Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable reductase | 0.0111 | 0.6806 | 0.8837 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0049 | 0.2299 | 0.2985 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.3494 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0017 | 0 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0049 | 0.2299 | 0.658 |
Plasmodium falciparum | thioredoxin reductase | 0.0049 | 0.2299 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0124 | 0.7701 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0111 | 0.6806 | 0.8837 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0111 | 0.6806 | 0.8837 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0111 | 0.6806 | 0.8837 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0111 | 0.6806 | 0.8837 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0017 | 0 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0124 | 0.7701 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0049 | 0.2299 | 0.658 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0017 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.2348 | 0.6722 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.3494 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3494 | 0.3494 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.2348 | 0.6722 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3494 | 0.3494 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0111 | 0.6806 | 0.8837 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0124 | 0.7701 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.2348 | 0.2348 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0 | 0.5 |
Brugia malayi | glutathione reductase | 0.0049 | 0.2299 | 0.658 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3494 | 0.3494 |
Plasmodium falciparum | glutathione reductase | 0.0049 | 0.2299 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0049 | 0.2299 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.2348 | 0.2348 |
Trypanosoma brucei | trypanothione reductase | 0.0049 | 0.2299 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0017 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.3494 | 1 |
Brugia malayi | RNA binding protein | 0.0065 | 0.3494 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.3494 | 1 |
Treponema pallidum | NADH oxidase | 0.0017 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.2348 | 0.6722 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.3494 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3494 | 0.3494 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0124 | 0.7701 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.3494 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0049 | 0.2299 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.2348 | 0.2348 |
Toxoplasma gondii | thioredoxin reductase | 0.0049 | 0.2299 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0049 | 0.2299 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0049 | 0.2299 | 0.658 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.2348 | 0.0414 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.2348 | 0.6722 |
Leishmania major | trypanothione reductase | 0.0049 | 0.2299 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.2348 | 0.6722 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3494 | 0.3494 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.3494 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0017 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.