Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0026 | 0.0921 | 0.2017 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.4564 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0047 | 0.3129 | 0.6855 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0921 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4564 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0921 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0921 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.4564 | 1 |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0115 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4564 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4564 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.4564 | 0.5 |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0115 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.4564 | 1 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0115 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0061 | 0.4564 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.4564 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.4564 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0921 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4564 | 0.5 |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0115 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4564 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0047 | 0.3129 | 0.6061 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.4564 | 1 |
Trypanosoma brucei | wee1-like protein kinase | 0.0115 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 10 uM | Huh7 cytotoxicity for Pf inhibitors | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | > 1.25 uM | PF proliferation inhibition 3D7 | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | = 1.338 uM | W2 Pf proliferation inhibition | Novartis-GNF Malaria Box. | No reference |
IFI promiscuity index | = 0.07692 | IFI promiscuity index | Novartis-GNF Malaria Box. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.