Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.1955 | 0.1847 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.1214 | 0.1287 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.3853 | 0.2673 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0894 | 0.0667 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.1955 | 0.2325 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.1214 | 0.1287 |
Leishmania major | hypothetical protein, conserved | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1872 | 0.1755 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.1955 | 0.2325 |
Onchocerca volvulus | 0.0033 | 0.1955 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.3864 | 0.3972 |
Trypanosoma brucei | ISWI complex protein | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.1955 | 0.2432 |
Schistosoma mansoni | lamin | 0.0033 | 0.1955 | 0.2432 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.0717 | 0.0592 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.3456 | 0.4427 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.4261 | 0.4413 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.7437 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.1955 | 0.1847 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.8037 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1955 | 0.1847 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0717 | 0.0891 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.1955 | 0.2325 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0021 | 0.0294 | 0.0366 |
Echinococcus granulosus | lamin | 0.0033 | 0.1955 | 0.2325 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0021 | 0.0294 | 0.0366 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.3456 | 0.4427 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.7437 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 0.1955 | 0.2325 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0397 | 0.0114 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.9283 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.1955 | 0.0411 |
Onchocerca volvulus | 0.0033 | 0.1955 | 0.5 | |
Schistosoma mansoni | lamin | 0.0033 | 0.1955 | 0.2432 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0894 | 0.1112 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0021 | 0.0294 | 0.0366 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.4581 | 0.4769 |
Echinococcus multilocularis | lamin | 0.0033 | 0.1955 | 0.2325 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0021 | 0.0294 | 0.0366 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.1955 | 0.0411 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.0717 | 0.0592 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.1214 | 0.151 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.2589 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | = 1.4125 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.