Detailed information for compound 613409

Basic information

Technical information
  • TDR Targets ID: 613409
  • Name: (Z)-2-[4-(4-methylphenyl)-1,3-thiazol-2-yl]-3 -[(2-nitrophenyl)amino]prop-2-enenitrile
  • MW: 362.405 | Formula: C19H14N4O2S
  • H donors: 1 H acceptors: 4 LogP: 4.87 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C/C(=C/Nc1ccccc1[N+](=O)[O-])/c1scc(n1)c1ccc(cc1)C
  • InChi: 1S/C19H14N4O2S/c1-13-6-8-14(9-7-13)17-12-26-19(22-17)15(10-20)11-21-16-4-2-3-5-18(16)23(24)25/h2-9,11-12,21H,1H3/b15-11-
  • InChiKey: MGOSDFJYTAUNNN-PTNGSMBKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (Z)-2-[4-(4-methylphenyl)thiazol-2-yl]-3-[(2-nitrophenyl)amino]prop-2-enenitrile
  • (Z)-2-[4-(4-methylphenyl)-2-thiazolyl]-3-[(2-nitrophenyl)amino]prop-2-enenitrile
  • (Z)-2-[4-(4-methylphenyl)thiazol-2-yl]-3-[(2-nitrophenyl)amino]acrylonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0109 0.0991 0.1718
Onchocerca volvulus Alhambra homolog 0.003 0.0046 0.0122
Brugia malayi hypothetical protein 0.0057 0.0376 0.1139
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0848 0.0602
Loa Loa (eye worm) hypothetical protein 0.0152 0.151 0.4639
Schistosoma mansoni methyl-cpg binding protein mbd 0.0068 0.0497 0.0857
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0759 0.1314
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0109 0.0991 0.3045
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0861 1 1
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0046 0.0128
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.0848 0.0926
Loa Loa (eye worm) RNA binding protein 0.0248 0.2655 0.8156
Brugia malayi nuclear hormone receptor family member nhr-6 0.0051 0.0302 0.0912
Schistosoma mansoni transient receptor potential channel 0.0064 0.0449 0.0773
Trichomonas vaginalis conserved hypothetical protein 0.0205 0.2146 0.1934
Brugia malayi hypothetical protein 0.0051 0.0302 0.0912
Brugia malayi PHD-finger family protein 0.003 0.0046 0.0122
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0109 0.0991 0.3032
Echinococcus multilocularis transcription factor btf3 0.0205 0.2146 0.2353
Loa Loa (eye worm) hypothetical protein 0.0068 0.0497 0.1528
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0861 0.094
Loa Loa (eye worm) hypothetical protein 0.0057 0.0376 0.1155
Schistosoma mansoni hypothetical protein 0.0505 0.574 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0759 0.1314
Schistosoma mansoni steroid hormone receptor ad4bp 0.0109 0.0991 0.1718
Entamoeba histolytica hypothetical protein 0.0105 0.0942 0.0512
Giardia lamblia Kinase, PLK 0.0097 0.0848 0.0806
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0068 0.0497 0.054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0109 0.0991 0.3045
Brugia malayi nuclear receptor NHR-67 0.0051 0.0302 0.0912
Brugia malayi tailless protein 0.0051 0.0302 0.0912
Trypanosoma cruzi transcription factor btf3, putative 0.0205 0.2146 1
Brugia malayi hypothetical protein 0.0298 0.3255 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0861 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0077 0.0237
Loa Loa (eye worm) bromodomain containing protein 0.007 0.0527 0.1617
Loa Loa (eye worm) ICD-1 protein 0.0205 0.2146 0.6591
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0848 0.0602
Trypanosoma brucei polo-like protein kinase 0.0097 0.0848 0.2508
Loa Loa (eye worm) hypothetical protein 0.0051 0.0302 0.0929
Entamoeba histolytica hypothetical protein 0.0105 0.0942 0.0512
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0057 0.0376 0.0646
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0237 0.2524 0.4391
Loa Loa (eye worm) hypothetical protein 0.0109 0.0991 0.3045
Schistosoma mansoni nuclear receptor 0.0051 0.0302 0.0517
Schistosoma mansoni tar DNA-binding protein 0.0248 0.2655 0.462
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0449 0.0773
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0848 0.2508
Loa Loa (eye worm) hypothetical protein 0.0036 0.0116 0.0355
Loa Loa (eye worm) steroid hormone receptor 0.0109 0.0991 0.3045
Brugia malayi Steroid receptor seven-up type 2 0.0109 0.0991 0.3032
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0648 0.0631
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.034 0.0367
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0759 0.0829
Brugia malayi PHD-finger family protein 0.0099 0.0871 0.2662
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0109 0.0991 0.3032
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0848 0.0602
Brugia malayi nuclear receptor NHR-88 0.0051 0.0302 0.0912
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0317 0.0342
Echinococcus granulosus peregrin 0.0039 0.0158 0.0265
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0142 0.1394 0.1527
Loa Loa (eye worm) hypothetical protein 0.0096 0.0839 0.2578
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0131 0.0218
Loa Loa (eye worm) hypothetical protein 0.0109 0.0991 0.3045
Schistosoma mansoni tar DNA-binding protein 0.0248 0.2655 0.462
Brugia malayi conserved hypotetical protein 0.0051 0.0302 0.0912
Schistosoma mansoni transcription factor btf3 0.0205 0.2146 0.3732
Brugia malayi jmjC domain containing protein 0.0044 0.0212 0.0633
Loa Loa (eye worm) hypothetical protein 0.0051 0.0302 0.0929
Onchocerca volvulus 0.0051 0.0302 0.0912
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0109 0.0991 0.1718
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0109 0.0991 0.3045
Loa Loa (eye worm) DR-78 0.0051 0.0302 0.0929
Trichomonas vaginalis conserved hypothetical protein 0.0205 0.2146 0.1934
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0109 0.0991 0.1718
Echinococcus granulosus methyl CpG binding domain protein 2 0.0068 0.0497 0.0857
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0861 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0411 0.1262
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0109 0.0991 0.1718
Loa Loa (eye worm) hypothetical protein 0.0051 0.0302 0.0929
Schistosoma mansoni hypothetical protein 0.0082 0.0667 0.1154
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0848 0.2508
Loa Loa (eye worm) hypothetical protein 0.0051 0.0302 0.0926
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0759 0.0829
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0759 0.1314
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0109 0.0991 0.3032
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0109 0.0991 0.3032
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0089 0.0758 0.0827
Echinococcus multilocularis transient receptor potential gamma protein 0.0096 0.0839 0.0916
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0116 0.0191
Echinococcus multilocularis transient receptor potential ion channel A 0.0093 0.0801 0.0874
Schistosoma mansoni nuclear hormone receptor 0.0109 0.0991 0.1718
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0861 1 1
Loa Loa (eye worm) TAR-binding protein 0.0248 0.2655 0.8156
Loa Loa (eye worm) hypothetical protein 0.0109 0.0991 0.3045
Echinococcus granulosus tar DNA binding protein 0.0248 0.2655 0.462
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0453 0.1393
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0109 0.0991 0.3032
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0057 0.0376 0.0646
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0109 0.0991 0.3045
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0046 0.0044
Brugia malayi Nuclear hormone receptor E75 0.0051 0.0302 0.0912
Schistosoma mansoni hypothetical protein 0.003 0.0046 0.0069
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0051 0.0302 0.0326
Echinococcus multilocularis FTZ F1 alpha 0.0109 0.0991 0.1083
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0142 0.1394 0.2422
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0051 0.0302 0.0326
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0109 0.0991 0.3032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0109 0.0991 0.3045
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0046 0.0069
Loa Loa (eye worm) hypothetical protein 0.0051 0.0302 0.0929
Brugia malayi TAR-binding protein 0.0248 0.2655 0.8153
Onchocerca volvulus 0.0109 0.0991 0.3032
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0109 0.0991 0.3032
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0109 0.0991 0.1718
Onchocerca volvulus Protein ultraspiracle homolog 0.0109 0.0991 0.3032
Brugia malayi photoreceptor-specific nuclear receptor 0.0109 0.0991 0.3032
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0186 0.0198
Echinococcus granulosus thyroid hormone receptor alpha 0.0051 0.0302 0.0517
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.0848 0.1469
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.0848 0.2606
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0051 0.0302 0.0912
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0453 0.0228
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0848 0.0602
Brugia malayi Bromodomain containing protein 0.0297 0.3251 0.9986
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.0848 0.2508
Loa Loa (eye worm) hypothetical protein 0.0109 0.0991 0.3045
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0648 0.5
Echinococcus multilocularis tar DNA binding protein 0.0248 0.2655 0.2913
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0861 1 1
Schistosoma mansoni kinase 0.0049 0.0277 0.0473
Echinococcus granulosus geminin 0.0505 0.574 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0648 0.0707
Echinococcus granulosus Nuclear hormone receptor HR96 0.0051 0.0302 0.0517
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0109 0.0991 0.3032
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0449 0.0487
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0861 1 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0648 0.1339
Schistosoma mansoni hypothetical protein 0.0105 0.0942 0.1633
Plasmodium falciparum basic transcription factor 3b, putative 0.0205 0.2146 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0648 0.2962
Loa Loa (eye worm) nuclear receptor NHR-67 0.0051 0.0302 0.0929
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0109 0.0991 0.3032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0759 0.1314
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0109 0.0991 0.1718
Loa Loa (eye worm) hypothetical protein 0.0051 0.0302 0.0929
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0105 0.0942 0.103
Loa Loa (eye worm) hypothetical protein 0.0051 0.0302 0.0929
Brugia malayi nuclear receptor RXR 0.0057 0.0376 0.1139
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0131 0.0137
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0057 0.0376 0.0407
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0648 0.1121
Treponema pallidum fructose-bisphosphate aldolase 0.0861 1 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.034 0.0582
Onchocerca volvulus Bile acid receptor homolog 0.0109 0.0991 0.3032
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.042 0.4725 1
Brugia malayi Nuclear hormone receptor-like 1 0.0057 0.0376 0.1139
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0212 0.0359
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0109 0.0991 0.1718
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0109 0.0991 0.3032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0109 0.0991 0.3045
Brugia malayi RNA recognition motif domain containing protein 0.0248 0.2655 0.8153
Schistosoma mansoni nuclear hormone receptor 0.0051 0.0302 0.0517
Loa Loa (eye worm) hypothetical protein 0.008 0.0648 0.1992
Onchocerca volvulus 0.0298 0.3255 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0057 0.0376 0.1155
Echinococcus granulosus histone lysine methyltransferase setb 0.0068 0.0497 0.0857
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0302 0.0326
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0046 0.014
Brugia malayi Nuclear hormone receptor-like 1 0.0109 0.0991 0.3032
Schistosoma mansoni lipoxygenase 0.0054 0.034 0.0582
Schistosoma mansoni transient receptor potential channel 4 0.0096 0.0839 0.1453
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0051 0.0302 0.0517
Echinococcus granulosus ecdysone induced protein 78C 0.0109 0.0991 0.1718
Loa Loa (eye worm) nuclear hormone receptor 0.0051 0.0302 0.0929
Brugia malayi nuclear hormone receptor 0.0109 0.0991 0.3032
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0109 0.0991 0.1718
Schistosoma mansoni nuclear receptor nhr-48 0.0051 0.0302 0.0517
Schistosoma mansoni transient receptor potential channel 0.0064 0.0449 0.0773
Brugia malayi Nuclear hormone receptor E75 0.0051 0.0302 0.0912
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0089 0.0758 0.1312
Brugia malayi nuclear hormone receptor family member odr-7 0.0051 0.0302 0.0912
Schistosoma mansoni tar DNA-binding protein 0.0248 0.2655 0.462
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0759 0.1314
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0109 0.0991 0.3032
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0248 0.2655 0.8156
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0759 0.2319
Loa Loa (eye worm) hypothetical protein 0.0298 0.3255 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0109 0.0991 0.1083
Loa Loa (eye worm) hypothetical protein 0.0051 0.0302 0.0929
Echinococcus multilocularis ecdysone induced protein 78C 0.0109 0.0991 0.1083
Echinococcus multilocularis geminin 0.0505 0.574 0.6305
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0648 0.2962
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0105 0.0942 0.1633
Brugia malayi RNA binding protein 0.0248 0.2655 0.8153
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0109 0.0991 0.1718
Brugia malayi Bromodomain containing protein 0.0039 0.0158 0.0468
Loa Loa (eye worm) hypothetical protein 0.0051 0.0302 0.0929
Loa Loa (eye worm) hypothetical protein 0.0051 0.0302 0.0929
Plasmodium vivax hypothetical protein, conserved 0.003 0.0046 0.0128
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0427 0.1312
Loa Loa (eye worm) hypothetical protein 0.028 0.3047 0.9362
Brugia malayi ecdysone receptor 0.0051 0.0302 0.0912
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0317 0.0635
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.0848 0.2593
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0121 0.0127
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0453 0.1377
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0497 0.0857
Echinococcus multilocularis nuclear receptor nhr 48 0.0051 0.0302 0.0326
Plasmodium vivax basic transcription factor 3b, putative 0.0205 0.2146 1
Schistosoma mansoni RAR-like nuclear receptor 0.0109 0.0991 0.1718
Loa Loa (eye worm) PHD-finger family protein 0.0082 0.0667 0.2051
Schistosoma mansoni transcription factor LCR-F1 0.0105 0.0942 0.1633
Schistosoma mansoni zinc finger protein 0.0078 0.0617 0.1066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0376 0.1155
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.042 0.4725 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0051 0.0302 0.0929
Loa Loa (eye worm) hypothetical protein 0.0109 0.0991 0.3045
Loa Loa (eye worm) hypothetical protein 0.0169 0.1713 0.5264
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0861 1 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0453 0.0492
Echinococcus granulosus zinc finger protein 0.0078 0.0617 0.1066
Echinococcus granulosus FTZ F1 alpha 0.0109 0.0991 0.1718
Brugia malayi ecdysteroid receptor 0.0109 0.0991 0.3032
Schistosoma mansoni nuclear receptor 0.0051 0.0302 0.0517
Schistosoma mansoni thyroid hormone receptor 0.0109 0.0991 0.1718
Brugia malayi beta-NAC-like protein 0.0205 0.2146 0.6585
Trypanosoma brucei transcription factor BTF3, putative 0.0205 0.2146 1
Echinococcus granulosus transient receptor potential ion channel A 0.0093 0.0801 0.1386
Loa Loa (eye worm) hypothetical protein 0.0109 0.0991 0.3045
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0497 0.0857
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0109 0.0991 0.1718
Entamoeba histolytica hypothetical protein 0.0105 0.0942 0.0512
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0186 0.0314
Echinococcus multilocularis thyroid hormone receptor alpha 0.0109 0.0991 0.1083
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0449 0.0487
Brugia malayi steroid hormone receptor 0.0109 0.0991 0.3032
Brugia malayi Nuclear hormone receptor-like 1 0.0057 0.0376 0.1139
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0051 0.0302 0.0912
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0109 0.0991 0.1718
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0109 0.0991 0.1083
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0861 1 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.0848 0.2593
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0848 0.1469
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0116 0.0338
Schistosoma mansoni jumonji domain containing protein 0.0078 0.062 0.107
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0051 0.0302 0.0517
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0302 0.0517
Echinococcus granulosus fetal alzheimer antigen falz 0.0089 0.0758 0.1312
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0051 0.0302 0.0517
Brugia malayi hypothetical protein 0.0105 0.0942 0.2882
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0648 0.2962
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0051 0.0302 0.0326
Schistosoma mansoni coup transcription factor 0.0109 0.0991 0.1718
Loa Loa (eye worm) hypothetical protein 0.0109 0.0991 0.3045
Loa Loa (eye worm) hypothetical protein 0.0109 0.0991 0.3045
Trichomonas vaginalis conserved hypothetical protein 0.0205 0.2146 0.1934
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0449 0.0773
Brugia malayi hypothetical protein 0.0057 0.0376 0.1139
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0453 0.0228
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0051 0.0302 0.0326
Brugia malayi nuclear hormone receptor 0.0051 0.0302 0.0912
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0861 1 1
Toxoplasma gondii NAC domain-containing protein 0.0205 0.2146 1
Entamoeba histolytica hypothetical protein 0.0205 0.2146 0.1773
Brugia malayi hypothetical protein 0.0051 0.0302 0.0912
Schistosoma mansoni hypothetical protein 0.0505 0.574 1
Brugia malayi orphan nuclear receptor NR2E1 0.0051 0.0302 0.0912
Echinococcus granulosus transient receptor potential gamma protein 0.0096 0.0839 0.1453
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0109 0.0991 0.3032
Leishmania major basic transcription factor 3a, putative 0.0205 0.2146 1
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0848 0.0602
Loa Loa (eye worm) hypothetical protein 0.0057 0.0376 0.1155
Loa Loa (eye worm) hypothetical protein 0.0051 0.0302 0.0929
Brugia malayi nuclear receptor NHR-88 0.0109 0.0991 0.3032
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0861 1 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.042 0.4725 1
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0648 0.1121
Entamoeba histolytica transcription factor BTF3, putative 0.0205 0.2146 0.1773
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.0848 0.0414
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.91 1
Echinococcus multilocularis zinc finger protein 0.0078 0.0617 0.0672
Schistosoma mansoni nuclear hormone receptor 0.0051 0.0302 0.0517
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0006 0.0018
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0453 0.0228
Brugia malayi nuclear receptor RXR 0.0051 0.0302 0.0912
Loa Loa (eye worm) hypothetical protein 0.0162 0.1623 0.4985
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0109 0.0991 0.1718
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0861 0.1491
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0317 0.0543
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0046 0.0128
Schistosoma mansoni transient receptor potential channel 0.0096 0.0839 0.1453
Onchocerca volvulus 0.0051 0.0302 0.0912
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0051 0.0302 0.0912
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0648 0.2962
Brugia malayi Probable ClpP-like protease 0.008 0.0648 0.1978
Schistosoma mansoni tar DNA-binding protein 0.0248 0.2655 0.462
Schistosoma mansoni bromodomain containing protein 0.0251 0.2694 0.4688
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0648 0.5
Loa Loa (eye worm) hypothetical protein 0.0057 0.0376 0.1155
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0109 0.0991 0.1083
Echinococcus multilocularis peregrin 0.0039 0.0158 0.0167
Loa Loa (eye worm) hypothetical protein 0.0027 0.0006 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0848 0.0602
Echinococcus granulosus nuclear receptor nhr 48 0.0051 0.0302 0.0517
Schistosoma mansoni thyroid hormone receptor 0.0109 0.0991 0.1718
Loa Loa (eye worm) hypothetical protein 0.0057 0.0376 0.1155
Schistosoma mansoni methyl-cpg binding protein mbd 0.0068 0.0497 0.0857
Trypanosoma cruzi transcription factor btf3, putative 0.0205 0.2146 1
Echinococcus granulosus transcription factor btf3 0.0205 0.2146 0.3732
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0453 0.0228
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0109 0.0991 0.3032
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0116 0.0121
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0109 0.0991 0.1083
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0109 0.0991 0.3045
Loa Loa (eye worm) hypothetical protein 0.0051 0.0302 0.0929
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0453 0.0781
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0006 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0248 0.2655 0.462
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0453 0.0781
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0212 0.0359
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0848 0.0602
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0237 0.2524 0.2769
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0759 0.2333
Echinococcus granulosus lysine specific demethylase 5A 0.0044 0.0212 0.0359
Loa Loa (eye worm) hypothetical protein 0.0051 0.0302 0.0929
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0212 0.065
Schistosoma mansoni zinc finger protein 0.0061 0.0414 0.0712
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0648 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0109 0.0991 0.1083
Brugia malayi jmjC domain containing protein 0.0098 0.0861 0.2631
Entamoeba histolytica hypothetical protein 0.0105 0.0942 0.0512
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0057 0.0376 0.0646
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0109 0.0991 0.1083
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0068 0.0497 0.054
Brugia malayi Bromodomain containing protein 0.0152 0.1507 0.4619
Plasmodium falciparum phd finger protein, putative 0.003 0.0046 0.0128
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0109 0.0991 0.1718
Echinococcus granulosus Nuclear hormone receptor HR96 0.0051 0.0302 0.0517
Schistosoma mansoni retinoic acid receptor RXR 0.0109 0.0991 0.1718
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0109 0.0991 0.3032
Schistosoma mansoni hypothetical protein 0.0061 0.0414 0.0712
Schistosoma mansoni zinc finger protein 0.0051 0.0302 0.0517
Loa Loa (eye worm) hypothetical protein 0.0051 0.0302 0.0929
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0046 0.0069

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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