Detailed information for compound 609600

Basic information

Technical information
  • TDR Targets ID: 609600
  • Name: 2-(4-chlorophenyl)sulfanyl-N-(5-propan-2-yl-1 ,3,4-thiadiazol-2-yl)butanamide
  • MW: 355.906 | Formula: C15H18ClN3OS2
  • H donors: 1 H acceptors: 3 LogP: 4.83 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(C(=O)Nc1nnc(s1)C(C)C)Sc1ccc(cc1)Cl
  • InChi: 1S/C15H18ClN3OS2/c1-4-12(21-11-7-5-10(16)6-8-11)13(20)17-15-19-18-14(22-15)9(2)3/h5-9,12H,4H2,1-3H3,(H,17,19,20)
  • InChiKey: PUCOARXZNIREQQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(4-chlorophenyl)sulfanyl-N-(5-isopropyl-1,3,4-thiadiazol-2-yl)butanamide
  • 2-[(4-chlorophenyl)thio]-N-(5-isopropyl-1,3,4-thiadiazol-2-yl)butanamide
  • 2-[(4-chlorophenyl)thio]-N-(5-isopropyl-1,3,4-thiadiazol-2-yl)butyramide
  • Oprea1_024304

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0078 0.0418
Schistosoma mansoni hypothetical protein 0.0015 0.0411 0.1121
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0078 0.004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0596 0.3176
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.1332 0.1264
Leishmania major hypothetical protein, conserved 0.005 0.186 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0078 0.004
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0596 0.3028
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.1332 0.1354
Mycobacterium ulcerans hypothetical protein 0.0023 0.0746 0.5437
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0007 0.0078 0.0238
Brugia malayi Pre-SET motif family protein 0.0031 0.1086 0.1191
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0468 0.0449
Echinococcus granulosus bloom syndrome protein 0.0024 0.0788 0.1206
Trypanosoma cruzi DNA damage repair protein, putative 0.0006 0.0047 0.0212
Loa Loa (eye worm) hypothetical protein 0.0037 0.1332 0.1513
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.4564 0.5204
Trypanosoma cruzi ISWI complex protein 0.0015 0.0411 0.2173
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0208 0.2924
Trypanosoma brucei unspecified product 0.0013 0.0349 0.1665
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0047 0.0212
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0078 0.0195
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0078 0.004
Schistosoma mansoni Smad4 0.0008 0.0125 0.0325
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0208 0.0221
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0078 0.0238
Loa Loa (eye worm) hypothetical protein 0.0041 0.1502 0.1706
Brugia malayi beta-lactamase family protein 0.0037 0.1332 0.1475
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.186 1
Brugia malayi beta-lactamase 0.0037 0.1332 0.1475
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.1332 0.1354
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.1332 0.1354
Mycobacterium ulcerans hypothetical protein 0.0037 0.1332 1
Echinococcus granulosus smad 0.0008 0.0125 0.008
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0078 0.004
Echinococcus granulosus dna polymerase kappa 0.0019 0.0596 0.0881
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.3599 1
Trypanosoma brucei unspecified product 0.0019 0.0596 0.3028
Leishmania major hypothetical protein, conserved 0.0037 0.1332 0.7089
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0746 0.5437
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0047 0.0212
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0328 0.1726
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0596 0.3176
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0596 0.063
Entamoeba histolytica hypothetical protein 0.0035 0.1236 0.3852
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0078 0.008
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.3599 0.5982
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0125 0.0133
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0746 0.2326
Mycobacterium tuberculosis Conserved protein 0.0037 0.1332 0.1354
Loa Loa (eye worm) hypothetical protein 0.001 0.0208 0.0228
Schistosoma mansoni DNA polymerase eta 0.0019 0.0596 0.1639
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.1332 0.1264
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0078 0.004
Schistosoma mansoni bromodomain containing protein 0.0061 0.2325 0.6453
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0078 0.0169
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0078 0.0035
Brugia malayi hypothetical protein 0.0035 0.1236 0.1364
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0596 0.3028
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0596 0.0881
Loa Loa (eye worm) hypothetical protein 0.0048 0.1766 0.2008
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0746 0.5437
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0078 0.0378
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0596 0.3028
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0507 0.2535
Mycobacterium leprae conserved hypothetical protein 0.0037 0.1332 1
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0047 0.011
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0468 0.2515
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0047 0.0212
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0.0078 0.0169
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.3599 0.5982
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0078 0.004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0746 0.0843
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0349 0.1665
Schistosoma mansoni zinc finger protein 0.0019 0.0581 0.1597
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0746 0.074
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0078 0.0378
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0596 0.3028
Mycobacterium tuberculosis Conserved protein 0.0037 0.1332 0.1354
Giardia lamblia DINP protein human, muc B family 0.0019 0.0596 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0468 0.0449
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0596 0.4272
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0007 0.0078 0.0238
Echinococcus multilocularis Smad4 0.0008 0.0125 0.008
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.186 1
Loa Loa (eye worm) oxidoreductase 0.0007 0.0078 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0047 0.0212
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.1332 0.3689
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0078 0.0169
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0746 0.5437
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0078 0.0169
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0468 0.0449
Trichomonas vaginalis set domain proteins, putative 0.0248 1 1
Brugia malayi MH1 domain containing protein 0.0008 0.0125 0.0089
Leishmania major hypothetical protein, conserved 0.0015 0.0411 0.2004
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.1038 0.1632
Schistosoma mansoni DNA helicase recq1 0.001 0.0208 0.0557
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0007 0.0078 0.0238
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.4564 0.5204
Loa Loa (eye worm) hypothetical protein 0.0007 0.0078 0.008
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0125 0.008
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0507 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.1332 0.3689
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.1086 0.3001
Schistosoma mansoni smad 0.0008 0.0125 0.0325
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0746 0.0802
Entamoeba histolytica hypothetical protein 0.0035 0.1236 0.3852
Echinococcus multilocularis zinc finger protein 0.0019 0.0581 0.0855
Mycobacterium leprae Probable lipase LipE 0.0037 0.1332 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0125 0.0325
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.1234 0.1964
Brugia malayi MH2 domain containing protein 0.0008 0.0125 0.0089
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0596 0.0523
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.1332 0.715
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0078 0.004
Loa Loa (eye worm) hypothetical protein 0.0037 0.1332 0.1513
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.1332 1
Schistosoma mansoni hypothetical protein 0.0022 0.0724 0.1995
Schistosoma mansoni smad1 5 8 and 0.0008 0.0125 0.0325
Loa Loa (eye worm) hypothetical protein 0.0069 0.2622 0.2986
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0507 0.2725
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0746 0.5437
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0078 0.0378
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0328 0.1547
Echinococcus multilocularis smad 0.0008 0.0125 0.008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.1766 0.4896
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0468 0.0449
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.1332 0.1264
Loa Loa (eye worm) hypothetical protein 0.0019 0.0596 0.0672
Entamoeba histolytica hypothetical protein 0.0035 0.1236 0.3852
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0078 0.004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0596 0.3176
Brugia malayi hypothetical protein 0.005 0.186 0.2081
Mycobacterium tuberculosis Conserved protein 0.0037 0.1332 0.1354
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.3599 0.4075
Loa Loa (eye worm) hypothetical protein 0.0006 0.0047 0.0045
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0078 0.0378
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0596 0.0523
Onchocerca volvulus 0.0037 0.1332 0.1264
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0078 0.0238
Echinococcus granulosus muscleblind protein 0.015 0.5963 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0596 0.3028
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.07 0.1056
Onchocerca volvulus 0.0037 0.1332 0.1264
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.1236 0.1967
Loa Loa (eye worm) beta-lactamase 0.0037 0.1332 0.1513
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.1332 0.1354
Loa Loa (eye worm) hypothetical protein 0.015 0.5963 0.6803
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0349 0.1665
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0078 0.0169
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.2182 0.3576
Loa Loa (eye worm) hypothetical protein 0.0017 0.0507 0.057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.3599 0.5982
Loa Loa (eye worm) hypothetical protein 0.005 0.186 0.2116
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0596 0.0583
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.1332 0.1354
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0078 0.0238
Loa Loa (eye worm) Smad1 0.0008 0.0125 0.0133
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0208 0.0221
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0078 0.008
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0125 0.008
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.1332 0.2132
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0596 0.063
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0328 0.1022
Echinococcus granulosus dna polymerase eta 0.0019 0.0596 0.0881
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0078 0.0035
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0788 0.085
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.186 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.1332 0.715
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0746 0.0802
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0078 0.0238
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.1766 0.2868
Trypanosoma cruzi DNA polymerase eta, putative 0.0006 0.0047 0.0212
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0668 0.3422
Schistosoma mansoni smad1 5 8 and 0.0008 0.0125 0.0325
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0078 0.004
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0208 0.0184
Trypanosoma brucei unspecified product 0.0013 0.0349 0.1665
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0208 0.0221
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0505 0.0568
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0208 0.0221
Trypanosoma cruzi DNA damage repair protein, putative 0.0006 0.0047 0.0212
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0746 0.5437
Echinococcus multilocularis muscleblind protein 1 0.015 0.5963 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0007 0.0078 0.0238
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.058 0.1593
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0208 0.1079
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.1332 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.07 0.1926
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.2182 0.3576
Treponema pallidum ATP-dependent DNA helicase 0.0005 0.0008 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0349 0.1665
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0724 0.1098
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0078 0.0035
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0596 0.3028
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0125 0.0325
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.1766 0.2868
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0125 0.0133
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0007 0.0078 0.0238
Trypanosoma brucei ISWI complex protein 0.0015 0.0411 0.2004
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0078 0.0238
Schistosoma mansoni zinc finger protein 0.0015 0.0411 0.1121
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.1332 0.1354
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0078 0.0035
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0596 0.0881
Plasmodium vivax SET domain protein, putative 0.0031 0.1086 0.5835
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0596 0.3028
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0596 0.3028
Loa Loa (eye worm) hypothetical protein 0.015 0.5963 0.6803
Brugia malayi Bromodomain containing protein 0.0037 0.1328 0.147
Loa Loa (eye worm) hypothetical protein 0.0017 0.0507 0.057
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0596 0.3028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.3599 1
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0006 0.0047 0.0212
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0007 0.0078 0.0243
Echinococcus multilocularis muscleblind protein 0.015 0.5963 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0507 0.057
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0481 0.1316
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0208 0.0886
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0623 0.0703
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0596 0.3028
Loa Loa (eye worm) hypothetical protein 0.0023 0.0746 0.0843
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.1086 0.5817
Onchocerca volvulus 0.0031 0.1086 0.1016
Entamoeba histolytica hypothetical protein 0.0035 0.1236 0.3852
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0078 0.0238
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0328 0.0252
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0596 0.3176
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.1332 0.1475
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0724 0.1098
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.0078 0.0169
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0078 0.0035
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.1332 0.1513
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0507 0.3577
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.046 0.244
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0746 0.2326
Loa Loa (eye worm) hypothetical protein 0.0017 0.0507 0.057
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0746 0.5437
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0596 0.0672
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.3599 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0125 0.008
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.1236 0.3419
Onchocerca volvulus 0.0037 0.1332 0.1264
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0238 0.959 1
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0083 0.3207 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0596 0.3028
Brugia malayi MH2 domain containing protein 0.0116 0.4564 0.5182
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0596 0.1859
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0596 0.1639
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0481 0.0684
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0746 0.3854
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0078 0.0238
Schistosoma mansoni hypothetical protein 0.0035 0.1236 0.3419
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.1332 0.1264
Loa Loa (eye worm) hypothetical protein 0.0007 0.0078 0.008
Trichomonas vaginalis esterase, putative 0.0037 0.1332 0.1264
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0007 0.0078 0.0238
Onchocerca volvulus 0.0023 0.0746 0.0673
Echinococcus granulosus Smad4 0.0008 0.0125 0.008
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0078 0.0378
Brugia malayi Muscleblind-like protein 0.015 0.5963 0.6788
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.3599 0.4102
Loa Loa (eye worm) hypothetical protein 0.0037 0.1332 0.1513
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.1332 0.1354
Echinococcus granulosus zinc finger protein 0.0019 0.0581 0.0855
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0788 0.0715
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.8762 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0746 0.0843
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0596 0.3176
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.1332 0.2132
Plasmodium vivax DNA repair protein REV1, putative 0.0006 0.0047 0.0254
Brugia malayi Smad1 0.0008 0.0125 0.0089
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0208 0.0228
Brugia malayi MH1 domain containing protein 0.0008 0.0125 0.0089
Brugia malayi MH2 domain containing protein 0.0008 0.0125 0.0089
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0746 0.3854
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0596 0.3028
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0078 0.004
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0078 0.0378
Loa Loa (eye worm) hypothetical protein 0.0037 0.1332 0.1513
Loa Loa (eye worm) hypothetical protein 0.0083 0.3207 0.3655
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.1236 0.1967
Loa Loa (eye worm) RecQ helicase 0.0024 0.0788 0.0891
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.186 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.1426 0.1619
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0788 0.1206
Mycobacterium ulcerans beta-lactamase 0.0037 0.1332 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0078 0.0238
Brugia malayi beta-lactamase family protein 0.0037 0.1332 0.1475
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0596 0.3028
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0125 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0596 0.3028
Plasmodium vivax hypothetical protein, conserved 0.0037 0.1332 0.7162
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0746 0.5326
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0007 0.0078 0.0238
Loa Loa (eye worm) hypothetical protein 0.0037 0.1332 0.1513
Entamoeba histolytica recQ family DNA helicase 0.0005 0.0008 0.0025
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0078 0.0378
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0746 0.5437
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0746 0.5326
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0596 0.3028
Loa Loa (eye worm) hypothetical protein 0.0121 0.4771 0.5442
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.186 1
Brugia malayi PHD-finger family protein 0.0024 0.0794 0.0857
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0078 0.004
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.186 1
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0078 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0596 0.3028
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.07 0.1056
Trypanosoma cruzi ISWI complex protein 0.0015 0.0411 0.2173
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0596 0.1639
Brugia malayi Pre-SET motif family protein 0.0218 0.8762 1
Schistosoma mansoni hypothetical protein 0.002 0.0623 0.1714
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.1332 0.7089
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0083 0.3207 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0208 0.0184
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0208 0.1079
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.186 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0746 0.074
Toxoplasma gondii ABC1 family protein 0.0037 0.1332 0.715
Brugia malayi Bromodomain containing protein 0.0073 0.2793 0.315
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0788 0.0715
Echinococcus multilocularis dna polymerase eta 0.0019 0.0596 0.0881
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.1332 0.1264
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.1086 0.3001
Schistosoma mansoni DNA helicase recq5 0.001 0.0208 0.0557
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0746 0.2326
Leishmania major DNA polymerase kappa, putative 0.0019 0.0596 0.3028
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0596 0.4272
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0746 0.3854
Mycobacterium ulcerans lipase LipD 0.0037 0.1332 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.3599 0.5982
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.1234 0.1964
Loa Loa (eye worm) hypothetical protein 0.0037 0.1331 0.1511
Loa Loa (eye worm) hypothetical protein 0.0017 0.0507 0.057
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0507 0.049
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0596 0.0881
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.1766 0.4896
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0328 0.1547
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0596 0.0583
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0746 0.0802
Brugia malayi hypothetical protein 0.0032 0.113 0.1243
Mycobacterium ulcerans acetyl-CoA synthetase 0.0007 0.0078 0.0238
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.1086 0.1712
Loa Loa (eye worm) hypothetical protein 0.0037 0.1332 0.1513
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0481 0.1316
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0481 0.0684
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0007 0.0078 0.0238

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.