TDR Targets

Basic information

Technical information

TDR Targets ID: 61139
Name: (1S,2R)-2-[2-(3,5-dioxomorpholin-4-yl)ethyl]- N-methyl-1-pyridin-3-ylcyclohexane-1-carbothi oamide
MW: 375.485 | Formula: C19H25N3O3S
H donors: 0 H acceptors: 3 LogP: 2.19 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: C/N=C(\[C@]1(CCCC[C@@H]1CCN1C(=O)COCC1=O)c1cccnc1)/S
InChi: 1S/C19H25N3O3S/c1-20-18(26)19(15-6-4-9-21-11-15)8-3-2-5-14(19)7-10-22-16(23)12-25-13-17(22)24/h4,6,9,11,14H,2-3,5,7-8,10,12-13H2,1H3,(H,20,26)/t14-,19+/m1/s1
InChiKey: OQKGDKBUMGZDKO-KUHUBIRLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(1S,2R)-2-[2-(3,5-dioxomorpholin-4-yl)ethyl]-N-methyl-1-(3-pyridyl)cyclohexanecarbothioamide
(1S,2R)-2-[2-(3,5-dioxo-4-morpholinyl)ethyl]-N-methyl-1-(3-pyridyl)cyclohexanecarbothioamide
(1S,2R)-2-[2-(3,5-dioxomorpholin-4-yl)ethyl]-N-methyl-1-pyridin-3-yl-cyclohexane-1-carbothioamide
(1S,2R)-2-[2-(3,5-diketomorpholino)ethyl]-N-methyl-1-(3-pyridyl)cyclohexanecarbothioamide
(1S,2R)-2-[2-(3,5-dioxomorpholin-4-yl)ethyl]-N-methyl-1-(3-pyridyl)cyclohexane-1-carbothioamide
(1S,2R)-2-[2-(3,5-dioxo-4-morpholinyl)ethyl]-N-methyl-1-(3-pyridyl)-1-cyclohexanecarbothioamide
(1S,2R)-2-[2-(3,5-diketomorpholin-4-yl)ethyl]-N-methyl-1-(3-pyridyl)cyclohexane-1-carbothioamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0078	0.0544	0.1133
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0532	0.48	0.48
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0037	0.0159	0.0159
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0251	0.0251
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0078	0.0544	0.1133
Trypanosoma cruzi	DNA polymerase eta, putative	0.0032	0.0116	0.0241
Schistosoma mansoni	RAR-like nuclear receptor	0.0078	0.0544	0.0544
Echinococcus multilocularis	flap endonuclease 1	0.0026	0.0064	0.0067
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0159	0.0159
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0078	0.0544	0.0544
Schistosoma mansoni	flap endonuclease-1	0.0024	0.004	0.004
Schistosoma mansoni	coup transcription factor	0.0078	0.0544	0.0544
Echinococcus granulosus	FTZ F1 alpha	0.0078	0.0544	0.0544
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0026	0.0064	0.0134
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0532	0.48	1
Brugia malayi	nuclear receptor NHR-88	0.0078	0.0544	0.1133
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0078	0.0544	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0159	0.0332
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0037	0.0159	0.0159
Brugia malayi	hypothetical protein	0.0037	0.0159	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0159	0.0332
Echinococcus multilocularis	transcription factor Dp 1	0.0308	0.2701	0.2809
Brugia malayi	nuclear receptor NHR-88	0.0037	0.0159	0.0332
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0419	0.0873
Leishmania major	DNA polymerase eta, putative	0.0045	0.0242	0.0505
Brugia malayi	RNA binding protein	0.0064	0.0419	0.0873
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0544	0.1133
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0037	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0159	0.0332
Schistosoma mansoni	nuclear hormone receptor	0.0037	0.0159	0.0159
Echinococcus granulosus	nuclear receptor nhr 48	0.0037	0.0159	0.0159
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0	0.5
Brugia malayi	photoreceptor-specific nuclear receptor	0.0078	0.0544	0.1133
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0251	0.0261
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.002	0	0.5
Leishmania major	hypothetical protein, conserved	0.0026	0.0056	0.0117
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0532	0.48	1
Echinococcus multilocularis	geminin	0.0172	0.1428	0.1485
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0544	0.1133
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0544	0.1133
Brugia malayi	hypothetical protein	0.0026	0.0056	0.0117
Schistosoma mansoni	nuclear receptor	0.0037	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0201	0.0418
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0532	0.48	1
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0544	0.1133
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0201	0.0418
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0037	0.0159	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0201	0.0418
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0041	0.0201	0.0418
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0078	0.0544	0.0565
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0078	0.0544	0.0565
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0078	0.0544	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0078	0.0544	0.1133
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0078	0.0544	0.1133
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0041	0.0201	0.0209
Schistosoma mansoni	hypothetical protein	0.0172	0.1428	0.1428
Brugia malayi	nuclear receptor NHR-67	0.0037	0.0159	0.0332
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0037	0.0159	0.0159
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0037	0.0159	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0159	0.0332
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0078	0.0544	0.1133
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0159	0.0159
Brugia malayi	ecdysteroid receptor	0.0078	0.0544	0.1133
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0532	0.48	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0037	0.0159	0.0332
Brugia malayi	hypothetical protein	0.0041	0.0201	0.0418
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0078	0.0544	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0159	0.0332
Schistosoma mansoni	nuclear receptor nhr-48	0.0037	0.0159	0.0159
Brugia malayi	ecdysone receptor	0.0037	0.0159	0.0332
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0251	0.0524
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0419	0.0419
Echinococcus granulosus	ecdysone induced protein 78C	0.0078	0.0544	0.0544
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0037	0.0159	0.0332
Schistosoma mansoni	nuclear hormone receptor	0.0078	0.0544	0.0544
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0419	0.0873
Entamoeba histolytica	hypothetical protein	0.0037	0.0159	0.033
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0078	0.0544	0.1133
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0419	0.0873
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0078	0.0544	0.0544
Brugia malayi	Nuclear hormone receptor E75	0.0037	0.0159	0.0332
Trypanosoma cruzi	DNA polymerase eta, putative	0.0045	0.0242	0.0505
Brugia malayi	conserved hypotetical protein	0.0037	0.0159	0.0332
Echinococcus multilocularis	dna polymerase eta	0.0045	0.0242	0.0252
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0037	0.0159	0.0166
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0032	0.0116	1
Echinococcus granulosus	dna polymerase eta	0.0045	0.0242	0.0242
Brugia malayi	nuclear hormone receptor	0.0078	0.0544	0.1133
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0078	0.0544	0.0565
Brugia malayi	Flap endonuclease-1	0.0026	0.0064	0.0134
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0078	0.0544	0.1133
Loa Loa (eye worm)	DR-78	0.0037	0.0159	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0159	0.0332
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0037	0.0159	0.0332
Leishmania major	DNA polymerase eta, putative	0.0032	0.0116	0.0241
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0078	0.0544	0.1133
Brugia malayi	Steroid receptor seven-up type 2	0.0078	0.0544	0.1133
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0041	0.0201	0.0201
Schistosoma mansoni	nuclear receptor	0.0037	0.0159	0.0159
Entamoeba histolytica	hypothetical protein	0.0037	0.0159	0.033
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0078	0.0544	0.1133
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0041	0.0201	0.0201
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0251	0.0251
Trichomonas vaginalis	flap endonuclease-1, putative	0.0026	0.0064	1
Trypanosoma brucei	DNA polymerase eta, putative	0.0045	0.0242	0.0505
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0159	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0201	0.0418
Brugia malayi	hypothetical protein	0.0041	0.0201	0.0418
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0251	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0544	0.1133
Echinococcus granulosus	thyroid hormone receptor alpha	0.0037	0.0159	0.0159
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0078	0.0544	0.0544
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0078	0.0544	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0242	0.0505
Schistosoma mansoni	retinoic acid receptor RXR	0.1087	1	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0056	0.0117
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0041	0.0201	0.0201
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0078	0.0544	0.1133
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0532	0.48	0.4991
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0078	0.0544	0.0544
Schistosoma mansoni	hypothetical protein	0.0037	0.0159	0.0159
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0419	0.0436
Schistosoma mansoni	thyroid hormone receptor	0.0078	0.0544	0.0544
Echinococcus granulosus	flap endonuclease 1	0.0026	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0159	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0056	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0544	0.1133
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.1046	0.9616	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0037	0.0159	0.0332
Echinococcus granulosus	geminin	0.0172	0.1428	0.1428
Entamoeba histolytica	hypothetical protein	0.0037	0.0159	0.033
Brugia malayi	TAR-binding protein	0.0064	0.0419	0.0873
Schistosoma mansoni	zinc finger protein	0.0037	0.0159	0.0159
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0026	0.0064	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0159	0.0332
Onchocerca volvulus	Bile acid receptor homolog	0.0078	0.0544	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0078	0.0544	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0159	0.0332
Onchocerca volvulus	Protein ultraspiracle homolog	0.0078	0.0544	1
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0419	0.0419
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0026	0.0064	0.1335
Brugia malayi	hypothetical protein	0.0037	0.0159	0.033
Schistosoma mansoni	hypothetical protein	0.0172	0.1428	0.1428
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0078	0.0544	0.0544
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0078	0.0544	0.0544
Brugia malayi	nuclear hormone receptor family member odr-7	0.0037	0.0159	0.0332
Plasmodium vivax	flap endonuclease 1, putative	0.0026	0.0064	1
Entamoeba histolytica	Flap nuclease, putative	0.0026	0.0064	0.0134
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0078	0.0544	0.1133
Brugia malayi	ImpB/MucB/SamB family protein	0.0045	0.0242	0.0505
Brugia malayi	hypothetical protein	0.0037	0.0159	0.0332
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0078	0.0544	0.0544
Mycobacterium ulcerans	DNA polymerase IV	0.002	0	0.5
Schistosoma mansoni	nuclear hormone receptor	0.0037	0.0159	0.0159
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0056	0.0117
Echinococcus granulosus	transcription factor Dp 1	0.0308	0.2701	0.2701
Echinococcus multilocularis	nuclear receptor nhr 48	0.0037	0.0159	0.0166
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0251	0.0251
Schistosoma mansoni	thyroid hormone receptor	0.0078	0.0544	0.0544
Brugia malayi	steroid hormone receptor	0.0078	0.0544	0.1133
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0201	0.0418
Echinococcus multilocularis	ecdysone induced protein 78C	0.0078	0.0544	0.0565
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0532	0.48	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0159	0.0332
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0078	0.0544	0.1133
Loa Loa (eye worm)	flap endonuclease-1	0.0026	0.0064	0.0134
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0078	0.0544	0.1133
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0078	0.0544	0.1133
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0078	0.0544	0.1133
Echinococcus multilocularis	FTZ F1 alpha	0.0078	0.0544	0.0565
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0419	0.0419
Loa Loa (eye worm)	steroid hormone receptor	0.0078	0.0544	0.1133
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0078	0.0544	0.0565
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0419	0.0873
Brugia malayi	Nuclear hormone receptor-like 1	0.0078	0.0544	0.1133
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0078	0.0544	0.0544
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0419	0.0419
Plasmodium falciparum	flap endonuclease 1	0.0026	0.0064	1
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0532	0.48	1
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0532	0.48	1
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0544	0.1133
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0078	0.0544	0.0544
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0026	0.0064	0.0134
Brugia malayi	Nuclear hormone receptor E75	0.0037	0.0159	0.0332
Brugia malayi	orphan nuclear receptor NR2E1	0.0037	0.0159	0.0332
Brugia malayi	Nuclear hormone receptor-like 1	0.0041	0.0201	0.0418
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0078	0.0544	0.0544
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0419	0.0419
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0532	0.48	0.48
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0037	0.0159	0.0166
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0037	0.0159	0.0159
Entamoeba histolytica	hypothetical protein	0.0037	0.0159	0.033
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0078	0.0544	0.1133
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0251	0.0261
Mycobacterium ulcerans	DNA polymerase IV	0.002	0	0.5
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0037	0.0159	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0159	0.0332
Giardia lamblia	Flap structure-specific endonuclease	0.0026	0.0064	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0251	0.0524
Brugia malayi	Nuclear hormone receptor-like 1	0.0041	0.0201	0.0418
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0037	0.0159	0.0159
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0078	0.0544	0.1133
Brugia malayi	nuclear receptor RXR	0.0037	0.0159	0.0332
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0078	0.0544	0.1133
Schistosoma mansoni	DNA polymerase eta	0.0045	0.0242	0.0242
Brugia malayi	tailless protein	0.0037	0.0159	0.0332
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0078	0.0544	0.0544
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0419	0.0419
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0078	0.0544	0.1133
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0159	0.0332
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0078	0.0544	0.1133
Brugia malayi	nuclear receptor RXR	0.0041	0.0201	0.0418
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0078	0.0544	0.0544
Brugia malayi	nuclear hormone receptor	0.0037	0.0159	0.0332
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0056	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0544	0.1133
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0251	0.0251
Onchocerca volvulus		0.0078	0.0544	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0159	0.0332

Activities

Activity type	Activity value	Assay description	Source	Reference
IC90 (functional)	= 0.1 uM	In vitro relaxation of de-endothelialized rat aortic strips toned with 20 mM KCl	ChEMBL.	8496928

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 9976767

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 61139