Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable lipase LipE | 0.0073 | 0.0517 | 0.0822 |
Toxoplasma gondii | ABC1 family protein | 0.0073 | 0.0517 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0325 | 0.352 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0073 | 0.0517 | 0.1468 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.007 | 0.0483 | 0.1319 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0073 | 0.0517 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0073 | 0.0517 | 0.0822 |
Trichomonas vaginalis | chromobox protein, putative | 0.0068 | 0.0453 | 0.8477 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.014 | 0.132 | 0.3711 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0132 | 0.0821 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0058 | 0.0337 | 0.0317 |
Mycobacterium tuberculosis | Conserved protein | 0.0073 | 0.0517 | 0.0822 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0073 | 0.0517 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0068 | 0.0453 | 0.8477 |
Schistosoma mansoni | tar DNA-binding protein | 0.0325 | 0.352 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0325 | 0.352 | 0.3506 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0325 | 0.352 | 1 |
Brugia malayi | RNA binding protein | 0.0325 | 0.352 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.1068 | 0.3035 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.014 | 0.132 | 0.3711 |
Loa Loa (eye worm) | glutathione reductase | 0.0038 | 0.0096 | 0.0273 |
Mycobacterium ulcerans | hypothetical protein | 0.0073 | 0.0517 | 0.5 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0068 | 0.0453 | 0.1287 |
Onchocerca volvulus | 0.0073 | 0.0517 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0098 | 0.0278 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0458 | 0.1303 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0517 | 0.1468 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.014 | 0.132 | 0.3711 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.014 | 0.132 | 0.3749 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0058 | 0.0337 | 0.5739 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0096 | 0.0788 | 0.1353 |
Plasmodium vivax | hypothetical protein, conserved | 0.0058 | 0.0337 | 0.5739 |
Loa Loa (eye worm) | RNA binding protein | 0.0325 | 0.352 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0337 | 0.0903 |
Brugia malayi | PHD-finger family protein | 0.0058 | 0.0337 | 0.0903 |
Schistosoma mansoni | tar DNA-binding protein | 0.0325 | 0.352 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0073 | 0.0517 | 0.5 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0058 | 0.0337 | 0.0903 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.019 | 0.1913 | 0.1895 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0073 | 0.0517 | 0.0822 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0517 | 0.1468 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.01 | 0.0835 | 0.2373 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0325 | 0.352 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.012 | 0.1075 | 0.3053 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0073 | 0.0517 | 0.1415 |
Schistosoma mansoni | tar DNA-binding protein | 0.0325 | 0.352 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0517 | 0.1468 |
Plasmodium falciparum | phd finger protein, putative | 0.0058 | 0.0337 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0086 | 0.0674 | 0.1129 |
Schistosoma mansoni | tar DNA-binding protein | 0.0325 | 0.352 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0073 | 0.0517 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0096 | 0.0788 | 0.1353 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0517 | 0.1468 |
Echinococcus granulosus | tar DNA binding protein | 0.0325 | 0.352 | 1 |
Giardia lamblia | PHD finger protein 15 | 0.0058 | 0.0337 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0073 | 0.0517 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0073 | 0.0517 | 0.1415 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0086 | 0.0674 | 0.1129 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0081 | 0.0609 | 0.0588 |
Echinococcus granulosus | jumonji domain containing protein | 0.0081 | 0.0609 | 0.1678 |
Onchocerca volvulus | 0.0073 | 0.0517 | 1 | |
Brugia malayi | beta-lactamase | 0.0073 | 0.0517 | 0.1415 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0073 | 0.0517 | 0.1415 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.1068 | 0.2992 |
Onchocerca volvulus | Alhambra homolog | 0.0058 | 0.0337 | 0.653 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0073 | 0.0517 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.014 | 0.132 | 0.3711 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0073 | 0.0517 | 0.0822 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0096 | 0.0788 | 0.1353 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.014 | 0.132 | 0.1301 |
Loa Loa (eye worm) | beta-lactamase | 0.0073 | 0.0517 | 0.1468 |
Echinococcus multilocularis | chromobox protein 1 | 0.0068 | 0.0453 | 0.0432 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0038 | 0.0096 | 0.0273 |
Schistosoma mansoni | chromobox protein | 0.0068 | 0.0453 | 0.1233 |
Plasmodium vivax | hypothetical protein, conserved | 0.0073 | 0.0517 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0038 | 0.0102 | 0.0081 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.01 | 0.0835 | 0.2326 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0086 | 0.0674 | 0.5776 |
Brugia malayi | glutathione reductase | 0.0038 | 0.0096 | 0.0213 |
Mycobacterium ulcerans | lipase LipD | 0.0073 | 0.0517 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0073 | 0.0517 | 0.0822 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.007 | 0.0483 | 0.1319 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0096 | 0.0788 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0073 | 0.0517 | 1 |
Brugia malayi | TAR-binding protein | 0.0325 | 0.352 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0058 | 0.0337 | 0.0903 |
Echinococcus granulosus | peregrin | 0.0058 | 0.0337 | 0.0903 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0022 | 0.0061 |
Echinococcus granulosus | chromobox protein 1 | 0.0068 | 0.0453 | 0.1233 |
Brugia malayi | Heterochromatin protein 1 | 0.0068 | 0.0453 | 0.1233 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0073 | 0.0517 | 0.1415 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.0458 | 0.1249 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0073 | 0.0517 | 0.0822 |
Brugia malayi | beta-lactamase family protein | 0.0073 | 0.0517 | 0.1415 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.007 | 0.0483 | 0.1319 |
Echinococcus multilocularis | chromobox protein 1 | 0.0068 | 0.0453 | 0.0432 |
Brugia malayi | beta-lactamase family protein | 0.0073 | 0.0517 | 0.1415 |
Brugia malayi | jmjC domain containing protein | 0.019 | 0.1913 | 0.5407 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0517 | 0.1468 |
Schistosoma mansoni | jumonji domain containing protein | 0.0151 | 0.1447 | 0.4074 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0086 | 0.0674 | 0.1129 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0132 | 0.0821 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0832 | 0.2364 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0337 | 0.0959 |
Leishmania major | hypothetical protein, conserved | 0.0073 | 0.0517 | 1 |
Onchocerca volvulus | 0.0073 | 0.0517 | 1 | |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0467 | 0.5214 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0073 | 0.0517 | 0.0822 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0038 | 0.0098 | 0.1894 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.014 | 0.132 | 0.1301 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0073 | 0.0517 | 0.0822 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0086 | 0.0674 | 0.1129 |
Mycobacterium tuberculosis | Probable reductase | 0.0086 | 0.0674 | 0.1129 |
Echinococcus granulosus | chromobox protein 1 | 0.0068 | 0.0453 | 0.1233 |
Brugia malayi | jmjC domain containing protein | 0.007 | 0.0483 | 0.1319 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0458 | 0.1249 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0073 | 0.0517 | 0.0822 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0517 | 0.1468 |
Loa Loa (eye worm) | TAR-binding protein | 0.0325 | 0.352 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.007 | 0.0483 | 0.1373 |
Echinococcus multilocularis | peregrin | 0.0058 | 0.0337 | 0.0317 |
Schistosoma mansoni | chromobox protein | 0.0068 | 0.0453 | 0.1233 |
Trichomonas vaginalis | esterase, putative | 0.0073 | 0.0517 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0086 | 0.0674 | 0.1129 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0038 | 0.0102 | 0.023 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.1068 | 0.3035 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.0022 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0835 | 0.2373 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0073 | 0.0517 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.014 | 0.132 | 0.3711 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0058 | 0.0337 | 0.0959 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0058 | 0.0337 | 0.0903 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.014 | 0.132 | 0.3711 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.007 | 0.0483 | 0.0463 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0073 | 0.0517 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.01 | 0.0835 | 0.2326 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0073 | 0.0517 | 0.5 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.0132 | 0.2559 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0073 | 0.0517 | 0.0496 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0058 | 0.0337 | 0.5739 |
Brugia malayi | chromobox protein homolog 3 | 0.0038 | 0.0098 | 0.0218 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0073 | 0.0517 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0038 | 0.0096 | 0.0213 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.019 | 0.1913 | 0.5407 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.