Detailed information for compound 612641

Basic information

Technical information
  • TDR Targets ID: 612641
  • Name: 4-(butyl-methylsulfamoyl)-N-[5-(2-methoxyphen yl)-1,3,4-oxadiazol-2-yl]benzamide
  • MW: 444.504 | Formula: C21H24N4O5S
  • H donors: 1 H acceptors: 5 LogP: 2.95 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN(S(=O)(=O)c1ccc(cc1)C(=O)Nc1nnc(o1)c1ccccc1OC)C
  • InChi: 1S/C21H24N4O5S/c1-4-5-14-25(2)31(27,28)16-12-10-15(11-13-16)19(26)22-21-24-23-20(30-21)17-8-6-7-9-18(17)29-3/h6-13H,4-5,14H2,1-3H3,(H,22,24,26)
  • InChiKey: NBCVQGMYEHKSOW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(butyl-methyl-sulfamoyl)-N-[5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl]benzamide
  • Oprea1_438126
  • ZINC02723454

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0425 0.0695
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.0788 0.0902
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0173 0.4057
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.0788 0.1287
Loa Loa (eye worm) nuclear receptor NHR-67 0.0013 0.0166 0.019
Brugia malayi nuclear hormone receptor 0.0027 0.0788 0.0902
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.0788 0.0902
Loa Loa (eye worm) hypothetical protein 0.0013 0.0166 0.019
Echinococcus multilocularis dna polymerase eta 0.0019 0.0425 0.0695
Loa Loa (eye worm) hypothetical protein 0.0012 0.0141 0.0162
Brugia malayi hypothetical protein 0.0013 0.0166 0.019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0425 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0425 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0425 1
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0141 0.3319
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.0788 0.0902
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.0788 0.1287
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0166 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0788 0.0902
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0141 0.0231
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0425 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0014 0.0233 0.038
Leishmania major DNA polymerase eta, putative 0.0019 0.0425 1
Schistosoma mansoni ap endonuclease 0.0018 0.0405 0.0661
Brugia malayi orphan nuclear receptor NR2E1 0.0013 0.0166 0.019
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0012 0.0141 0.3319
Loa Loa (eye worm) hypothetical protein 0.0013 0.0166 0.019
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0788 0.0902
Loa Loa (eye worm) hypothetical protein 0.0014 0.0233 0.0266
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0425 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0166 0.019
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.0788 0.1287
Loa Loa (eye worm) hypothetical protein 0.0013 0.0166 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0425 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0425 0.0487
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.092 0.1503
Brugia malayi tailless protein 0.0013 0.0166 0.019
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0012 0.0141 0.1535
Trichomonas vaginalis set domain proteins, putative 0.0238 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0425 1
Echinococcus granulosus nuclear receptor nhr 48 0.0013 0.0166 0.0336
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0425 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.0788 0.0902
Echinococcus granulosus CTD small phosphatase protein like 0.0012 0.0141 0.0286
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0012 0.0141 0.3489
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.092 0.1503
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0425 1
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0425 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.0788 0.1287
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0425 0.0861
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0012 0.0141 0.0162
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0166 0.0271
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0425 0.0695
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0012 0.0141 0.0231
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0405 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.0166 0.019
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.092 0.1861
Schistosoma mansoni ap endonuclease 0.0018 0.0405 0.0661
Brugia malayi ecdysone receptor 0.0013 0.0166 0.019
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.0788 0.1594
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0166 0.0336
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.0788 0.1594
Brugia malayi nuclear receptor RXR 0.0013 0.0166 0.019
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.0788 0.0902
Schistosoma mansoni thyroid hormone receptor 0.0149 0.612 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0788 0.1287
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0405 0.9512
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0166 0.0336
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0013 0.0166 0.019
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0872 0.1764
Loa Loa (eye worm) hypothetical protein 0.0013 0.0166 0.019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.092 0.1503
Brugia malayi nuclear receptor RXR 0.0014 0.0233 0.0266
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.0788 0.0902
Brugia malayi MH2 domain containing protein 0.012 0.4847 0.5546
Leishmania major hypothetical protein, conserved 0.0012 0.0141 0.3319
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0425 0.0288
Loa Loa (eye worm) hypothetical protein 0.0014 0.0233 0.0266
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0788 0.1287
Brugia malayi hypothetical protein 0.0013 0.0166 0.019
Schistosoma mansoni zinc finger protein 0.0013 0.0166 0.0271
Loa Loa (eye worm) hypothetical protein 0.0014 0.0233 0.0266
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0405 0.0463
Echinococcus granulosus thyroid hormone receptor alpha 0.0013 0.0166 0.0336
Brugia malayi steroid hormone receptor 0.0027 0.0788 0.0902
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0425 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0425 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.0788 0.0902
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0233 0.0266
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.0788 0.0902
Loa Loa (eye worm) hypothetical protein 0.0027 0.0788 0.0902
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0788 0.0902
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.0788 0.1594
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0425 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0425 0.0487
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0425 0.0695
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0405 0.9269
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0425 0.0487
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.0788 0.0902
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0425 0.0288
Brugia malayi nuclear hormone receptor family member odr-7 0.0013 0.0166 0.019
Echinococcus multilocularis 0.0012 0.0141 0.0231
Schistosoma mansoni nuclear receptor 0.0013 0.0166 0.0271
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.092 1
Schistosoma mansoni thyroid hormone receptor 0.0149 0.612 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0788 0.0902
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0788 0.1287
Brugia malayi hypothetical protein 0.0014 0.0233 0.0266
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.0788 0.1287
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0173 0.4057
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0425 1
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.4847 0.5546
Brugia malayi nuclear receptor NHR-67 0.0013 0.0166 0.019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0788 0.0902
Echinococcus granulosus dna polymerase eta 0.0019 0.0425 0.0861
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0425 0.0695
Loa Loa (eye worm) hypothetical protein 0.0027 0.0788 0.0902
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.0788 0.1287
Loa Loa (eye worm) hypothetical protein 0.0013 0.0166 0.019
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0425 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.8739 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0788 0.0902
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0405 0.0463
Echinococcus multilocularis nuclear receptor nhr 48 0.0013 0.0166 0.0271
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0012 0.0141 0.1535
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0014 0.0233 0.0471
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0788 0.1594
Loa Loa (eye worm) hypothetical protein 0.0013 0.0166 0.019
Loa Loa (eye worm) hypothetical protein 0.003 0.092 0.1053
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0013 0.0166 0.0271
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0233 0.0266
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0166 0.0271
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0014 0.0233 0.0266
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0141 0.0231
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.0788 0.0902
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.4847 0.5546
Loa Loa (eye worm) hypothetical protein 0.0013 0.0166 0.019
Echinococcus multilocularis thyroid hormone receptor alpha 0.0149 0.612 1
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0788 0.1287
Brugia malayi nuclear hormone receptor family member nhr-6 0.0013 0.0166 0.019
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.0788 0.1287
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.0788 0.0902
Trypanosoma brucei unspecified product 0.0019 0.0425 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.0788 0.1287
Brugia malayi nuclear receptor NHR-88 0.0027 0.0788 0.0902
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.0788 0.1287
Brugia malayi conserved hypotetical protein 0.0013 0.0166 0.019
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.0788 0.0632
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0425 1
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0012 0.0141 0.1535
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0013 0.0166 0.019
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0405 0.0267
Loa Loa (eye worm) nuclear hormone receptor 0.0013 0.0166 0.019
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0405 0.4399
Toxoplasma gondii exonuclease III APE 0.0018 0.0405 0.4399
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0425 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0788 0.0902
Loa Loa (eye worm) hypothetical protein 0.0027 0.0788 0.0902
Schistosoma mansoni hypothetical protein 0.0122 0.4943 0.8077
Echinococcus granulosus FTZ F1 alpha 0.0027 0.0788 0.1594
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0166 0.0271
Loa Loa (eye worm) hypothetical protein 0.0014 0.0233 0.0266
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0425 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0788 0.0902
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0233 0.038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.0788 0.0902
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0166 0.019
Giardia lamblia DINP protein human, muc B family 0.0019 0.0425 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0166 0.019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0425 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.0788 0.0632
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0425 0.0487
Loa Loa (eye worm) hypothetical protein 0.0013 0.0166 0.019
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0405 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0405 0.0267
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0425 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.0788 0.0902
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0405 0.9512
Onchocerca volvulus 0.0027 0.0788 0.0632
Loa Loa (eye worm) hypothetical protein 0.0013 0.0166 0.019
Trypanosoma brucei unspecified product 0.0013 0.0173 0.4057
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.0788 0.1594
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.0788 0.0632
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0405 0.9269
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.0788 0.1594
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0425 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.0788 0.0902
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0166 0.019
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0425 1
Schistosoma mansoni nuclear receptor nhr-48 0.0013 0.0166 0.0271
Brugia malayi Pre-SET motif family protein 0.0209 0.8739 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0788 0.0902
Loa Loa (eye worm) hypothetical protein 0.0013 0.0166 0.019
Brugia malayi hypothetical protein 0.0014 0.0233 0.0266
Schistosoma mansoni coup transcription factor 0.0027 0.0788 0.1287
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.0788 0.0902
Schistosoma mansoni nuclear receptor 0.0013 0.0166 0.0271
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0405 0.0819
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0788 0.0902
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.092 0.1503
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.4943 0.8077
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0014 0.0233 0.038
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.092 0.1503
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0013 0.0166 0.0271
Schistosoma mansoni hypothetical protein 0.0012 0.0135 0.022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.0788 0.0902
Loa Loa (eye worm) hypothetical protein 0.0027 0.0788 0.0902
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0166 0.0271
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0012 0.0141 0.0286
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0013 0.0166 0.0271
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0405 0.5
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.0788 0.1287
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0405 0.9512
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.0788 0.0902
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0425 1
Loa Loa (eye worm) DR-78 0.0013 0.0166 0.019
Brugia malayi Pre-SET motif family protein 0.003 0.092 0.1053
Echinococcus granulosus dna polymerase kappa 0.0019 0.0425 0.0861
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0405 0.0661
Brugia malayi nuclear hormone receptor 0.0013 0.0166 0.019
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.0788 0.1287
Brugia malayi nuclear receptor NHR-88 0.0013 0.0166 0.019
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0166 0.0271
Trypanosoma brucei unspecified product 0.0013 0.0173 0.4057
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.0788 0.1594
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0425 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0233 0.0266
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.092 0.1503
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0788 0.1594
Loa Loa (eye worm) hypothetical protein 0.0012 0.0135 0.0154
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.0788 0.1287
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0173 0.4057
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.0788 0.1287
Brugia malayi ecdysteroid receptor 0.0027 0.0788 0.0902
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.0788 0.1287
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.4943 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0013 0.0166 0.0271
Schistosoma mansoni DNA polymerase eta 0.0019 0.0425 0.0695
Onchocerca volvulus 0.003 0.092 0.0767
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0425 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0788 0.0902
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0405 0.9512
Plasmodium vivax SET domain protein, putative 0.003 0.092 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0013 0.0166 0.0336
Leishmania major DNA polymerase kappa, putative 0.0019 0.0425 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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