Detailed information for compound 609440

Basic information

Technical information
  • TDR Targets ID: 609440
  • Name: 4-[5-(3-nitrophenyl)-3-phenyl-4,5-dihydropyra zol-1-yl]-4-oxobutanoic acid
  • MW: 367.355 | Formula: C19H17N3O5
  • H donors: 1 H acceptors: 5 LogP: 1.96 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CCC(=O)N1N=C(CC1c1cccc(c1)[N+](=O)[O-])c1ccccc1
  • InChi: 1S/C19H17N3O5/c23-18(9-10-19(24)25)21-17(14-7-4-8-15(11-14)22(26)27)12-16(20-21)13-5-2-1-3-6-13/h1-8,11,17H,9-10,12H2,(H,24,25)
  • InChiKey: WFOSEASVKFXYAB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[5-(3-nitrophenyl)-3-phenyl-4,5-dihydropyrazol-1-yl]-4-oxo-butanoic acid
  • 4-keto-4-[5-(3-nitrophenyl)-3-phenyl-4,5-dihydropyrazol-1-yl]butyric acid
  • BAS 01855528
  • Oprea1_795437
  • 4-[5-(3-Nitro-phenyl)-3-phenyl-4,5-dihydro-pyrazol-1-yl]-4-oxo-butyric acid
  • Oprea1_119877

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0027 0.029 0.073
Echinococcus multilocularis G protein coupled receptor 139 0.0027 0.029 0.073
Brugia malayi hypothetical protein 0.0027 0.029 0.0935
Echinococcus granulosus neuropeptide Y receptor 0.0027 0.029 0.073
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.1296 0.3699
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.029 0.073
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1781 1
Brugia malayi beta-lactamase 0.0071 0.1296 0.4171
Echinococcus multilocularis tar DNA binding protein 0.0066 0.1172 0.3334
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1781 1
Schistosoma mansoni bromodomain containing protein 0.0127 0.2571 0.7464
Echinococcus multilocularis neuropeptide receptor 0.0027 0.029 0.073
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0027 0.029 0.073
Echinococcus granulosus 7tm_1 domain containing protein 0.0027 0.029 0.073
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0043 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0027 0.029 0.073
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.029 0.096
Brugia malayi RE15519p 0.0027 0.029 0.0935
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0045 0.071 0.197
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0623 0.206
Schistosoma mansoni amine GPCR 0.0027 0.029 0.073
Loa Loa (eye worm) hypothetical protein 0.0147 0.3024 1
Leishmania major hypothetical protein, conserved 0.0071 0.1296 0.7209
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Brugia malayi glutathione reductase 0.0046 0.0727 0.2339
Schistosoma mansoni amine GPCR 0.0027 0.029 0.073
Echinococcus granulosus sex peptide receptor 0.0027 0.029 0.073
Echinococcus multilocularis lamin 0.0026 0.0277 0.0691
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Schistosoma mansoni hypothetical protein 0.0027 0.029 0.073
Echinococcus multilocularis orexin receptor type 2 0.0027 0.029 0.073
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1172 0.3334
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.029 0.073
Toxoplasma gondii thioredoxin reductase 0.0046 0.0727 0.5458
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1172 0.3334
Echinococcus granulosus biogenic amine 5HT receptor 0.0027 0.029 0.073
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0027 0.029 0.073
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0815 0.2694
Brugia malayi Dopamine receptor protein 2 0.0027 0.029 0.0935
Loa Loa (eye worm) hypothetical protein 0.0071 0.1296 0.4285
Echinococcus granulosus tachykinin peptides receptor 99D 0.0027 0.029 0.073
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.029 0.073
Echinococcus multilocularis g-protein coupled receptor 0.0027 0.029 0.073
Brugia malayi MAP kinase sur-1 0.005 0.0815 0.2623
Schistosoma mansoni intermediate filament proteins 0.0026 0.0277 0.0691
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1296 0.7209
Schistosoma mansoni myosin xvIII 0.0027 0.029 0.073
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0027 0.029 0.073
Brugia malayi PHD-finger family protein 0.005 0.0818 0.2634
Schistosoma mansoni hypothetical protein 0.0031 0.0379 0.0993
Echinococcus granulosus serotonin receptor 0.0027 0.029 0.073
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.1296 0.3699
Loa Loa (eye worm) hypothetical protein 0.0071 0.1296 0.4285
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.029 0.073
Echinococcus granulosus peptide allatostatin:somatostatin 0.0027 0.029 0.073
Echinococcus granulosus G protein coupled receptor 139 0.0027 0.029 0.073
Echinococcus granulosus hypothetical protein 0.0027 0.029 0.073
Echinococcus granulosus neuropeptide receptor A26 0.0027 0.029 0.073
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.1296 0.3699
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.1296 0.1258
Echinococcus multilocularis neuropeptide Y receptor 0.0027 0.029 0.073
Schistosoma mansoni hypothetical protein 0.0165 0.343 1
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0727 0.2403
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Onchocerca volvulus 0.0027 0.029 0.0048
Echinococcus granulosus somatostatin receptor 0.0027 0.029 0.073
Mycobacterium tuberculosis Conserved protein 0.0071 0.1296 0.1258
Loa Loa (eye worm) hypothetical protein 0.0082 0.1541 0.5096
Echinococcus granulosus g protein coupled receptor 0.0027 0.029 0.073
Onchocerca volvulus 0.0071 0.1296 0.3708
Brugia malayi Melatonin receptor type 1A 0.0027 0.029 0.0935
Schistosoma mansoni biogenic amine receptor 0.0027 0.029 0.073
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0027 0.029 0.073
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2322 0.7679
Echinococcus multilocularis g protein coupled receptor 0.0027 0.029 0.073
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.2067 0.2033
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0027 0.029 0.096
Echinococcus multilocularis neuropeptides capa receptor 0.0027 0.029 0.073
Brugia malayi AKH receptor 0.0027 0.029 0.0935
Echinococcus granulosus neuropeptide Y receptor 0.0027 0.029 0.073
Brugia malayi ORL1-like opioid receptor 0.0027 0.029 0.0935
Schistosoma mansoni opsin-like receptor 0.0027 0.029 0.073
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0027 0.029 0.073
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.029 0.073
Echinococcus multilocularis neuropeptide FF receptor 2 0.0027 0.029 0.073
Brugia malayi neuropeptide F receptor 0.0027 0.029 0.0935
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0045 0.071 0.197
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.029 0.073
Echinococcus granulosus neuropeptide s receptor 0.0027 0.029 0.073
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0727 0.2019
Schistosoma mansoni biogenic amine (5HT) receptor 0.0027 0.029 0.073
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.2333 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1172 0.3334
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0027 0.029 0.073
Trypanosoma brucei protein kinase, putative 0.005 0.0815 0.4441
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0043 0.0138
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.2067 0.2033
Schistosoma mansoni neuropeptide F-like receptor 0.0027 0.029 0.073
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.029 0.073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.029 0.073
Brugia malayi sulfakinin receptor protein 0.0027 0.029 0.0935
Loa Loa (eye worm) beta-lactamase 0.0071 0.1296 0.4285
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1781 1
Schistosoma mansoni hypothetical protein 0.0027 0.029 0.073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.029 0.073
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1172 0.3334
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.1296 1
Schistosoma mansoni amine GPCR 0.0027 0.029 0.073
Mycobacterium ulcerans hypothetical protein 0.0071 0.1296 1
Brugia malayi G-protein coupled receptor 0.0027 0.029 0.0935
Brugia malayi G protein-coupled receptor 0.0027 0.029 0.0935
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0027 0.029 0.0935
Schistosoma mansoni growth hormone secretagogue receptor 0.0027 0.029 0.073
Plasmodium falciparum thioredoxin reductase 0.0046 0.0727 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0815 0.4441
Onchocerca volvulus 0.0027 0.029 0.0048
Echinococcus granulosus dro:myosuppressin receptor 0.0027 0.029 0.073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.029 0.073
Brugia malayi Tachykinin-like peptides receptor 99D 0.0027 0.029 0.0935
Schistosoma mansoni neuropeptide receptor 0.0027 0.029 0.073
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.1296 0.3699
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0027 0.029 0.073
Schistosoma mansoni kinase 0.0047 0.0753 0.2096
Echinococcus granulosus allatostatin A receptor 0.0027 0.029 0.073
Schistosoma mansoni lamin 0.0026 0.0277 0.0691
Plasmodium falciparum glutathione reductase 0.0046 0.0727 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1781 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Echinococcus granulosus zinc finger protein 0.0039 0.0574 0.157
Schistosoma mansoni neuropeptide receptor 0.0027 0.029 0.073
Echinococcus multilocularis fmrfamide receptor 0.0027 0.029 0.073
Echinococcus multilocularis allatostatin A receptor 0.0027 0.029 0.073
Schistosoma mansoni biogenic amine receptor 0.0027 0.029 0.073
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0815 0.4441
Brugia malayi hypothetical protein 0.0027 0.029 0.0935
Schistosoma mansoni hypothetical protein 0.0027 0.029 0.073
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0815 0.2279
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.029 0.073
Brugia malayi Bromodomain containing protein 0.0077 0.143 0.4603
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1781 1
Brugia malayi putative neuropeptide receptor NPR1 0.0027 0.029 0.0935
Brugia malayi larval opioid receptor 0.0027 0.029 0.0935
Echinococcus multilocularis g protein coupled receptor 0.0027 0.029 0.073
Schistosoma mansoni neuropeptide receptor 0.0027 0.029 0.073
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0815 0.4441
Brugia malayi Dopamine receptor protein 1 0.0027 0.029 0.0935
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0027 0.029 0.0935
Echinococcus granulosus tar DNA binding protein 0.0066 0.1172 0.3334
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.029 0.073
Echinococcus granulosus fmrfamide receptor 0.0027 0.029 0.073
Onchocerca volvulus 0.0027 0.029 0.0048
Mycobacterium tuberculosis Probable reductase 0.0105 0.2067 0.2033
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.1296 0.1258
Echinococcus multilocularis neuropeptides capa receptor 0.0027 0.029 0.073
Brugia malayi GnHR receptor homolog 0.0027 0.029 0.0935
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Loa Loa (eye worm) hypothetical protein 0.0071 0.1296 0.4285
Echinococcus granulosus neuropeptide receptor 0.0027 0.029 0.073
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0027 0.029 0.073
Trypanosoma brucei trypanothione reductase 0.0046 0.0727 0.3934
Brugia malayi hypothetical protein 0.0027 0.029 0.0935
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Loa Loa (eye worm) TYRA-2 protein 0.0027 0.029 0.096
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0459 0.1229
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0027 0.029 0.0935
Onchocerca volvulus 0.0027 0.029 0.0048
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.1781 0.5889
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Brugia malayi Dopamine receptor 0.0027 0.029 0.0935
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Loa Loa (eye worm) hypothetical protein 0.0026 0.0266 0.088
Echinococcus multilocularis neuropeptide receptor 0.0027 0.029 0.073
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Brugia malayi Serotonin receptor 0.0027 0.029 0.0935
Schistosoma mansoni neuropeptide F-like receptor 0.0027 0.029 0.073
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0487 0.1611
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1781 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.012 0.2407 0.6981
Brugia malayi Bromodomain containing protein 0.0151 0.3106 1
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2322 0.7679
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0815 0.4441
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0727 0.0687
Schistosoma mansoni lamin 0.0026 0.0277 0.0691
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.1296 0.7209
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0027 0.029 0.096
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0459 0.1229
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.029 0.096
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.2333 0.23
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0027 0.029 0.096
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.1781 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.029 0.073
Mycobacterium tuberculosis Conserved protein 0.0071 0.1296 0.1258
Echinococcus multilocularis neuropeptide s receptor 0.0027 0.029 0.073
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.029 0.073
Echinococcus multilocularis zinc finger protein 0.0039 0.0574 0.157
Loa Loa (eye worm) hypothetical protein 0.0071 0.1296 0.4285
Brugia malayi neuropeptide F receptor 0.0027 0.029 0.0935
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.029 0.073
Loa Loa (eye worm) TAR-binding protein 0.0066 0.1172 0.3876
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.1296 0.1258
Trypanosoma brucei polo-like protein kinase 0.0092 0.1781 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0027 0.029 0.073
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.1296 0.1258
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1296 0.7209
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.1296 0.4285
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.029 0.073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.029 0.073
Echinococcus multilocularis serotonin receptor 0.0027 0.029 0.073
Echinococcus granulosus geminin 0.0165 0.343 1
Echinococcus multilocularis g protein coupled receptor 0.0027 0.029 0.073
Schistosoma mansoni histamine h1 receptor 0.0027 0.029 0.073
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0027 0.029 0.073
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.1322 0.3775
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0027 0.029 0.073
Schistosoma mansoni amine GPCR 0.0027 0.029 0.073
Schistosoma mansoni opsin-like receptor 0.0027 0.029 0.073
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.1781 0.5733
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0815 0.4441
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Schistosoma mansoni adenoreceptor 0.0027 0.029 0.073
Brugia malayi G protein-coupled receptor F59B2.13 0.0027 0.029 0.0935
Onchocerca volvulus 0.0027 0.029 0.0048
Echinococcus granulosus lamin 0.0026 0.0277 0.0691
Onchocerca volvulus 0.0071 0.1296 0.3708
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.029 0.073
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0727 0.5458
Onchocerca volvulus 0.0027 0.029 0.0048
Leishmania major hypothetical protein, conserved 0.0031 0.0379 0.1935
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0043 0.5
Plasmodium vivax hypothetical protein, conserved 0.0071 0.1296 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.029 0.073
Onchocerca volvulus 0.0027 0.029 0.0048
Echinococcus granulosus alpha 1A adrenergic receptor 0.0027 0.029 0.073
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0459 0.1229
Onchocerca volvulus 0.0027 0.029 0.0048
Echinococcus multilocularis somatostatin receptor 0.0027 0.029 0.073
Echinococcus granulosus neuropeptides capa receptor 0.0027 0.029 0.073
Giardia lamblia Kinase, PLK 0.0092 0.1781 1
Onchocerca volvulus 0.0071 0.1296 0.3708
Schistosoma mansoni neuropeptide receptor 0.0027 0.029 0.073
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0027 0.029 0.073
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1781 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0727 0.2019
Echinococcus multilocularis serotonin receptor 0.0027 0.029 0.073
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.029 0.096
Echinococcus granulosus g protein coupled receptor 0.0027 0.029 0.073
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.1172 0.3774
Loa Loa (eye worm) hypothetical protein 0.0071 0.1296 0.4285
Brugia malayi putative neuropeptide receptor 0.0027 0.029 0.0935
Echinococcus granulosus fetal alzheimer antigen falz 0.0045 0.071 0.197
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.029 0.073
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Brugia malayi hypothetical protein 0.0147 0.3024 0.9736
Brugia malayi intermediate filament protein 0.0026 0.0277 0.0892
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.2067 0.2033
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.1296 0.1258
Echinococcus multilocularis neuropeptide receptor A26 0.0027 0.029 0.073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.029 0.073
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0459 0.1229
Plasmodium vivax glutathione reductase, putative 0.0046 0.0727 0.5458
Loa Loa (eye worm) hypothetical protein 0.0077 0.1433 0.4739
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Brugia malayi hypothetical protein 0.0027 0.029 0.0935
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0725 0.3926
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.2333 0.23
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1172 0.3334
Echinococcus multilocularis G-protein coupled receptor, putative 0.0027 0.029 0.073
Echinococcus granulosus neuropeptide receptor 0.0027 0.029 0.073
Loa Loa (eye worm) glutathione reductase 0.0046 0.0727 0.2403
Echinococcus granulosus neuropeptides capa receptor 0.0027 0.029 0.073
Echinococcus multilocularis sex peptide receptor 0.0027 0.029 0.073
Loa Loa (eye worm) hypothetical protein 0.0026 0.0277 0.0916
Mycobacterium tuberculosis Conserved protein 0.0071 0.1296 0.1258
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0027 0.029 0.073
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0459 0.1229
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Brugia malayi hypothetical protein 0.0027 0.029 0.0935
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.2067 0.2033
Echinococcus multilocularis fmrfamide receptor 0.0027 0.029 0.073
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0459 0.1229
Brugia malayi G-protein coupled receptor 0.0027 0.029 0.0935
Onchocerca volvulus 0.0027 0.029 0.0048
Loa Loa (eye worm) hypothetical protein 0.0086 0.1628 0.5385
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0815 0.2279
Brugia malayi hypothetical protein 0.0027 0.029 0.0935
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Brugia malayi hypothetical protein 0.0027 0.029 0.0935
Echinococcus multilocularis dro:myosuppressin receptor 0.0027 0.029 0.073
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.1296 1
Schistosoma mansoni hypothetical protein 0.0041 0.0623 0.1712
Echinococcus granulosus biogenic amine 5HT receptor 0.0027 0.029 0.073
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0027 0.029 0.073
Brugia malayi hypothetical protein 0.0027 0.029 0.0935
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.1296 0.7209
Loa Loa (eye worm) hypothetical protein 0.0142 0.2911 0.9625
Mycobacterium ulcerans beta-lactamase 0.0071 0.1296 1
Onchocerca volvulus 0.0027 0.029 0.0048
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0027 0.029 0.073
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Toxoplasma gondii ABC1 family protein 0.0071 0.1296 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1781 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0027 0.029 0.096
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0027 0.029 0.073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.029 0.073
Trypanosoma cruzi ISWI complex protein 0.0031 0.0379 0.1935
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.1781 0.5131
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0815 0.4441
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0027 0.029 0.073
Trypanosoma brucei ISWI complex protein 0.0031 0.0379 0.1935
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0277 0.0916
Echinococcus granulosus lamin dm0 0.0026 0.0277 0.0691
Echinococcus multilocularis lamin dm0 0.0026 0.0277 0.0691
Onchocerca volvulus 0.0027 0.029 0.0048
Brugia malayi TAR-binding protein 0.0066 0.1172 0.3774
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.1296 0.1258
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Brugia malayi beta-lactamase family protein 0.0071 0.1296 0.4171
Echinococcus granulosus g protein coupled receptor 0.0027 0.029 0.073
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0027 0.029 0.073
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0727 0.3934
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.029 0.096
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.2067 0.7433
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.029 0.073
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0277 0.0892
Echinococcus granulosus g-protein coupled receptor 0.0027 0.029 0.073
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Echinococcus multilocularis musashi 0.0026 0.0277 0.0691
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.1781 0.5474
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0815 0.2279
Loa Loa (eye worm) RNA binding protein 0.0066 0.1172 0.3876
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0815 0.4441
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0027 0.029 0.0935
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0027 0.029 0.0048
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0027 0.029 0.073
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0027 0.029 0.073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.029 0.073
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0043 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0027 0.029 0.073
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0725 0.3926
Schistosoma mansoni alpha-1 adrenergic receptor 0.0027 0.029 0.073
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0815 0.2279
Onchocerca volvulus 0.0027 0.029 0.0048
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.029 0.073
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.1172 0.3876
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0027 0.029 0.073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.029 0.073
Brugia malayi MH2 domain containing protein 0.0116 0.2322 0.7476
Echinococcus granulosus 7TM GPCR rhodopsin 0.0027 0.029 0.073
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.029 0.073
Onchocerca volvulus 0.0027 0.029 0.0048
Echinococcus multilocularis geminin 0.0165 0.343 1
Onchocerca volvulus 0.0027 0.029 0.0048
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0815 0.4441
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0027 0.029 0.073
Brugia malayi follicle stimulating hormone receptor 0.0027 0.029 0.0935
Treponema pallidum NADH oxidase 0.0016 0.0043 0.5
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.012 0.2407 0.6981
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.1781 0.5
Brugia malayi beta-lactamase family protein 0.0071 0.1296 0.4171
Onchocerca volvulus Neuropeptide F receptor homolog 0.0027 0.029 0.0048
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0459 0.1229
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.029 0.073
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.029 0.073
Schistosoma mansoni zinc finger protein 0.0039 0.0574 0.157
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.2067 0.2033
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0027 0.029 0.073
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0027 0.029 0.096
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.1322 0.3775
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Leishmania major trypanothione reductase 0.0046 0.0727 0.3934
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.029 0.073
Onchocerca volvulus 0.0147 0.3024 1
Mycobacterium ulcerans lipase LipD 0.0071 0.1296 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0027 0.029 0.073
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Onchocerca volvulus 0.0027 0.029 0.0048
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0027 0.029 0.073
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.2333 0.23
Schistosoma mansoni biogenic amine receptor 0.0027 0.029 0.073
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0027 0.029 0.073
Echinococcus granulosus orexin receptor type 2 0.0027 0.029 0.073
Schistosoma mansoni hypothetical protein 0.0027 0.029 0.073
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0815 0.4441
Trichomonas vaginalis esterase, putative 0.0071 0.1296 0.7209
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1296 0.7209
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Brugia malayi Thioredoxin reductase 0.0046 0.0727 0.2339
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0277 0.0916
Loa Loa (eye worm) hypothetical protein 0.0034 0.0459 0.1519
Brugia malayi Serotonin receptor 0.0027 0.029 0.0935
Onchocerca volvulus 0.0027 0.029 0.0048
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.1296 0.7209
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0027 0.029 0.0935
Schistosoma mansoni amine GPCR 0.0027 0.029 0.073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.029 0.073
Brugia malayi RNA binding protein 0.0066 0.1172 0.3774
Echinococcus multilocularis neuropeptide Y receptor 0.0027 0.029 0.073
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.1781 0.5131
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0815 0.4441
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1781 1
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0815 0.2279
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0815 0.4441
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.1781 0.5131
Schistosoma mansoni opsin-like receptor 0.0027 0.029 0.073
Brugia malayi hypothetical protein 0.0027 0.029 0.0935
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.1296 0.7209
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.029 0.073
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.1296 0.1258
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.1296 0.7209
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0815 0.616
Onchocerca volvulus 0.0027 0.029 0.0048
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Schistosoma mansoni neuropeptide f receptor 76f 0.0027 0.029 0.073
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0459 0.1229
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0815 0.4441
Schistosoma mansoni hypothetical protein 0.0165 0.343 1
Schistosoma mansoni zinc finger protein 0.0031 0.0379 0.0993
Brugia malayi hypothetical protein 0.0027 0.029 0.0935
Trypanosoma cruzi ISWI complex protein 0.0031 0.0379 0.1935
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.029 0.073
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.1296 0.4171
Loa Loa (eye worm) hypothetical protein 0.0027 0.029 0.096
Loa Loa (eye worm) hypothetical protein 0.0071 0.1296 0.4285
Echinococcus granulosus intermediate filament protein 0.0026 0.0277 0.0691
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0027 0.029 0.096

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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