Detailed information for compound 60748

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 646.654 | Formula: C30H34N10O7
  • H donors: 8 H acceptors: 9 LogP: -0.58 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 3
  • SMILES: NCC[C@@H]1NC(=O)CCNC(=O)c2c(OC[C@H](NC1=O)Cc1ccc(cc1)O)ccc(c2)NC(=O)Cn1cnc2c1nc(N)nc2O
  • InChi: 1S/C30H34N10O7/c31-9-7-21-28(45)36-18(11-16-1-4-19(41)5-2-16)14-47-22-6-3-17(12-20(22)27(44)33-10-8-23(42)37-21)35-24(43)13-40-15-34-25-26(40)38-30(32)39-29(25)46/h1-6,12,15,18,21,41H,7-11,13-14,31H2,(H,33,44)(H,35,43)(H,36,45)(H,37,42)(H3,32,38,39,46)/t18-,21+/m1/s1
  • InChiKey: KQJAHSRHHBVCLD-NQIIRXRSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans DNA polymerase IV 0.0186 0.0808 0.7767
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0234 0.103 0.3251
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0068 0.0255 0.0359
Loa Loa (eye worm) nuclear factor I 0.005 0.017 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.0186 0.0808 0.2525
Brugia malayi nuclear receptor RXR 0.0036 0.0105 0.0112
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0062 0.0227 0.0241
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0062 0.0227 0.0623
Leishmania major DNA polymerase kappa, putative 0.0186 0.0808 0.2525
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0342 0.1538 1
Brugia malayi Nuclear hormone receptor-like 1 0.0068 0.0255 0.0359
Brugia malayi polk-prov protein 0.0058 0.0207 0.0281
Leishmania major NADH dehydrogenase, putative 0.0062 0.0227 0.0623
Echinococcus multilocularis Smad4 0.009 0.0358 0.052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0342 0.1538 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0068 0.0255 0.0354
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0068 0.0255 0.0359
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0062 0.0227 0.0623
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0062 0.0227 0.0623
Mycobacterium ulcerans glutamate synthase subunit beta 0.0062 0.0227 0.1915
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0055 0.006
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0037 0.0002
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0062 0.0227 0.0623
Giardia lamblia DNA damage repair protein 0.0058 0.0207 0.1136
Loa Loa (eye worm) hypothetical protein 0.0068 0.0255 0.0359
Brugia malayi glutamate synthase 0.0062 0.0227 0.0313
Echinococcus granulosus dna polymerase eta 0.0186 0.0808 0.125
Brugia malayi CXXC zinc finger family protein 0.0094 0.0377 0.056
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0068 0.0255 0.0354
Brugia malayi nuclear hormone receptor family member odr-7 0.0032 0.0087 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0128 0.0538 0.164
Loa Loa (eye worm) hypothetical protein 0.0068 0.0255 0.0359
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0167 0.0719 0.0864
Brugia malayi Nuclear hormone receptor E75 0.0032 0.0087 0.0082
Trypanosoma brucei chrX additional, unordered contigs 0.0058 0.0207 0.0558
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0234 0.103 0.3251
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0068 0.0255 0.0359
Plasmodium vivax ferrodoxin reductase, putative 0.0062 0.0227 0.0623
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0234 0.103 0.3251
Echinococcus multilocularis dna polymerase kappa 0.0186 0.0808 0.125
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0062 0.0227 0.0308
Mycobacterium ulcerans monoxygenase 0.0062 0.0227 0.1915
Entamoeba histolytica deoxycytidyl transferase, putative 0.0186 0.0808 0.5139
Loa Loa (eye worm) hypothetical protein 0.0068 0.0255 0.0359
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0062 0.0227 0.0241
Schistosoma mansoni nuclear receptor 0.0032 0.0087 0.0087
Trypanosoma brucei hypothetical protein, conserved 0.0062 0.0227 0.0623
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0062 0.0227 0.0623
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0342 0.1538 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0105 0.0112
Loa Loa (eye worm) MH2 domain-containing protein 0.1319 0.6112 1
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0062 0.0227 0.1268
Echinococcus granulosus Smad4 0.009 0.0358 0.052
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0062 0.0227 0.1915
Trichomonas vaginalis DNA polymerase eta, putative 0.0186 0.0808 0.514
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0234 0.103 0.3251
Mycobacterium ulcerans hypothetical protein 0.0058 0.0207 0.1716
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0032 0.0087 0.0081
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0234 0.103 0.3251
Schistosoma mansoni smad1 5 8 and 0.009 0.0358 0.0358
Loa Loa (eye worm) hypothetical protein 0.0068 0.0255 0.0359
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0062 0.0227 0.0623
Brugia malayi nuclear receptor NHR-88 0.0068 0.0255 0.0359
Loa Loa (eye worm) thioredoxin reductase 0.0674 0.3092 0.503
Mycobacterium tuberculosis Probable reductase 0.1538 0.7135 0.8983
Echinococcus granulosus dnaJ subfamily B 0.134 0.6207 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0342 0.1538 1
Brugia malayi MH1 domain containing protein 0.009 0.0358 0.0528
Onchocerca volvulus Bile acid receptor homolog 0.0068 0.0255 0.5792
Brugia malayi MH1 domain containing protein 0.005 0.017 0.0218
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0068 0.0255 0.0354
Schistosoma mansoni nuclear receptor nhr-48 0.0032 0.0087 0.0087
Trypanosoma cruzi NADH dehydrogenase, putative 0.0062 0.0227 0.0623
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0062 0.0227 0.0623
Treponema pallidum oxidoreductase 0.0062 0.0227 0.1267
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0234 0.103 0.3251
Giardia lamblia DINP protein human, muc B family 0.0186 0.0808 0.5139
Loa Loa (eye worm) CXXC zinc finger family protein 0.0094 0.0377 0.056
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0046 0.0015
Loa Loa (eye worm) hypothetical protein 0.0032 0.0087 0.0082
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0062 0.0227 0.0313
Echinococcus granulosus glutamate synthase 0.0062 0.0227 0.0308
Trichomonas vaginalis glutamate synthase, putative 0.0062 0.0227 0.1268
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0062 0.0227 0.1915
Brugia malayi MH1 domain containing protein 0.009 0.0358 0.0528
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0032 0.0087 0.0082
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0068 0.0255 0.0255
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0068 0.0255 0.0354
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0062 0.0227 0.0623
Plasmodium falciparum glutathione reductase 0.0674 0.3092 1
Plasmodium vivax thioredoxin reductase, putative 0.0674 0.3092 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0068 0.0255 0.0255
Echinococcus multilocularis nuclear receptor nhr 48 0.0032 0.0087 0.0081
Plasmodium falciparum ferrodoxin reductase-like protein 0.0062 0.0227 0.0623
Loa Loa (eye worm) hypothetical protein 0.0068 0.0255 0.0359
Mycobacterium tuberculosis Conserved hypothetical protein 0.0186 0.0808 0.0977
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0062 0.0227 0.0313
Leishmania major hypothetical protein, conserved 0.0062 0.0227 0.0623
Loa Loa (eye worm) hypothetical protein 0.0091 0.0365 0.054
Schistosoma mansoni disulfide oxidoreductase 0.0062 0.0227 0.0227
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0068 0.0255 0.0354
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0234 0.103 0.3251
Leishmania major hypothetical protein, conserved 0.0062 0.0227 0.0623
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0062 0.0227 0.0308
Trypanosoma brucei DNA polymerase IV, putative 0.0186 0.0808 0.2525
Brugia malayi hypothetical protein 0.0036 0.0105 0.0112
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0234 0.103 0.1257
Mycobacterium ulcerans ferredoxin reductase 0.0062 0.0227 0.1915
Brugia malayi conserved hypotetical protein 0.0032 0.0087 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0186 0.0808 0.2525
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0032 0.0087 0.0081
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0055 0.0121
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0234 0.103 0.1635
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0087 0.0087
Echinococcus multilocularis mothers against decapentaplegic 5 0.009 0.0358 0.052
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0234 0.103 0.161
Onchocerca volvulus Protein ultraspiracle homolog 0.0068 0.0255 0.5792
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0058 0.0207 0.0558
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0186 0.0808 0.125
Leishmania major DNA polymerase eta, putative 0.0186 0.0808 0.2525
Entamoeba histolytica thioredoxin reductase, putative 0.0062 0.0227 0.1267
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0068 0.0255 0.0354
Trypanosoma brucei unspecified product 0.0186 0.0808 0.2525
Trypanosoma brucei DNA polymerase kappa, putative 0.0128 0.0538 0.164
Giardia lamblia Thioredoxin reductase 0.0062 0.0227 0.1267
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0032 0.0087 0.0087
Trypanosoma cruzi DNA polymerase kappa, putative 0.0186 0.0808 0.2525
Trypanosoma brucei DNA polymerase IV, putative 0.0186 0.0808 0.2525
Plasmodium falciparum DNA repair protein REV1, putative 0.0058 0.0207 0.0558
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0062 0.0227 0.1268
Schistosoma mansoni zinc finger protein 0.0032 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0091 0.0365 0.054
Schistosoma mansoni Smad4 0.009 0.0358 0.0358
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0062 0.0227 0.0623
Trypanosoma brucei DNA polymerase kappa, putative 0.0186 0.0808 0.2525
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0062 0.0227 0.0308
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1538 0.7135 0.8983
Toxoplasma gondii selenide, water dikinase 0.0062 0.0227 0.0623
Loa Loa (eye worm) hypothetical protein 0.0032 0.0087 0.0082
Loa Loa (eye worm) hypothetical protein 0.0032 0.0087 0.0082
Brugia malayi photoreceptor-specific nuclear receptor 0.0068 0.0255 0.0359
Mycobacterium ulcerans hypothetical protein 0.0062 0.0227 0.1915
Schistosoma mansoni glutamate synthase 0.0062 0.0227 0.0227
Schistosoma mansoni thyroid hormone receptor 0.0068 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0032 0.0087 0.0082
Echinococcus granulosus nuclear receptor nhr 48 0.0032 0.0087 0.0081
Echinococcus granulosus cpg binding protein 0.0099 0.0402 0.0592
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0062 0.0227 0.1915
Echinococcus granulosus FTZ F1 alpha 0.0068 0.0255 0.0354
Plasmodium falciparum glutathione reductase 0.0234 0.103 0.3251
Brugia malayi Steroid receptor seven-up type 2 0.0068 0.0255 0.0359
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0342 0.1538 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0207 0.0281
Leishmania major DNA polymerase eta, putative 0.0058 0.0207 0.0558
Trypanosoma brucei DNA polymerase kappa, putative 0.0186 0.0808 0.2525
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0234 0.103 0.3251
Loa Loa (eye worm) steroid hormone receptor 0.0068 0.0255 0.0359
Brugia malayi MH1 domain containing protein 0.005 0.017 0.0218
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0068 0.0255 0.0359
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0062 0.0227 0.1268
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0105 0.0112
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0062 0.0227 0.0308
Mycobacterium tuberculosis Probable dehydrogenase 0.1538 0.7135 0.8983
Trypanosoma cruzi trypanothione reductase, putative 0.0234 0.103 0.3251
Schistosoma mansoni DNA polymerase eta 0.0186 0.0808 0.0808
Trypanosoma brucei trypanothione reductase 0.0674 0.3092 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0055 0.006
Brugia malayi nuclear hormone receptor 0.0032 0.0087 0.0082
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0186 0.0808 0.2525
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0062 0.0227 0.1915
Schistosoma mansoni hypothetical protein 0.134 0.6207 0.6207
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0068 0.0255 0.0359
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0167 0.0719 0.6868
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0032 0.0087 0.0081
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0234 0.103 0.3251
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0062 0.0227 0.1915
Brugia malayi tailless protein 0.0032 0.0087 0.0082
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0342 0.1538 1
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0062 0.0227 0.0623
Loa Loa (eye worm) hypothetical protein 0.0036 0.0105 0.0112
Trypanosoma cruzi NADH dehydrogenase, putative 0.0062 0.0227 0.0623
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0062 0.0227 0.0241
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0207 0.0558
Schistosoma mansoni smad 0.004 0.0125 0.0125
Leishmania major trypanothione reductase 0.0674 0.3092 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0062 0.0227 0.0308
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0068 0.0255 0.0359
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0105 0.0112
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0062 0.0227 0.1268
Schistosoma mansoni smad1 5 8 and 0.009 0.0358 0.0358
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0062 0.0227 0.1268
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0105 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0068 0.0255 0.0359
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0062 0.0227 0.0308
Leishmania major hypothetical protein, conserved 0.0062 0.0227 0.0623
Brugia malayi ecdysteroid receptor 0.0068 0.0255 0.0359
Schistosoma mansoni steroid hormone receptor ad4bp 0.0068 0.0255 0.0255
Echinococcus multilocularis cpg binding protein 0.0099 0.0402 0.0592
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0046 0.0015
Brugia malayi nuclear hormone receptor 0.0068 0.0255 0.0359
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0234 0.103 0.3251
Brugia malayi hypothetical protein 0.0036 0.0105 0.0112
Schistosoma mansoni DNA polymerase IV / kappa 0.0058 0.0207 0.0207
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0234 0.103 1
Brugia malayi MH2 domain containing protein 0.1319 0.6112 1
Trypanosoma brucei DNA damage repair protein, putative 0.0058 0.0207 0.0558
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0068 0.0255 0.0359
Trypanosoma brucei NADH dehydrogenase 0.0062 0.0227 0.0623
Giardia lamblia NADH oxidase lateral transfer candidate 0.0234 0.103 0.6617
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0227 0.0623
Trypanosoma cruzi DNA damage repair protein, putative 0.0058 0.0207 0.0558
Echinococcus granulosus mothers against decapentaplegic 2 0.004 0.0125 0.0143
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0207 0.0558
Brugia malayi orphan nuclear receptor NR2E1 0.0032 0.0087 0.0082
Loa Loa (eye worm) hypothetical protein 0.0032 0.0087 0.0082
Echinococcus granulosus Nuclear hormone receptor HR96 0.0032 0.0087 0.0081
Schistosoma mansoni nuclear receptor 0.0032 0.0087 0.0087
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0068 0.0255 0.0354
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.171 0.7938 1
Trichomonas vaginalis mercuric reductase, putative 0.0234 0.103 0.6617
Loa Loa (eye worm) hypothetical protein 0.0186 0.0808 0.127
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0068 0.0255 0.0359
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0055 0.003
Loa Loa (eye worm) hypothetical protein 0.0032 0.0087 0.0082
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0172 0.074 0.1158
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0062 0.0227 0.1915
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0186 0.0808 0.514
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0062 0.0227 0.0623
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0068 0.0255 0.0255
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0062 0.0227 0.1915
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0068 0.0255 0.0359
Loa Loa (eye worm) nuclear hormone receptor 0.0032 0.0087 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0128 0.0538 0.164
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0046 0.0046
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0036 0.0105 0.0105
Leishmania major DNA polymerase kappa, putative 0.0058 0.0207 0.0558
Schistosoma mansoni glutamate synthase 0.0062 0.0227 0.0227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0068 0.0255 0.0359
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.171 0.7938 1
Echinococcus multilocularis glutamate synthase 0.0062 0.0227 0.0308
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0186 0.0808 0.0977
Loa Loa (eye worm) hypothetical protein 0.0068 0.0255 0.0359
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0068 0.0255 0.0359
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0062 0.0227 0.1915
Loa Loa (eye worm) glutathione reductase 0.0674 0.3092 0.503
Plasmodium vivax glutathione reductase, putative 0.0674 0.3092 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0172 0.074 0.1158
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0087 0.0081
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0073 0.0059
Echinococcus granulosus dna polymerase kappa 0.0186 0.0808 0.125
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0037 0.0002
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0186 0.0808 0.127
Brugia malayi Thioredoxin reductase 0.0674 0.3092 0.503
Schistosoma mansoni thyroid hormone receptor 0.0068 0.0255 0.0255
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0036 0.0105 0.011
Onchocerca volvulus Mothers against decapentaplegic homolog 0.004 0.0125 0.1309
Brugia malayi nuclear hormone receptor family member nhr-6 0.0032 0.0087 0.0082
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0073 0.006
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0062 0.0227 0.0313
Brugia malayi steroid hormone receptor 0.0068 0.0255 0.0359
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0068 0.0255 0.5792
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0062 0.0227 0.0308
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0062 0.0227 0.0308
Giardia lamblia Glutamate synthase 0.0062 0.0227 0.1267
Loa Loa (eye worm) hypothetical protein 0.0032 0.0087 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0186 0.0808 0.2525
Echinococcus multilocularis smad 0.009 0.0358 0.052
Schistosoma mansoni sulfide quinone reductase 0.0062 0.0227 0.0227
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0032 0.0087 0.0082
Loa Loa (eye worm) nuclear receptor NHR-67 0.0032 0.0087 0.0082
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0167 0.0719 0.0638
Loa Loa (eye worm) MH2 domain-containing protein 0.004 0.0125 0.0145
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0234 0.103 0.3251
Loa Loa (eye worm) hypothetical protein 0.0062 0.0227 0.0313
Plasmodium falciparum thioredoxin reductase 0.0234 0.103 0.3251
Trypanosoma brucei hypothetical protein, conserved 0.0058 0.0207 0.0558
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0068 0.0255 0.0354
Entamoeba histolytica disulphide oxidoreductase, putative 0.0062 0.0227 0.1267
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0227 0.0623
Brugia malayi Flap endonuclease-1 0.0025 0.0055 0.003
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0055 0.006
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0068 0.0255 0.0255
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0062 0.0227 0.1267
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0674 0.3092 0.3867
Loa Loa (eye worm) hypothetical protein 0.005 0.017 0.0218
Brugia malayi hypothetical protein 0.0032 0.0087 0.0082
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0068 0.0255 0.0354
Trypanosoma brucei DNA polymerase kappa, putative 0.0186 0.0808 0.2525
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0342 0.1538 1
Brugia malayi nuclear receptor NHR-67 0.0032 0.0087 0.0082
Echinococcus granulosus TGF beta signal transducer SmadC 0.009 0.0358 0.052
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0068 0.0255 0.0255
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0068 0.0255 0.0255
Brugia malayi MH2 domain containing protein 0.004 0.0125 0.0145
Mycobacterium ulcerans dehydrogenase 0.0062 0.0227 0.1915
Brugia malayi Smad1 0.009 0.0358 0.0528
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0068 0.0255 0.0354
Loa Loa (eye worm) hypothetical protein 0.0032 0.0087 0.0082
Trypanosoma brucei DNA polymerase eta, putative 0.0186 0.0808 0.2525
Loa Loa (eye worm) DR-78 0.0032 0.0087 0.0082
Schistosoma mansoni Smad4 0.004 0.0125 0.0125
Schistosoma mansoni flap endonuclease-1 0.0023 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0062 0.0227 0.0227
Mycobacterium tuberculosis Probable oxidoreductase 0.171 0.7938 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0178 0.0771 0.2403
Loa Loa (eye worm) MH2 domain-containing protein 0.009 0.0358 0.0528
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0055 0.006
Schistosoma mansoni retinoic acid receptor RXR 0.0068 0.0255 0.0255
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0234 0.103 0.3251
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0046 0.0015
Trypanosoma cruzi DNA polymerase eta, putative 0.0058 0.0207 0.0558
Schistosoma mansoni smad1 5 8 and 0.009 0.0358 0.0358
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0068 0.0255 0.0354
Trypanosoma brucei DNA polymerase kappa, putative 0.0186 0.0808 0.2525
Loa Loa (eye worm) hypothetical protein 0.0036 0.0105 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0068 0.0255 0.0359
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0342 0.1538 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0342 0.1538 1
Echinococcus multilocularis dna polymerase eta 0.0186 0.0808 0.125
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0062 0.0227 0.1268
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0062 0.0227 0.1915
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0062 0.0227 0.0241
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0234 0.103 0.3251
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0062 0.0227 0.1268
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0234 0.103 0.3251
Trichomonas vaginalis glutathione reductase, putative 0.0234 0.103 0.6617
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0234 0.103 0.3251
Trypanosoma cruzi DNA polymerase kappa, putative 0.0186 0.0808 0.2525
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0062 0.0227 0.1268
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0186 0.0808 0.125
Mycobacterium ulcerans DNA polymerase IV 0.0186 0.0808 0.7767
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0062 0.0227 0.0308
Schistosoma mansoni glutamate synthase 0.0062 0.0227 0.0227
Echinococcus multilocularis thioredoxin glutathione reductase 0.0674 0.3092 0.4952
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0062 0.0227 0.0623
Brugia malayi ImpB/MucB/SamB family protein 0.0186 0.0808 0.127
Trypanosoma brucei DNA polymerase kappa, putative 0.0186 0.0808 0.2525
Brugia malayi ImpB/MucB/SamB family protein 0.0186 0.0808 0.127
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0062 0.0227 0.0308
Loa Loa (eye worm) hypothetical protein 0.0032 0.0087 0.0082
Brugia malayi Nuclear hormone receptor E75 0.0032 0.0087 0.0082
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0032 0.0087 0.0081
Brugia malayi hypothetical protein 0.0091 0.0365 0.054
Loa Loa (eye worm) hypothetical protein 0.0032 0.0087 0.0082
Echinococcus granulosus mothers against decapentaplegic 5 0.009 0.0358 0.052
Treponema pallidum thioredoxin reductase (trxB) 0.0062 0.0227 0.1267
Echinococcus granulosus flap endonuclease 1 0.0025 0.0055 0.0029
Loa Loa (eye worm) hypothetical protein 0.004 0.0125 0.0145
Schistosoma mansoni ap endonuclease 0.0021 0.0037 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0068 0.0255 0.0359
Echinococcus granulosus thioredoxin glutathione reductase 0.0674 0.3092 0.4952
Schistosoma mansoni smad 0.009 0.0358 0.0358
Echinococcus granulosus thyroid hormone receptor alpha 0.0032 0.0087 0.0081
Plasmodium falciparum thioredoxin reductase 0.0674 0.3092 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0087 0.0082
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1538 0.7135 0.8983
Echinococcus granulosus smad 0.009 0.0358 0.052
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0068 0.0255 0.0354
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0234 0.103 0.3251
Echinococcus granulosus ecdysone induced protein 78C 0.0068 0.0255 0.0354
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0062 0.0227 0.0313
Schistosoma mansoni Smad4 0.004 0.0125 0.0125
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0062 0.0227 0.0623
Echinococcus multilocularis dnaJ subfamily B 0.134 0.6207 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0234 0.103 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0068 0.0255 0.0359
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1538 0.7135 0.8983
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0068 0.0255 0.0359
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0234 0.103 0.3251
Schistosoma mansoni nuclear hormone receptor 0.0068 0.0255 0.0255
Trypanosoma brucei unspecified product 0.0128 0.0538 0.164
Trypanosoma brucei hypothetical protein, conserved 0.0058 0.0207 0.0558
Treponema pallidum fructose-bisphosphate aldolase 0.0342 0.1538 1
Schistosoma mansoni cpg binding protein 0.0099 0.0402 0.0402
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0062 0.0227 0.1267
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0342 0.1538 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0068 0.0255 0.0354
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0036 0.0105 0.011
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0186 0.0808 0.0808
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0062 0.0227 0.0623
Schistosoma mansoni ap endonuclease 0.0021 0.0037 0.0037
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0062 0.0227 0.0623
Schistosoma mansoni mixed-lineage leukemia protein mll 0.02 0.0871 0.0871
Schistosoma mansoni terminal deoxycytidyl transferase 0.0186 0.0808 0.0808
Schistosoma mansoni eyes absent homolog 0.0091 0.0365 0.0365
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0087 0.0087
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0055 0.006
Loa Loa (eye worm) hypothetical protein 0.0068 0.0255 0.0359
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0032 0.0087 0.0087
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0062 0.0227 0.0308
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0068 0.0255 0.0354
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0234 0.103 0.3251
Schistosoma mansoni cpg binding protein 0.0099 0.0402 0.0402
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0207 0.0558
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0062 0.0227 0.1267
Schistosoma mansoni TGF-beta signal transducer Smad2 0.009 0.0358 0.0358
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0062 0.0227 0.1268
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0058 0.0207 0.0558
Plasmodium falciparum flap endonuclease 1 0.0025 0.0055 0.006
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0071 0.0057
Brugia malayi ecdysone receptor 0.0032 0.0087 0.0082
Brugia malayi MH2 domain containing protein 0.009 0.0358 0.0528
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0062 0.0227 0.1915
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0234 0.103 1
Echinococcus multilocularis mothers against decapentaplegic 6 0.004 0.0125 0.0143
Trypanosoma cruzi DNA polymerase eta, putative 0.0186 0.0808 0.2525
Trypanosoma cruzi trypanothione reductase, putative 0.0674 0.3092 1
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0062 0.0227 0.0623
Trypanosoma brucei DNA damage repair protein, putative 0.0058 0.0207 0.0558
Loa Loa (eye worm) hypothetical protein 0.0032 0.0087 0.0082
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0062 0.0227 0.0623
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0234 0.103 0.3251
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0036 0.0105 0.0112
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0062 0.0227 0.1267
Loa Loa (eye worm) hypothetical protein 0.0032 0.0087 0.0082
Onchocerca volvulus 0.0062 0.0227 0.483
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0062 0.0227 0.1267
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0234 0.103 0.161
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0058 0.0207 0.0558
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0342 0.1538 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0234 0.103 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0186 0.0808 0.2525
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0062 0.0227 0.1267
Loa Loa (eye worm) hypothetical protein 0.0036 0.0105 0.0112
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0087 0.0081
Loa Loa (eye worm) hypothetical protein 0.0068 0.0255 0.0359
Schistosoma mansoni sulfide quinone reductase 0.0062 0.0227 0.0227
Plasmodium vivax DNA repair protein REV1, putative 0.0058 0.0207 0.0558
Trypanosoma brucei DNA polymerase kappa, putative 0.0186 0.0808 0.2525
Onchocerca volvulus 0.0068 0.0255 0.5792
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.171 0.7938 1
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0062 0.0227 0.0241
Trichomonas vaginalis glutamate synthase, putative 0.0062 0.0227 0.1268
Treponema pallidum NADH oxidase 0.0234 0.103 0.6617
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0046 0.0015
Loa Loa (eye worm) MH1 domain-containing protein 0.009 0.0358 0.0528
Echinococcus multilocularis mothers against decapentaplegic 2 0.004 0.0125 0.0143
Echinococcus granulosus Nuclear hormone receptor HR96 0.0032 0.0087 0.0081
Echinococcus multilocularis FTZ F1 alpha 0.0068 0.0255 0.0354
Echinococcus granulosus mothers against decapentaplegic 6 0.004 0.0125 0.0143
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0234 0.103 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0234 0.103 0.3251
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1538 0.7135 0.8983
Schistosoma mansoni coup transcription factor 0.0068 0.0255 0.0255
Echinococcus multilocularis TGF beta signal transducer SmadC 0.009 0.0358 0.052
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0062 0.0227 0.0623
Toxoplasma gondii thioredoxin reductase 0.0674 0.3092 1
Loa Loa (eye worm) programmed cell death 8 0.0062 0.0227 0.0313
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0062 0.0227 0.0623
Leishmania major DNA damage repair protein, putative 0.0058 0.0207 0.0558
Echinococcus multilocularis thyroid hormone receptor alpha 0.0068 0.0255 0.0354
Toxoplasma gondii NADPH-glutathione reductase 0.0234 0.103 0.3251
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0068 0.0255 0.0359
Brugia malayi nuclear receptor NHR-88 0.0032 0.0087 0.0082
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0062 0.0227 0.0308
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0062 0.0227 0.0623
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0234 0.103 0.103
Trypanosoma cruzi DNA polymerase kappa, putative 0.0186 0.0808 0.2525
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0068 0.0255 0.0359
Trypanosoma cruzi DNA damage repair protein, putative 0.0058 0.0207 0.0558
Onchocerca volvulus 0.0094 0.0377 1
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0055 0.0029
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0207 0.0558
Trypanosoma brucei unspecified product 0.0128 0.0538 0.164
Schistosoma mansoni RAR-like nuclear receptor 0.0068 0.0255 0.0255
Trypanosoma brucei DNA polymerase IV, putative 0.0186 0.0808 0.2525
Brugia malayi hypothetical protein 0.0032 0.0087 0.0082
Loa Loa (eye worm) transcription factor SMAD2 0.1319 0.6112 1
Brugia malayi mothers against decapentaplegic homolog 3 0.004 0.0125 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0068 0.0255 0.0359
Brugia malayi MH2 domain containing protein 0.009 0.0358 0.0528
Trypanosoma cruzi DNA polymerase kappa, putative 0.0186 0.0808 0.2525
Loa Loa (eye worm) hypothetical protein 0.0036 0.0105 0.0112
Brugia malayi nuclear receptor RXR 0.0032 0.0087 0.0082
Trichomonas vaginalis apoptosis inducing factor, putative 0.0062 0.0227 0.1268
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0055 0.0123
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0234 0.103 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0073 0.0059
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0062 0.0227 0.1268
Loa Loa (eye worm) MH1 domain-containing protein 0.004 0.0125 0.0145
Brugia malayi glutathione reductase 0.0674 0.3092 0.503
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0032 0.0087 0.0081
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0055 0.0121
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1538 0.7135 0.8958
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0068 0.0255 0.0359
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0062 0.0227 0.0241
Loa Loa (eye worm) Smad1 0.009 0.0358 0.0528
Mycobacterium ulcerans NADH dehydrogenase 0.0062 0.0227 0.1915
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0234 0.103 0.3251
Schistosoma mansoni cpg binding protein 0.0094 0.0377 0.0377

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) > 100 uM Minimum inhibitory concentration against E. coli ATCC 25922 ChEMBL. 12729630
MIC (functional) > 100 uM Minimum inhibitory concentration (MIC) against S. aureus ATCC 13709 ChEMBL. 12729630
MIC (functional) > 100 uM Minimum inhibitory concentration against E. coli ATCC 25922 ChEMBL. 12729630

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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