0.0047	0.0232	0.024
Plasmodium vivax	thioredoxin reductase, putative	0.0047	0.0232	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0644	0.0666
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0065	0.0465	0.0465
Echinococcus granulosus	carboxylesterase 5A	0.0785	0.9669	1
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1324	0.1369
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Echinococcus granulosus	acetylcholinesterase	0.0785	0.9669	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0292	0.3366	0.5
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Brugia malayi	Dopamine receptor protein 2	0.0065	0.0465	0.0481
Loa Loa (eye worm)	melatonin receptor type 1A	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Echinococcus granulosus	somatostatin receptor	0.0065	0.0465	0.0481
Schistosoma mansoni	gliotactin	0.0133	0.1324	0.1369
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0133	0.1324	0.8938
Echinococcus granulosus	neuropeptide Y receptor	0.0065	0.0465	0.0481
Echinococcus granulosus	7TM GPCR rhodopsin	0.0065	0.0465	0.0481
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0065	0.0465	0.0481
Treponema pallidum	fructose-bisphosphate aldolase	0.0292	0.3366	0.5
Echinococcus granulosus	sex peptide receptor	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0127	0.0131
Echinococcus multilocularis	neuropeptides capa receptor	0.0065	0.0465	0.0465
Echinococcus granulosus	biogenic amine 5HT receptor	0.0065	0.0465	0.0481
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0065	0.0465	0.0481
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0065	0.0465	0.0465
Schistosoma mansoni	biogenic amine receptor	0.0065	0.0465	0.0481
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0065	0.0465	0.0481
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0065	0.0465	0.0481
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0065	0.0465	0.0481
Loa Loa (eye worm)	TYRA-2 protein	0.0065	0.0465	0.0481
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0065	0.0465	0.0465
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0065	0.0465	0.0481
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.0465	0.0481
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0146	0.0151
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0065	0.0465	0.0465
Onchocerca volvulus		0.0133	0.1324	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0065	0.0465	0.0481
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0042	0.0165	0.1243
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Brugia malayi	Heterochromatin protein 1	0.007	0.0518	0.0536
Schistosoma mansoni	growth hormone secretagogue receptor	0.0065	0.0465	0.0481
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0065	0.0465	0.0481
Echinococcus granulosus	7tm_1 domain containing protein	0.0065	0.0465	0.0481
Brugia malayi	hypothetical protein	0.0133	0.1324	0.1369
Echinococcus granulosus	rhodopsin orphan GPCR	0.0065	0.0465	0.0481
Echinococcus multilocularis	Squalene phytoene synthase	0.0079	0.0644	0.0644
Echinococcus granulosus	neuropeptide FF receptor 2	0.0065	0.0465	0.0481
Echinococcus granulosus	g protein coupled receptor	0.0065	0.0465	0.0481
Echinococcus granulosus	rhodopsin orphan GPCR	0.0065	0.0465	0.0481
Echinococcus granulosus	tm gpcr rhodopsin	0.0065	0.0465	0.0481
Echinococcus granulosus	lysine specific demethylase 5A	0.0035	0.0078	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Schistosoma mansoni	BC026374 protein (S09 family)	0.0133	0.1324	0.1369
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Schistosoma mansoni	neuropeptide receptor	0.0065	0.0465	0.0481
Echinococcus granulosus	neuropeptide receptor	0.0065	0.0465	0.0481
Schistosoma mansoni	histamine h1 receptor	0.0065	0.0465	0.0481
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0133	0.1324	0.1324
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Echinococcus granulosus	orexin receptor type 2	0.0065	0.0465	0.0481
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Echinococcus multilocularis	neuropeptides capa receptor	0.0065	0.0465	0.0465
Onchocerca volvulus		0.0065	0.0465	0.3512
Echinococcus granulosus	BC026374 protein S09 family	0.0133	0.1324	0.1369
Echinococcus granulosus	neuropeptides capa receptor	0.0065	0.0465	0.0481
Brugia malayi	hypothetical protein	0.0065	0.0465	0.0481
Onchocerca volvulus		0.0065	0.0465	0.3512
Brugia malayi	neuropeptide F receptor	0.0065	0.0465	0.0481
Brugia malayi	follicle stimulating hormone receptor	0.0065	0.0465	0.0481
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0065	0.0465	0.0481
Echinococcus granulosus	neuropeptides capa receptor	0.0065	0.0465	0.0481
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0143	0.1453	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0065	0.0465	0.0481
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Trichomonas vaginalis	chromobox protein, putative	0.007	0.0518	0.1209
Schistosoma mansoni	opsin-like receptor	0.0065	0.0465	0.0481
Echinococcus granulosus	neuropeptide receptor A26	0.0065	0.0465	0.0481
Echinococcus granulosus	g protein coupled receptor	0.0065	0.0465	0.0481
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.3366	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0065	0.0465	0.0465
Echinococcus granulosus	fmrfamide receptor	0.0065	0.0465	0.0481
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0095	0.0849	0.0849
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0065	0.0465	0.0481
Echinococcus multilocularis	somatostatin receptor	0.0065	0.0465	0.0465
Onchocerca volvulus		0.0133	0.1324	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0065	0.0465	0.0465
Schistosoma mansoni	opsin-like receptor	0.0065	0.0465	0.0481
Echinococcus granulosus	dro:myosuppressin receptor	0.0065	0.0465	0.0481
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0065	0.0465	0.0481
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.3366	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0065	0.0465	0.0481
Onchocerca volvulus		0.0065	0.0465	0.3512
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1324	0.1369
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0065	0.0465	0.0465
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.0465	0.0481
Schistosoma mansoni	biogenic amine receptor	0.0065	0.0465	0.0481
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0133	0.1324	0.3696
Schistosoma mansoni	chromobox protein	0.007	0.0518	0.0536
Onchocerca volvulus		0.0133	0.1324	1
Schistosoma mansoni	opsin-like receptor	0.0065	0.0465	0.0481
Echinococcus granulosus	biogenic amine 5HT receptor	0.0065	0.0465	0.0481
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0065	0.0465	0.0481
Brugia malayi	jmjC domain containing protein	0.0035	0.0078	0.0081
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0065	0.0465	0.0465
Brugia malayi	Carboxylesterase family protein	0.0785	0.9669	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.3366	1
Echinococcus multilocularis	serotonin receptor	0.0065	0.0465	0.0465
Schistosoma mansoni	acetylcholinesterase	0.0133	0.1324	0.1369
Loa Loa (eye worm)	hypothetical protein	0.0785	0.9669	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Echinococcus multilocularis	G protein coupled receptor 139	0.0065	0.0465	0.0465
Echinococcus multilocularis	neuropeptide receptor A26	0.0065	0.0465	0.0465
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0465	0.0481
Brugia malayi	RE15519p	0.0065	0.0465	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1324	0.1369

Activities

Activity type	Activity value	Assay description	Source	Reference
DHP-I susceptibility (functional)	= 2.21	Relative rate of hydrolysis of porcine renal dehydropeptidase-I (DHP-I) to imipenem	ChEMBL.	No reference
DHP-I susceptibility (functional)	= 2.21	Relative rate of hydrolysis of porcine renal dehydropeptidase-I (DHP-I) to imipenem	ChEMBL.	No reference
MIC (functional)	= 0.025 ug ml-1	In vitro antibacterial activity against staphylococcus aureus 209P NIHJ JC1 organism	ChEMBL.	No reference
MIC (functional)	= 0.78 ug ml-1	In vitro antibacterial activity against E. coli NIHJ JC2 organism	ChEMBL.	No reference
MIC (functional)	= 0.78 ug ml-1	In vitro antibacterial activity against E. coli NIHJ JC2 organism	ChEMBL.	No reference
MIC (functional)	= 3.13 ug ml-1	In vitro antibacterial activity against S. epidermidis MB5181a organism	ChEMBL.	No reference
MIC (functional)	= 6.25 ug ml-1	In vitro antibacterial activity against staphylococcus aureus BB6294 organism(Methicillin-resistant strain)	ChEMBL.	No reference
MIC (functional)	= 6.25 ug ml-1	In vitro antibacterial activity against staphylococcus aureus CSa1009 (Methicillin-resistant strain and b beta-Lactamase producing strain)	ChEMBL.	No reference
MIC (functional)	= 6.25 ug ml-1	In vitro antibacterial activity against E. faecalis MB4996 organism	ChEMBL.	No reference
MIC (functional)	> 25 ug ml-1	In vitro antibacterial activity against P. aeruginosa MB5002 organism	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL297144

Bibliographic References

No literature references available for this target.

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Detailed information for compound 60686