Detailed information for compound 609309

Basic information

Technical information
  • TDR Targets ID: 609309
  • Name: methyl 4-[(4-pyridin-4-yl-1,3-thiazol-2-yl)ca rbamoyl]benzoate
  • MW: 339.368 | Formula: C17H13N3O3S
  • H donors: 1 H acceptors: 4 LogP: 2.57 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccc(cc1)C(=O)Nc1scc(n1)c1ccncc1
  • InChi: 1S/C17H13N3O3S/c1-23-16(22)13-4-2-12(3-5-13)15(21)20-17-19-14(10-24-17)11-6-8-18-9-7-11/h2-10H,1H3,(H,19,20,21)
  • InChiKey: XABBHFOUAHTFHN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 4-[[4-(4-pyridyl)thiazol-2-yl]carbamoyl]benzoate
  • 4-[oxo-[[4-(4-pyridyl)-2-thiazolyl]amino]methyl]benzoic acid methyl ester
  • 4-[[4-(4-pyridyl)thiazol-2-yl]carbamoyl]benzoic acid methyl ester
  • IFLab1_003403
  • Oprea1_341209
  • ZINC00755257

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.4734 0.8263
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0019 0.0235 0.0213
Echinococcus granulosus neuropeptide s receptor 0.0019 0.0235 0.0213
Echinococcus granulosus neuropeptide receptor 0.0019 0.0235 0.0213
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.363 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0019 0.0235 0.0213
Loa Loa (eye worm) hypothetical protein 0.0036 0.1016 0.1773
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Echinococcus multilocularis serotonin receptor 0.0019 0.0235 0.0213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0235 0.0213
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0235 0.0213
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.1016 0.2619
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Trichomonas vaginalis esterase, putative 0.0036 0.1016 0.2619
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.1481 0.3934
Brugia malayi hypothetical protein 0.0019 0.0235 0.0384
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1479 0.3926
Loa Loa (eye worm) PHD-finger family protein 0.004 0.121 0.2112
Echinococcus multilocularis geminin 0.0164 0.6992 1
Echinococcus multilocularis lamin dm0 0.0026 0.0565 0.0691
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.4214 0.8549
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0235 0.0213
Echinococcus granulosus G protein coupled receptor 139 0.0019 0.0235 0.0213
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.1016 0.1344
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.1481 0.2019
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0019 0.0235 0.0213
Echinococcus granulosus geminin 0.0164 0.6992 1
Brugia malayi beta-lactamase family protein 0.0036 0.1016 0.1661
Leishmania major trypanothione reductase 0.0046 0.1481 0.3934
Echinococcus granulosus intermediate filament protein 0.0026 0.0565 0.0691
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0235 0.0213
Loa Loa (eye worm) TAR-binding protein 0.0061 0.2206 0.385
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0235 0.0213
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0019 0.0235 0.0384
Echinococcus granulosus zinc finger protein 0.0038 0.1115 0.1487
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Brugia malayi G-protein coupled receptor 0.0019 0.0235 0.0384
Schistosoma mansoni amine GPCR 0.0019 0.0235 0.0213
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.4757 0.4711
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0115 0.4735 0.673
Plasmodium falciparum glutathione reductase 0.0046 0.1481 1
Brugia malayi Serotonin receptor 0.0019 0.0235 0.0384
Schistosoma mansoni serine/threonine protein kinase 0.005 0.1661 0.2279
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.1016 0.1344
Echinococcus multilocularis neuropeptide receptor A26 0.0019 0.0235 0.0213
Brugia malayi hypothetical protein 0.0019 0.0235 0.0384
Brugia malayi RE15519p 0.0019 0.0235 0.0384
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0235 0.0213
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0235 0.0213
Schistosoma mansoni kinase 0.0047 0.1535 0.2096
Brugia malayi Bromodomain containing protein 0.0074 0.2804 0.4585
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Schistosoma mansoni lamin 0.0026 0.0565 0.0691
Brugia malayi Bromodomain containing protein 0.0145 0.6115 1
Trypanosoma cruzi ISWI complex protein 0.003 0.0729 0.181
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.1016 0.0936
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0235 0.0213
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.363 0.5131
Schistosoma mansoni amine GPCR 0.0019 0.0235 0.0213
Loa Loa (eye worm) bromodomain containing protein 0.0034 0.0942 0.1645
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.1481 0.1406
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0019 0.0235 0.0213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0019 0.0235 0.0213
Echinococcus granulosus 7TM GPCR rhodopsin 0.0019 0.0235 0.0213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Loa Loa (eye worm) hypothetical protein 0.0036 0.1016 0.1773
Schistosoma mansoni hypothetical protein 0.0019 0.0235 0.0213
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0235 0.0213
Echinococcus granulosus lamin dm0 0.0026 0.0565 0.0691
Echinococcus granulosus tachykinin peptides receptor 99D 0.0019 0.0235 0.0213
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0235 0.0213
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0235 0.0213
Brugia malayi Dopamine receptor protein 2 0.0019 0.0235 0.0384
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0087 0.5
Schistosoma mansoni zinc finger protein 0.0038 0.1115 0.1487
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0235 0.0213
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0019 0.0235 0.0213
Loa Loa (eye worm) hypothetical protein 0.0036 0.1016 0.1773
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0887 0.1158
Loa Loa (eye worm) RNA binding protein 0.0061 0.2206 0.385
Plasmodium vivax hypothetical protein, conserved 0.0036 0.1016 0.6658
Schistosoma mansoni neuropeptide f receptor 76f 0.0019 0.0235 0.0213
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0019 0.0235 0.0213
Echinococcus granulosus alpha 1A adrenergic receptor 0.0019 0.0235 0.0213
Brugia malayi hypothetical protein 0.0019 0.0235 0.0384
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Echinococcus granulosus g-protein coupled receptor 0.0019 0.0235 0.0213
Echinococcus granulosus allatostatin A receptor 0.0019 0.0235 0.0213
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0235 0.0213
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.4757 1
Echinococcus granulosus g protein coupled receptor 0.0019 0.0235 0.0213
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0235 0.0213
Echinococcus multilocularis neuropeptide s receptor 0.0019 0.0235 0.0213
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0235 0.0213
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0235 0.0213
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0235 0.0213
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1661 0.4441
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Loa Loa (eye worm) hypothetical protein 0.0026 0.0543 0.0947
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.4214 0.4163
Brugia malayi hypothetical protein 0.0019 0.0235 0.0384
Onchocerca volvulus 0.0036 0.1016 0.2299
Echinococcus granulosus methyl CpG binding domain protein 2 0.0033 0.0887 0.1158
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.1016 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0235 0.0213
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0235 0.0213
Mycobacterium tuberculosis Conserved protein 0.0036 0.1016 0.0936
Echinococcus multilocularis dro:myosuppressin receptor 0.0019 0.0235 0.0213
Mycobacterium tuberculosis Conserved protein 0.0036 0.1016 0.0936
Echinococcus granulosus somatostatin receptor 0.0019 0.0235 0.0213
Schistosoma mansoni methyl-cpg binding protein mbd 0.0033 0.0887 0.1158
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.4214 0.4163
Echinococcus granulosus fetal alzheimer antigen falz 0.0044 0.1382 0.1875
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.1016 0.2619
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.1661 0.4441
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.363 0.5937
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.363 1
Mycobacterium ulcerans hypothetical protein 0.0036 0.1016 1
Schistosoma mansoni zinc finger protein 0.003 0.0729 0.0928
Brugia malayi MAP kinase sur-1 0.005 0.1661 0.2716
Brugia malayi beta-lactamase family protein 0.0036 0.1016 0.1661
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.363 1
Echinococcus multilocularis tar DNA binding protein 0.0061 0.2206 0.3068
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1479 0.3926
Brugia malayi hypothetical protein 0.0019 0.0235 0.0384
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0235 0.0213
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0235 0.0213
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0019 0.0235 0.0213
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0235 0.0213
Onchocerca volvulus 0.0026 0.0565 0.0972
Loa Loa (eye worm) hypothetical protein 0.0079 0.3024 0.5278
Trypanosoma brucei ISWI complex protein 0.003 0.0729 0.181
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0235 0.041
Loa Loa (eye worm) glutathione reductase 0.0046 0.1481 0.2586
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0019 0.0235 0.0213
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0235 0.0213
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.1016 0.0936
Brugia malayi beta-lactamase 0.0036 0.1016 0.1661
Mycobacterium ulcerans beta-lactamase 0.0036 0.1016 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Brugia malayi hypothetical protein 0.0019 0.0235 0.0384
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.363 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0019 0.0235 0.0384
Brugia malayi TAR-binding protein 0.0061 0.2206 0.3607
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.1016 1
Brugia malayi PHD-finger family protein 0.0048 0.1596 0.261
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.363 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.259 0.3624
Brugia malayi hypothetical protein 0.0019 0.0235 0.0384
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0235 0.0213
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0044 0.1382 0.1875
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.1016 0.1344
Schistosoma mansoni opsin-like receptor 0.0019 0.0235 0.0213
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0235 0.041
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0235 0.0213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Brugia malayi Melatonin receptor type 1A 0.0019 0.0235 0.0384
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0019 0.0235 0.041
Loa Loa (eye worm) melatonin receptor type 1A 0.0019 0.0235 0.041
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0235 0.0213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Schistosoma mansoni hypothetical protein 0.0019 0.0235 0.0213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Mycobacterium tuberculosis Conserved protein 0.0036 0.1016 0.0936
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0235 0.0213
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.363 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0019 0.0235 0.0213
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0235 0.0213
Echinococcus granulosus neuropeptide receptor 0.0019 0.0235 0.0213
Mycobacterium ulcerans lipase LipD 0.0036 0.1016 1
Schistosoma mansoni opsin-like receptor 0.0019 0.0235 0.0213
Schistosoma mansoni hypothetical protein 0.0164 0.6992 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0887 0.1158
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.1661 0.4441
Schistosoma mansoni intermediate filament proteins 0.0026 0.0565 0.0691
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.1016 0.2619
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0235 0.041
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0235 0.041
Schistosoma mansoni tar DNA-binding protein 0.0061 0.2206 0.3068
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Echinococcus granulosus mitogen activated protein kinase 0.005 0.1661 0.2279
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0887 0.1158
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Loa Loa (eye worm) hypothetical protein 0.0036 0.1016 0.1773
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.1016 0.1344
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.4757 0.4711
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0235 0.0213
Trypanosoma brucei polo-like protein kinase 0.0092 0.363 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0019 0.0235 0.0213
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.1016 0.2619
Brugia malayi G-protein coupled receptor 0.0019 0.0235 0.0384
Brugia malayi neuropeptide F receptor 0.0019 0.0235 0.0384
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.1661 0.2899
Schistosoma mansoni biogenic amine receptor 0.0019 0.0235 0.0213
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0019 0.0235 0.0213
Echinococcus multilocularis zinc finger protein 0.0038 0.1115 0.1487
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Onchocerca volvulus 0.0026 0.0565 0.0972
Onchocerca volvulus 0.0036 0.1016 0.2299
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.363 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0235 0.0213
Schistosoma mansoni neuropeptide receptor 0.0019 0.0235 0.0213
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.363 0.6337
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0019 0.0235 0.0384
Leishmania major hypothetical protein, conserved 0.003 0.0729 0.181
Schistosoma mansoni tar DNA-binding protein 0.0061 0.2206 0.3068
Echinococcus multilocularis G protein coupled receptor 139 0.0019 0.0235 0.0213
Brugia malayi hypothetical protein 0.0019 0.0235 0.0384
Echinococcus multilocularis neuropeptide FF receptor 2 0.0019 0.0235 0.0213
Brugia malayi Serotonin receptor 0.0019 0.0235 0.0384
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0235 0.0213
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0044 0.1382 0.1875
Brugia malayi sulfakinin receptor protein 0.0019 0.0235 0.0384
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.4214 0.4163
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0033 0.0887 0.1158
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0235 0.0213
Schistosoma mansoni lamin 0.0026 0.0565 0.0691
Echinococcus multilocularis allatostatin A receptor 0.0019 0.0235 0.0213
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0019 0.0235 0.0384
Echinococcus granulosus g protein coupled receptor 0.0019 0.0235 0.0213
Echinococcus granulosus 7tm_1 domain containing protein 0.0019 0.0235 0.0213
Schistosoma mansoni tar DNA-binding protein 0.0061 0.2206 0.3068
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0235 0.0213
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0087 0.0143
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.1481 0.2586
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.1016 0.2619
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0235 0.0213
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.1016 0.2619
Brugia malayi ORL1-like opioid receptor 0.0019 0.0235 0.0384
Echinococcus multilocularis serotonin receptor 0.0019 0.0235 0.0213
Schistosoma mansoni biogenic amine receptor 0.0019 0.0235 0.0213
Brugia malayi hypothetical protein 0.0019 0.0235 0.0384
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.2206 0.3607
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0087 0.5
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.1016 0.0936
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0019 0.0235 0.0213
Schistosoma mansoni hypothetical protein 0.0164 0.6992 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0019 0.0235 0.0213
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0235 0.0213
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0235 0.0213
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.1016 0.0936
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Echinococcus multilocularis g-protein coupled receptor 0.0019 0.0235 0.0213
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0235 0.0213
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.1016 0.1773
Echinococcus granulosus serotonin receptor 0.0019 0.0235 0.0213
Brugia malayi Dopamine receptor 0.0019 0.0235 0.0384
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.4214 0.4163
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0019 0.0235 0.0384
Treponema pallidum NADH oxidase 0.0016 0.0087 0.5
Schistosoma mansoni amine GPCR 0.0019 0.0235 0.0213
Schistosoma mansoni myosin xvIII 0.0019 0.0235 0.0213
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.363 1
Toxoplasma gondii thioredoxin reductase 0.0046 0.1481 0.886
Schistosoma mansoni methyl-cpg binding protein mbd 0.0033 0.0887 0.1158
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0019 0.0235 0.0213
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0235 0.0213
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0235 0.0213
Brugia malayi G protein-coupled receptor 0.0019 0.0235 0.0384
Schistosoma mansoni tar DNA-binding protein 0.0061 0.2206 0.3068
Brugia malayi MH2 domain containing protein 0.0115 0.4734 0.7742
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0235 0.0213
Loa Loa (eye worm) hypothetical protein 0.0036 0.1016 0.1773
Toxoplasma gondii ABC1 family protein 0.0036 0.1016 0.5899
Echinococcus multilocularis G-protein coupled receptor, putative 0.0019 0.0235 0.0213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0235 0.0213
Brugia malayi AKH receptor 0.0019 0.0235 0.0384
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0235 0.0213
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0235 0.0213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0235 0.0213
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0235 0.0213
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0235 0.0213
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0565 0.0986
Schistosoma mansoni histamine h1 receptor 0.0019 0.0235 0.0213
Schistosoma mansoni amine GPCR 0.0019 0.0235 0.0213
Echinococcus multilocularis orexin receptor type 2 0.0019 0.0235 0.0213
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0019 0.0235 0.041
Schistosoma mansoni biogenic amine receptor 0.0019 0.0235 0.0213
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.2206 0.385
Schistosoma mansoni growth hormone secretagogue receptor 0.0019 0.0235 0.0213
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.363 1
Trypanosoma cruzi ISWI complex protein 0.003 0.0729 0.181
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.1661 0.4441
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0235 0.0213
Leishmania major hypothetical protein, conserved 0.0036 0.1016 0.2619
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.1661 0.4441
Loa Loa (eye worm) TYRA-2 protein 0.0019 0.0235 0.041
Brugia malayi hypothetical protein 0.0019 0.0235 0.0384
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0019 0.0235 0.0213
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1661 0.4441
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.4214 0.4163
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0565 0.0986
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1661 0.4441
Onchocerca volvulus 0.0036 0.1016 0.2299
Brugia malayi putative neuropeptide receptor NPR1 0.0019 0.0235 0.0384
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0019 0.0235 0.041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0235 0.0213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0019 0.0235 0.0213
Brugia malayi follicle stimulating hormone receptor 0.0019 0.0235 0.0384
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0235 0.0213
Echinococcus granulosus g protein coupled receptor 0.0019 0.0235 0.0213
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.363 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.1661 0.4441
Plasmodium falciparum thioredoxin reductase 0.0046 0.1481 1
Echinococcus granulosus hypothetical protein 0.0019 0.0235 0.0213
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.259 0.3624
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.1661 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0115 0.4735 0.673
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.363 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Brugia malayi neuropeptide F receptor 0.0019 0.0235 0.0384
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.1661 0.4441
Schistosoma mansoni hypothetical protein 0.003 0.0729 0.0928
Schistosoma mansoni hypothetical protein 0.0019 0.0235 0.0213
Schistosoma mansoni amine GPCR 0.0019 0.0235 0.0213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Echinococcus multilocularis somatostatin receptor 0.0019 0.0235 0.0213
Echinococcus granulosus tar DNA binding protein 0.0061 0.2206 0.3068
Echinococcus multilocularis lamin 0.0026 0.0565 0.0691
Schistosoma mansoni neuropeptide receptor 0.0019 0.0235 0.0213
Schistosoma mansoni hypothetical protein 0.004 0.121 0.1626
Trypanosoma brucei protein kinase, putative 0.005 0.1661 0.4441
Brugia malayi G protein-coupled receptor F59B2.13 0.0019 0.0235 0.0384
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.363 0.5131
Echinococcus granulosus orexin receptor type 2 0.0019 0.0235 0.0213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Plasmodium vivax glutathione reductase, putative 0.0046 0.1481 1
Schistosoma mansoni bromodomain containing protein 0.0122 0.5058 0.7198
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0087 0.5
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Echinococcus multilocularis sex peptide receptor 0.0019 0.0235 0.0213
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0019 0.0235 0.0213
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0019 0.0235 0.041
Echinococcus granulosus peptide allatostatin:somatostatin 0.0019 0.0235 0.0213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Brugia malayi Tachykinin-like peptides receptor 99D 0.0019 0.0235 0.0384
Loa Loa (eye worm) hypothetical protein 0.0033 0.0887 0.1548
Loa Loa (eye worm) hypothetical protein 0.0137 0.5729 1
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0235 0.0213
Brugia malayi Dopamine receptor protein 1 0.0019 0.0235 0.0384
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.1016 0.2619
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0235 0.0213
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.1016 0.1661
Schistosoma mansoni neuropeptide receptor 0.0019 0.0235 0.0213
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.363 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.1481 0.2019
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.1016 0.2619
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0019 0.0235 0.0213
Loa Loa (eye worm) hypothetical protein 0.0082 0.3196 0.5579
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0235 0.0213
Echinococcus granulosus sex peptide receptor 0.0019 0.0235 0.0213
Brugia malayi glutathione reductase 0.0046 0.1481 0.2423
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0565 0.0924
Brugia malayi Thioredoxin reductase 0.0046 0.1481 0.2423
Echinococcus multilocularis musashi 0.0026 0.0565 0.0691
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0235 0.0213
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.1661 0.2279
Echinococcus granulosus neuropeptide FF receptor 2 0.0019 0.0235 0.0213
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0235 0.0213
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0235 0.0213
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.1016 0.0936
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.1481 1
Schistosoma mansoni hypothetical protein 0.0019 0.0235 0.0213
Loa Loa (eye worm) beta-lactamase 0.0036 0.1016 0.1773
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.1661 0.2279
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.1661 0.4441
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.363 0.5131
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.4734 0.8263
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0019 0.0235 0.0213
Schistosoma mansoni tar DNA-binding protein 0.0061 0.2206 0.3068
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.1016 0.0936
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.1016 0.0936
Schistosoma mansoni neuropeptide receptor 0.0019 0.0235 0.0213
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0235 0.0213
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0235 0.0213
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0235 0.0213
Brugia malayi intermediate filament protein 0.0026 0.0565 0.0924
Brugia malayi larval opioid receptor 0.0019 0.0235 0.0384
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.1661 0.2279
Giardia lamblia Kinase, PLK 0.0092 0.363 1
Echinococcus granulosus lamin 0.0026 0.0565 0.0691
Giardia lamblia Kinase, CMGC MAPK 0.005 0.1661 0.4441
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0235 0.0213
Mycobacterium tuberculosis Probable reductase 0.0104 0.4214 0.4163
Brugia malayi GnHR receptor homolog 0.0019 0.0235 0.0384
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1661 0.4441
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.4757 0.4711
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0235 0.0213
Brugia malayi putative neuropeptide receptor 0.0019 0.0235 0.0384
Loa Loa (eye worm) hypothetical protein 0.0026 0.0565 0.0986
Loa Loa (eye worm) hypothetical protein 0.0036 0.1016 0.1773
Echinococcus granulosus dro:myosuppressin receptor 0.0019 0.0235 0.0213
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0235 0.0213
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0235 0.0213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.041
Loa Loa (eye worm) hypothetical protein 0.0074 0.281 0.4905
Schistosoma mansoni opsin-like receptor 0.0019 0.0235 0.0213
Schistosoma mansoni adenoreceptor 0.0019 0.0235 0.0213
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0887 0.1158
Trypanosoma brucei trypanothione reductase 0.0046 0.1481 0.3934
Schistosoma mansoni alpha-1 adrenergic receptor 0.0019 0.0235 0.0213
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0019 0.0235 0.041
Brugia malayi RNA binding protein 0.0061 0.2206 0.3607
Echinococcus granulosus fmrfamide receptor 0.0019 0.0235 0.0213

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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