Detailed information for compound 606915

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 406.899 | Formula: C11H7Br3N2
  • H donors: 0 H acceptors: 2 LogP: 3.99 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: BrC(c1ncc(cn1)c1ccccc1)(Br)Br
  • InChi: 1S/C11H7Br3N2/c12-11(13,14)10-15-6-9(7-16-10)8-4-2-1-3-5-8/h1-7H
  • InChiKey: NLMVTNQQGRMRPC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0025 0.0008 0.0006
Schistosoma mansoni microtubule-associated protein tau 0.1722 0.4594 0.4592
Loa Loa (eye worm) inositol-1 0.0131 0.0295 0.0295
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0025 0.0008 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0025 0.0008 0.0006
Mycobacterium ulcerans aldehyde dehydrogenase 0.0103 0.0219 0.0944
Echinococcus granulosus nuclear receptor 2DBD gamma 0.1756 0.4687 0.4685
Brugia malayi conserved hypotetical protein 0.1756 0.4687 0.4684
Echinococcus granulosus mitogen activated protein kinase 3 0.0123 0.0274 0.0272
Schistosoma mansoni myelin transcription factor 1 myt1 0.0065 0.0117 0.0113
Trichomonas vaginalis mercuric reductase, putative 0.0035 0.0035 0.0167
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0096 0.0401
Leishmania major hypothetical protein, conserved 0.0085 0.0173 0.0809
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0006 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0114 0.025 0.0246
Treponema pallidum NADH oxidase 0.0035 0.0035 0.0617
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0114 0.025 0.0247
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0025 0.0008 0.0006
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0227 0.0557 0.1163
Toxoplasma gondii histone lysine methyltransferase SET1 0.0182 0.0434 0.2074
Mycobacterium tuberculosis Probable lipase LipD 0.0024 0.0006 0.0002
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.1756 0.4687 0.4684
Trypanosoma cruzi hypothetical protein, conserved 0.0085 0.0173 0.0806
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0008 0.0006
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0165 0.0388 0.0386
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0025 0.0008 0.0006
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0126 0.0584
Loa Loa (eye worm) hypothetical protein 0.3722 1 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0035 0.0035 0.0132
Loa Loa (eye worm) hypothetical protein 0.0034 0.0034 0.0034
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0253 0.0625 0.1308
Echinococcus granulosus peptidase Clp S14 family 0.0058 0.0098 0.0095
Mycobacterium ulcerans recombinase A 0.0057 0.0095 0.0394
Schistosoma mansoni methyl-cpg binding protein mbd 0.0028 0.0017 0.0013
Loa Loa (eye worm) hypothetical protein 0.1756 0.4687 0.4687
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.04 0.1022 0.1019
Loa Loa (eye worm) hypothetical protein 0.3722 1 1
Leishmania major hypothetical protein, conserved 0.0025 0.0009 0.0018
Echinococcus granulosus GPCR family 2 0.0089 0.0182 0.018
Echinococcus multilocularis geminin 0.0284 0.0711 0.0709
Loa Loa (eye worm) hypothetical protein 0.04 0.1022 0.1022
Brugia malayi Dihydrofolate reductase 0.0862 0.2271 0.2267
Trichomonas vaginalis CMGC family protein kinase 0.0123 0.0274 0.1536
Brugia malayi tailless protein 0.1756 0.4687 0.4684
Loa Loa (eye worm) hypothetical protein 0.1756 0.4687 0.4687
Plasmodium falciparum glutathione reductase 0.0035 0.0035 0.0151
Schistosoma mansoni tar DNA-binding protein 0.0032 0.0029 0.0025
Brugia malayi Thioredoxin reductase 0.01 0.0211 0.0207
Trypanosoma cruzi PAB1-binding protein , putative 0.0122 0.0271 0.128
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0025 0.0008 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-14 0.3722 1 1
Schistosoma mansoni nuclear receptor nhr-48 0.1756 0.4687 0.4684
Loa Loa (eye worm) pax transcription factor protein 2 0.0142 0.0326 0.0326
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.3722 1 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.1756 0.4687 0.4684
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.3722 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0124 0.0278 0.0274
Trypanosoma brucei trypanothione reductase 0.01 0.0211 0.0997
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.01 0.0211 0.0435
Brugia malayi nuclear receptor RXR 0.1966 0.5256 0.5254
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0024 0.0006 0.0016
Echinococcus multilocularis musashi 0.0046 0.0067 0.0065
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0017 0.0064
Brugia malayi F/Y-rich N-terminus family protein 0.004 0.005 0.0046
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0025 0.0008 0.0006
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.003 0.0022 0.008
Echinococcus multilocularis mitogen activated protein kinase 3 0.0123 0.0274 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-25 0.3722 1 1
Onchocerca volvulus 0.0024 0.0006 0.0002
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0058 0.0098 0.0194
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0131 0.0295 0.1658
Echinococcus multilocularis Smad4 0.0025 0.0008 0.0006
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0788 0.2071 1
Echinococcus granulosus chromobox protein 1 0.0044 0.0061 0.0059
Leishmania major hypothetical protein, conserved 0.0122 0.0271 0.1283
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0058 0.0098 0.0407
Schistosoma mansoni smad1 5 8 and 0.0025 0.0008 0.0004
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0025 0.0008 0.0006
Schistosoma mansoni lamin 0.0046 0.0067 0.0063
Loa Loa (eye worm) hypothetical protein 0.0115 0.0253 0.0253
Schistosoma mansoni hypothetical protein 0.0351 0.0892 0.0888
Brugia malayi mbt repeat family protein 0.0057 0.0096 0.0092
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0089 0.0182 0.018
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.0045 0.0045
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0025 0.0008 0.0006
Trichomonas vaginalis inositol monophosphatase, putative 0.0131 0.0295 0.1658
Brugia malayi MH1 domain containing protein 0.0025 0.0008 0.0004
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0034 0.0034 0.0136
Loa Loa (eye worm) hypothetical protein 0.3722 1 1
Schistosoma mansoni polycystin 1-related 0.0029 0.002 0.0016
Onchocerca volvulus 0.0057 0.0096 0.0092
Loa Loa (eye worm) hypothetical protein 0.1756 0.4687 0.4687
Echinococcus granulosus thyroid hormone receptor alpha 0.1756 0.4687 0.4685
Brugia malayi beta-lactamase 0.0024 0.0006 0.0002
Schistosoma mansoni sex comb on midleg homolog 0.0057 0.0096 0.0092
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0024 0.0006 0.0002
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0055 0.0091 0.0415
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0203 0.0489 0.2136
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0008 0.0006
Entamoeba histolytica acetyltransferase, GNAT family 0.0024 0.0006 0.0008
Trichomonas vaginalis CMGC family protein kinase 0.0123 0.0274 0.1536
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0025 0.0008 0.0012
Trypanosoma cruzi cytochrome P450, putative 0.0038 0.0045 0.0187
Brugia malayi hypothetical protein 0.1756 0.4687 0.4684
Trypanosoma cruzi polo-like protein kinase, putative 0.0039 0.0047 0.02
Brugia malayi MH2 domain containing protein 0.0025 0.0008 0.0004
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0017 0.0064
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0055 0.0091 0.0089
Schistosoma mansoni jumonji domain containing protein 0.0034 0.0034 0.0029
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0031 0.0027 0.0024
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0253 0.0625 0.2735
Brugia malayi photoreceptor-specific nuclear receptor 0.3722 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0096 0.0192
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0086 0.0175 0.0172
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0035 0.0141
Echinococcus multilocularis SAM and MBT domain containing protein 0.0057 0.0096 0.0094
Brugia malayi Coelomocyte uptake defective protein 5 0.0072 0.0135 0.0131
Brugia malayi Pre-SET motif family protein 0.0086 0.0175 0.0171
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0788 0.2071 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0035 0.0035 0.1102
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0039 0.0047 0.0047
Echinococcus granulosus lamin 0.0046 0.0067 0.0065
Mycobacterium ulcerans esterase/lipase LipP 0.0024 0.0006 0.0004
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0088 0.0179 0.0177
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0138 0.0314 0.0312
Loa Loa (eye worm) hypothetical protein 0.0023 0.0004 0.0004
Mycobacterium tuberculosis Conserved protein 0.0024 0.0006 0.0002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.1756 0.4687 0.4685
Echinococcus granulosus smad 0.0025 0.0008 0.0006
Echinococcus multilocularis tar DNA binding protein 0.0032 0.0029 0.0027
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.003 0.0022 0.009
Schistosoma mansoni phosphatidylserine receptor 0.0034 0.0034 0.0029
Brugia malayi MH2 domain containing protein 0.036 0.0914 0.091
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0035 0.0035 0.0151
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0025 0.0009 0.0004
Plasmodium falciparum glutathione reductase 0.01 0.0211 0.1003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.3722 1 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0055 0.0091 0.0415
Brugia malayi Cytochrome P450 family protein 0.0038 0.0045 0.0041
Loa Loa (eye worm) mbt repeat family protein 0.0057 0.0096 0.0096
Onchocerca volvulus 0.0046 0.0067 0.0063
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0047 0.0236
Schistosoma mansoni peptidase Clp (S14 family) 0.0088 0.0179 0.0175
Brugia malayi nuclear hormone receptor 0.3722 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0006 0.0001
Echinococcus multilocularis isocitrate dehydrogenase 0.0055 0.0091 0.0089
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0126 0.0126
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.3722 1 1
Brugia malayi Steroid receptor seven-up type 2 0.3722 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0004 0.0004
Echinococcus granulosus Polycystic kidney disease protein 0.0029 0.002 0.0018
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0025 0.0008 0.0013
Schistosoma mansoni jumonji/arid domain-containing protein 0.0135 0.0308 0.0304
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0017 0.0064
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0055 0.0091 0.0181
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.0168 0.0166
Schistosoma mansoni cpg binding protein 0.0091 0.0189 0.0185
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0025 0.0008 0.0013
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0035 0.0141
Schistosoma mansoni thyroid hormone receptor 0.3722 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0017 0.0064
Plasmodium vivax thioredoxin reductase, putative 0.01 0.0211 0.1003
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0035 0.0144
Loa Loa (eye worm) beta-lactamase 0.0024 0.0006 0.0006
Toxoplasma gondii ABC1 family protein 0.0024 0.0006 0.0004
Schistosoma mansoni chromobox protein 0.0044 0.0061 0.0057
Brugia malayi Heterochromatin protein 1 0.0044 0.0061 0.0057
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0788 0.2071 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0024 0.0095
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0124 0.0278 0.0274
Brugia malayi CXXC zinc finger family protein 0.0091 0.0189 0.0185
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0034 0.0034
Loa Loa (eye worm) TAR-binding protein 0.0032 0.0029 0.0029
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0004 0.0002
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0061 0.0313
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0086 0.0175 0.0171
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0025 0.0008 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-31 0.3722 1 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0029 0.002 0.0018
Schistosoma mansoni sex comb on midleg homolog 0.0057 0.0096 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-41 0.3722 1 1
Giardia lamblia Kinase, CMGC MAPK 0.0123 0.0274 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0026 0.0012 0.0009
Echinococcus multilocularis jumonji domain containing 1A 0.0034 0.0034 0.0031
Trichomonas vaginalis chromobox protein, putative 0.0027 0.0014 0.0043
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0042 0.0055 0.0053
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0088 0.0179 0.3594
Loa Loa (eye worm) hypothetical protein 0.3722 1 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0035 0.0035 0.0031
Loa Loa (eye worm) intermediate filament protein 0.0046 0.0067 0.0067
Echinococcus granulosus cpg binding protein 0.01 0.0211 0.0209
Brugia malayi nuclear hormone receptor family member nhr-6 0.1756 0.4687 0.4684
Brugia malayi Intermediate filament tail domain containing protein 0.0046 0.0067 0.0063
Schistosoma mansoni hypothetical protein 0.0032 0.0028 0.0024
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0126 0.4159
Brugia malayi Isocitrate dehydrogenase 0.0055 0.0091 0.0087
Brugia malayi beta-lactamase family protein 0.0024 0.0006 0.0002
Loa Loa (eye worm) MBCTL1 0.0065 0.0117 0.0117
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0008 0.0006
Schistosoma mansoni inositol monophosphatase 0.0131 0.0295 0.0291
Loa Loa (eye worm) latrophilin receptor protein 2 0.0089 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.3722 1 1
Echinococcus granulosus inositol monophosphatase 1 0.0131 0.0295 0.0293
Echinococcus multilocularis Nuclear hormone receptor HR96 0.1756 0.4687 0.4685
Brugia malayi Nuclear hormone receptor family member nhr-49 0.3722 1 1
Onchocerca volvulus 0.0024 0.0006 0.0002
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0131 0.0295 0.1401
Loa Loa (eye worm) histone methyltransferase 0.0031 0.0027 0.0027
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0088 0.0179 0.3594
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0862 0.2271 0.4782
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0032 0.0028 0.0026
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0055 0.0089 0.0087
Toxoplasma gondii cytochrome p450 superfamily protein 0.0025 0.0008 0.0013
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0057 0.0095 0.0394
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0096 0.0401
Onchocerca volvulus 0.0669 0.1751 0.1748
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0588 0.1532 0.1532
Echinococcus multilocularis smad 0.0025 0.0008 0.0006
Brugia malayi RNA binding protein 0.0032 0.0029 0.0025
Schistosoma mansoni intermediate filament proteins 0.0046 0.0067 0.0063
Loa Loa (eye worm) hypothetical protein 0.0022 0.0002 0.0002
Echinococcus multilocularis Nuclear hormone receptor HR96 0.1756 0.4687 0.4685
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0025 0.0008 0.0012
Mycobacterium tuberculosis Probable hydrolase 0.0024 0.0006 0.0002
Brugia malayi Calcitonin receptor-like protein seb-1 0.0281 0.0701 0.0697
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0276 0.0687 0.0687
Brugia malayi jmjC domain containing protein 0.0034 0.0034 0.0029
Mycobacterium ulcerans lipase LipD 0.0024 0.0006 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.3722 1 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0035 0.0035 0.0031
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0024 0.0006 0.0004
Echinococcus multilocularis thioredoxin glutathione reductase 0.01 0.0213 0.0211
Echinococcus multilocularis lysine specific demethylase 5A 0.0127 0.0285 0.0283
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0788 0.2071 1
Echinococcus granulosus polycomb protein SCMH1 0.0057 0.0096 0.0094
Brugia malayi hypothetical protein 0.0032 0.0028 0.0024
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.163 0.4348 0.9167
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0203 0.0489 1
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0047 0.0236
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0039 0.0047 0.0045
Trichomonas vaginalis bromodomain-containing protein, putative 0.003 0.0022 0.009
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.3722 1 1
Onchocerca volvulus 0.0091 0.0189 0.0185
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0253 0.0625 0.1308
Echinococcus multilocularis ecdysone induced protein 78C 0.3722 1 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0065 0.0117 0.0115
Brugia malayi Bromodomain containing protein 0.0024 0.0008 0.0004
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0091 0.0189 0.0185
Echinococcus multilocularis zinc finger protein 0.0039 0.0048 0.0046
Schistosoma mansoni nuclear hormone receptor 0.1756 0.4687 0.4684
Echinococcus granulosus FTZ F1 alpha 0.3722 1 1
Schistosoma mansoni hypothetical protein 0.0089 0.0182 0.0178
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0017 0.0064
Schistosoma mansoni hypothetical protein 0.0025 0.0009 0.0005
Schistosoma mansoni phd/f-box containing protein 0.0034 0.0034 0.0029
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0025 0.0008 0.0006
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0123 0.0274 0.1301
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.003 0.0024 0.0081
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0035 0.0144
Entamoeba histolytica serine/threonine protein kinase, putative 0.0039 0.0047 0.1445
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0123 0.0274 0.1301
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0035 0.0035 0.0151
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0035 0.0035 0.0144
Trichomonas vaginalis CMGC family protein kinase 0.0123 0.0274 0.1536
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0047 0.0236
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0024 0.0006 0.0004
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0012 0.0009
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0131 0.0295 0.128
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.3722 1 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0024 0.0006 0.0023
Brugia malayi hypothetical protein 0.1756 0.4687 0.4684
Trypanosoma cruzi ISWI complex protein 0.0025 0.0009 0.0015
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0055 0.0091 0.0089
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0035 0.0035 0.0033
Schistosoma mansoni lamin 0.0046 0.0067 0.0063
Echinococcus multilocularis thyroid hormone receptor alpha 0.3722 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.3722 1 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.023 0.0562 0.056
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0034 0.0034
Echinococcus multilocularis dihydrofolate reductase 0.0862 0.2271 0.2269
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0088 0.0179 0.0768
Schistosoma mansoni ap endonuclease 0.0024 0.0006 0.0002
Chlamydia trachomatis replicative DNA helicase 0.0203 0.0489 0.2136
Plasmodium falciparum ataxin-2 like protein, putative 0.0122 0.0271 0.1289
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0049 0.0046
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0034 0.0034 0.0136
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.1756 0.4687 0.4685
Schistosoma mansoni zinc finger protein 0.1756 0.4687 0.4684
Loa Loa (eye worm) hypothetical protein 0.0062 0.0111 0.0111
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0091 0.0189 0.0187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0088 0.0179 0.0842
Brugia malayi hypothetical protein 0.0143 0.0328 0.0324
Onchocerca volvulus 0.0024 0.0006 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0035 0.0141
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0025 0.0008 0.0012
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0104 0.0224 0.0222
Schistosoma mansoni tar DNA-binding protein 0.0032 0.0029 0.0025
Mycobacterium tuberculosis Conserved protein 0.0024 0.0006 0.0002
Loa Loa (eye worm) thioredoxin reductase 0.01 0.0211 0.0211
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0006 0.0001
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0024 0.0006 0.0004
Echinococcus granulosus histone lysine methyltransferase setb 0.0114 0.025 0.0247
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0123 0.0274 0.0274
Echinococcus multilocularis jumonji domain containing protein 0.0026 0.0011 0.0009
Plasmodium falciparum JmjC domain-containing protein, putative 0.0034 0.0034 0.0142
Loa Loa (eye worm) hypothetical protein 0.1756 0.4687 0.4687
Loa Loa (eye worm) hypothetical protein 0.0143 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0006
Schistosoma mansoni smad1 5 8 and 0.0025 0.0008 0.0004
Brugia malayi Nuclear hormone receptor E75 0.1756 0.4687 0.4684
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.0009
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0025 0.0008 0.0012
Schistosoma mansoni jumonji domain containing protein 0.0153 0.0355 0.0351
Mycobacterium tuberculosis Conserved protein 0.0024 0.0006 0.0002
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0035 0.0144
Schistosoma mansoni Tr4/Tr2 (homologue) 0.3722 1 1
Schistosoma mansoni hypothetical protein 0.016 0.0373 0.0369
Schistosoma mansoni nuclear receptor 0.1756 0.4687 0.4684
Echinococcus multilocularis mucolipin 3 0.0072 0.0135 0.0133
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0047 0.0236
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0124 0.0278 0.0276
Echinococcus granulosus beta LACTamase domain containing family member 0.0024 0.0006 0.0004
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0035 0.0035 0.0144
Echinococcus granulosus dihydrofolate reductase 0.0862 0.2271 0.2269
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0012 0.0009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0017 0.0064
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0104 0.0224 0.0222
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0035 0.0141
Mycobacterium leprae putative cytochrome p450 0.0025 0.0008 0.0012
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0035 0.0617
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0024 0.0006 0.0002
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0025 0.0009 0.0009
Schistosoma mansoni cytochrome P450 0.0025 0.0008 0.0004
Onchocerca volvulus 0.0142 0.0326 0.0322
Plasmodium vivax ataxin-2 like protein, putative 0.0122 0.0271 0.1289
Echinococcus granulosus zinc finger protein 0.0039 0.0048 0.0046
Schistosoma mansoni hypothetical protein 0.0284 0.0711 0.0707
Echinococcus granulosus histone acetyltransferase KAT2B 0.003 0.0022 0.002
Onchocerca volvulus 0.1756 0.4687 0.4684
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0227 0.0557 0.1163
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0055 0.0091 0.0415
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0081 0.0161 0.0159
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0006 0.0007
Echinococcus multilocularis peregrin 0.0024 0.0008 0.0006
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0024 0.0006 0.0002
Schistosoma mansoni coup transcription factor 0.3722 1 1
Schistosoma mansoni hypothetical protein 0.0192 0.0461 0.0457
Echinococcus multilocularis beta LACTamase domain containing family member 0.0024 0.0006 0.0004
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0035 0.0035 0.0144
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0004 0.0002
Schistosoma mansoni hypothetical protein 0.0089 0.0182 0.0178
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0096 0.0094
Entamoeba histolytica hypothetical protein 0.0032 0.0028 0.0779
Mycobacterium ulcerans aldehyde dehydrogenase 0.0103 0.0219 0.0944
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.003 0.0024 0.0378
Brugia malayi Nuclear hormone receptor family member nhr-40 0.3722 1 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0057 0.0096 0.0094
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0025 0.0008 0.0006
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0035 0.0141
Brugia malayi hypothetical protein 0.0122 0.0271 0.0267
Mycobacterium leprae Probable lipase LipE 0.0024 0.0006 0.0004
Echinococcus granulosus Nuclear hormone receptor HR96 0.1756 0.4687 0.4685
Treponema pallidum recombinase A 0.0057 0.0095 0.1846
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0055 0.0091 0.0421
Trypanosoma brucei protein kinase, putative 0.0123 0.0274 0.1301
Trypanosoma brucei cytochrome P450, putative 0.0038 0.0045 0.019
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0035 0.0144
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0032 0.0029 0.0029
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.3722 1 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0126 0.0124
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.1756 0.4687 0.4685
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0131 0.0295 0.1404
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0124 0.0278 0.0276
Schistosoma mansoni hypothetical protein 0.13 0.3456 0.3453
Echinococcus granulosus thioredoxin glutathione reductase 0.01 0.0213 0.0211
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0006
Onchocerca volvulus Huntingtin homolog 0.0204 0.0492 0.0488
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0008 0.0008
Loa Loa (eye worm) glutathione reductase 0.01 0.0211 0.0211
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0088 0.0179 0.0842
Brugia malayi Nuclear hormone receptor family member nhr-19 0.3722 1 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0046 0.0067 0.0067
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0152 0.0354 0.0735
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0025 0.0008 0.0006
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0117 0.0258 0.1117
Loa Loa (eye worm) transcription factor SMAD2 0.036 0.0914 0.0914
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0126 0.0124
Echinococcus multilocularis nuclear receptor nhr 48 0.1756 0.4687 0.4685
Brugia malayi Cytochrome P450 family protein 0.0025 0.0008 0.0004
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1049 0.2776 0.2774
Echinococcus multilocularis dnaJ subfamily B 0.13 0.3456 0.3454
Trypanosoma cruzi trypanothione reductase, putative 0.01 0.0211 0.0994
Brugia malayi Nuclear hormone receptor E75 0.1756 0.4687 0.4684
Loa Loa (eye worm) RNA binding protein 0.0032 0.0029 0.0029
Loa Loa (eye worm) steroid hormone receptor 0.3722 1 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0039 0.0047 0.0043
Plasmodium vivax glutathione reductase, putative 0.01 0.0211 0.1003
Loa Loa (eye worm) hypothetical protein 0.0114 0.025 0.025
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0025 0.0008 0.0012
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0057 0.0095 0.1846
Echinococcus multilocularis lamin 0.0046 0.0067 0.0065
Mycobacterium ulcerans hypothetical protein 0.0024 0.0006 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0124 0.0278 0.0276
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0124 0.0278 0.0274
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0024 0.0006 0.001
Entamoeba histolytica hypothetical protein 0.0032 0.0028 0.0779
Schistosoma mansoni retinoic acid receptor RXR 0.3722 1 1
Brugia malayi jmjC domain containing protein 0.0165 0.0388 0.0384
Treponema pallidum exodeoxyribonuclease (exoA) 0.0024 0.0006 0.0014
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.3722 1 1
Brugia malayi Latrophilin receptor protein 2 0.0089 0.0182 0.0178
Loa Loa (eye worm) hypothetical protein 0.1756 0.4687 0.4687
Brugia malayi hypothetical protein 0.1966 0.5256 0.5254
Echinococcus granulosus X box binding protein 1 0.016 0.0373 0.0371
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0024 0.0006 0.0002
Loa Loa (eye worm) jmjC domain-containing protein 0.0135 0.0308 0.0308
Echinococcus granulosus cytochrome P450 2K1 0.0025 0.0008 0.0006
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0055 0.0091 0.0412
Echinococcus granulosus intermediate filament protein 0.0046 0.0067 0.0065
Trypanosoma brucei polo-like protein kinase 0.0039 0.0047 0.0203
Onchocerca volvulus Bile acid receptor homolog 0.3722 1 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0126 0.0581
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0126 0.0122
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0006
Plasmodium vivax histone acetyltransferase GCN5, putative 0.003 0.0022 0.0086
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0131 0.0295 1
Schistosoma mansoni mucolipin 0.0066 0.0119 0.0115
Loa Loa (eye worm) acetyltransferase 0.0091 0.0189 0.0189
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0035 0.0141
Trichomonas vaginalis D-aminoacylase, putative 0.0024 0.0006 0.0001
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0024 0.0006 0.0003
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0045 0.0045
Brugia malayi Smad1 0.0025 0.0008 0.0004
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0088 0.0179 0.0848
Toxoplasma gondii aldehyde dehydrogenase 0.0103 0.0219 0.1036
Brugia malayi nuclear receptor RXR 0.1756 0.4687 0.4684
Loa Loa (eye worm) DR-78 0.1756 0.4687 0.4687
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0034 0.0034
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0025 0.0008 0.0012
Brugia malayi jmjC domain containing protein 0.0034 0.0034 0.0029
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0862 0.2271 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0057 0.0096 0.0092
Echinococcus granulosus Smad4 0.0025 0.0008 0.0006
Echinococcus granulosus phd:f box containing protein 0.0034 0.0034 0.0031
Schistosoma mansoni Smad4 0.0025 0.0008 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0009 0.0014
Brugia malayi nuclear receptor NHR-88 0.1756 0.4687 0.4684
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0026 0.0012 0.0009
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0065 0.0117 0.0113
Echinococcus granulosus geminin 0.0284 0.0711 0.0709
Schistosoma mansoni nuclear hormone receptor 0.3722 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0009 0.0014
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.3722 1 1
Echinococcus granulosus neuropeptide receptor A26 0.2676 0.7174 0.7174
Brugia malayi Nuclear hormone receptor family member nhr-3 0.3722 1 1
Mycobacterium leprae Conserved hypothetical protein 0.0025 0.0008 0.0012
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0025 0.0008 0.0012
Brugia malayi follicle stimulating hormone receptor 0.0276 0.0687 0.0683
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0025 0.0008 0.0006
Loa Loa (eye worm) isocitrate dehydrogenase 0.0055 0.0091 0.0091
Schistosoma mansoni dihydrofolate reductase 0.0862 0.2271 0.2267
Brugia malayi steroid hormone receptor 0.3722 1 1
Brugia malayi isocitrate dehydrogenase 0.0055 0.0091 0.0087
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0024 0.0006 0.0014
Brugia malayi mbt repeat family protein 0.0057 0.0096 0.0092
Toxoplasma gondii hypothetical protein 0.003 0.0024 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.3722 1 1
Brugia malayi MH2 domain containing protein 0.0025 0.0008 0.0004
Brugia malayi MH1 domain containing protein 0.0025 0.0008 0.0004
Loa Loa (eye worm) dihydrofolate reductase 0.0862 0.2271 0.2271
Schistosoma mansoni retinoid-x-receptor (RXR) 0.1966 0.5256 0.5254
Brugia malayi ecdysone receptor 0.1756 0.4687 0.4684
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0035 0.0035 0.0144
Onchocerca volvulus 0.0084 0.0168 0.0164
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0103 0.0219 0.0452
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0055 0.0091 0.0089
Trichomonas vaginalis set domain proteins, putative 0.0669 0.1751 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.3722 1 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0025 0.0008 0.0012
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0055 0.0091 0.0087
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0055 0.0091 0.0089
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0788 0.2071 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0085 0.0172 0.017
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0123 0.0274 0.1298
Brugia malayi hypothetical protein 0.0381 0.0973 0.0969
Echinococcus granulosus fetal alzheimer antigen falz 0.0042 0.0055 0.0053
Schistosoma mansoni RAR-like nuclear receptor 0.3722 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0124 0.0278 0.0276
Loa Loa (eye worm) hypothetical protein 0.1966 0.5256 0.5256
Loa Loa (eye worm) hypothetical protein 0.1966 0.5256 0.5256
Brugia malayi exodeoxyribonuclease III family protein 0.0024 0.0006 0.0002
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0028 0.0017 0.0015
Brugia malayi orphan nuclear receptor NR2E1 0.1756 0.4687 0.4684
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0006 0.0004
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0006 0.0007
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0197 0.0474 0.047
Loa Loa (eye worm) hypothetical protein 0.0068 0.0127 0.0127
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0039 0.0047 0.0203
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0035 0.0035 0.0151
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0024 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.1756 0.4687 0.4687
Echinococcus granulosus tar DNA binding protein 0.0032 0.0029 0.0027
Plasmodium vivax SET domain protein, putative 0.0086 0.0175 0.0825
Echinococcus granulosus neuropeptide s receptor 0.2676 0.7174 0.7174
Schistosoma mansoni hypothetical protein 0.0089 0.0182 0.0178
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0035 0.0141
Schistosoma mansoni nuclear receptor 0.1756 0.4687 0.4684
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.01 0.0098
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0025 0.0008 0.0006
Trypanosoma cruzi polo-like protein kinase, putative 0.0039 0.0047 0.02
Entamoeba histolytica hypothetical protein 0.0032 0.0028 0.0779
Schistosoma mansoni nuclear hormone receptor 0.1756 0.4687 0.4684
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0057 0.0096 0.0092
Brugia malayi nuclear receptor NHR-88 0.3722 1 1
Brugia malayi Pre-SET motif family protein 0.0588 0.1532 0.1529
Brugia malayi latrophilin 2 splice variant baaae 0.0192 0.0461 0.0457
Brugia malayi Bromodomain containing protein 0.0129 0.0291 0.0287
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0055 0.0091 0.0089
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0055 0.0091 0.0412
Brugia malayi Nuclear hormone receptor family member nhr-25 0.3722 1 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0088 0.0179 0.0177
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0131 0.0295 0.1404
Onchocerca volvulus 0.0381 0.0973 0.0969
Loa Loa (eye worm) hypothetical protein 0.0084 0.0168 0.0168
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0103 0.0219 0.1036
Giardia lamblia Kinase, PLK 0.0039 0.0047 0.1552
Schistosoma mansoni lipoxygenase 0.0138 0.0314 0.031
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0227 0.0557 0.1163
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.1756 0.4687 0.4684
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.3722 1 1
Trypanosoma brucei ISWI complex protein 0.0025 0.0009 0.0018
Schistosoma mansoni aldehyde dehydrogenase 0.0103 0.0219 0.0215
Echinococcus granulosus lysine specific demethylase 5A 0.0135 0.0308 0.0306
Plasmodium falciparum thioredoxin reductase 0.0035 0.0035 0.0151
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0123 0.0274 0.1298
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0008 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0114 0.025 0.0246
Schistosoma mansoni hypothetical protein 0.0284 0.0711 0.0707
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0025 0.0008 0.0006
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0123 0.0274 0.1301
Brugia malayi jmjC domain containing protein 0.0135 0.0308 0.0304
Echinococcus granulosus jumonji domain containing protein 0.0026 0.0011 0.0009
Loa Loa (eye worm) nuclear receptor nhr-7B 0.1756 0.4687 0.4687
Brugia malayi Pax transcription factor protein 2 0.0142 0.0326 0.0322
Mycobacterium ulcerans beta-lactamase 0.0024 0.0006 0.0004
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0011 0.0006
Echinococcus granulosus jumonji domain containing 1A 0.0034 0.0034 0.0031
Brugia malayi glutathione reductase 0.01 0.0211 0.0207
Trichomonas vaginalis penicillin-binding protein, putative 0.0024 0.0006 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.3722 1 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0025 0.0008 0.001
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0065 0.0117 0.0115
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0096 0.0439
Brugia malayi nuclear hormone receptor 0.1756 0.4687 0.4684
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.1756 0.4687 0.4685
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0025 0.0008 0.001
Leishmania major hypothetical protein, conserved 0.0034 0.0034 0.0136
Echinococcus multilocularis phd:f box containing protein 0.0034 0.0034 0.0031
Brugia malayi MAP kinase sur-1 0.0123 0.0274 0.027
Loa Loa (eye worm) hypothetical protein 0.0204 0.0492 0.0492
Mycobacterium tuberculosis Probable esterase LipL 0.0024 0.0006 0.0002
Loa Loa (eye worm) hypothetical protein 0.1756 0.4687 0.4687
Loa Loa (eye worm) hypothetical protein 0.0077 0.0149 0.0149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0124 0.0278 0.0274
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.01 0.0098
Toxoplasma gondii isocitrate dehydrogenase 0.0055 0.0091 0.0415
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0088 0.0179 0.0768
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0033 0.0033
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0034 0.0034 0.0136
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.1756 0.4687 0.4684
Loa Loa (eye worm) hypothetical protein 0.1756 0.4687 0.4687
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0096 0.0094
Echinococcus multilocularis FTZ F1 alpha 0.3722 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0208 0.0504 0.0502
Loa Loa (eye worm) hypothetical protein 0.0034 0.0034 0.0034
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0862 0.2271 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0123 0.0274 0.1298
Echinococcus granulosus ecdysone induced protein 78C 0.3722 1 1
Echinococcus multilocularis microtubule associated protein 2 0.1722 0.4594 0.4593
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0025 0.0008 0.0012
Plasmodium vivax JmjC domain containing protein 0.0034 0.0034 0.0142
Brugia malayi jmjC domain containing protein 0.0034 0.0034 0.0029
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0124 0.0278 0.0278
Echinococcus multilocularis histone acetyltransferase MYST2 0.0065 0.0117 0.0115
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.3722 1 1
Brugia malayi hypothetical protein 0.0204 0.0492 0.0488
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0086 0.0175 0.0819
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0011 0.0006
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0035 0.0035 0.0132
Echinococcus multilocularis neuropeptide s receptor 0.2676 0.7174 0.7174
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0042 0.0056 0.0054
Loa Loa (eye worm) MH2 domain-containing protein 0.036 0.0914 0.0914
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0039 0.0047 0.0045
Plasmodium falciparum thioredoxin reductase 0.01 0.0211 0.1003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0006
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.1966 0.5256 0.5254
Echinococcus multilocularis JmjC domain containing protein 4 0.0034 0.0034 0.0031
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0038 0.0045 0.0173
Brugia malayi dihydrofolate reductase family protein 0.0862 0.2271 0.2267
Trichomonas vaginalis penicillin-binding protein, putative 0.0024 0.0006 0.0001
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0035 0.0035 0.0144
Treponema pallidum replicative DNA helicase (dnaB) 0.0203 0.0489 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0208 0.0504 0.0502
Echinococcus multilocularis polycomb protein SCMH1 0.0057 0.0096 0.0094
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0131 0.0295 0.1404
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0025 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.1756 0.4687 0.4687
Onchocerca volvulus Protein ultraspiracle homolog 0.3722 1 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0029 0.0021 0.0017
Echinococcus multilocularis cpg binding protein 0.01 0.0211 0.0209
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0025 0.0008 0.0012
Onchocerca volvulus 0.0029 0.0021 0.0017
Schistosoma mansoni transcription factor LCR-F1 0.0032 0.0028 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-1 0.3722 1 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0058 0.0098 0.0194
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0131 0.0295 0.5992
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0035 0.0035 0.0033
Echinococcus multilocularis chromobox protein 1 0.0044 0.0061 0.0059
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0025 0.0008 0.001
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0035 0.0035 0.0063
Schistosoma mansoni protein phosphatase 2C 0.0034 0.0034 0.0029
Loa Loa (eye worm) nuclear hormone receptor 0.1756 0.4687 0.4687
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0089 0.0182 0.0178
Mycobacterium ulcerans aldehyde dehydrogenase 0.0103 0.0219 0.0944
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0103 0.0219 0.0217
Brugia malayi Cytochrome P450 family protein 0.0083 0.0167 0.0163
Schistosoma mansoni mucolipin 0.0072 0.0135 0.0131
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0126 0.0581
Echinococcus granulosus survival motor neuron protein 1 0.0143 0.0328 0.0326
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0034 0.0133
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.1966 0.5256 0.5254
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0117 0.0258 0.0534
Schistosoma mansoni Replicative DNA helicase 0.0203 0.0489 0.0485
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0025 0.0008 0.0012
Schistosoma mansoni hypothetical protein 0.0029 0.0021 0.0017
Schistosoma mansoni ap endonuclease 0.0024 0.0006 0.0002
Brugia malayi Inositol-1 0.0131 0.0295 0.0291
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0025 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.1966 0.5256 0.5256
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0088 0.0179 0.0848
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0025 0.0008 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.3722 1 1
Schistosoma mansoni thyroid hormone receptor 0.3722 1 1
Brugia malayi nuclear receptor NHR-67 0.1756 0.4687 0.4684
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0024 0.0006 0.0002
Echinococcus multilocularis inositol monophosphatase 1 0.0131 0.0295 0.0293
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.1966 0.5256 0.5254
Echinococcus granulosus dnaJ subfamily B 0.13 0.3456 0.3454
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.023 0.0562 0.056
Trichomonas vaginalis esterase, putative 0.0024 0.0006 0.0001
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0034 0.0034 0.0029
Onchocerca volvulus 0.0046 0.0067 0.0063
Loa Loa (eye worm) hypothetical protein 0.0192 0.0461 0.0461
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0025 0.0008 0.0006
Loa Loa (eye worm) mucolipin 1 0.0072 0.0135 0.0135
Brugia malayi nuclear hormone receptor family member odr-7 0.1756 0.4687 0.4684
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0123 0.0274 0.1298
Toxoplasma gondii isocitrate dehydrogenase 0.0055 0.0091 0.0415
Echinococcus multilocularis mitogen activated protein kinase 0.0123 0.0274 0.0272
Brugia malayi intermediate filament protein 0.0046 0.0067 0.0063
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0004 0.0002
Schistosoma mansoni aldehyde dehydrogenase 0.0103 0.0219 0.0215
Echinococcus granulosus retinoic acid receptor rxr beta a 0.3722 1 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.1966 0.5256 0.5256
Echinococcus granulosus RUN 0.0023 0.0004 0.0002
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0047 0.0236
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0088 0.0179 0.0768
Brugia malayi RNA recognition motif domain containing protein 0.0032 0.0029 0.0025
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0061 0.0313
Loa Loa (eye worm) CYP4Cod1 0.0038 0.0045 0.0045
Loa Loa (eye worm) CXXC zinc finger family protein 0.0091 0.0189 0.0189
Echinococcus granulosus methyl CpG binding domain protein 2 0.0028 0.0017 0.0015
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0131 0.0295 0.1658
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0131 0.0295 0.1401
Schistosoma mansoni zinc finger protein 0.0039 0.0048 0.0044
Trypanosoma brucei PAB1-binding protein , putative 0.0122 0.0271 0.1283
Schistosoma mansoni hypothetical protein 0.0025 0.0008 0.0004
Schistosoma mansoni methyl-cpg binding protein mbd 0.0028 0.0017 0.0013
Schistosoma mansoni lipoxygenase 0.0096 0.0202 0.0198
Loa Loa (eye worm) cytochrome P450 0.0025 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.1966 0.5256 0.5256
Schistosoma mansoni tar DNA-binding protein 0.0032 0.0029 0.0025
Schistosoma mansoni inositol monophosphatase 0.0131 0.0295 0.0291
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.0168 0.0166
Schistosoma mansoni hypothetical protein 0.0034 0.0033 0.0029
Plasmodium falciparum histone acetyltransferase GCN5 0.0024 0.0006 0.0008
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0024 0.0006 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.0024 0.0006 0.0001
Loa Loa (eye worm) bromodomain containing protein 0.0031 0.0025 0.0025
Echinococcus multilocularis survival motor neuron protein 1 0.0143 0.0328 0.0326
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0103 0.0219 0.0217
Echinococcus multilocularis RUN 0.0023 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.1756 0.4687 0.4687
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0126 0.0122
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0035 0.0035 0.0132
Echinococcus multilocularis lamin dm0 0.0046 0.0067 0.0065
Mycobacterium tuberculosis Probable lipase LipE 0.0024 0.0006 0.0002
Brugia malayi TAR-binding protein 0.0032 0.0029 0.0025
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.3722 1 1
Chlamydia trachomatis dihydrofolate reductase 0.0862 0.2271 1
Echinococcus granulosus JmjC domain containing protein 4 0.0034 0.0034 0.0031
Schistosoma mansoni jumonji/arid domain-containing protein 0.0135 0.0308 0.0304
Loa Loa (eye worm) hypothetical protein 0.3722 1 1
Leishmania major cytochrome p450-like protein 0.0038 0.0045 0.019
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.0168 0.0164
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.3722 1 1
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0788 0.2071 1
Schistosoma mansoni smad1 5 8 and 0.0025 0.0008 0.0004
Echinococcus granulosus lysine specific demethylase 6a 0.0034 0.0034 0.0031
Brugia malayi cytoplasmic intermediate filament protein 0.0025 0.0009 0.0005
Echinococcus multilocularis lysine specific demethylase 6a 0.0034 0.0034 0.0031
Onchocerca volvulus 0.1756 0.4687 0.4684
Echinococcus multilocularis peptidase Clp (S14 family) 0.0058 0.0098 0.0095
Mycobacterium tuberculosis Probable dehydrogenase 0.0227 0.0557 0.1163
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0047 0.0236
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.3722 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.3722 1 1
Brugia malayi Bromodomain containing protein 0.0064 0.0116 0.0112
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0006
Toxoplasma gondii thioredoxin reductase 0.01 0.0211 0.0997
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0025 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.0057 0.0096 0.0096
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0088 0.0179 0.0768
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0138 0.0314 0.0312
Onchocerca volvulus Serine\/threonine kinase homolog 0.0039 0.0047 0.0043
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.3722 1 1
Loa Loa (eye worm) hypothetical protein 0.0204 0.0492 0.0492
Trichomonas vaginalis glutathione reductase, putative 0.0035 0.0035 0.0167
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0024 0.0006 0.0003
Entamoeba histolytica hypothetical protein 0.0032 0.0028 0.0779
Loa Loa (eye worm) hypothetical protein 0.0045 0.0065 0.0065
Echinococcus granulosus Nuclear hormone receptor HR96 0.1756 0.4687 0.4685
Echinococcus granulosus microtubule associated protein 2 0.1722 0.4594 0.4593
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0025 0.0008 0.0006
Mycobacterium tuberculosis Probable oxidoreductase 0.0253 0.0625 0.1308
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0017 0.0064
Brugia malayi acetyltransferase, GNAT family protein 0.0091 0.0189 0.0185
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0096 0.0092
Toxoplasma gondii LsmAD domain-containing protein 0.0122 0.0271 0.1283
Echinococcus multilocularis neuropeptide receptor A26 0.2676 0.7174 0.7174
Echinococcus multilocularis chromobox protein 1 0.0044 0.0061 0.0059
Brugia malayi Nuclear hormone receptor-like 1 0.1966 0.5256 0.5254
Schistosoma mansoni cpg binding protein 0.01 0.0211 0.0207
Loa Loa (eye worm) hypothetical protein 0.0046 0.0067 0.0067
Plasmodium falciparum ataxin-2 like protein, putative 0.0122 0.0271 0.1289
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.3722 1 1
Echinococcus multilocularis GPCR, family 2 0.0089 0.0182 0.018
Leishmania major trypanothione reductase 0.01 0.0211 0.0997
Brugia malayi PHD-finger family protein 0.0048 0.0071 0.0067
Loa Loa (eye worm) hypothetical protein 0.1756 0.4687 0.4687
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0006 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0047 0.0043
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0027 0.0014 0.0009
Brugia malayi Probable ClpP-like protease 0.0088 0.0179 0.0175
Trypanosoma cruzi ISWI complex protein 0.0025 0.0009 0.0015
Schistosoma mansoni cpg binding protein 0.01 0.0211 0.0207
Schistosoma mansoni bromodomain containing protein 0.011 0.024 0.0236
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0025 0.0008 0.0012
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0055 0.0089 0.0087
Schistosoma mansoni hypothetical protein 0.0055 0.0089 0.0085
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0035 0.0035 0.0151
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0025 0.0008 0.0012
Toxoplasma gondii exonuclease III APE 0.0024 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0381 0.0973 0.0973
Brugia malayi Nuclear hormone receptor family member nhr-19 0.3722 1 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0004 0.0002
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0165 0.0388 0.0386
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0035 0.0141
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0089 0.0182 0.018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.3722 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0006
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0032 0.0028 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0093 0.0194 0.019
Brugia malayi hypothetical protein 0.1966 0.5256 0.5254
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0024 0.0006 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0024 0.0006 0.0001
Onchocerca volvulus 0.3722 1 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0088 0.0179 0.0768
Schistosoma mansoni steroid hormone receptor ad4bp 0.3722 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0035 0.0141
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0032 0.0028 0.0026
Loa Loa (eye worm) hypothetical protein 0.3722 1 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0227 0.0557 0.2433
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.1777 0.4742 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0055 0.0091 0.0421
Toxoplasma gondii NADPH-glutathione reductase 0.0035 0.0035 0.0144
Trypanosoma cruzi hypothetical protein, conserved 0.0085 0.0173 0.0806
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0041 0.0053 0.0053
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0096 0.0092
Loa Loa (eye worm) hypothetical protein 0.0089 0.0182 0.0182
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0042 0.0056 0.0054
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0126 0.0584
Loa Loa (eye worm) hypothetical protein 0.0065 0.0117 0.0117
Schistosoma mansoni zinc finger protein 0.0025 0.0009 0.0005
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.3722 1 1
Echinococcus granulosus mucolipin 3 0.0072 0.0135 0.0133
Trypanosoma cruzi PAB1-binding protein , putative 0.0122 0.0271 0.128
Echinococcus granulosus chromobox protein 1 0.0044 0.0061 0.0059
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0024 0.0095
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.3722 1 1
Schistosoma mansoni survival motor neuron protein 0.0029 0.0021 0.0017
Loa Loa (eye worm) hypothetical protein 0.1756 0.4687 0.4687
Mycobacterium tuberculosis Probable reductase 0.0227 0.0557 0.1163
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0025 0.0008 0.0012
Echinococcus multilocularis 0.0025 0.0008 0.0006
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0042 0.0055 0.0051
Trichomonas vaginalis chromobox protein, putative 0.0027 0.0014 0.0043
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.0168 0.0164
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0031 0.0027 0.0024
Loa Loa (eye worm) Smad1 0.0025 0.0008 0.0008
Loa Loa (eye worm) cytochrome P450 family protein 0.0083 0.0167 0.0167
Brugia malayi beta-lactamase family protein 0.0024 0.0006 0.0002
Echinococcus multilocularis X box binding protein 1 0.016 0.0373 0.0371
Loa Loa (eye worm) hypothetical protein 0.0122 0.0271 0.0271
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0024 0.0006 0.0006
Brugia malayi chromobox protein homolog 3 0.0025 0.0009 0.0004
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0035 0.0035 0.0132
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0008 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0047 0.0236
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0025 0.0008 0.0006
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.0045 0.0045
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0024 0.0006 0.0006
Trypanosoma brucei hypothetical protein, conserved 0.0085 0.0173 0.0809
Schistosoma mansoni chromobox protein 0.0044 0.0061 0.0057
Schistosoma mansoni smad 0.0025 0.0008 0.0004
Onchocerca volvulus 0.0093 0.0194 0.019
Leishmania major hypothetical protein, conserved 0.0024 0.0006 0.0004
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0123 0.0274 0.1301
Leishmania major cytochrome p450-like protein 0.0025 0.0008 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0032 0.0029 0.0025
Loa Loa (eye worm) hypothetical protein 0.0059 0.0103 0.0103
Leishmania major cytochrome p450-like protein 0.0025 0.0008 0.0013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0281 0.0701 0.0701
Trichomonas vaginalis CMGC family protein kinase 0.0123 0.0274 0.1536
Echinococcus granulosus peregrin 0.0024 0.0008 0.0006
Brugia malayi jmjC domain containing protein 0.0034 0.0034 0.0029
Chlamydia trachomatis recombinase RecA 0.0057 0.0095 0.0394
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0227 0.0557 0.1163
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0025 0.0008 0.0012
Brugia malayi hypothetical protein 0.0079 0.0154 0.015
Loa Loa (eye worm) hypothetical protein 0.3722 1 1
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0049 0.0046
Schistosoma mansoni retinoid-x-receptor (RXR) 0.3722 1 1
Schistosoma mansoni hypothetical protein 0.0089 0.0182 0.0178
Trypanosoma cruzi cytochrome P450, putative 0.0038 0.0045 0.0187
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0024 0.0006 0.001
Brugia malayi cytochrome P450 0.0025 0.0008 0.0004
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0025 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0088 0.0179 0.0179
Mycobacterium leprae Conserved hypothetical protein 0.0597 0.1556 0.6845
Schistosoma mansoni tar DNA-binding protein 0.0032 0.0029 0.0025
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.3722 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.1966 0.5256 0.5254
Schistosoma mansoni serine/threonine protein kinase 0.0123 0.0274 0.027
Echinococcus granulosus lamin dm0 0.0046 0.0067 0.0065
Loa Loa (eye worm) twinkle helicase 0.0058 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.1756 0.4687 0.4687
Loa Loa (eye worm) heterochromatin protein 1 0.0044 0.0061 0.0061
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0025 0.0008 0.0012
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.1756 0.4687 0.4684
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0017 0.0064
Loa Loa (eye worm) hypothetical protein 0.1966 0.5256 0.5256
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0008 0.0008
Echinococcus granulosus histone acetyltransferase MYST2 0.0065 0.0117 0.0115
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.003 0.0022 0.008
Echinococcus granulosus mitogen activated protein kinase 0.0123 0.0274 0.0272
Onchocerca volvulus Huntingtin homolog 0.0204 0.0492 0.0488
Brugia malayi Cytochrome P450 family protein 0.0038 0.0045 0.0041
Loa Loa (eye worm) nuclear receptor NHR-67 0.1756 0.4687 0.4687
Echinococcus granulosus nuclear receptor nhr 48 0.1756 0.4687 0.4685
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0034 0.0133
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0203 0.0489 0.2136
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0004 0.0004
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0035 0.0617

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. ChEMBL. 22096101
CC50 (functional) > 10 uM Huh7 cytotoxicity for Pf inhibitors Novartis-GNF Malaria Box. No reference
CC50 > 10 uM NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) ChEMBL. 18579783
EC50 (functional) = 0.0433 uM PF proliferation inhibition 3D7 Novartis-GNF Malaria Box. No reference
EC50 (functional) = 0.0433 uM NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
EC50 (functional) = 0.1428 uM W2 Pf proliferation inhibition Novartis-GNF Malaria Box. No reference
EC50 (functional) = 0.1428 uM NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
IFI promiscuity index = 0.07143 IFI promiscuity index Novartis-GNF Malaria Box. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 18579783

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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