Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.2527 | 0.2527 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0015 | 0.5544 | 0.5544 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.2527 | 0.2527 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.2527 | 0.2527 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.2527 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.2527 | 0.2527 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.2527 | 0.2527 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0024 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.2527 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.2527 | 0.2527 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.2527 | 0.2527 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.2527 | 0.2527 |
Brugia malayi | isocitrate dehydrogenase | 0.0015 | 0.5544 | 0.5544 |
Plasmodium vivax | T-complex protein 1 subunit beta, putative | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.2527 | 0.2527 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.2527 | 0.2527 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.2527 | 0.2527 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.2527 | 0.2527 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.2527 | 0.2527 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.2527 | 0.2527 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.2527 | 0.2527 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.2527 | 0.2527 |
Trypanosoma cruzi | T-complex protein 1, beta subunit, putative | 0.0024 | 1 | 1 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0024 | 1 | 1 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.2527 | 0.2527 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.2527 | 0.2527 |
Toxoplasma gondii | t-complex protein beta subunit | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0015 | 0.5544 | 0.5544 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.2527 | 0.2527 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.2527 | 0.2527 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.2527 | 0.2527 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.2527 | 0.2527 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.5544 | 0.5544 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.2527 | 0.2527 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.2527 | 0.2527 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.2527 | 0.2527 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.2527 | 0.2527 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.2527 | 0.2527 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.2527 | 0.2527 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.2527 | 0.2527 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.2527 | 0.2527 |
Onchocerca volvulus | 0.001 | 0.2527 | 0.5 | |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.2527 | 0.2527 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.2527 | 0.2527 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.2527 | 0.2527 |
Trypanosoma brucei | T-complex protein 1, beta subunit, putative | 0.0024 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.2527 | 0.2527 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.2527 | 0.2527 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.2527 | 0.2527 |
Trichomonas vaginalis | chaperonin-60kD, ch60, putative | 0.0024 | 1 | 0.5 |
Entamoeba histolytica | T-complex protein 1 beta subunit, putative | 0.0024 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.2527 | 0.2527 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.2527 | 0.2527 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.2527 | 0.2527 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.2527 | 0.2527 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.2527 | 0.2527 |
Brugia malayi | Isocitrate dehydrogenase | 0.0015 | 0.5544 | 0.5544 |
Echinococcus granulosus | chaperonin containing TCP1 subunit 2 beta | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.2527 | 0.2527 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.2527 | 0.2527 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0015 | 0.5544 | 0.5 |
Leishmania major | T-complex protein 1, beta subunit, putative | 0.0024 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.2527 | 0.2527 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.2527 | 0.2527 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.5544 | 0.5544 |
Trichomonas vaginalis | chaperonin, putative | 0.0024 | 1 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.2527 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.2527 | 0.2527 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.2527 | 0.2527 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.2527 | 0.2527 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.2527 | 0.2527 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0024 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.2527 | 0.2527 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.2527 | 0.2527 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.5544 | 0.5544 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.2527 | 0.2527 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.2527 | 0.2527 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0015 | 0.5544 | 0.5544 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0015 | 0.5544 | 0.5544 |
Plasmodium falciparum | T-complex protein 1 subunit beta | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | T-complex protein 1 | 0.0024 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.2527 | 0.2527 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.2527 | 0.2527 |
Echinococcus multilocularis | chaperonin containing TCP1, subunit 2 (beta) | 0.0024 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.2527 | 0.2527 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.2527 | 0.2527 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.2527 | 0.2527 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.2527 | 0.2527 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0024 | 1 | 1 |
Giardia lamblia | TCP-1 chaperonin subunit beta | 0.0024 | 1 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.2527 | 0.2527 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.2527 | 0.2527 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.2527 | 0.2527 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.2527 | 0.2527 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.5544 | 0.5544 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.2527 | 0.2527 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.2527 | 0.2527 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.2527 | 0.2527 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.2527 | 0.2527 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.