Detailed information for compound 611029

Basic information

Technical information
  • TDR Targets ID: 611029
  • Name: 2-(4-methoxyphenyl)indolizine
  • MW: 223.27 | Formula: C15H13NO
  • H donors: 0 H acceptors: 0 LogP: 4.1 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1cc2n(c1)cccc2
  • InChi: 1S/C15H13NO/c1-17-15-7-5-12(6-8-15)13-10-14-4-2-3-9-16(14)11-13/h2-11H,1H3
  • InChiKey: MUMVZZLEJULVAE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 7496-82-4
  • BAS 03813236
  • A0781/0036570
  • EU-0084296
  • GL-0637
  • Oprea1_155202
  • ZINC00060167
  • NSC405331
  • 2-(4-Methoxy-phenyl)-indolizine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) beta-lactamase 0.0035 0.1235 0.1466
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1872 0.2222
Brugia malayi beta-lactamase family protein 0.0035 0.1235 0.1466
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.1235 0.4566
Schistosoma mansoni intermediate filament proteins 0.0028 0.0906 0.1075
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.1235 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1872 0.2222
Schistosoma mansoni lamin 0.0028 0.0906 0.1075
Echinococcus multilocularis lamin 0.0028 0.0906 0.1075
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.1872 0.2222
Loa Loa (eye worm) TAR-binding protein 0.0191 0.8426 1
Schistosoma mansoni tar DNA-binding protein 0.0191 0.8426 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.2677 1
Plasmodium vivax vivapain-2 0.0017 0.0414 0.3223
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0414 0.3223
Echinococcus multilocularis cysteine protease 0.0017 0.0414 0.0491
Schistosoma mansoni tar DNA-binding protein 0.0191 0.8426 1
Brugia malayi intermediate filament protein 0.0028 0.0906 0.1075
Mycobacterium ulcerans hypothetical protein 0.0035 0.1235 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0148 0.3182
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.0176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0414 0.3223
Onchocerca volvulus 0.0028 0.0906 0.6971
Loa Loa (eye worm) hypothetical protein 0.0014 0.0235 0.0279
Onchocerca volvulus 0.0017 0.0414 0.2448
Echinococcus granulosus lamin dm0 0.0028 0.0906 0.1075
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.1235 0.4566
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0414 0.3223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0414 0.3223
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0414 0.0491
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0414 1
Echinococcus granulosus cathepsin l1 0.0017 0.0414 0.0491
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.1235 0.1466
Loa Loa (eye worm) hypothetical protein 0.0035 0.1235 0.1466
Brugia malayi beta-lactamase family protein 0.0035 0.1235 0.1466
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.202 0.7525
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0414 0.1472
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0414 0.3223
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.2677 1
Echinococcus multilocularis musashi 0.0028 0.0906 0.1075
Echinococcus granulosus intermediate filament protein 0.0028 0.0906 0.1075
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.1235 0.1466
Entamoeba histolytica cysteine protease, putative 0.0017 0.0414 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0304 0.036
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.1235 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.1235 0.1466
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0024 0.0028
Onchocerca volvulus 0.0035 0.1235 1
Echinococcus granulosus tar DNA binding protein 0.0191 0.8426 1
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.2677 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.1235 1
Brugia malayi RNA recognition motif domain containing protein 0.0191 0.8426 1
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0414 0.0491
Plasmodium vivax vivapain-2 0.0017 0.0414 0.3223
Loa Loa (eye worm) hypothetical protein 0.0028 0.0882 0.1047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1872 0.2222
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0414 0.0491
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0148 0.1025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0414 0.3223
Loa Loa (eye worm) hypothetical protein 0.0035 0.1235 0.1466
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.1872 0.2222
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0414 1
Echinococcus granulosus cathepsin l1 0.0012 0.0148 0.0176
Onchocerca volvulus 0.0028 0.0906 0.6971
Echinococcus granulosus geminin 0.0171 0.746 0.8854
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0414 0.3223
Echinococcus multilocularis geminin 0.0171 0.746 0.8854
Leishmania major hypothetical protein, conserved 0.0035 0.1235 0.3628
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0906 0.1075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0414 0.3223
Leishmania major cathepsin L-like protease 0.0067 0.2677 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.2677 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.1235 0.1466
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0414 0.3223
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1872 0.2222
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0414 0.0491
Brugia malayi Cathepsin L-like precursor 0.0017 0.0414 0.0491
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0414 0.0491
Mycobacterium leprae conserved hypothetical protein 0.0035 0.1235 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.2677 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0414 0.0491
Loa Loa (eye worm) cysteine protease 0.0017 0.0414 0.0491
Loa Loa (eye worm) RNA binding protein 0.0191 0.8426 1
Echinococcus granulosus cathepsin L cysteine protease 0.0009 0.0024 0.0028
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.1235 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.1235 0.1466
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.2677 1
Schistosoma mansoni tar DNA-binding protein 0.0191 0.8426 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.1235 1
Brugia malayi Cathepsin L-like precursor 0.0012 0.0148 0.0176
Loa Loa (eye worm) hypothetical protein 0.0028 0.0906 0.1075
Loa Loa (eye worm) hypothetical protein 0.0035 0.1235 0.1466
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.0176
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.2677 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0211 0.025
Schistosoma mansoni lamin 0.0028 0.0906 0.1075
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0414 0.0491
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0304 0.036
Leishmania major cathepsin L-like protease 0.0067 0.2677 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0414 0.0491
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0414 0.3223
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0414 0.3223
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0414 0.2448
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0024 0.0028
Loa Loa (eye worm) ctsf protein 0.0017 0.0414 0.0491
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0414 0.2448
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0414 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.1235 1
Mycobacterium ulcerans beta-lactamase 0.0035 0.1235 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.1235 0.1466
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0148 0.0176
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.2411 0.8997
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0414 0.0491
Brugia malayi Cathepsin L-like precursor 0.0017 0.0414 0.0491
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.2677 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0414 0.0491
Loa Loa (eye worm) fibroinase 0.0017 0.0414 0.0491
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0024 0.0028
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.5351 0.6351
Onchocerca volvulus 0.0017 0.0414 0.2448
Brugia malayi Cathepsin L-like precursor 0.0017 0.0414 0.0491
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0148 0.0176
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1872 0.2222
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0414 1
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0414 0.0491
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0414 0.3223
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0414 0.0491
Onchocerca volvulus 0.0017 0.0414 0.2448
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0191 0.8426 1
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.2677 1
Brugia malayi MH2 domain containing protein 0.0125 0.5351 0.6351
Leishmania major cathepsin L-like protease 0.0067 0.2677 1
Echinococcus granulosus cathepsin L 0.0009 0.0024 0.0028
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.2677 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0414 0.3223
Schistosoma mansoni tar DNA-binding protein 0.0191 0.8426 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.2677 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0024 0.0028
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.1235 0.4566
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0414 0.3223
Brugia malayi Cathepsin L-like precursor 0.0017 0.0414 0.0491
Brugia malayi Cathepsin L-like precursor 0.0012 0.0148 0.0176
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0414 1
Schistosoma mansoni hypothetical protein 0.0171 0.746 0.8854
Onchocerca volvulus 0.0035 0.1235 1
Echinococcus multilocularis cathepsin L 0.0009 0.0024 0.0028
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.1235 0.5
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0024 0.0028
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0414 0.3223
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.1235 1
Echinococcus multilocularis tar DNA binding protein 0.0191 0.8426 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.1235 0.1466
Echinococcus multilocularis lamin dm0 0.0028 0.0906 0.1075
Onchocerca volvulus 0.0017 0.0414 0.2448
Echinococcus granulosus lamin 0.0028 0.0906 0.1075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0414 0.3223
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.0176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0148 0.1025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0414 0.3223
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0414 0.3223
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.2677 1
Onchocerca volvulus 0.0017 0.0414 0.2448
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.2677 1
Onchocerca volvulus 0.0017 0.0414 0.2448
Schistosoma mansoni tar DNA-binding protein 0.0191 0.8426 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1872 0.2222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0414 0.3223
Echinococcus granulosus cysteine protease 0.0009 0.0024 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.2677 1
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.5351 0.6351
Brugia malayi RNA binding protein 0.0191 0.8426 1
Toxoplasma gondii ABC1 family protein 0.0035 0.1235 1
Brugia malayi beta-lactamase 0.0035 0.1235 0.1466
Loa Loa (eye worm) hypothetical protein 0.0035 0.1235 0.1466
Mycobacterium leprae Probable lipase LipE 0.0035 0.1235 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.1235 0.1466
Echinococcus multilocularis cysteine protease 0.0017 0.0414 0.0491
Onchocerca volvulus 0.0017 0.0414 0.2448
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0414 0.0491
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0414 0.3223
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0414 0.2448
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.2677 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1872 0.2222
Brugia malayi cathepsin L-like precursor 0.0012 0.0148 0.0176
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0414 0.3223
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0235 0.0279
Schistosoma mansoni hypothetical protein 0.0171 0.746 0.8854
Loa Loa (eye worm) hypothetical protein 0.0013 0.0211 0.025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0414 0.3223
Onchocerca volvulus 0.0035 0.1235 1
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0906 0.1075
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0906 0.1075
Brugia malayi TAR-binding protein 0.0191 0.8426 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0414 0.0491
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0414 0.3223
Trichomonas vaginalis esterase, putative 0.0035 0.1235 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0414 0.3223
Mycobacterium ulcerans lipase LipD 0.0035 0.1235 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0414 0.3223
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0235 0.0279

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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