Detailed information for compound 60812

Basic information

Technical information
  • TDR Targets ID: 60812
  • Name: 2-[[6-(dimethylamino)-9-[(4-methylphenyl)meth yl]-2-(trifluoromethyl)purin-8-yl]amino]ethan ol
  • MW: 394.394 | Formula: C18H21F3N6O
  • H donors: 2 H acceptors: 4 LogP: 3.02 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCNc1nc2c(n1Cc1ccc(cc1)C)nc(nc2N(C)C)C(F)(F)F
  • InChi: 1S/C18H21F3N6O/c1-11-4-6-12(7-5-11)10-27-15-13(23-17(27)22-8-9-28)14(26(2)3)24-16(25-15)18(19,20)21/h4-7,28H,8-10H2,1-3H3,(H,22,23)
  • InChiKey: HYUBJYDITSEAMS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[6-(dimethylamino)-9-(p-tolylmethyl)-2-(trifluoromethyl)purin-8-yl]amino]ethanol
  • 2-[[6-(dimethylamino)-9-(p-tolylmethyl)-2-(trifluoromethyl)-8-purinyl]amino]ethanol
  • 2-[[6-(dimethylamino)-9-(4-methylbenzyl)-2-(trifluoromethyl)purin-8-yl]amino]ethanol
  • 2-[[6-dimethylamino-9-[(4-methylphenyl)methyl]-2-(trifluoromethyl)purin-8-yl]amino]ethanol
  • 2-[[6-dimethylamino-9-[(4-methylphenyl)methyl]-2-(trifluoromethyl)-8-purinyl]amino]ethanol
  • 2-[[6-dimethylamino-9-(4-methylbenzyl)-2-(trifluoromethyl)purin-8-yl]amino]ethanol
  • Ethanol, 2-[[6-(dimethylamino)-9-[(4-methylphenyl)methyl]-2-(trifluoromethyl)-9H-purin-8-yl]amino]-
  • AIDS-208320
  • AIDS208320

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 1 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0022 0.3489 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Schistosoma mansoni neuropeptide receptor 0.0051 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0051 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 1 1
Onchocerca volvulus 0.0051 1 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0051 1 1
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0022 0.3489 0.5
Onchocerca volvulus 0.0051 1 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0051 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0051 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0051 1 1
Echinococcus multilocularis fmrfamide receptor 0.0051 1 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0051 1 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0022 0.3489 0.5
Brugia malayi hypothetical protein 0.0051 1 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0051 1 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.3489 0.5
Onchocerca volvulus 0.0051 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.3489 0.3489
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 1 1
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0022 0.3489 0.5
Brugia malayi Melatonin receptor type 1A 0.0051 1 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.3489 0.5
Echinococcus multilocularis dro:myosuppressin receptor 0.0051 1 1
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.3489 0.5
Brugia malayi hypothetical protein 0.0051 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0051 1 1
Echinococcus granulosus G protein coupled receptor 139 0.0051 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0051 1 1
Onchocerca volvulus 0.0051 1 0.5
Echinococcus multilocularis neuropeptide receptor A26 0.0051 1 1
Schistosoma mansoni histamine h1 receptor 0.0051 1 1
Schistosoma mansoni amine GPCR 0.0051 1 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0022 0.3489 0.5
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0022 0.3489 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Echinococcus granulosus somatostatin receptor 0.0051 1 1
Onchocerca volvulus 0.0051 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Leishmania major cytochrome p450-like protein 0.0022 0.3489 0.5
Echinococcus multilocularis fmrfamide receptor 0.0051 1 1
Brugia malayi Serotonin receptor 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0051 1 1
Brugia malayi Cytochrome P450 family protein 0.0022 0.3489 0.3489
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0022 0.3489 0.5
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.3489 0.3489
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0754 0.0754
Loa Loa (eye worm) TYRA-2 protein 0.0051 1 1
Schistosoma mansoni opsin-like receptor 0.0051 1 1
Schistosoma mansoni hypothetical protein 0.0051 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.734 0.734
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0022 0.3489 0.5
Echinococcus granulosus 7TM GPCR rhodopsin 0.0051 1 1
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0022 0.3489 0.5
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0022 0.3489 0.5
Schistosoma mansoni hypothetical protein 0.0051 1 1
Brugia malayi neuropeptide F receptor 0.0051 1 1
Echinococcus multilocularis neuropeptide receptor 0.0051 1 1
Brugia malayi RE15519p 0.0051 1 1
Echinococcus granulosus allatostatin A receptor 0.0051 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Brugia malayi hypothetical protein 0.0051 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0051 1 1
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0022 0.3489 0.5
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0051 1 1
Echinococcus multilocularis serotonin receptor 0.0051 1 1
Echinococcus granulosus sex peptide receptor 0.0051 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0051 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0051 1 1
Brugia malayi follicle stimulating hormone receptor 0.0051 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0051 1 1
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0022 0.3489 0.5
Mycobacterium leprae Conserved hypothetical protein 0.0022 0.3489 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0051 1 1
Brugia malayi hypothetical protein 0.0051 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0051 1 1
Brugia malayi G-protein coupled receptor 0.0051 1 1
Echinococcus granulosus g protein coupled receptor 0.0051 1 1
Echinococcus granulosus neuropeptide receptor 0.0051 1 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0022 0.3489 0.5
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.3489 0.5
Loa Loa (eye worm) CYP4Cod1 0.0022 0.3489 0.3489
Schistosoma mansoni neuropeptide receptor 0.0051 1 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0022 0.3489 0.5
Echinococcus multilocularis serotonin receptor 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Schistosoma mansoni amine GPCR 0.0051 1 1
Echinococcus multilocularis g protein coupled receptor 0.0051 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Schistosoma mansoni amine GPCR 0.0051 1 1
Loa Loa (eye worm) cytochrome P450 0.0022 0.3489 0.3489
Echinococcus granulosus neuropeptide receptor A26 0.0051 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0051 1 1
Echinococcus multilocularis voltage gated potassium channel 0.001 0.0754 0.0754
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0022 0.3489 0.5
Onchocerca volvulus 0.0051 1 0.5
Schistosoma mansoni hypothetical protein 0.0051 1 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.001 0.0754 0.0754
Mycobacterium leprae putative cytochrome p450 0.0022 0.3489 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Schistosoma mansoni biogenic amine receptor 0.0051 1 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0022 0.3489 0.5
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.3489 0.5
Onchocerca volvulus 0.0051 1 0.5
Echinococcus granulosus hypothetical protein 0.0051 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 1 1
Brugia malayi Dopamine receptor protein 2 0.0051 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0051 1 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.3489 0.5
Echinococcus granulosus 7tm_1 domain containing protein 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0051 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 1 1
Brugia malayi putative neuropeptide receptor 0.0051 1 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0022 0.3489 0.5
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0022 0.3489 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0051 1 1
Echinococcus multilocularis somatostatin receptor 0.0051 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.001 0.0754 0.0754
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0051 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.6045 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0022 0.3489 0.5
Schistosoma mansoni hypothetical protein 0.0051 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0051 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0051 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Brugia malayi hypothetical protein 0.0051 1 1
Onchocerca volvulus 0.0051 1 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 1 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0022 0.3489 0.5
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0022 0.3489 0.5
Brugia malayi larval opioid receptor 0.0051 1 1
Echinococcus granulosus neuropeptide s receptor 0.0051 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0051 1 1
Echinococcus multilocularis g-protein coupled receptor 0.0051 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0051 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0051 1 1
Schistosoma mansoni opsin-like receptor 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Echinococcus granulosus fmrfamide receptor 0.0051 1 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0022 0.3489 0.5
Onchocerca volvulus 0.0051 1 0.5
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0022 0.3489 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0051 1 0.5
Brugia malayi neuropeptide F receptor 0.0051 1 1
Brugia malayi Dopamine receptor 0.0051 1 1
Schistosoma mansoni adenoreceptor 0.0051 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 1 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0051 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0051 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.734 0.734
Brugia malayi hypothetical protein 0.0051 1 1
Leishmania major cytochrome p450-like protein 0.0022 0.3489 0.5
Schistosoma mansoni biogenic amine receptor 0.0051 1 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0022 0.3489 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0022 0.3489 0.5
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0022 0.3489 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0051 1 1
Brugia malayi Cytochrome P450 family protein 0.0022 0.3489 0.3489
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.6585 0.6585
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.6585 0.6585
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 1 1
Echinococcus granulosus neuropeptide receptor 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Onchocerca volvulus 0.0051 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.5501 0.5501
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 1 1
Schistosoma mansoni hypothetical protein 0.0022 0.3489 0.3489
Echinococcus granulosus g protein coupled receptor 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0754 0.0754
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0051 1 1
Echinococcus multilocularis sex peptide receptor 0.0051 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0051 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0051 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0051 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Brugia malayi ORL1-like opioid receptor 0.0051 1 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0051 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.001 0.0754 0.0754
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0022 0.3489 0.5
Echinococcus granulosus orexin receptor type 2 0.0051 1 1
Echinococcus granulosus serotonin receptor 0.0051 1 1
Echinococcus granulosus g-protein coupled receptor 0.0051 1 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.6585 0.6585
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 1 1
Echinococcus multilocularis allatostatin A receptor 0.0051 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0051 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0051 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 1 1
Brugia malayi AKH receptor 0.0051 1 1
Onchocerca volvulus 0.0051 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Brugia malayi hypothetical protein 0.0051 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0051 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0051 1 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0022 0.3489 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 1 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0022 0.3489 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0051 1 1
Brugia malayi Cytochrome P450 family protein 0.0022 0.3489 0.3489
Schistosoma mansoni neuropeptide receptor 0.0051 1 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0022 0.3489 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0051 1 1
Schistosoma mansoni neuropeptide receptor 0.0051 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0051 1 1
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0022 0.3489 0.5
Onchocerca volvulus 0.0051 1 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.3489 0.3489
Brugia malayi G-protein coupled receptor 0.0051 1 1
Leishmania major cytochrome p450-like protein 0.0022 0.3489 0.5
Brugia malayi G protein-coupled receptor F59B2.13 0.0051 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0051 1 1
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0022 0.3489 0.5
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Brugia malayi sulfakinin receptor protein 0.0051 1 1
Schistosoma mansoni biogenic amine receptor 0.0051 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0051 1 1
Schistosoma mansoni amine GPCR 0.0051 1 1
Echinococcus multilocularis 0.0022 0.3489 0.3489
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 1 1
Onchocerca volvulus 0.0051 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 1 1
Brugia malayi cytochrome P450 0.0022 0.3489 0.3489
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0051 1 1
Brugia malayi hypothetical protein 0.0051 1 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.3489 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0754 0.0754
Schistosoma mansoni biogenic amine (5HT) receptor 0.0051 1 1
Echinococcus multilocularis g protein coupled receptor 0.0051 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0051 1 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0022 0.3489 0.5
Echinococcus multilocularis G protein coupled receptor 139 0.0051 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0051 1 1
Trypanosoma brucei cytochrome P450, putative 0.0022 0.3489 0.5
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0051 1 1
Echinococcus granulosus g protein coupled receptor 0.0051 1 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0022 0.3489 0.5
Schistosoma mansoni cytochrome P450 0.0022 0.3489 0.3489
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0051 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.6585 0.6585
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0051 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0051 1 1
Brugia malayi putative neuropeptide receptor NPR1 0.0051 1 1
Brugia malayi Dopamine receptor protein 1 0.0051 1 1
Brugia malayi G protein-coupled receptor 0.0051 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0051 1 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0022 0.3489 0.5
Onchocerca volvulus 0.0051 1 0.5
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0022 0.3489 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0051 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 1 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0051 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0051 1 1
Brugia malayi GnHR receptor homolog 0.0051 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0051 1 1
Onchocerca volvulus 0.0051 1 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.0051 1 1
Schistosoma mansoni amine GPCR 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0022 0.3489 0.5
Echinococcus granulosus voltage gated potassium channel 0.001 0.0754 0.0754
Echinococcus multilocularis orexin receptor type 2 0.0051 1 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0051 1 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0022 0.3489 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0051 1 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0022 0.3489 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0051 1 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0051 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0022 0.3489 0.5
Brugia malayi Cytochrome P450 family protein 0.0022 0.3489 0.3489
Onchocerca volvulus 0.0051 1 0.5
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0051 1 1
Echinococcus multilocularis neuropeptide receptor 0.0051 1 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.3489 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.0051 1 1
Schistosoma mansoni myosin xvIII 0.0051 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.6045 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0051 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 1 1
Onchocerca volvulus 0.0051 1 0.5
Brugia malayi Serotonin receptor 0.0051 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.3489 0.3489
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0022 0.3489 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0051 1 1
Brugia malayi hypothetical protein 0.0051 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Echinococcus multilocularis g protein coupled receptor 0.0051 1 1
Schistosoma mansoni opsin-like receptor 0.0051 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 8.6 uM Compound was tested for its inhibitory concentration against rhinovirus 1B through plaque-inhibition assay at 50 ug/disk using monolayers of M-HeLa cells ChEMBL. 1846916

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.