Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.00306158 | 0 | 0.5 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0156204 | 0.857535 | 0.857535 |
Echinococcus multilocularis | acetylcholinesterase | 0.0131884 | 0.691472 | 0.806348 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0156204 | 0.857535 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0131884 | 0.691472 | 0.806348 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.00306158 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0131884 | 0.691472 | 0.806348 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.00306158 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0131884 | 0.691472 | 0.691472 |
Brugia malayi | Carboxylesterase family protein | 0.0131884 | 0.691472 | 0.691472 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0131884 | 0.691472 | 0.806348 |
Toxoplasma gondii | hypothetical protein | 0.00306158 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0131884 | 0.691472 | 0.691472 |
Loa Loa (eye worm) | hypothetical protein | 0.0156204 | 0.857535 | 0.857535 |
Onchocerca volvulus | 0.00306158 | 0 | 0.5 | |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0156204 | 0.857535 | 1 |
Plasmodium vivax | amine transporter, putative | 0.00306158 | 0 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.00306158 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0172223 | 0.966913 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0131884 | 0.691472 | 0.806348 |
Plasmodium falciparum | transporter, putative | 0.00306158 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0131884 | 0.691472 | 0.806348 |
Loa Loa (eye worm) | hypothetical protein | 0.0131884 | 0.691472 | 0.691472 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0156204 | 0.857535 | 1 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0156204 | 0.857535 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0177069 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.00306158 | 0 | 0.5 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.00306158 | 0 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0156204 | 0.857535 | 1 |
Plasmodium falciparum | amino acid transporter, putative | 0.00306158 | 0 | 0.5 |
Onchocerca volvulus | 0.00306158 | 0 | 0.5 | |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0156204 | 0.857535 | 0.857535 |
Onchocerca volvulus | 0.00306158 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0156204 | 0.857535 | 0.857535 |
Echinococcus multilocularis | acetylcholinesterase | 0.0131884 | 0.691472 | 0.806348 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0131884 | 0.691472 | 0.691472 |
Onchocerca volvulus | 0.00306158 | 0 | 0.5 | |
Plasmodium vivax | hypothetical protein, conserved | 0.00306158 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0131884 | 0.691472 | 0.691472 |
Brugia malayi | Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog | 0.0177069 | 1 | 1 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0156204 | 0.857535 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. | ChEMBL. | 22096101 | |
CC50 (functional) | = 23.13 uM | Huh7 cytotoxicity for Pf inhibitors | Novartis-GNF Malaria Box. | No reference |
CC50 | = 23.13 uM | NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) | ChEMBL. | 18579783 |
EC50 (functional) | = 0.1475 uM | W2 Pf proliferation inhibition | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | = 0.1475 uM | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
EC50 (functional) | = 0.457 uM | PF proliferation inhibition 3D7 | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | = 0.457 uM | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
IFI promiscuity index | = 0.02174 | IFI promiscuity index | Novartis-GNF Malaria Box. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 18579783 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.