Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dna polymerase eta | 0.0043 | 0.0325 | 0.0325 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0243 | 0.0663 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0194 | 0.0229 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0217 | 0.073 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0041 | 0.0297 | 0.0819 |
Onchocerca volvulus | 0.0046 | 0.0366 | 1 | |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0687 | 0.8477 | 0.8477 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0292 | 0.3474 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0037 | 0.0243 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0037 | 0.0243 | 0.6501 |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.0243 | 0.0815 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0033 | 0.0194 | 0.1055 |
Brugia malayi | AMP-binding enzyme family protein | 0.0046 | 0.0366 | 0.123 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0231 | 0.0272 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0387 | 0.1301 |
Mycobacterium ulcerans | hypothetical protein | 0.0154 | 0.1724 | 1 |
Echinococcus granulosus | nuclear receptor co repressor related ncor | 0.0274 | 0.3251 | 0.3835 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0231 | 0.0231 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0041 | 0.0297 | 0.0819 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0231 | 0.0775 |
Schistosoma mansoni | DNA polymerase eta | 0.0043 | 0.0325 | 0.0384 |
Leishmania major | DNA polymerase eta, putative | 0.0043 | 0.0325 | 0.0901 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0046 | 0.0366 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0013 | 0.0045 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0046 | 0.0366 | 0.2062 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.003 | 0.0162 | 0.043 |
Echinococcus multilocularis | nuclear receptor co repressor related (ncor) | 0.0274 | 0.3251 | 0.3251 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0046 | 0.0366 | 0.102 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0046 | 0.0366 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0138 | 0.1527 | 0.4373 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.046 | 0.5607 | 0.6614 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0366 | 0.123 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0387 | 0.1301 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0037 | 0.0243 | 0.3812 |
Toxoplasma gondii | hypothetical protein | 0.0047 | 0.0373 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0154 | 0.1724 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0046 | 0.0366 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0243 | 0.0663 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0035 | 0.0217 | 0.1192 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0013 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0217 | 0.073 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.0243 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0046 | 0.0366 | 0.2062 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0217 | 0.073 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.2976 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0035 | 0.0217 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0043 | 0.0325 | 0.0384 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0687 | 0.8477 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0252 | 0.2976 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0043 | 0.0325 | 0.0901 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0046 | 0.0366 | 0.2062 |
Mycobacterium ulcerans | hypothetical protein | 0.0046 | 0.0366 | 0.2062 |
Echinococcus granulosus | neuropeptide s receptor | 0.046 | 0.5607 | 0.6614 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0231 | 0.6159 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0217 | 0.073 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.0243 | 0.0286 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0043 | 0.0325 | 0.0901 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0387 | 0.1301 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0387 | 0.1301 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0292 | 0.3474 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0046 | 0.0366 | 1 |
Brugia malayi | Inositol-1 | 0.0037 | 0.0243 | 0.0815 |
Echinococcus multilocularis | neuropeptide s receptor | 0.046 | 0.5607 | 0.5607 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0033 | 0.0193 | 0.1051 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.005 | 0.0411 | 0.1148 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0231 | 0.0272 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0194 | 0.0652 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0013 | 0.0016 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0687 | 0.8477 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0043 | 0.0325 | 0.1092 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0366 | 0.123 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0325 | 0.1092 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0138 | 0.1527 | 0.4373 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0013 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0243 | 0.0663 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0046 | 0.0366 | 0.2062 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0033 | 0.0193 | 0.1051 |
Brugia malayi | AMP-binding enzyme family protein | 0.0046 | 0.0366 | 0.123 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0013 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0366 | 0.123 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0035 | 0.0217 | 0.5 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0013 | 0.0016 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0231 | 0.6159 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0041 | 0.0297 | 0.0819 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0033 | 0.0193 | 0.1051 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0046 | 0.0366 | 0.2062 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0046 | 0.0366 | 0.2062 |
Leishmania major | DNA polymerase eta, putative | 0.003 | 0.0162 | 0.043 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0138 | 0.1527 | 0.4373 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0033 | 0.0193 | 0.1051 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0243 | 0.0663 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0243 | 0.0286 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0041 | 0.0297 | 0.0819 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.0243 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0046 | 0.0366 | 0.2062 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0292 | 0.3474 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0013 | 0.0013 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0035 | 0.0217 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0046 | 0.0366 | 0.123 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0013 | 0.0016 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0013 | 0.0016 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0231 | 0.6159 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0046 | 0.0366 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0046 | 0.0366 | 0.2062 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.046 | 0.5607 | 0.5607 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0292 | 0.3474 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0231 | 0.6159 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0046 | 0.0366 | 0.102 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.0243 | 0.0243 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0243 | 0.0286 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0231 | 0.0272 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0037 | 0.0243 | 0.5 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0035 | 0.0217 | 0.1192 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0037 | 0.0243 | 0.1341 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0046 | 0.0366 | 0.2062 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0046 | 0.0366 | 0.102 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0217 | 0.073 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0194 | 0.0652 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.