Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.016 | 0.7321 | 0.7321 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0189 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.016 | 0.7321 | 0.7236 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.016 | 0.7321 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0189 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.016 | 0.7321 | 0.7321 |
Leishmania major | cathepsin L-like protease | 0.016 | 0.7321 | 1 |
Onchocerca volvulus | 0.016 | 0.7321 | 1 | |
Leishmania major | cathepsin L-like protease | 0.016 | 0.7321 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.016 | 0.7321 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0109 | 0.2537 | 0.2537 |
Onchocerca volvulus | Cathepsin L homolog | 0.016 | 0.7321 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.016 | 0.7321 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.016 | 0.7321 | 0.7236 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.016 | 0.7321 | 0.7236 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.016 | 0.7321 | 0.7321 |
Brugia malayi | Cathepsin L-like precursor | 0.016 | 0.7321 | 0.7236 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.016 | 0.7321 | 0.7321 |
Echinococcus granulosus | cathepsin b | 0.0189 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.016 | 0.7321 | 0.7321 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0085 | 0.0305 | 0.0305 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.2537 | 0.2537 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0189 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 1 | 1 |
Onchocerca volvulus | 0.016 | 0.7321 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.016 | 0.7321 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.016 | 0.7321 | 0.7236 |
Leishmania major | cathepsin L-like protease | 0.016 | 0.7321 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.016 | 0.7321 | 0.7236 |
Onchocerca volvulus | Cathepsin L homolog | 0.016 | 0.7321 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.016 | 0.7321 | 0.7321 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.016 | 0.7321 | 1 |
Onchocerca volvulus | 0.016 | 0.7321 | 1 | |
Leishmania major | cathepsin L-like protease | 0.016 | 0.7321 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.016 | 0.7321 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0189 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0085 | 0.0305 | 0.0417 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.016 | 0.7321 | 0.7236 |
Brugia malayi | cathepsin L-like precursor | 0.0109 | 0.2537 | 0.2302 |
Loa Loa (eye worm) | ctsf protein | 0.016 | 0.7321 | 0.7321 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.016 | 0.7321 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0085 | 0.0305 | 0.0305 |
Plasmodium vivax | vivapain-2 | 0.016 | 0.7321 | 1 |
Leishmania major | cathepsin L-like protease | 0.016 | 0.7321 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.016 | 0.7321 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.016 | 0.7321 | 0.7236 |
Plasmodium vivax | vivapain-2 | 0.016 | 0.7321 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0085 | 0.0305 | 0.0417 |
Onchocerca volvulus | 0.016 | 0.7321 | 1 | |
Leishmania major | cathepsin L-like protease | 0.016 | 0.7321 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.016 | 0.7321 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.016 | 0.7321 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0189 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.016 | 0.7321 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.016 | 0.7321 | 0.7236 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.016 | 0.7321 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.016 | 0.7321 | 0.7321 |
Entamoeba histolytica | cysteine proteinase, putative | 0.016 | 0.7321 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0174 | 0.8591 | 0.8591 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.016 | 0.7321 | 0.7236 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.016 | 0.7321 | 0.7321 |
Brugia malayi | Cathepsin L-like precursor | 0.0109 | 0.2537 | 0.2302 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0085 | 0.0305 | 0.0305 |
Loa Loa (eye worm) | cysteine protease | 0.016 | 0.7321 | 0.7321 |
Loa Loa (eye worm) | fibroinase | 0.016 | 0.7321 | 0.7321 |
Leishmania major | cathepsin L-like protease | 0.016 | 0.7321 | 1 |
Leishmania major | cathepsin L-like protease | 0.016 | 0.7321 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Trypanosoma cruzi | cysteine protease, putative | 0.0085 | 0.0305 | 0.0305 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0085 | 0.0305 | 0.0305 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0085 | 0.0305 | 0.0417 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0189 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.016 | 0.7321 | 0.7236 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0085 | 0.0305 | 0.0417 |
Onchocerca volvulus | 0.016 | 0.7321 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0174 | 0.8591 | 0.8591 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0109 | 0.2537 | 0.3182 |
Leishmania major | cysteine peptidase A (CPA) | 0.016 | 0.7321 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.016 | 0.7321 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.016 | 0.7321 | 0.7236 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.016 | 0.7321 | 0.7321 |
Brugia malayi | Cathepsin L-like precursor | 0.016 | 0.7321 | 0.7236 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0085 | 0.0305 | 0.0305 |
Echinococcus granulosus | cathepsin b | 0.0189 | 1 | 1 |
Onchocerca volvulus | 0.016 | 0.7321 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0109 | 0.2537 | 0.2302 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.016 | 0.7321 | 0.7236 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.016 | 0.7321 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.016 | 0.7321 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.016 | 0.7321 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0082 | 0 | 0.5 |
Onchocerca volvulus | 0.016 | 0.7321 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.7321 | 0.7321 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.016 | 0.7321 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0109 | 0.2537 | 0.2537 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0109 | 0.2537 | 0.3466 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0085 | 0.0305 | 0.0305 |
Echinococcus granulosus | cathepsin l1 | 0.0109 | 0.2537 | 0.2302 |
Giardia lamblia | Cathepsin B precursor | 0.0082 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.016 | 0.7321 | 0.7236 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0189 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0109 | 0.2537 | 0.3466 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0085 | 0.0305 | 0.0305 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.016 | 0.7321 | 1 |
Echinococcus multilocularis | cysteine protease | 0.016 | 0.7321 | 0.7236 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.2537 | 0.2537 |
Onchocerca volvulus | Cathepsin F homolog | 0.016 | 0.7321 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0082 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.2537 | 0.2537 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0109 | 0.2537 | 0.2302 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.09 uM | Inhibition of human renal renin at the pH optimum 6.0. | ChEMBL. | 3305946 |
Inhibition (binding) | = 51 % | The compound was tested for inhibition of human renal renin at the concentration of 10e-7 M | ChEMBL. | 3305946 |
Inhibition (binding) | = 92 % | The compound was tested for inhibition of human renal renin at the concentration of 10e-6 M | ChEMBL. | 3305946 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.