Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0828 | 0.1651 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.0828 | 0.2504 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0828 | 0.1651 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0093 | 0.7728 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0828 | 0.1651 |
Leishmania major | trypanothione reductase | 0.0037 | 0.2497 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0828 | 0.1651 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0828 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0013 | 0.027 | 0.0539 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0084 | 0.6861 | 0.8837 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0828 | 0.2504 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0037 | 0.2497 | 0.2985 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0.0828 | 0.2504 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 0.0828 | 0.1651 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 0.0828 | 0.1651 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0013 | 0.027 | 0.027 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0093 | 0.7728 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0013 | 0.027 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0037 | 0.2497 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0084 | 0.6861 | 0.8837 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.5014 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0037 | 0.2497 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0828 | 0.1651 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.5014 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.5014 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0828 | 0.2504 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.0828 | 0.2504 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0828 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.2497 | 0.4979 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0828 | 0.2504 |
Trypanosoma brucei | unspecified product | 0.0013 | 0.0288 | 0.0081 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0828 | 0.2504 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.5014 | 0.5014 |
Treponema pallidum | NADH oxidase | 0.0013 | 0.027 | 0.5 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0828 | 0.2504 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0037 | 0.2542 | 0.507 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0828 | 0.2504 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0828 | 0.2504 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.5014 | 0.5014 |
Plasmodium falciparum | thioredoxin reductase | 0.0037 | 0.2497 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0828 | 0.0828 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0828 | 0.0748 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0828 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0828 | 0.2504 |
Plasmodium vivax | glutathione reductase, putative | 0.0037 | 0.2497 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.5014 | 0.5014 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0828 | 0.2504 |
Brugia malayi | glutathione reductase | 0.0037 | 0.2497 | 0.4979 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.5014 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0037 | 0.2497 | 0.4979 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0828 | 0.0748 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0.027 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0828 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0828 | 0.2504 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0828 | 0.1651 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0084 | 0.6861 | 0.8837 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0093 | 0.7728 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0084 | 0.6861 | 0.8837 |
Mycobacterium tuberculosis | Probable reductase | 0.0084 | 0.6861 | 0.8837 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0084 | 0.6861 | 0.8837 |
Plasmodium falciparum | glutathione reductase | 0.0037 | 0.2497 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.5014 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0828 | 0.2504 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0288 | 0.0081 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0828 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 0.0828 | 0.2504 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.5014 | 0.5014 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.0828 | 0.2504 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0013 | 0.027 | 0.0539 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0828 | 0.0828 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0828 | 0.2504 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 0.0828 | 0.0828 |
Loa Loa (eye worm) | glutathione reductase | 0.0037 | 0.2497 | 0.4979 |
Trypanosoma brucei | unspecified product | 0.0013 | 0.0288 | 0.0081 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0288 | 0.0081 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0037 | 0.2542 | 0.507 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.0828 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0828 | 0.1651 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.5014 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0093 | 0.7728 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0828 | 0.1651 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0828 | 0.2504 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.0828 | 0.2504 |
Brugia malayi | RNA binding protein | 0.0064 | 0.5014 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0828 | 0.2504 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.5014 | 0.5014 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.5014 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0828 | 0.2504 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0013 | 0.027 | 0.0539 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0288 | 0.0081 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0.027 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0828 | 0.2504 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0037 | 0.2497 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0037 | 0.2497 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0828 | 0.2504 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.