Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0063 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0456 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0456 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0456 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0456 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0456 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.2168 | 0.7043 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0456 | 0.1313 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.2168 | 0.6595 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0456 | 1 |
Onchocerca volvulus | 0.0023 | 0.0456 | 0.5 | |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0456 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2168 | 0.7043 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1135 | 0.2616 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0456 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0456 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0456 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.3052 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0456 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0456 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0456 | 1 |
Echinococcus multilocularis | geminin | 0.0167 | 1 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0063 | 0.139 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3052 | 0.2162 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.3052 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3052 | 0.2162 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0456 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3052 | 0.2162 |
Brugia malayi | RNA binding protein | 0.0063 | 0.3052 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1135 | 0.3586 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0456 | 0.5 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0456 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.3052 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3052 | 0.2162 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0063 | 0.5 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0063 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0456 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.3052 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0456 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.3052 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3052 | 0.2162 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0456 | 0.1313 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0456 | 0.1313 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.2168 | 0.6595 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. | ChEMBL. | 22096101 | |
CC50 (functional) | > 10 uM | Huh7 cytotoxicity for Pf inhibitors | Novartis-GNF Malaria Box. | No reference |
CC50 | > 10 uM | NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) | ChEMBL. | 18579783 |
EC50 (functional) | = 1.065 uM | PF proliferation inhibition 3D7 | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | = 1.065 uM | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
EC50 (functional) | > 1.182 uM | W2 Pf proliferation inhibition | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | > 1.182 uM | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
IFI promiscuity index | = 0.02679 | IFI promiscuity index | Novartis-GNF Malaria Box. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 18579783 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.