Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0026 | 0.0828 | 0.6142 | |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0215 | 0.0251 |
Onchocerca volvulus | 0.0026 | 0.0828 | 0.6142 | |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0016 | 0.0379 | 0.0443 |
Echinococcus multilocularis | musashi | 0.0026 | 0.0828 | 0.0968 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0828 | 0.0968 |
Onchocerca volvulus | 0.0016 | 0.0379 | 0.2157 | |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0828 | 0.0968 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0828 | 0.0968 |
Plasmodium vivax | vivapain-2 | 0.0016 | 0.0379 | 0.2875 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Brugia malayi | beta-lactamase | 0.0036 | 0.1264 | 0.1477 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.1264 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0016 | 0.0379 | 0.2157 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0135 | 0.0158 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0197 | 0.8553 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.0379 | 0.0443 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.1945 | 0.2274 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.2448 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.1264 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.4892 | 0.572 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0016 | 0.0379 | 0.0443 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.1264 | 1 |
Echinococcus multilocularis | geminin | 0.0176 | 0.7612 | 0.89 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0215 | 0.0251 |
Echinococcus multilocularis | cathepsin L | 0.0008 | 0.0022 | 0.0025 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.0828 | 0.0968 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.1264 | 0.1477 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1945 | 0.2274 |
Onchocerca volvulus | 0.0036 | 0.1264 | 1 | |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0016 | 0.0379 | 0.0443 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0016 | 0.0379 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.2448 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0016 | 0.0379 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0806 | 0.0943 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0016 | 0.0379 | 0.0443 |
Onchocerca volvulus | 0.0016 | 0.0379 | 0.2157 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 0.8553 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Onchocerca volvulus | 0.0036 | 0.1264 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0011 | 0.0135 | 0.0158 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0062 | 0.2448 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0016 | 0.0379 | 0.0443 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0008 | 0.0022 | 0.0025 |
Brugia malayi | cathepsin L-like precursor | 0.0011 | 0.0135 | 0.0158 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Onchocerca volvulus | 0.0016 | 0.0379 | 0.2157 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.2448 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.1264 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.2448 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0008 | 0.0022 | 0.0025 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.2448 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0011 | 0.0135 | 0.0915 |
Echinococcus granulosus | geminin | 0.0176 | 0.7612 | 0.89 |
Onchocerca volvulus | 0.0016 | 0.0379 | 0.2157 | |
Loa Loa (eye worm) | cysteine protease | 0.0016 | 0.0379 | 0.0443 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.0379 | 0.0443 |
Echinococcus multilocularis | lamin | 0.0026 | 0.0828 | 0.0968 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0008 | 0.0022 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1264 | 0.1477 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0016 | 0.0379 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.1264 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.1264 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.2448 | 1 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.2448 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0016 | 0.0379 | 0.0443 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0008 | 0.0022 | 0.0025 |
Schistosoma mansoni | lamin | 0.0026 | 0.0828 | 0.0968 |
Schistosoma mansoni | lamin | 0.0026 | 0.0828 | 0.0968 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1945 | 0.2274 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.0828 | 0.0968 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.1945 | 0.2274 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.1264 | 0.4277 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.0278 | 0.0325 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.2448 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.1264 | 0.5119 |
Loa Loa (eye worm) | ctsf protein | 0.0016 | 0.0379 | 0.0443 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0278 | 0.0325 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0193 | 0.0226 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0011 | 0.0135 | 0.3182 |
Echinococcus granulosus | lamin | 0.0026 | 0.0828 | 0.0968 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0197 | 0.8553 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0011 | 0.0135 | 0.0158 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.1264 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1945 | 0.2274 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.0379 | 0.0443 |
Echinococcus multilocularis | cysteine protease | 0.0016 | 0.0379 | 0.0443 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1264 | 0.1477 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.1264 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0135 | 0.0158 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.0379 | 0.0443 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0011 | 0.0135 | 0.0915 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.1264 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0379 | 0.0443 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.1264 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.2448 | 1 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.2448 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0016 | 0.0379 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0016 | 0.0379 | 0.0443 |
Onchocerca volvulus | 0.0016 | 0.0379 | 0.2157 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.2448 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0057 | 0.2204 | 0.8997 |
Onchocerca volvulus | 0.0016 | 0.0379 | 0.2157 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.2448 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Entamoeba histolytica | cysteine protease, putative | 0.0016 | 0.0379 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1264 | 0.1477 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0016 | 0.0379 | 0.0443 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.0828 | 0.0968 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.1264 | 0.5119 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.1264 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 0.8553 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0011 | 0.0135 | 0.0158 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1264 | 0.1477 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0828 | 0.0968 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.1264 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0215 | 0.0251 |
Loa Loa (eye worm) | TAR-binding protein | 0.0197 | 0.8553 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0197 | 0.8553 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0197 | 0.8553 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 0.8553 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0008 | 0.0022 | 0.0025 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0008 | 0.0022 | 0.0025 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0828 | 0.0968 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.0379 | 0.0443 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.1264 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0016 | 0.0379 | 0.2157 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0016 | 0.0379 | 0.1472 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0011 | 0.0135 | 0.0158 |
Onchocerca volvulus | 0.0016 | 0.0379 | 0.2157 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.4892 | 0.572 |
Echinococcus granulosus | cysteine protease | 0.0008 | 0.0022 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0135 | 0.0158 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0049 | 0.1847 | 0.7525 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.1264 | 0.5119 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.0379 | 0.0443 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1945 | 0.2274 |
Plasmodium vivax | vivapain-2 | 0.0016 | 0.0379 | 0.2875 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.0828 | 0.0968 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0016 | 0.0379 | 0.0443 |
Loa Loa (eye worm) | RNA binding protein | 0.0197 | 0.8553 | 1 |
Echinococcus granulosus | cathepsin L | 0.0008 | 0.0022 | 0.0025 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.1264 | 0.1477 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0016 | 0.0379 | 0.0443 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.2448 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1945 | 0.2274 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.2448 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.1264 | 0.1477 |
Onchocerca volvulus | Cathepsin L homolog | 0.0016 | 0.0379 | 0.2157 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.4892 | 0.572 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0193 | 0.0226 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.1264 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1264 | 0.1477 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1945 | 0.2274 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.1264 | 0.1477 |
Echinococcus granulosus | cathepsin l1 | 0.0011 | 0.0135 | 0.0158 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.1264 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 0.8553 | 1 |
Brugia malayi | TAR-binding protein | 0.0197 | 0.8553 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0016 | 0.0379 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.1264 | 0.1477 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.2448 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.1264 | 0.1477 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.2448 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1264 | 0.1477 |
Echinococcus multilocularis | cysteine protease | 0.0016 | 0.0379 | 0.0443 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.1264 | 0.1477 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.7612 | 0.89 |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 0.8553 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.7612 | 0.89 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0016 | 0.0379 | 0.0443 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0016 | 0.0379 | 0.0443 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.2448 | 1 |
Onchocerca volvulus | 0.0036 | 0.1264 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0379 | 0.2875 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.1264 | 0.1477 |
Brugia malayi | RNA binding protein | 0.0197 | 0.8553 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0016 | 0.0379 | 0.0443 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.1264 | 0.1477 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1945 | 0.2274 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.