Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.2772 | 0.2772 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0285 | 0.0285 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0033 | 0.2772 | 0.2772 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.2772 | 0.2772 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.2772 | 0.2772 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.2772 | 0.2561 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.2674 | 0.2674 |
Echinococcus multilocularis | musashi | 0.0033 | 0.2772 | 0.2772 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2772 | 0.2772 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.2772 | 0.2772 |
Onchocerca volvulus | 0.0033 | 0.2772 | 0.5 | |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.2772 | 0.2772 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.2772 | 0.2561 |
Echinococcus granulosus | lamin | 0.0033 | 0.2772 | 0.2772 |
Onchocerca volvulus | 0.0033 | 0.2772 | 0.5 | |
Brugia malayi | TAR-binding protein | 0.0076 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.4125 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 141.2538 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.