Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.504 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0828 | 0.2504 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.0288 | 0.0081 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0828 | 0.2504 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.0828 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0039 | 0.2497 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0039 | 0.2497 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0828 | 0.2504 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.002 | 0.0828 | 0.0828 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.002 | 0.0828 | 0.0748 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.504 | 0.504 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0.0828 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0039 | 0.2497 | 0.2985 |
Trypanosoma brucei | unspecified product | 0.002 | 0.0828 | 0.2504 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0828 | 0.2504 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.004 | 0.2542 | 0.5044 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0828 | 0.2504 |
Treponema pallidum | NADH oxidase | 0.0014 | 0.027 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0828 | 0.2504 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.504 | 0.504 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0828 | 0.2504 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0014 | 0.027 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0828 | 0.2504 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0.0828 | 0.0748 |
Loa Loa (eye worm) | glutathione reductase | 0.0039 | 0.2497 | 0.4953 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.504 | 1 |
Leishmania major | trypanothione reductase | 0.0039 | 0.2497 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0039 | 0.2497 | 0.4953 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0828 | 0.1643 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0099 | 0.7728 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.0828 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.002 | 0.0828 | 0.2504 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0828 | 0.1643 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0014 | 0.027 | 0.0536 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0828 | 0.2504 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0089 | 0.6861 | 0.8837 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0.0828 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.002 | 0.0828 | 0.1643 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0089 | 0.6861 | 0.8837 |
Brugia malayi | Thioredoxin reductase | 0.0039 | 0.2497 | 0.4953 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0014 | 0.027 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0099 | 0.7728 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0014 | 0.027 | 0.027 |
Echinococcus granulosus | dna polymerase eta | 0.002 | 0.0828 | 0.1643 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.002 | 0.0828 | 0.2504 |
Echinococcus multilocularis | dna polymerase eta | 0.002 | 0.0828 | 0.1643 |
Plasmodium falciparum | thioredoxin reductase | 0.0039 | 0.2497 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.002 | 0.0828 | 0.2504 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0828 | 0.2504 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.504 | 0.504 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.504 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0828 | 0.1643 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0039 | 0.2497 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.504 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0828 | 0.2504 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0828 | 0.1643 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0099 | 0.7728 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.504 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.0828 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.002 | 0.0828 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0039 | 0.2497 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0828 | 0.2504 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.504 | 0.504 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.504 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0828 | 0.2504 |
Brugia malayi | RNA binding protein | 0.0068 | 0.504 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.002 | 0.0828 | 0.2504 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0828 | 0.2504 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0288 | 0.0081 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0014 | 0.027 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0014 | 0.027 | 0.0536 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0828 | 0.2504 |
Plasmodium vivax | glutathione reductase, putative | 0.0039 | 0.2497 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.004 | 0.2542 | 0.5044 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0089 | 0.6861 | 0.8837 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0089 | 0.6861 | 0.8837 |
Mycobacterium tuberculosis | Probable reductase | 0.0089 | 0.6861 | 0.8837 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0099 | 0.7728 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0089 | 0.6861 | 0.8837 |
Echinococcus granulosus | dna polymerase kappa | 0.002 | 0.0828 | 0.1643 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0288 | 0.0081 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0828 | 0.2504 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.504 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0039 | 0.2497 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0828 | 0.2504 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.002 | 0.0828 | 0.0828 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0014 | 0.027 | 0.0536 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.504 | 0.504 |
Echinococcus multilocularis | dna polymerase kappa | 0.002 | 0.0828 | 0.1643 |
Leishmania major | DNA polymerase eta, putative | 0.002 | 0.0828 | 0.2504 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0828 | 0.1643 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0288 | 0.0081 |
Brugia malayi | glutathione reductase | 0.0039 | 0.2497 | 0.4953 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.0288 | 0.0081 |
Schistosoma mansoni | DNA polymerase eta | 0.002 | 0.0828 | 0.0828 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.