Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.2293 | 0.4216 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0456 | 0.0742 |
Brugia malayi | CHE-14 protein | 0.0041 | 0.167 | 0.2481 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0041 | 0.167 | 0.3039 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.157 | 0.0491 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.2168 | 0.398 |
Echinococcus multilocularis | expressed conserved protein | 0.009 | 0.496 | 0.3949 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0456 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0456 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0456 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1135 | 0.2027 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.3622 | 0.6468 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.2168 | 0.3498 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.157 | 0.0491 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0456 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0063 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.3622 | 0.6468 |
Echinococcus multilocularis | geminin | 0.0165 | 1 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0456 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2168 | 0.398 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.007 | 0.3622 | 0.2343 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.167 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0456 | 1 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.3622 | 0.6468 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0456 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.3622 | 0.6468 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0456 | 0.0742 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.157 | 0.0491 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.3622 | 0.2805 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0456 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0456 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0096 | 0.5351 | 0.4418 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0456 | 0.5 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0063 | 0.139 |
Schistosoma mansoni | patched 1 | 0.0041 | 0.167 | 0.0604 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0063 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0456 | 1 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0096 | 0.5351 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 1 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0047 | 0.2061 | 0.0469 |
Echinococcus granulosus | expressed conserved protein | 0.009 | 0.496 | 0.3949 |
Brugia malayi | hypothetical protein | 0.007 | 0.3622 | 0.6468 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.2168 | 0.3498 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.007 | 0.3622 | 0.2343 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.167 | 0.3039 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0456 | 0.0742 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0063 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0456 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0456 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.1135 | 0.1387 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0137 | 0.8117 | 0.774 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.5351 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0097 | 0.545 | 0.4868 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0096 | 0.5351 | 0.4418 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0096 | 0.5351 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0456 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.157 | 0.0491 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0456 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.007 | 0.3622 | 0.2805 |
Onchocerca volvulus | 0.0023 | 0.0456 | 0.5 | |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0137 | 0.8117 | 0.774 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.