Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0015 | 0.0044 |
Loa Loa (eye worm) | TAR-binding protein | 0.0138 | 0.3501 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0138 | 0.3501 | 1 |
Onchocerca volvulus | 0.0027 | 0.0015 | 0.5 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0015 | 0.0044 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3501 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3501 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0138 | 0.3501 | 1 |
Brugia malayi | RNA binding protein | 0.0138 | 0.3501 | 1 |
Onchocerca volvulus | 0.0027 | 0.0015 | 0.5 | |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0059 | 0.1028 | 0.0358 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0344 | 1 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0138 | 0.3501 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0181 | 0.4876 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0138 | 0.3501 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0163 | 0.4297 | 0.3871 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0163 | 0.4297 | 0.3871 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3501 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0138 | 0.3501 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0015 | 0.0044 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3501 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3501 | 1 |
Brugia malayi | TAR-binding protein | 0.0138 | 0.3501 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0056 | 0.0919 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0181 | 0.4876 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 95.92 uM | Huh7 cytotoxicity for Pf inhibitors | Novartis-GNF Malaria Box. | No reference |
CC50 | > 95.92 uM | NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) | ChEMBL. | 18579783 |
EC50 (functional) | = 1.012 uM | PF proliferation inhibition 3D7 | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | = 1.012 uM | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
EC50 (functional) | = 1.113 uM | W2 Pf proliferation inhibition | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | = 1.113 uM | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
IFI promiscuity index | = 0.04762 | IFI promiscuity index | Novartis-GNF Malaria Box. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 18579783 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.